MSLT in primary insomnia: stability and relation to nocturnal sleep
Open accessAbstract
MSLT Stability in Insomnia-Roehrs et alniacs and controls with mean daily sleep latencies of 10.3 vs 8.6 min.15 What is evident in the studies above reporting significant MSLT differences between insomniacs and controls are the differences among the studies in the control sample MSLT mean sleep latencies, which range from 8.6 min to 12.3 min.All these studies used samples of convenience, recruiting their control samples through newspaper advertisements for normal sleepers.To better understand whether the MSLT is elevated in insomniacs it would be valuable to compare insomniacs to a population-based, representative sample of healthy non-insomniacs.The studies of MSLT in insomnia also differ in the definition of insomnia used.Some of the above cited studies defined insomnia based on a single complaint only, others used the standard clinical diagnostic criteria, and others included nocturnal polysomnographic (NPSG) entry criteria.How nocturnal sleep time relates to MSLT in insomnia is an important theoretical question.In studies of healthy normals, short MSLT mean daily sleep latencies are associated with diary-reported short total sleep times and high laboratory sleep efficiencies the night before the MSLT.16 These results suggest that the less the habitual nocturnal sleep, the greater the degree of daytime sleepiness.The question arises as to how sleep time in insomniacs relates to their MSLTs the following day.Finally, the studies of MSLT in insomnia report relatively large standard deviations.The wide variability among insomniacs may reflect high test-retest variability in a given individual's MSLT.No study has assessed the repeatability of MSLT results in insomniacs across time.Will an insomniac with an elevated MSLT show the same elevation across time?In this paper, we report MSLT results of a large sample of insomniacs participating in a chronic pharmacological treatment trial; compare these results to a representative population control sample; evaluate the relation of MSLT to NPSG sleep time; and importantly, assess the stability of the MSLT in insomnia.
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Daytime sleepiness as a characteristic effect of sleep deprivation is not present in patients with insomnia.
“Daytime sleepiness as a characteristic effect of sleep deprivation is not present in patients with insomnia [69].”
From Cognitive behavioral therapy for insomnia in patients with mental disorders and comorbid insomnia: A systematic review and meta-analysis (2022) · cites this paper as [69]
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Cites
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772 · see citing works
Guidelines for the Multiple Sleep Latency Test (MSLT): A Standard Measure of Sleepiness
Carskadon, M. A. (1986) · SLEEP · doi:10.1093/sleep/9.4.519 · Cited by 1,607 · see citing works
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7778 · Cited by 884 · see citing works
Functional Neuroimaging Evidence for Hyperarousal in Insomnia
Nofzinger, E. A., Buysse, D. J., Germain, A., Price, J. C., Miewald, J. M., & Kupfer, D. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2126 · Cited by 752 · see citing works
Sleeping and waking disorders : indications and techniques
Guilleminault, C. (1982) · Medical Entomology and Zoology · Cited by 591 · see citing works
24-Hour Metabolic Rate in Insomniacs and Matched Normal Sleepers
Bonnet, M. H., & Arand, D. L. (1995) · Sleep · doi:10.1093/sleep/18.7.581 · Cited by 557 · see citing works
Beta/Gamma EEG Activity in Patients with Primary and Secondary Insomnia and Good Sleeper Controls
Perlis, M. L., Smith, M. T., Andrews, P. J., Orff, H. J., & Giles, D. E. (2001) · SLEEP · doi:10.1093/sleep/24.1.110 · Cited by 493 · see citing works
Heart Rate Variability in Insomniacs and Matched Normal Sleepers
Bonnet, M. H., & Arand, D. L. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199809000-00017 · Cited by 451 · see citing works
Sleep Fragmentation and Daytime Sleepiness
Stepanski, E. J., Lamphere, J. K., Badia, P., Zorick, F. J., & Roth, T. G. (1984) · SLEEP · doi:10.1093/sleep/7.1.18 · Cited by 347 · see citing works
Self-citationDaytime Alertness in Patients with Chronic Insomnia Compared with Asymptomatic Control Subjects
Stepanski, E. J., Zorick, F. J., Roehrs, T., Young, D. K., & Roth, T. G. (1988) · SLEEP · doi:10.1093/sleep/11.1.54 · Cited by 303 · see citing works
Self-citationPeriodic movements in sleep (nocturnal myoclonus) and restless legs syndrome
Coleman, R. (1982) · Medical Entomology and Zoology · Cited by 287 · see citing works
Age-Related Reduction in the Maximal Capacity for Sleep—Implications for Insomnia
Klerman, E. B., & Dijk, D. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.047 · Cited by 193 · see citing works
The experience of insomnia and daytime and nightime functioning
Mendelson, W. B., Garnett, D., Gillin, J. C., & Weingartner, H. (1984) · Psychiatry Research · doi:10.1016/0165-1781(84)90029-5 · Cited by 166 · see citing works
Seidel, W. F., Stephen, B., Cohen, S. A., Patterson, N., Yost, D., & Dement, W. C. (1984) · SLEEP · doi:10.1093/sleep/7.3.230 · Cited by 159 · see citing works
Daytime alertness in subjective and objective insomnia: Some preliminary findings
Sugerman, J. L., Stern, J. A., & Walsh, J. K. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90153-2 · Cited by 134 · see citing works
The 10-Year Risk of Verifed Motor Vehicle Crashes in Relation to Physiologic Sleepiness
Drake, C. L., Roehrs, T., Breslau, N., Johnson, E. O., Jefferson, C., Scofield, H., & Roth, T. G. (2010) · SLEEP · doi:10.1093/sleep/33.6.745 · Cited by 123 · see citing works
Self-citationDaytime Sleepiness in Insomnia: Behavioral, Biological and Subjective Indices
Lichstein, K. L., Wilson, N. M., Noe, S. L., Aguillard, R. N., & Bellur, S. N. (1994) · SLEEP · doi:10.1093/sleep/17.8.693 · Cited by 117 · see citing works
Core Body Temperature is Elevated During Constant Wakefulness in Elderly Poor Sleepers
Lushington, K., Dawson, D. E., & Lack, L. C. (2000) · SLEEP · doi:10.1093/sleep/23.4.1d · Cited by 94 · see citing works
Edinger, J. D., Fins, A. I., Robert J. Sullivan, Jr., Marsh, G. R., Dailey, D. S., Hope, T. V., Young, M., Shaw, E., Carlson, D., & Vasilas, D. (1997) · SLEEP · doi:10.1093/sleep/20.12.1127 · Cited by 44 · see citing works
Chapter 81 – Pharmacologic Treatment of Insomnia: Benzodiazepine Receptor Agonists
Walsh, J., & Roth, T. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00081-5 · Cited by 26 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 5
- Bonnet MH, Arand DL. 24-hour metabolic rate in insomnia and matched normal sleepers. Sleep 1995;18:581-8.
- Drake C, Roehrs T, Breslau N, et al. The 10-year risk of verified motor ve- hicle crashes in relation of physiologic sleepiness. Sleep 2010;33:745-52.
- Walsh JK, Roth T. Pharmacologic treatment of insomnia: Benzodiazepine receptor agonists. In: Kryger MH, Roth T, Dement WC. (eds), Principles and practice of sleep medicine. 5 th ed, St Louis, MO: Elsevier Saunders, 2011,905-15.
- Randall S, Roehrs T, Harris E, Maan R, Roth T. Chronic use of zolpidem is not associated with loss of efficacy. Sleep 2010;33:A221 REFERENCES
- Nofzinger E, Nowell P, Buysse D. Towards a neurobiology of sleep dis- turbance in primary insomnia and depression: a comparison of subjective, visually scored and periodic amplitude, and power spectral density sleep measures. Sleep 1999;22:S99.
Cited by
Sorted by citations
Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder
Vgontzas, A. N., Fernandez-Mendoza, J., Liao, D., & Bixler, E. O. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.09.005 · Cited by 776 · see citing works
Morin, C. M., Drake, C. L., Harvey, A. G., Krystal, A. D., Manber, R., Riemann, D., & Spiegelhalder, K. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.26 · Cited by 746 · see citing works
Hertenstein, E., Trinca, E., Wunderlin, M., Schneider, C. L., Züst, M. A., Fehér, K. D., Su, T., Straten, A. V., Berger, T., Baglioni, C., et al. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101597 · Cited by 391 · see citing works
Hyperarousal in insomnia disorder: Current evidence and potential mechanisms
Dressle, R. J., & Riemann, D. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13928 · Cited by 218 · see citing works
Kalmbach, D. A., Buysse, D. J., Cheng, P., Roth, T., Yang, A., & Drake, C. L. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2019.11.1184 · Cited by 100 · see citing works
Self-citationAcute and Chronic Insomnia: What Has Time and/or Hyperarousal Got to Do with It?
Vargas, I., Nguyen, A. M., Muench, A., Bastien, C. H., Ellis, J. G., & Perlis, M. L. (2020) · Brain Sciences · doi:10.3390/brainsci10020071 · Cited by 58 · see citing works
Pérusse, A. D., Pedneault-Drolet, M., Rancourt, C., Turcotte, I., St-Jean, G., & Bastien, C. H. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.01.005 · Cited by 27 · see citing works
- Authors
- Roehrs, T. A., Randall, S., Harris, E., Maan, R., & Roth, T.
- Affiliations
- Henry Ford Health (US)
- Corresponding author
- Roehrs, Timothy A.
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-12
- Volume
- 34
- Issue
- 12
- Pages
- 1647-1652
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC3208841
- OpenAlex
- W2063200548
- Cited by
- 84
- References
- 20
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 6 · 2016: 7 · 2015: 11 · 2014: 7 · 2013: 11 · 2012: 1
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- SLEEP (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA017355)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- multiple sleep latency test, primary insomnia, daytime sleepiness, test-retest stability, sleep latency, nocturnal polysomnography
- MeSH terms
- Zolpidem, Adult, Arousal, Double-Blind Method, Female, Humans, Hypnotics and Sedatives, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Pyridines, Sleep, Time Factors, Case-Control Studies, Polysomnography
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