Comparative investigation of the psychophysiologic and idiopathic insomnia disorder phenotypes: Psychologic characteristics, patients' perspectives, and implications for clinical management
Open accessAbstract
Study Objectives: Insomnia is a common disorder, yet its proposed behavioral phenotypes are seldom differentiated. Two consecutive studies were designed to investigate psychologic characteristics and treatment preferences of people with idiopathic insomnia (IdI) relative to psychophysiologic insomnia (PI). Design: Cross-sectional, two-group comparison studies. Setting: Specialized sleep research center. Participants: 40 participants (29 female, mean age 46 yr) participated in study 1. An additional cohort of 61 adults (48 female, mean age 37 yr) participated in study 2. In total, samples comprised 51 participants with PI and 50 with IdI. All participants met diagnostic criteria for their respective insomnia phenotype. Interventions: N/A Measurements and Results: Study 1 investigated sensitivity to arousal conditioning and sleep effort using self-report measures. Consistent with a model of conditioned arousal, participants with PI exhibited greater behavioral inhibition, i.e., sensitivity to threat and higher levels of sleep preoccupation. Study 2 investigated illness perceptions and cognitions and coping styles using self-report scales, and explored treatment acceptability based on the evaluation of 3 therapeutic scenarios. Results lend support to the hypothesis that IdI is considered somewhat more permanent than PI. Behavioral intervention was preferred to pharmacotherapy by both groups, and an acceptance treatment was considered more favorably by IdI study participants than by those with PI. Conclusions: Many similarities between IdI and PI were observed across psychologic measures, and both groups exhibited a preference for behavioral treatment. However, their distinctive characteristics appear to suggest that an acceptance-based therapy may also be appropriate for some people with IdI.
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Claims the paper makes
2 of 14 cited sources checked · 0 supported · 0 flagged · accuracy not yet measured
- Background§ Submitted for publication May, 2011 Submitted in final revised form September, 2011 Accepted for publication September, 2011
The authors suggest that idiopathic insomnia may be partly defined by the absence of precipitating and maintaining factors and by only minor psychologic abnormalities.
“IdI is partly defined by the absence of precipitating and maintaining factors, and patients appear to exhibit only minor psychologic abnormalities.”
Quote in the paperNot yet classified1 of 2 sources checked- cites [12] Hauri, 1980, Childhood-onset insomnia, Sleep source
In Sleep Variables (page unavailable), most childhood-onset patients could not identify a stress at onset, and the authors report a trend toward less fluctuation with mood than in adult-onset patients. The Discussion (page unavailable) suggests a less psychological basis. But the paper studies childhood-onset insomnia, not idiopathic insomnia as a whole; it does not establish an absence of maintaining factors or that patients have only minor psychological abnormalities. (LLM, conf=0.84)
Experimental — accuracy not yet measured - cites [13] Hauri, 1983, A cluster analysis of insomnia, Sleep source
- Finding§ DISCUSSION
The authors conclude that cognitive behavioral therapy is a rational intervention for both psychophysiologic and idiopathic insomnia patients.
“there is a rationale for using CBT with both PI and IdI patients.”
Quote in the paperNot yet classified1 of 4 sources checked- cites [44] Morin, 2006, Psychological and behavioral treatment of insomnia: update of the recent evidence (1998-2004), Sleep source
Section 4.2 reports CBT treatment involving patients with psychophysiologic insomnia, and Section 5 concludes that CBT is a well-established treatment for insomnia. The copy does not identify patients with idiopathic insomnia or make a recommendation specific to them, so the claim's application to both named groups is not fully supported. The supplied passages and retrieved passages have no page numbers. (LLM, conf=0.84)
Experimental — accuracy not yet measured - cites [45] Riemann, 2009, The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies, Sleep Med Rev source
- cites [46] 2005, NIH state-of-the-science conference statement on manifestations and management of chronic insomnia in adults, NIH Consens Sci Statements
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [47] Wilson, 2010, British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders, J Psychopharmacology source
- Finding§ Illness perception
In Study 2, both groups viewed their sleep problems as chronic and were uncertain about treatability and control.
“mean scores suggest that both groups tended to view their insomnia as variable and outside of their control, and had doubts about its treatability.”
Quote in the paperNot yet classified - Finding§ Illness perception
In Study 2, the idiopathic insomnia group perceived their insomnia as more permanent than the psychophysiologic insomnia group.
“perceived their insomnia to have greater permanency than did the PI group ( t (59) = 2.18, P = 0.033).”
Quote in the paperNot yet classified - Finding§ Coping strategies
The idiopathic insomnia group reported using humor to cope more often than the psychophysiologic insomnia group.
“patients with IdI rated using humor to cope significantly more often than those with PI ( t (59) = -2.73,”
Quote in the paperNot yet classified
- Finding§ Behavioral sensitivity
People with psychophysiologic insomnia had higher behavioral inhibition, indicating greater threat sensitivity than people with idiopathic insomnia.
“the PI group scored higher than the IdI group on the BIS scale ( t (38) = 4.04, P < 0.001) indicating higher levels of threat sensitivity in PI.”
Quote in the paperNot yet classified - Finding§ Treatment acceptability
The idiopathic insomnia group rated acceptance therapy as more acceptable than the psychophysiologic insomnia group.
“for the acceptance-based approach to insomnia, however, there was a significant effect, with the IdI group rating this intervention as acceptable relative to the PI group's lower ratings ( t (61) = 2.40, P = 0.02).”
Quote in the paperNot yet classified - Finding§ Sleep effort
Study 1 found that the psychophysiologic insomnia group endorsed more sleep effort and sleep-related worry than the idiopathic insomnia group.
“Specifically, PI endorsed 'putting too much effort into sleeping' ( F (2) = 4.41, P = 0.019), being 'anxious about sleeping before going to bed' ( F (2) = 3.87, P = 0.030) and 'worrying about the consequences of not sleeping' ( F (2) = 3.34, P = 0.046) more strongly than did IdI.”
Quote in the paperNot yet classified - Finding§ Coping strategies
The idiopathic insomnia group also used self-distraction more often than the psychophysiologic insomnia group, though this did not survive correction for multiple comparisons.
“The only other strategy that differentiated between group was self-distraction, which also was used more often by patients with IdI than by those with PI ( t (59) = -2.72, P = 0.009]. These findings fail to achieve significance after conservative adjustment for multiple comparisons (critical value: P < 0.004).”
Quote in the paperNot yet classified - Finding§ Comparative Investigation of the Psychophysiologic and Idiopathic Insomnia Disorder Phenotypes: Psychologic Characteristics, Patients' Perspectives, and Implications for Clinical Management
The authors suggest that acceptance-based therapy may be appropriate for some people with idiopathic insomnia.
“their distinctive characteristics appear to suggest that an acceptance-based therapy may also be appropriate for some people with IdI.”
Quote in the paperNot yet classified - Finding§ Comparative Investigation of the Psychophysiologic and Idiopathic Insomnia Disorder Phenotypes: Psychologic Characteristics, Patients' Perspectives, and Implications for Clinical Management
The authors conclude that many psychologic similarities exist between idiopathic and psychophysiologic insomnia, and that both groups prefer behavioral treatment.
“Many similarities between IdI and PI were observed across psychologic measures, and both groups exhibited a preference for behavioral treatment.”
Quote in the paperNot yet classified - Finding§ Sleep effort
Study 1 broadly confirmed the hypothesis that psychophysiologic insomnia involves greater threat sensitivity and more pronounced sleep-related focus than idiopathic insomnia.
“The results from Study 1, therefore, broadly confirm the hypothesis that people with PI exhibit greater levels of threat sensitivity in general and a more pronounced sleep-related focus than people with IdI.”
Quote in the paperNot yet classified - Finding§ Illness cognition
Both groups showed similar levels of acceptance and helplessness on the illness cognition measure.
“there were no significant differences between participants with PI and IdI. Likewise, there were no differences between groups on the ICQ helplessness scale (both P > 0.05).”
Quote in the paperNot yet classified - Finding§ DISCUSSION
The authors speculate that acceptance-based therapy could be a second-line treatment for psychophysiologic insomnia and a first-line treatment for idiopathic insomnia.
“there is a rationale for considering an acceptance-based therapy as a second-line intervention for PI patients who have not responded to CBT; and potentially, as a first-line treatment for IdI.”
Quote in the paperNot yet classified - Background§ INTRODUCTION
The paper says psychophysiologic insomnia develops in adulthood and may be linked to precipitating events or stressors.
“PI develops in adulthood, may be linked to identifiable precipitating events and/or stressors, and comprises both psychologic and physiologic features”
Quote in the paperNot yet classified0 of 1 sources checked- cites [5] 2005, International Classification of Sleep Disorders: Diagnostic and Coding Manual
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Background§ Submitted for publication May, 2011 Submitted in final revised form September, 2011 Accepted for publication September, 2011
The paper says idiopathic insomnia may be resistant to treatment.
“It has been suggested that IdI may be resistant to treatment.”
Quote in the paperNot yet classified0 of 1 sources checked- cites [6] Edinger, 1988, Cluster analysis of insomniacs' MMPI profiles: relation of subtypes to sleep history and treatment outcome, Psychosom Med source
- Background§ Submitted for publication May, 2011 Submitted in final revised form September, 2011 Accepted for publication September, 2011
The authors note that conceptualizations of insomnia development and maintenance fit more closely with psychophysiologic insomnia than with idiopathic insomnia.
“conceptualizations of insomnia development and maintenance seem to fit more closely with PI than they do with IdI.”
Quote in the paperNot yet classified0 of 5 sources checked- cites [7] Spielman, 1987, Treatment of chronic insomnia by restriction of time in bed, Sleep source
- cites [8] Perlis, 1997, Psychophysiological insomnia: the behavioural model and a neurocognitive perspective, J Sleep Res source
- cites [9] Espie, 2002, Insomnia: conceptual issues in the development, persistence, and treatment of sleep disorder in adults, Annu Rev Psychol source
- cites [10] Espie, 2006, The attention-intention-effort pathway in the development of psychophysiologic insomnia: a theoretical review, Sleep Med Rev source
- cites [11] Harvey, 2002, A cognitive model of insomnia, Behav Res Ther source
- Method§ Comparative Investigation of the Psychophysiologic and Idiopathic Insomnia Disorder Phenotypes: Psychologic Characteristics, Patients' Perspectives, and Implications for Clinical Management
Study 1 used a cross-sectional, two-group comparison design in a specialized sleep research center.
“Design: Cross-sectional, two-group comparison studies.”
Quote in the paperNot yet classified - Method§ Comparative Investigation of the Psychophysiologic and Idiopathic Insomnia Disorder Phenotypes: Psychologic Characteristics, Patients' Perspectives, and Implications for Clinical Management
The study set out to compare psychologic characteristics and treatment preferences in idiopathic insomnia relative to psychophysiologic insomnia.
“Two consecutive studies were designed to investigate psychologic characteristics and treatment preferences of people with idiopathic insomnia (IdI) relative to psychophysiologic insomnia (PI).”
Quote in the paperNot yet classified - Background§ Submitted for publication May, 2011 Submitted in final revised form September, 2011 Accepted for publication September, 2011
The authors state that idiopathic insomnia is a lifelong complaint with a chronic course and few periods of sustained remission.
“IdI is a lifelong complaint with a chronic course and few periods of sustained remission.”
Quote in the paperNot yet classified - Method§ Design
Study 2 used the same cross-sectional, two-group comparison design.
“Cross-sectional, two-group comparison of PI and IdI.”
Quote in the paperNot yet classified - Background§ Submitted for publication May, 2011 Submitted in final revised form September, 2011 Accepted for publication September, 2011
The paper notes that idiopathic insomnia affects fewer than 10% of people presenting with insomnia complaints.
“the condition is relatively uncommon and affects fewer than 10% of those presenting with insomnia complaints.”
Quote in the paperNot yet classified0 of 1 sources checked- cites [1] Ohayon, 2002, Epidemiology of insomnia: what we know and what we still need to learn, Sleep Med Review source
Statistics recomputed
Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.
- Consistentt(38) = 4.04reported p < .001 · recomputed p < .001
“t (38) = 4.04, p < .001”
- ConsistentF(2, 37) = 7.98reported p = .001 · recomputed p = .001
“F(2,37) = 7.98, p = .001”
- ConsistentF(7, 31) = 3.4reported p = .008 · recomputed p = .008
“F(7, 31) = 3.40, p = .008”
- Consistentt(38) = 9.1reported p < .0001 · recomputed p < .001
“t (38) = 9.1, p < .0001”
- Consistentt(38) = 5.01reported p < .001 · recomputed p < .001
“t (38) = 5.01, p < .001”
- Consistentt(59) = 2.18reported p = .033 · recomputed p = .033
“t (59) = 2.18, p = .033”
- Consistentt(59) = -2.72reported p = .009 · recomputed p = .009
“t (59) = -2.72,p = .009”
- Consistentt(61) = 2.4reported p = .02 · recomputed p = .019
“t (61) = 2.40, p = .02”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Minimum illness-cognition score is misstated
MinorEach subscale has six items scored from 1 to 4, so its minimum score is 6, not 4. The stated maximum of 24 is consistent with six items.
Reported 4 · recomputed 6
“A high score indicates less helplessness/more control. Items are rated ranging from 1 (agree) to 4 (disagree) (subscale score range = 4-24)”
Treatment-test degrees of freedom imply a larger sample
MinorStudy 2 lists 31 participants with PI and 30 with IdI. Paired tests within those groups would have 30 and 29 degrees of freedom, respectively, rather than the reported 31 and 30; the reported between-group t-test likewise uses 61 rather than the expected 59 degrees of freedom.
“behavioral versus pharmacologic: t (31) = 3.30; P = 0.003; behavioral versus acceptance: t (31) = 5.03; P < 0.001] and the IdI group (behavioral versus pharmacologic: t (30) = 3.45; P = 0.002; behavioral versus acceptance: t (30) = 2.79; P = 0.01)”
“| | (n = 31) | (n = 30) |”
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- Authors
- Espie, C. A., Barrie, L. M., & Forgan, G. S.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Espie, Colin A.
- ORCID
- Espie, Colin A.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03
- Volume
- 35
- Issue
- 3
- Pages
- 385-393
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC3274340
- OpenAlex
- W2007322699
- Cited by
- 38
- References
- 66
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- SLEEP (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- insomnia phenotypes, behavioral inhibition, sleep effort, illness perception, coping styles, treatment preferences, acceptance-based therapy, pharmacotherapy
- MeSH terms
- Adaptation, Psychological, Adult, Arousal, Cognition, Cross-Sectional Studies, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Patient Acceptance of Health Care, Phenotype, Self Concept, Cohort Studies
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