Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise‐Induced Muscle Damage through Enhancement of Mitochondrial Quality Control
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Mounting evidence has firmly established that increased exercise capacity (EC) is associated with considerable improvements in the survival of patients with cardiovascular disease (CVD) and that antistress capacity is a prognostic predictor of adverse cardiovascular events in patients with CVD. Previous studies have indicated that aerobic exercise (AE) and supplementation with Rhodiola sacra (RS), a natural plant pharmaceutical, improve EC and enable resistance to stress; however, the underlying mechanism remains unclear. This study explored the ability of AE and RS, alone or combined, to improve EC and ameliorate exhaustive exercise‐ (EE‐) induced stress and elucidate the mechanism involved. We found that AE and RS significantly increased EC in mice and ameliorated EE‐induced stress damage in skeletal and cardiac muscles (SCM); furthermore, a synergistic effect was detected for the first time. To our knowledge, the present work is the first to report that AE and RS activate mitophagy, mitochondrial dynamics, and biogenesis in SCM, both in the resting state and after EE. These data indicate that AE and RS synergistically improve EC in mice and protect SCM from EE‐induced stress by enhancing mitochondrial quality control, including the activation of mitophagy, mitochondrial dynamics, and biogenesis, both at rest and after EE.
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After 5 weeks of swimming training, mice exhibited increased basal mitophagy in vivo, indicated by a higher LC3-II/LC3-I ratio and elevated BNIP3 in the mitochondrial fraction, contributing to skeletal muscle adaptation and enhanced muscle strength.
“after 5 weeks of swimming training, mice exhibited increased levels of basal mitophagy in vivo, as indicated by a higher LC3-II/LC3-I ratio and elevated BNIP3 levels in the mitochondrial fraction, thereby contributing to skeletal muscle adaptation and enhanced muscle strength [45].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [45]
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The Use of Vitamins, Supplements, Herbs, and Essential Oils in Rehabilitation
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Exercise prevents fatal stress-induced myocardial injury in obese mice
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Enhancing Exercise Performance with Natural Products: A Comprehensive Review
Rani, A. S., 강소진, Kim, S., Kim, J., Kim, J., Eldeen, M. A., Ko, E., Im, C.-J., Park, M. N., Jeong, Y., et al. (2026) · Nutrients · doi:10.3390/nu18152450
- Authors
- Dun, Y., Liu, S., Zhang, W., Xie, M., & Qiu, L.
- Affiliations
- Central South University (CN)
- Corresponding author
- Liu, Suixin
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 8024857-8024857
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5735688
- OpenAlex
- W2770854947
- Cited by
- 46
- References
- 56
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 1 · 2023: 4 · 2022: 10 · 2021: 8 · 2020: 3 · 2019: 6 · 2018: 3
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Natural Science Foundation of Hunan Province (2013SK5076)
- National Natural Science Foundation of China (81672262)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- aerobic exercise, exercise capacity, exhaustive exercise, exercise-induced muscle damage, mitochondrial quality control, mitophagy, mitochondrial dynamics, mitochondrial biogenesis, skeletal muscle, myocardium, synergistic supplementation, stress tolerance
- MeSH terms
- Animals, Male, Mice, Inbred C57BL, Mitochondria, Physical Conditioning, Animal, Plant Extracts, Quality Control, Muscle, Skeletal, Muscle Fatigue, Dietary Supplements, Rhodiola, Mice
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