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Cited by 391

The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.

Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment

Open access
Salvadori, Maurizio, Rosso, Giuseppina, Bertoni, Elisabetta·2015·World Journal of Transplantation
DOI 10.5500/wjt.v5.i2.52
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Abstract

Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney transplantation and influences short term as well as long-term graft outcome. Clinically ischemia/reperfusion injury is associated with delayed graft function, graft rejection, chronic rejection and chronic graft dysfunction. Ischemia/reperfusion affects many regulatory systems at the cellular level as well as in the renal tissue that result in a distinct inflammatory reaction of the kidney graft. Underlying factors of ischemia reperfusion include energy metabolism, cellular changes of the mitochondria and cellular membranes, initiation of different forms of cell death-like apoptosis and necrosis together with a recently discovered mixed form termed necroptosis. Chemokines and cytokines together with other factors promote the inflammatory response leading to activation of the innate immune system as well as the adaptive immune system. If the inflammatory reaction continues within the graft tissue, a progressive interstitial fibrosis develops that impacts long-term graft outcome. It is of particular importance in kidney transplantation to understand the underlying mechanisms and effects of ischemia/reperfusion on the graft as this knowledge also opens strategies to prevent or treat ischemia/reperfusion injury after transplantation in order to improve graft outcome.

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Metadata

Authors
Salvadori, M., Rosso, G., & Bertoni, E.
Venue
World Journal of Transplantation
Publisher
Baishideng Publishing Group Inc.
Published
2015
Volume
5
Issue
2
Pages
52
ISSN
2220-3230 (ISSN-L)
DOI
10.5500/wjt.v5.i2.52
OpenAlex
W2407574550
Cited by
391
References
115
FWCI
23.11
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. https://app.cochat.ai/papers/10.5500/wjt.v5.i2.52
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Salvadori, M., Rosso, G., & Bertoni, E. (2015). Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. World Journal of Transplantation. https://doi.org/10.5500/wjt.v5.i2.52

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.