Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study
Abstract
Background and aims Higher intake of fish or n-3 polyunsaturated fatty acids (PUFAs) has been associated with reduced risk of coronary heart disease (CHD). However, it is unclear whether increased blood levels of n-3 PUFAs are associated with reduced risk of CHD in the Japanese population.Methods The relationship between circulating levels of n-3 PUFAs (eicosapentaenoic acid + docosapentaenoic acid + docosahexaenoic acid) and risk of CHD was examined in a nested case-control study among participants in the Japan Public Health Center (JPHC)-based Study Cohort. Plasma n-3 PUFA phospholipid levels were measured at baseline by gas chromatography in 209 cases with CHD and 418 controls matched for sex, age, date of blood draw, time elapsed since last meal before blood collection, and study location. The CHD cases (n = 209) comprised 168 cases of myocardial infarction and 41 of sudden cardiac death, otherwise classified as 157 non-fatal and 52 fatal coronary events, respectively. Mean duration of follow-up was 13.5 years.Results Multivariate conditional logistic analysis showed no significant association between n-3 PUFAs and risk of total CHD. The odds ratio (OR) for the highest versus lowest quartiles of plasma n-3 PUFAs was 0.79 (95% confidence interval [95% CI]: 0.41-1.51, p for trend = 0.51). Subtype analysis of CHD revealed that the multivariate ORs for the highest versus lowest quartiles for n-3 PUFAs were 0.91 (95% CI: 0.43-1.89, p for trend = 0.90) for myocardial infarction, 0.08 (95% CI: 0.01-0.88, p for trend = 0.04) for sudden cardiac death, 0.89 (95% CI: 0.42-1.89, p for trend = 0.97) for nonfatal coronary events, and 0.12 (95% CI: 0.02-0.75, p for trend = 0.03) for fatal coronary events.Conclusions Plasma n-3 PUFA levels were not associated with risk of total CHD but were inversely associated with risks of sudden cardiac death and fatal coronary events among middle-aged Japanese individuals.
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There are conflicting data on whether PUFA affects sudden cardiac death.
“There are also some opposite data on the possible effect of polyunsaturated omega-3 fatty acids (PUFA) on sudden cardiac death (138,139).”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [139]
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- Authors
- Hamazaki, K., Iso, H., Eshak, E. S., Ikehara, S., Ikeda, A., Iwasaki, M., Hamazaki, T., Tsugane, S., Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Goto, A., Hidaka, A., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Doi, M., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R., Sou, Y., Sakiyama, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., & Sato, Y.
- Affiliations
- University of Toyama (JP)
- Minia University (EG)
- The University of Osaka (JP)
- Juntendo University (JP)
- National Cancer Centre Japan (JP)
- Corresponding author
- Hamazaki, Kei
- ORCID
- Hamazaki, Kei
- Eshak, Ehab S.
- Ikehara, Satoyo
- Ikeda, Ai
- Iwasaki, Motoki
- Sawada, N.
- Yamaji, T.
- Shimazu, T.
- Hidaka, A.
- Hanaoka, T.
- Okayama, A.
- Kokubo, Y.
- Suzuki, H.
- Suzuki, N.
- Shirai, Y.
- Sasaki, R.
- Watanabe, Y.
- Kobayashi, Y.
- Kobayashi, K.
- Ito, F.
- Abe, T.
- Suzuki, M.
- Ishikawa, Y.
- Goto, H.
- Nakasone, T.
- Yamaguchi, H.
- Suzuki, K.
- Yamagishi, K.
- Matsumura, Y.
- Sasaki, S.
- Kadowaki, T.
- Inoue, M.
- Noda, M.
- Nakamura, K.
- Ishihara, J.
- Shimizu, H.
- Hamajima, N.
- Saito, I.
- Yasuda, N.
- Kono, S.
- Akiba, S.
- Sato, Y.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 272
- Pages
- 226-232
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2771403408
- Cited by
- 27
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2014: 1
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center of Neurology and Psychiatry
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- omega-3 fatty acids, coronary artery disease, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, myocardial infarction, sudden cardiac death, Japanese population, fish consumption, cardiovascular risk factors, nested case-control
- MeSH terms
- Adult, Aged, Coronary Disease, Feeding Behavior, Female, Fish Products, Follow-Up Studies, Humans, Japan, Male, Middle Aged, Public Health, Surveys and Questionnaires, Risk Factors, Fatty Acids, Omega-3, Multivariate Analysis, Odds Ratio, Case-Control Studies, Death, Sudden, Cardiac
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