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Cited by 452Obstructive Sleep Apnea ResearchCardiovascular Function and Risk FactorsSleep and related disorders

Left Ventricular Hypertrophy and Abnormal Ventricular Geometry in Children and Adolescents with Obstructive Sleep Apnea

Amin, Raouf S., Kimball, Thomas R., Bean, Judy A., Jeffries, Jenny L., Willging, J. Paul, Cotton, Robin T., Witt, Sandra A., Glascock, Betty J. +1 more·2002·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.2105118
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Abstract

Obstructive sleep apnea (OSA) has been shown to be an independent risk factor for cardiovascular disease in adults. However, there are severe limitations in the extent to which the cardiovascular consequences of OSA are being studied in children. To investigate the echocardiographic changes in children with OSA, right and left ventricular (RV, LV) dimensions and LV mass index and geometry were measured in 28 children with OSA and 19 children with primary snoring (PS). The study showed that LV mass index and relative wall thickness were greater in the OSA group compared with those with PS (p = 0.012 and p &BLDlt; 0.0001, respectively). An apnea–hypopnea index of more than 10 per hour was significantly associated with RV dimension above the 95th percentile (odds ratios, 6.7; 95% confidence interval, 1.4–32) and LV mass index above the 95th percentile (odds ratios, 11.2; confidence interval, 1.9–64). Abnormality of LV geometry was present in 15% of children with PS compared with 39% of children with OSA. We conclude that OSA in children is associated with increased LV mass.

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Crossref · 10.1164/rccm.2105118

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  • Although some studies have failed to show a relationship between sleep apnea and LV hypertrophy, the majority do support such an association.

    “Although some studies have failed to show a relationship between sleep apnea and LV hypertrophy, the majority do support such an association (18, 22, 69, 250, 256–258, 284, 287, 331, 373).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [18]

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Authors
Amin, R. S., Kimball, T. R., Bean, J. A., Jeffries, J. L., Willging, J. P., Cotton, R. T., Witt, S. A., Glascock, B. J., & Daniels, S. R.
Affiliations
Cincinnati Children's Hospital Medical Center (US)
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2002-05
Volume
165
Issue
10
Pages
1395-1399
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.2105118
OpenAlex
W2087225497
Cited by
452
References
38
Citations by year
2026: 10 · 2025: 5 · 2024: 14 · 2023: 12 · 2022: 11 · 2021: 17 · 2020: 15 · 2019: 20 · 2018: 14 · 2017: 19 · 2016: 13 · 2015: 8 · 2014: 36 · 2013: 19 · 2012: 25
FWCI
11.21
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
obstructive sleep apnea, left ventricular hypertrophy, left ventricular mass, left ventricular geometry, right ventricular size, children, adolescents, primary snoring, apnea-hypopnea index, cardiovascular risk, echocardiography
MeSH terms
Adolescent, Blood Pressure Determination, Child, Child, Preschool, Female, Heart Ventricles, Humans, Male, Probability, Prospective Studies, Reference Values, Regression Analysis, Severity of Illness Index, Snoring, Echocardiography, Doppler, Cohort Studies, Prevalence, Logistic Models, Polysomnography, Hypertrophy, Left Ventricular, Age Distribution, Sex Distribution, Risk Assessment, Ventricular Dysfunction, Sleep Apnea, Obstructive

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