The DOI matches its Crossref record; 359 of the 359 references it cites were found in a registry or an index.
Sperm DNA Fragmentation: A New Guideline for Clinicians
Open accessAbstract
Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. In light of these clinical case reports and recent scientific evidence, this review provides expert recommendations on SDF testing and examines the advantages and drawbacks of the clinical utility of SDF testing using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis.
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Cites
1 retracted
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The International Glossary on Infertility and Fertility Care, 2017
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The importance of repairing stalled replication forks
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Cited by
Bibi, R., Jahan, S., Afsar, T., Almajwal, A., Hammadeh, M. E., Amor, H., Abusharha, A., & Razak, S. (2023) · Biomedicines · doi:10.3390/biomedicines11020467 · Cited by 15
Metadata
- Authors
- Agarwal, A., Majzoub, A., Baskaran, S., Panner Selvam, M. K., Cho, C. L., Henkel, R., Finelli, R., Leisegang, K., Sengupta, P., Barbarosie, C., Parekh, N., Alves, M. G., Ko, E., Arafa, M., Tadros, N., Ramasamy, R., Kavoussi, P., Ambar, R., Kuchakulla, M., Robert, K. A., Iovine, C., Durairajanayagam, D., Jindal, S., & Shah, R.
- Venue
- The World Journal of Men's Health
- Publisher
- XMLink
- Published
- 2020
- Volume
- 38
- Issue
- 4
- Pages
- 412
- ISSN
- 2287-4208 (ISSN-L)
- 2287-4690
- OpenAlex
- W3048835988
- Cited by
- 316
- References
- 359
- FWCI
- 24.59
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Agarwal, A., Majzoub, A., Baskaran, S., Panner Selvam, M. K., Cho, C. L., Henkel, R., Finelli, R., Leisegang, K., Sengupta, P., Barbarosie, C., Parekh, N., Alves, M. G., Ko, E., Arafa, M., Tadros, N., Ramasamy, R., Kavoussi, P., Ambar, R., Kuchakulla, M., . . . Shah, R. (2020). Sperm DNA Fragmentation: A New Guideline for Clinicians. The World Journal of Men's Health. https://doi.org/10.5534/wjmh.200128
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
