Biomedicinal Implications of High-Density Lipoprotein: Its Composition, Structure, Functions, and Clinical Applications

Cho, Kyung-Hyun

doi:10.5483/bmbrep.2009.42.7.393

Cited by 74Cholesterol and Lipid MetabolismParaoxonase enzyme and polymorphismsLipoproteins and Cardiovascular Health

Biomedicinal Implications of High-Density Lipoprotein: Its Composition, Structure, Functions, and Clinical Applications

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Cho, Kyung-Hyun·2009·BMB Reports

DOI 10.5483/bmbrep.2009.42.7.393

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Abstract

High-density lipoprotein (HDL) is a proven biomarker for the monitoring of changes in antioxidant and anti-inflammation capability of body fluids. The beneficial virtues of HDL are highly dependent on its lipids and protein compositions, and their ratios. In normal state, the HDL particle is enriched with lipids and several HDL-associated enzymes, which are responsible for its antioxidant activity. Lower HDL-cholesterol levels (40 mg/dL) have been recognized as an independent risk factor for coronary artery disease, as well as being a known component of metabolic syndrome. Functional and structural changes of HDL have been recognized as factors pivotal to the evaluation of HDL-quality. In this review, I have elected to focus on the functional and structural correlations of HDL and the roles of HDL-associated apolipoproteins and enzymes. Recent clinical applications of HDL have also been reviewed, particularly the therapeutic targeting of HDL metabolism and reconstituted HDL; these techniques represent promising emerging strategies for the treatment of cardiovascular disease, for drug or gene therapy.

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Ascorbic acid fosters anti-senescence and anti-atherosclerotic effects via an improvement of lipoprotein parameters and microRNA expression through anti-oxidation and anti-glycation, especially in smokers.
“This vitamin has also been demonstrated to foster anti-senescence and anti-atherosclerotic effects via an improvement of lipoprotein parameters and microRNA expression through anti-oxidation and anti-glycation, especially in smokers [127,128,129].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [128]

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Authors: Cho, K.-H.
Affiliations: Yeungnam University (KR)
Corresponding author: Cho, Kyung-Hyun
ORCID: Cho, Kyung-Hyun
Venue: BMB Reports
Publisher: Korean Society for Biochemistry and Molecular Biology - BMB Reports
Published: 2009-07-31
Volume: 42
Issue: 7
Pages: 393-400
ISSN: 1976-6696 (ISSN-L)
DOI: 10.5483/bmbrep.2009.42.7.393
OpenAlex: W2040707824
Cited by: 74
References: 73
Citations by year: 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 8 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 8 · 2012: 8
FWCI: 1.06
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: BMB Reports (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Yeungnam University
Korea Science and Engineering Foundation (R13-2005-005-01003-0)
Topics: Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords: high-density lipoprotein, HDL structure, HDL composition, antioxidant activity, anti-inflammatory activity, apolipoproteins, HDL-associated enzymes, HDL cholesterol, coronary artery disease, metabolic syndrome, HDL quality, HDL metabolism, reconstituted HDL, cardiovascular disease treatment, drug delivery, gene therapy
MeSH terms: Animals, Anti-Inflammatory Agents, Antioxidants, Apolipoproteins, Humans, Phosphatidylcholine-Sterol O-Acyltransferase, Lipoproteins, HDL, Models, Biological, Drug Delivery Systems, Biomedical Technology, Aryldialkylphosphatase, Atherosclerosis, Cholesterol Ester Transfer Proteins

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Biomedicinal Implications of High-Density Lipoprotein: Its Composition, Structure, Functions, and Clinical Applications

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