Sarcopenia and obesity
Abstract
PURPOSE OF REVIEW: Together with age-related body composition changes, the increased prevalence of obesity observed in the past few decades in older individuals has led to a condition called sarcopenic obesity, characterized by a mismatch between muscle mass and fat mass. The operative definition of sarcopenic obesity is still under discussion and creates difficulties in clinical practice. Muscle weakness, rather than low muscle mass, was previously proposed as an alternative criterion and, more recently, the dynapenic abdominal obese phenotype is of increasing interest because of its unfavorable health consequences and usability in clinical practice. RECENT FINDINGS: This review focuses on the most recent findings of pathogenic inter-relationships between adipose tissue and muscle. Recent studies on health consequences of sarcopenic obesity and dynapenic abdominal obesity are also examined. Despite the lack of consensus on a definition for sarcopenic obesity, progress has been made in the delineation of the treatment principles for this condition. SUMMARY: Further research is needed to compare different definitions of sarcopenic/dynapenic obesity to clarify the relationship between obesity and the most important adverse outcomes in the elderly. The next step will be the definition of best possible therapeutic approaches for this condition.
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Aging is associated with a decrease in muscle mass and strength and an increase in body fat mass, leading to frailty, falls, disability, social isolation, and hospitalization.
“Aging is associated with the decrease in muscle mass and strength and the increase in body fat mass, which leads to frailty, falls, disability, social isolation, and hospitalization.”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [1]
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- Authors
- Zamboni, M., Rubele, S., & Rossi, A. P.
- Affiliations
- University of Verona (IT)
- Corresponding author
- Zamboni, Mauro
- Venue
- Current Opinion in Clinical Nutrition & Metabolic Care
- Published
- 2019-01
- Volume
- 22
- Issue
- 1
- Pages
- 13-19
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2901760191
- Semantic Scholar
- 13fc3622d0c666a65da0dce484eebff3de0c4a5f
- Cited by
- 173
- References
- 37
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 42 · 2023: 25 · 2022: 39 · 2021: 19 · 2020: 20 · 2019: 4
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenic obesity, dynapenic obesity, muscle weakness, muscle mass, fat mass, older adults, body composition, obesity treatment, health consequences of obesity
- MeSH terms
- Adipose Tissue, Aged, Aging, Diet Therapy, Exercise Therapy, Humans, Obesity, Muscle, Skeletal, Muscle Weakness, Adiposity, Sarcopenia
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