Sick euthyroid syndrome is associated with poor prognosis in patients with ST segment elevation myocardial infarction undergoing primary percutaneous intervention
Open accessAbstract
BACKGROUND: Concomitant thyroid and heart disease are frequently encountered in clinical practice. There are many studies evaluating thyroid function in acute and critical conditions. Information on thyroid dysfunction in ST-segment elevation myocardial infarction (STEMI) is limited; its correlation with short and long-term outcome is not fully known. METHODS: Four hundred and fifty seven patients diagnosed with STEMI in our emergency department were included in the study. Patients were divided into two groups: patients with normal thyroid function (euthyroid) and patients with thyroid dysfunction. STEMI was diagnosed with 12 derivation surface electrocardiogram. Thyroid hormone levels (TSH, free T3 and free T4) were measured. Patients with other acute coronary syndromes and endocrine pathologies except diabetes mellitus were excluded. Two patient groups were compared in terms of in-hospital and long-term outcome. RESULTS: Out of 457, 72 (15%) patients with thyroid dysfunction were detected. The other patients were euthyroid and constituted the control group. In-hospital cardiogenic shock (15% vs. 3% in the control group; p < 0.01) and death (7% vs. 1% in the control group; p < 0.01) were more frequently observed in the thyroid dysfunction group. In the subgroup analysis, it was observed that patients with sick euthyroid syndrome have the poorest outcome. Other markers for poor outcome were anemia and renal failure. CONCLUSIONS: Thyroid dysfunction, particularly sick euthyroid syndrome, was found to be related to in-hospital and long term mortality in patients with STEMI undergoing primary percutaneous intervention.
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In a study of 457 acute myocardial infarction patients, thyroid dysfunction including subclinical hypothyroidism, subclinical hyperthyroidism, and low T3 syndrome was associated with a higher incidence of major cardiac events.
“In another study of 457 AMI patients, thyroid dysfunction including SCH, SHyper, and low T 3 syndrome was associated with higher incidence of major cardiac events (112).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [112]
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- Authors
- Özcan, K. S., Osmonov, D., Toprak, E., Güngör, B., Tatlısu, A., Ekmekçi, A., Kaya, A., Tayyareci, G., & Erdinler, İ.
- Venue
- Cardiology Journal
- Publisher
- VM Media SP. zo.o VM Group SK
- Published
- 2014-06-09
- Volume
- 21
- Issue
- 3
- Pages
- 238-244
- ISSN
- 1897-5593 (ISSN-L)
- 1898-018X
- OpenAlex
- W2333159507
- Cited by
- 50
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 1
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cardiology Journal (publishedVersion)
- PubMed (publishedVersion)
- Via Medica Journals (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- low T3 syndrome, thyroid dysfunction, ST-elevation myocardial infarction, primary percutaneous coronary intervention, in-hospital mortality, long-term prognosis, cardiogenic shock, thyroid-stimulating hormone, anemia, renal failure
- MeSH terms
- Electrocardiography, Euthyroid Sick Syndromes, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Prognosis, Retrospective Studies, Risk Factors, Time Factors, Turkey, Survival Rate, Hospital Mortality, Percutaneous Coronary Intervention
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