The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Predictors of Conversion to Multiple Sclerosis in Patients with Clinical Isolated Syndrome Using the 2010 Revised McDonald Criteria
Open accessAbstract
Background. Clinically isolated syndrome (CIS) is the first neurologic episode of multiple sclerosis (MS). Magnetic resonance imaging (MRI) and clinical features are used to predict risk of conversion to MS. Objectives. The aim of this prospective study is to evaluate predictors of conversion of CIS to McDonald MS. Method. 97 patients with CIS have been followed for 2 years. Age of onset, gender, initial clinical presentation, and MRI brain and spine were assessed. The 2010 revised McDonald criteria were applied. Results. Fifty-nine patients (60.8%) with CIS converted to McDonald MS after 10.1 + 4.2 months. Thirty-seven (38.1%) of the convertors satisfied the diagnostic criteria based on the radiological parameters, while 21.7% sustained their second clinical events. A multivariate regression analysis revealed that high number of lesions in MRI (P=0.001) and earlier age of onset (P=0.043) predicted the conversion of CIS to McDonald MS. Gender (P=0.5) and initial clinical presentation (optic pathway (P=0.4), supratentorial (P=0.91), brain stem/ cerebellum (P=0.97), and spinal (P=0.76)) were not statistically significant. Conclusion. Age of onset and MRI parameters can be used as predictors of CIS conversion to McDonald MS. Application of the 2010 revised McDonald criteria allows an earlier MS diagnosis.
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Several studies support the applicability of the 2010 McDonald Criteria in children.
“Several studies support the applicability of the 2010 McDonald Criteria in children. 29-36”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [30]
The Discussion states that the 2010 McDonald criteria were applicable in this study and allowed earlier MS diagnosis. But the Results describe a CIS cohort with a mean age of 26.88 years, and the paper does not establish applicability specifically in children. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe McDonald Criteria are generally most applicable for patients 11 years of age or older; special care is needed in patients younger than 11 years old in whom the likelihood of MS is lower.
“The McDonald Criteria are generally most applicable for patients 11 years of age or older; special care is needed in patients younger than 11 years old in whom the likelihood of MS is lower. 30”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [30]
The Methods section groups patients by age at onset below or above 30, and the Results and Discussion associate younger onset with greater conversion risk in this cohort. No passage found addresses whether the McDonald criteria are generally applicable from age 11 or require special care below that age (searched: age 11, pediatric applicability). (LLM, conf=0.72)
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A longitudinal study of abnormalities on MRI and disability from multiple sclerosis
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Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167
Metadata
- Authors
- Alroughani, R., Al Hashel, J., Lamdhade, S., & Ahmed, S. F.
- Affiliations
- Amiri Hospital (KW)
- Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait
- Ibn Sina Hospital (KW)
- Corresponding author
- Alroughani, R.
- Venue
- ISRN Neurology
- Publisher
- Hindawi Limited
- Published
- 2012-11-01
- Volume
- 2012
- Pages
- 1-6
- ISSN
- 2090-5505 (ISSN-L)
- 2090-5513
- PMC
- PMC3503301
- OpenAlex
- W2015313650
- Cited by
- 28
- References
- 1
- Citations by year
- 2026: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- ISRN Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Keywords
- clinically isolated syndrome, conversion to multiple sclerosis, age of onset, risk prediction, spinal MRI
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