Pravastatin Use and Risk of Coronary Events and Cerebral Infarction in Japanese Men with Moderate Hypercholesterolemia : The Kyushu Lipid Intervention Study
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The Kyushu Lipid Intervention Study (KLIS) aimed to investigate the effects of pravastatin in the primary prevention of coronary events and cerebral infarction in Japanese men aged 45-74 years with serum total cholesterol of > or = 220 mg/dl (5.69 mmol/l). The coronary events included myocardial infarction, coronary artery surgery and angioplasty, cardiac death, and sudden death. A total of 5,640 patients were recruited, and 3,061 and 2,579 were allocated to the pravastatin (10-20 mg/day) and conventional treatment, respectively. They were followed up for 5 years on average. Due to unsuccessful randomization, a protocol-based analysis was carried out with adjustment for coronary risk factors at baseline using the Cox proportional hazards model. For several reasons (serum total cholesterol of > or = 300 mg/dl, use of drugs excluded in protocol, etc.), 2,219 men in the pravastain group and 1,634 in the conventional treatment group were used in the analysis. The baseline total cholesterol levels were 254 mg/dl in the pravastain group and 243 mg/dl in the conventional treatment group. Serum total cholesterol levels fell by 15% in the pravastain group and by 8% with the conventional treatment group. Adjusted relative risks for pravastatin versus conventional treatment were: coronary events 0.86 (one-side p=0.23), cerebral infarction 0.78 (p=0.13), and the two outcomes combined 0.81 (p=0.08). These findings add to evidence that pravastatin use is beneficial in the prevention of coronary events and cerebral infarction in hypercholesterolemic Japanese patients, and suggest that pravastatin may be more protective against cerebral infarction.
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Large-scale Japanese clinical studies showed that treating hyper-LDL cholesterolemia decreased CAD occurrence.
“Large-scale clinical studies conducted in Japan have also reported similar results41–44), in which it was evident that the occurrence of CAD in the Japanese subjects decreased as a result of treating the hyper-LDL cholesterolemia.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [42]
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内科 １００年のあゆみ 内分泌・代謝 ＩＩＩ． 主要疾患の歴史 ８． 高脂血症
博仁, 曽., & 信博, 山. (2002) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.91.1202
Alsheikh-Ali, A. A. A., & Karas, R. H. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.024
- Authors
- The Kyushu Lipid Intervention Study Group
- Affiliations
- Fukuoka University (JP)
- Corresponding author
- The Kyushu Lipid Intervention Study Group
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2000
- Volume
- 7
- Issue
- 2
- Pages
- 110-121
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W4233377863
- Cited by
- 67
- References
- 34
- Citations by year
- 2023: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- pravastatin, hypercholesterolemia, coronary events, cerebral infarction, primary prevention, statins, Japanese men, myocardial infarction, stroke prevention
- MeSH terms
- Aged, Anticholesteremic Agents, Cerebral Infarction, Coronary Disease, Follow-Up Studies, Humans, Hypercholesterolemia, Japan, Lipids, Male, Middle Aged, Neoplasms, Patient Compliance, Risk Factors, Pravastatin
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