Leptin resistance and lipolysis of white adipose tissue: an implication to ectopic fat disposition and its consequences
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Dysfunctional insulin production occurs, gradually leading to insulin resistance.
“Thereby, dysfunctional insulin production occurs, gradually leading to insulin resistance (28).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [28]
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Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327 · see citing works
Obesity and leptin resistance: distinguishing cause from effect
Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.002 · Cited by 906 · see citing works
Direct antidiabetic effect of leptin through triglyceride depletion of tissues
Shimabukuro, M., Koyama, K., Chen, G., Wang, M.-Y., Trieu, F., Lee, Y., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4637 · Cited by 646 · see citing works
Self-citationThe Function of Leptin in Nutrition, Weight, and Physiology
Friedman, J. M. (2002) · Nutrition Reviews · doi:10.1301/002966402320634878 · Cited by 505 · see citing works
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O'Doherty, R. M., Newgard, C. B., & Unger, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14795 · Cited by 315 · see citing works
Cardiac Adiposity and Global Cardiometabolic Risk New Concept and Clinical Implication
Shimabukuro, M. (2008) · Circulation Journal · doi:10.1253/circj.cj-08-1012 · Cited by 116 · see citing works
Self-citationCircumventing leptin resistance for weight control
Kalra, S. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091101498 · Cited by 60 · see citing works
Koyama, K., Shimabukuro, M., Chen, G., Wang, M. Y., Lee, Y., Kalra, P. S., Dube, M. G., Kalra, S. P., Newgard, C. B., & Unger, R. H. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3353 · Cited by 45 · see citing works
Self-citationRole of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering
Takanashi, M., Taira, Y., Okazaki, S., Takase, S., Kimura, T., Li, C. C., Xu, P., Noda, A., Sakata, I., Kumagai, H., et al. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.39552 · Cited by 9 · see citing works
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Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
Zamboni, M., Rubele, S., & Rossi, A. P. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000519 · Cited by 173 · see citing works
- Authors
- Shimabukuro, M.
- Affiliations
- Fukushima Medical University (JP)
- Corresponding author
- Shimabukuro, Michio
- ORCID
- Shimabukuro, Michio
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2017
- Volume
- 24
- Issue
- 11
- Pages
- 1088-1089
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- PMC
- PMC5684473
- OpenAlex
- W2745164748
- Cited by
- 34
- References
- 10
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 9 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 1 · 2018: 4
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- leptin resistance, lipolysis, white adipose tissue, ectopic fat deposition, visceral fat, adipose tissue dysfunction
- MeSH terms
- Body Composition, Cardiovascular Diseases, Diabetes Mellitus, Humans, Lipolysis, Obesity, Leptin, Metabolic Syndrome, Adipose Tissue, White
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