Elevated Levels of Oxidative Stress as a Prognostic Predictor of Major Adverse Cardiovascular Events in Patients with Coronary Artery Disease
Open accessAbstract
AIMS: To evaluate the prognostic significance of oxidative stress on the rate of major adverse cardiovascular events (MACEs: cardiac and all-cause death, nonfatal myocardial infarction, coronary revascularization-PTCA/CABG) in CAD. METHODS: We studied 97 angiographically proven CAD patients (78 males, age: 67±11 years, mean± SD). Reactive oxygen metabolites and total antioxidant status, assessed by commercially assays (d-ROMs and OXY-Adsorbent Test; Diacron, Grosseto, GR, Italy), were used to calculate the oxidant/antioxidant balance. Patient data were collected from the Institute's electronic databank, which saves demographic, clinical, instrumental and follow-up data of all patients admitted to our department. RESULTS: Kaplan-Meier survival estimates showed a significantly worst outcome in patients presenting with elevated oxidative stress levels (>75th percentile, p<0.01). Multivariate Cox models showed that a higher level of oxidative stress was an independent predictor of developing MACEs (hazard ratio=2.1, confidence intervals 1.2-3.6, p<0.01). CONCLUSION: Oxidative stress may represent a useful additional tool in the prediction of MACE in CAD.
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A reduction in elevated CRP and reactive oxygen metabolites is associated with a reduction in major cardiovascular events.
“there is evidence to suggest that a reduction in elevated CRP 79 and reactive oxygen metabolites 80 is associated with a reduction in major cardiovascular events.”
From <scp>Glucagon‐like peptide‐1 receptor agonists</scp> improve biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomised controlled trials (2021) · cites this paper as [80]
The Results (page not provided) show that patients with higher baseline oxidative stress had more major adverse cardiovascular events; reactive oxygen metabolites were one component of the index measured. The paper does not show that reducing metabolite levels reduces events: it measured baseline levels and followed patients for outcomes. CRP is attached to a different citation in the citing sentence and is not judged here. (LLM, conf=0.85)
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“Clinical and experimental studies have shown that disturbing of oxidant-antioxidant balance system is involved in the pathogenesis of chronic diseases such as cancer (6), coronary heart disease (7, 8), diabetes and many diabetic complications (9).”
Background"Aluminium Induces Iron-Mediated Oxidative Stress in Brain Tissue"
Vieželienė, D. (2022) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2022.42.006771 · Cited by 2 · see citing works
Balta, Ş., Akar, M., & Demırkol, S. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.17384 · Cited by 2 · see citing works
Colombino, E., Biasato, I., Vezzaro, G., Amante, E., Biagini, D., Cavallarin, L., Guerra, N., Guil-Alcalà, P., Mioletti, S., Perona, G., et al. (2021) · Italian Journal of Animal Science · doi:10.1080/1828051x.2021.1993756
“In human medicine, it has been pointed out that oxidative stress can be considered a negative prognostic factor for cardiovascular diseases (Vassalle et al. 2012).”
Background
- Authors
- Vassalle, C., Bianchi, S., Battaglia, D., Landi, P., Bianchi, F., & Carpeggiani, C.
- Affiliations
- Istituto di Fisiologia Clinica (IT)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2012
- Volume
- 19
- Issue
- 8
- Pages
- 712-7
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2014263101
- Cited by
- 55
- References
- 24
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 5
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- oxidative stress, major adverse cardiovascular events, coronary artery disease, prognostic factors, prooxidant-antioxidant balance, reactive oxygen species, total antioxidant status, myocardial infarction, coronary revascularization, mortality
- MeSH terms
- Aged, Antioxidants, Coronary Artery Disease, Female, Humans, Male, Prognosis, Risk Factors, Tomography, X-Ray Computed, Survival Rate, Coronary Angiography, Reactive Oxygen Species, Oxidative Stress
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