Rapid tolerance development to the NREM sleep promoting effect of alcohol
Open accessAbstract
STUDY OBJECTIVES: Alcohol tolerance is a major contributor towards the development of alcohol dependence. Does alcohol intake result in rapid tolerance development to alcohol induced NREM sleep promotion? This has never been examined. Our objective was to examine whether two bouts of alcohol consumption on consecutive days results in rapid tolerance development to alcohol-induced NREM sleep promotion. DESIGN: N/A. SETTING: N/A. PATIENTS OR PARTICIPANTS: C57BL/6J mice. INTERVENTIONS: Mice (N = 5) were implanted with sleep electrodes using standard surgical conditions. Following postoperative recovery and habituation, the experiment was begun. On baseline day, water bottle changes were performed at 10:00 (3 h after dark onset) and 14:00 to mimic conditions during alcohol consumption days. On next 2 days, (Days 1 and 2) mice were allowed to self-administer alcohol (20% v/v) for 4 h beginning at 10:00 and ending at 14:00. Sleep-wakefulness was continuously recorded from 10:00 to 18:00 (8 h; 4 h during alcohol + 4 h post-alcohol) on all 3 days. MEASUREMENTS AND RESULTS: Although mice consumed comparable amounts of alcohol on Days 1 and 2, NREM sleep and wakefulness were significantly and differentially affected during 4 h post-alcohol period. A robust alcohol-induced NREM sleep promotion was observed on Day 1. However, no such sleep promotion was observed on Day 2, suggesting rapid tolerance development. CONCLUSIONS: Our study is the first to demonstrate that alcohol consumption for two consecutive days results in development of rapid tolerance to alcohol-induced sleep promotion.
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In mice, alcohol-induced increases in non-REM sleep disappear by the second day of alcohol self-administration.
“A study in mice suggests that even the limited sleep-promoting effects of alcohol are short-lived, with alcohol-induced increases in non-REM sleep disappearing by the second day of alcohol self-administration (Sharma, Sahota, & Thakkar, 2014).”
From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Sharma et al., 2014
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- Authors
- Sharma, R., Sahota, P., & Thakkar, M. M.
- Affiliations
- Harry S. Truman Memorial Veterans' Hospital (US)
- Corresponding author
- Thakkar, Mahesh M.
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-01
- Volume
- 37
- Issue
- 4
- Pages
- 821-824
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC4044753
- OpenAlex
- W2075308031
- Cited by
- 23
- References
- 46
- Citations by year
- 2024: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 1 · 2015: 1 · 2014: 4
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R21AA020334, AA020334, AA0174720)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcohol tolerance, alcoholism, alcohol self-administration, sleep-wake behavior, alcohol consumption, mice
- MeSH terms
- Ethanol, Animals, Drug Tolerance, Male, Mice, Inbred C57BL, Sleep, Time Factors, Wakefulness, Mice
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