Alcohol disrupts sleep homeostasis

Thakkar, Mahesh M.; Sharma, Rishi; Sahota, Pradeep

doi:10.1016/j.alcohol.2014.07.019

Cited by 262Sleep and Wakefulness ResearchSleep and related disordersCircadian rhythm and melatonin

Alcohol disrupts sleep homeostasis

Open access

Thakkar, Mahesh M., Sharma, Rishi, Sahota, Pradeep·2015·Alcohol

DOI 10.1016/j.alcohol.2014.07.019PMC PMC4427543

Open this paper in CoChat — free account

Abstract

Alcohol is a potent somnogen and one of the most commonly used "over the counter" sleep aids. In healthy non-alcoholics, acute alcohol decreases sleep latency, consolidates and increases the quality (delta power) and quantity of NREM sleep during the first half of the night. However, sleep is disrupted during the second half. Alcoholics, both during drinking periods and during abstinences, suffer from a multitude of sleep disruptions manifested by profound insomnia, excessive daytime sleepiness, and altered sleep architecture. Furthermore, subjective and objective indicators of sleep disturbances are predictors of relapse. Finally, within the USA, it is estimated that societal costs of alcohol-related sleep disorders exceeds $18 billion. Thus, although alcohol-associated sleep problems have significant economic and clinical consequences, very little is known about how and where alcohol acts to affect sleep. In this review, we have described our attempts to unravel the mechanism of alcohol-induced sleep disruptions. We have conducted a series of experiments using two different species, rats and mice, as animal models. We performed microdialysis, immunohistochemical, pharmacological, sleep deprivation and lesion studies which suggest that the sleep-promoting effects of alcohol may be mediated via alcohol's action on the mediators of sleep homeostasis: adenosine (AD) and the wake-promoting cholinergic neurons of the basal forebrain (BF). Alcohol, via its action on AD uptake, increases extracellular AD resulting in the inhibition of BF wake-promoting neurons. Since binge alcohol consumption is a highly prevalent pattern of alcohol consumption and disrupts sleep, we examined the effects of binge drinking on sleep-wakefulness. Our results suggest that disrupted sleep homeostasis may be the primary cause of sleep disruption observed following binge drinking. Finally, we have also shown that sleep disruptions observed during acute withdrawal, are caused due to impaired sleep homeostasis. In conclusion, we suggest that alcohol may disrupt sleep homeostasis to cause sleep disruptions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.alcohol.2014.07.019

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Both periods of binge drinking and alcohol abstinence have been shown to disrupt sleep.
“Both periods of binge drinking and alcohol abstinence have been shown to disrupt sleep [98].”
From The Cyclical Battle of Insomnia and Mental Health Impairment in Firefighters: A Narrative Review (2024) · cites this paper as [98]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,895 · see citing works
Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders
Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870 · see citing works
The Role and Regulation of Adenosine in the Central Nervous System
Dunwiddie, T. V., & Masino, S. A. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.31 · Cited by 1,624 · see citing works
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Adenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness
Porkka-Heiskanen, T., Strecker, R. E., Thakkar, M., Bjørkum, A. A., Greene, R. W., & McCarley, R. W. (1997) · Science · doi:10.1126/science.276.5316.1265 · Cited by 1,252 · see citing works
Self-citation
Nucleus basalis and thalamic control of neocortical activity in the freely moving rat
Buzsáki, G., Bickford, R. G., Ponomareff, G., Thal, L. J., Mandel, R. J., & Gage, F. H. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04007.1988 · Cited by 1,039 · see citing works
Animal sleep: A review of sleep duration across phylogeny
Campbell, S. S., & Tobler, I. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90054-x · Cited by 832 · see citing works
Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice
Rhodes, J. S., Best, K., Belknap, J. K., Finn, D. A., & Crabbe, J. C. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.10.007 · Cited by 820 · see citing works
Current Protocols in Neuroscience
(2018) · Current Protocols in Neuroscience · doi:10.1002/(issn)1934-8576 · Cited by 771 · see citing works
Induction of physical dependence upon ethanol and the associated behavioral changes in rats
Majchrowicz, E. (1975) · Psychopharmacologia · doi:10.1007/bf00429258 · Cited by 738 · see citing works
Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation
Edgar, D. M., Dement, W., & Fuller, C. A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01065.1993 · Cited by 685 · see citing works
Development and Validation of the Biphasic Alcohol Effects Scale
Martin, C. S., Earleywine, M., Musty, R. E., Perrine, M. W., & Swift, R. M. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00739.x · Cited by 683 · see citing works
Adenosine and sleep–wake regulation
Basheer, R., Strecker, R. E., Thakkar, M. M., & McCarley, R. W. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.004 · Cited by 589 · see citing works
Self-citation
From waking to sleeping: neuronal and chemical substrates
Jones, B. E. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.09.009 · Cited by 577 · see citing works
Voluntary consumption of ethanol in 15 inbred mouse strains
Belknap, J. K., Crabbe, J. C., & Young, E. R. (1993) · Psychopharmacology · doi:10.1007/bf02244901 · Cited by 565 · see citing works
Neurobiology of REM and NREM sleep
McCarley, R. W. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.005 · Cited by 538 · see citing works
Arousal systems
Jones, B. E. (2003) · Frontiers in bioscience · doi:10.2741/1074 · Cited by 532 · see citing works
Reassessment of the structural basis of the ascending arousal system
Fuller, P. M., Sherman, D. L., Pedersen, N. P., Saper, C. B., & Lu, J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22559 · Cited by 507 · see citing works
Insomnia, self-medication, and relapse to alcoholism
Brower, K. J., Aldrich, M. S., Robinson, E. A. R., Zucker, R. A., & Greden, J. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.399 · Cited by 423 · see citing works
Alcohol and sleep I: effects on normal sleep
Ebrahim, I. O., Shapiro, C. M., Williams, A. J., & Fenwick, P. B. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12006 · Cited by 391 · see citing works
The rat ponto‐medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study
Boissard, R., Gervasoni, D., Schmidt, M. H., Barbagli, B., Fort, P., & Luppi, P. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02257.x · Cited by 367 · see citing works
Mouse inbred strain differences in ethanol drinking to intoxication
Rhodes, J. S., Ford, M. M., Yu, C. ‐., Brown, L. L., Finn, D. A., Garland, T., & Crabbe, J. C. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00210.x · Cited by 340 · see citing works
Sleep, sleepiness, and alcohol use.
Roehrs, T., & Roth, T. (2001) · PubMed · Cited by 326 · see citing works
Alcohol's effects on sleep in alcoholics.
Brower, K. J. (2001) · PubMed Central · Cited by 316 · see citing works
Neurobiological mechanisms for the regulation of mammalian sleep–wake behavior: Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence
Datta, S., & MacLean, R. R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.004 · Cited by 296 · see citing works
Optogenetic Stimulation of MCH Neurons Increases Sleep
Konadhode, R. R., Pelluru, D., Blanco‐Centurion, C., Zayachkivsky, A., Liu, M., Uhde, T., Glen, W. B., van den Pol, A. N., Mulholland, P. J., & Shiromani, P. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1225-13.2013 · Cited by 273 · see citing works
Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter.
Nagy, L. E., Diamond, I., Casso, D. J., Franklin, C. C., & Gordon, A. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39923-5 · Cited by 261 · see citing works
The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference
Choi, D., Cascini, M. G., Mailliard, W. S., Young, H., Paredes, P., McMahon, T., Diamond, I., Bonci, A., & Messing, R. O. (2004) · Nature Neuroscience · doi:10.1038/nn1288 · Cited by 255 · see citing works
Histamine in the regulation of wakefulness
Thakkar, M. M. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2010.06.004 · Cited by 251 · see citing works
Self-citation
The Sleep of Abstinent Pure Primary Alcoholic Patients
Drummond, S. P. A., Gillin, J. C., Smith, T. L., & DeModena, A. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03983.x · Cited by 251 · see citing works
Adenosine analogs and sleep in rats.
Radulovacki, M. G., Virus, R. M., Djuricic-Nedelson, M., & Green, R. D. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21636-6 · Cited by 251 · see citing works
Epidemiology Of Alcohol and Medication As Aids To Sleep in Early Adulthood
Johnson, E. O., Roehrs, T., Roth, T. G., & Breslau, N. (1998) · SLEEP · doi:10.1093/sleep/21.2.178 · Cited by 246 · see citing works
Stimulation of A1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation
Benington, J. H., Kodali, S., & Heller, H. C. (1995) · Brain Research · doi:10.1016/0006-8993(95)00590-m · Cited by 228 · see citing works
Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances
Brower, K. J., & Perron, B. E. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.10.020 · Cited by 226 · see citing works
Preclinical studies of alcohol binge drinking
Crabbe, J. C., Harris, R. A., & Koob, G. F. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05895.x · Cited by 221 · see citing works
Behavioral State Control through Differential Serotonergic Inhibition in the Mesopontine Cholinergic Nuclei: A Simultaneous Unit Recording and Microdialysis Study
Thakkar, M. M., Strecker, R. E., & McCarley, R. W. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05490.1998 · Cited by 190 · see citing works
Self-citation
Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep
Mizoguchi, A., Eguchi, N., Kimura, K., Kiyohara, Y., Qu, W., Huang, Z., Mochizuki, T., Lazarus, M., Kobayashi, T., Kaneko, T., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201398898 · Cited by 185 · see citing works
Sleep homeostasis in the rat: Simulation of the time course of EEG slow-wave activity
Franken, P., Tobler, I., & Borbély, A. A. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90382-4 · Cited by 180 · see citing works
The effect of sleep deprivation on sleep in rats with suprachiasmatic lesions
Tobler, I., Borbély, A. A., & Groos, G. A. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90420-2 · Cited by 178 · see citing works
Alcohol Consumption and the Body???s Biological Clock
Spanagel, R., Rosenwasser, A. M., Schumann, G., & Sarkar, D. K. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000175074.70807.fd · Cited by 172 · see citing works
A1Receptor and Adenosinergic Homeostatic Regulation of Sleep-Wakefulness: Effects of Antisense to the A1Receptor in the Cholinergic Basal Forebrain
Thakkar, M. M., Winston, S. H., & McCarley, R. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04278.2003 · Cited by 169 · see citing works
Self-citation
The tipsy terminal: presynaptic effects of ethanol.
Siggins, G., Roberto, M., & Nie, Z. (2005) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2005.01.006 · Cited by 167 · see citing works
Circadian rhythms and addiction: Mechanistic insights and future directions.
Logan, R. W., Williams, W. P., & McClung, C. A. (2014) · Behavioral Neuroscience · doi:10.1037/a0036268 · Cited by 142 · see citing works
Separate and combined effects of the social drugs on psychomotor performance
Kerr, J. S., Sherwood, N., & Hindmarch, I. (1991) · Psychopharmacology · doi:10.1007/bf02244564 · Cited by 138 · see citing works
Adenosine A 1 and A 2A Receptors in Mouse Prefrontal Cortex Modulate Acetylcholine Release and Behavioral Arousal
Dort, C. J. V., Baghdoyan, H. A., & Lydic, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4111-08.2009 · Cited by 138 · see citing works
Sleep-wakefulness, EEG and behavioral studies of chronic cats without the thalamus: the 'athalamic' cat.
Villablanca, J. R., & Salinas-Zeballos, M. E. (1972) · PubMed · Cited by 131 · see citing works
Caffeine antagonism of alcohol-induced driving impairment
Liguori, A., & Robinson, J. H. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00196-4 · Cited by 124 · see citing works
Functional neuroanatomy of sleep and circadian rhythms
Rosenwasser, A. M. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.08.001 · Cited by 122 · see citing works
GABA-A Receptors as Molecular Sites of Ethanol Action. Direct or Indirect Actions?
Aguayo, L. G., Peoples, R. W., Yeh, H. H., & Yévenes, G. E. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023393426 · Cited by 117 · see citing works
Alcohol-impaired speed and accuracy of cognitive functions: A review of acute tolerance and recovery of cognitive performance.
Schweizer, T. A., & Vogel-Sprott, M. D. (2008) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.16.3.240 · Cited by 115 · see citing works
Waves associated with eye movement in the awake and sleeping cat
Brooks, D. C. (1968) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(68)90042-4 · Cited by 110 · see citing works
Melanin-concentrating hormone control of sleep–wake behavior
Monti, J. M., Torterolo, P., & Lagos, P. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.10.002 · Cited by 110 · see citing works
Insomnia Pharmacotherapy
Roehrs, T., & Roth, T. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0148-3 · Cited by 107 · see citing works
The effect of caffeine on human performance, alone and in combination with ethanol
Franks, H. M., Hagedorn, H., Hensley, V. R., Hensley, W. J., & Starmer, G. A. (1975) · Psychopharmacology · doi:10.1007/bf00429058 · Cited by 106 · see citing works
Molecular Profiles of Drinking Alcohol to Intoxication in C57BL/6J Mice
Mulligan, M. K., Rhodes, J. S., Crabbe, J. C., Mayfield, R. D., Harris, R. A., & Ponomarev, I. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01384.x · Cited by 104 · see citing works
Low dose acute alcohol effects on GABAA receptor subtypes
Wallner, M., Hanchar, H. J., & Olsen, R. W. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.004 · Cited by 103 · see citing works
Intracellular signaling pathways that regulate behavioral responses to ethanol
Newton, P. M., & Messing, R. O. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.07.004 · Cited by 103 · see citing works
Optogenetically induced sleep spindle rhythms alter sleep architectures in mice
Kim, A., Latchoumane, C.-F. V., Lee, S., Kim, G. B., Cheong, E., Augustine, G. J., & Shin, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217897109 · Cited by 103 · see citing works
Sleep homeostasis
Porkka‐Heiskanen, T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.010 · Cited by 103 · see citing works
Impact of Alcoholism on Sleep Architecture and EEG Power Spectra in Men and Women
Colrain, I. M., Turlington, S. R., & Baker, F. C. (2009) · SLEEP · doi:10.1093/sleep/32.10.1341 · Cited by 99 · see citing works
Clock gene variants in mood and anxiety disorders
Partonen, T. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0810-2 · Cited by 99 · see citing works
Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving cats
Thakkar, M. M., Delgiacco, R. A., Strecker, R. E., & McCarley, R. W. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.006 · Cited by 99 · see citing works
Self-citation
Activation of Adenosine A1 Receptors Reduces Anxiety-Like Behavior During Acute Ethanol Withdrawal (Hangover) in Mice
Prediger, R. D., Silva, G. E. D., Batista, L. C., Bittencourt, A. L., & Takahashi, R. N. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301001 · Cited by 97 · see citing works
Sleep Abnormalities During Abstinence in Alcohol-Dependent Patients
Landolt, H., & Gillin, J. C. (2001) · CNS Drugs · doi:10.2165/00023210-200115050-00006 · Cited by 96 · see citing works
The neurobiology of binge-like ethanol drinking: Evidence from rodent models
Sprow, G. M., & Thiele, T. E. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.12.026 · Cited by 94 · see citing works
Circadian clock genes: Non-circadian roles in sleep, addiction, and psychiatric disorders?
Rosenwasser, A. M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.03.004 · Cited by 92 · see citing works
Norepinephrine-Deficient Mice Exhibit Normal Sleep-Wake States but have Shorter Sleep Latency after Mild Stress and Low Doses of Amphetamine
Hunsley, M. S., & Palmiter, R. D. (2003) · SLEEP · doi:10.1093/sleep/26.5.521 · Cited by 92 · see citing works
Binge drinking and sleep problems among young adults
Popovici, I., & French, M. T. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.02.001 · Cited by 88 · see citing works
Adenosine: a Mediator of Interleukin-1β-Induced Hippocampal Synaptic Inhibition
Luk, W. P., Zhang, Y., White, T. D., Lue, F. A., Wu, C., Jiang, C., Zhang, L., & Moldofsky, H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04238.1999 · Cited by 85 · see citing works
A Noradrenergic Mechanism Functions to Couple Motor Behavior with Arousal State
Burgess, C. R., & Peever, J. H. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.014 · Cited by 85 · see citing works
The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABAAδ‐subunit‐containing receptors
Winsky‐Sommerer, R., Vyazovskiy, V. V., Homanics, G. E., & Tobler, I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05455.x · Cited by 80 · see citing works
Rapid Eye Movement Sleep induction by microinjection of the GABA-A antagonist bicuculline into the dorsal subcoeruleus area of the rat
Pollock, M. S., & Mistlberger, R. E. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03956-2 · Cited by 77 · see citing works
Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep.
Hayaishi, O., Urade, Y., Eguchi, N., & Huang, Z. (2004) · PubMed · Cited by 75 · see citing works
Role of adenosine and wake‐promoting basal forebrain in insomnia and associated sleep disruptions caused by ethanol dependence
Sharma, R., Engemann, S. C., Sahota, P. K., & Thakkar, M. M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06980.x · Cited by 75 · see citing works
Self-citation
Mortality and Potential Years of Life Lost Attributable to Alcohol Consumption by Race and Sex in the United States in 2005
Shield, K. D., Gmel, G. E., Kehoe‐Chan, T. A. K., Dawson, D. A., Grant, B. F., & Rehm, J. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051923 · Cited by 74 · see citing works
Nitric Oxide-Stimulated Increase in Extracellular Adenosine Accumulation in Rat Forebrain Neurons in Culture Is Associated with ATP Hydrolysis and Inhibition of Adenosine Kinase Activity
Rosenberg, P. A., Li, Y., Le, M., & Zhang, Y. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06294.2000 · Cited by 73 · see citing works
Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics
Irwin, M. R., Gillin, J. C., Dang, J., Weissman, J., Phillips, E., & Ehlers, C. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01304-x · Cited by 72 · see citing works
Mammalian Sleep Dynamics: How Diverse Features Arise from a Common Physiological Framework
Phillips, A. J. K., Robinson, P. A., Kedziora, D. J., & Abeysuriya, R. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000826 · Cited by 70 · see citing works
Inhibition of adenosine uptake by ethanol is specific for one class of nucleoside transporters.
Krauss, S. W., Ghirnikar, R. B., Diamond, I., et al. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13260-4 · Cited by 68 · see citing works
Adaptations in Adenosine Signaling in Drug Dependence: Therapeutic Implications
Hack, S. P., & Christie, M. J. (2004) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v15.i34.30 · Cited by 66 · see citing works
Basis of the Gabamimetic Profile of Ethanol
Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., et al. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.0145-6008.2006.00086.x · Cited by 66 · see citing works
The Majchrowicz Binge Alcohol Protocol: An Intubation Technique to Study Alcohol Dependence in Rats
Faingold, C. L. (2008) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0928s44 · Cited by 63 · see citing works
Induction of wakefulness and inhibition of active (REM) sleep by GABAergic processes in the nucleus pontis oralis.
Xi, M., Morales, F. R., & Chase, M. H. (2001) · PubMed · Cited by 60 · see citing works
Effects of Ethanol on Extracellular Levels of Adenosine in the Basal Forebrain: An In Vivo Microdialysis Study in Freely Behaving Rats
Sharma, R., Engemann, S. C., Sahota, P. K., & Thakkar, M. M. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01153.x · Cited by 59 · see citing works
Self-citation
Dim light melatonin onset in alcohol-dependent men and women compared with healthy controls
Conroy, D. A., Hairston, I. S., Arnedt, J. T., Hoffmann, R. F., Armitage, R., & Brower, K. J. (2012) · Chronobiology International · doi:10.3109/07420528.2011.636852 · Cited by 58 · see citing works
Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP
Dar, M. S. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01263-2 · Cited by 58 · see citing works
Acute ethanol modulates glutamatergic and serotonergic phase shifts of the mouse circadian clock in vitro
Prosser, R. A., Mangrum, C. A., & Glass, J. D. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.12.049 · Cited by 57 · see citing works
Modulation of ethanol-induced motor incoordination by mouse striatal A1 adenosinergic receptor
Dar, M. S. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00552-4 · Cited by 57 · see citing works
Role of Wake‐Promoting Basal Forebrain and Adenosinergic Mechanisms in Sleep‐Promoting Effects of Ethanol
Thakkar, M. M., Engemann, S. C., Sharma, R., & Sahota, P. K. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01174.x · Cited by 56 · see citing works
Self-citation
Antagonistic effects of caffeine and alcohol on mental performance parameters
Hasenfratz, M., Bunge, A., Pra, G. D., & Bättig, K. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90380-c · Cited by 56 · see citing works
Endogenous GABA Levels in the Pontine Reticular Formation Are Greater during Wakefulness than during Rapid Eye Movement Sleep
Vanini, G., Wathen, B. L., Lydic, R., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5674-10.2011 · Cited by 56 · see citing works
REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation.
Thakkar, M. M., Ramesh, V., Cape, E., et al. (1999) · PubMed · Cited by 54 · see citing works
Self-citation
Prenatal ethanol exposure alters the expression of period genes governing the circadian function of β‐endorphin neurons in the hypothalamus
Chen, C. P., Kuhn, P. E., Advis, J. P., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03839.x · Cited by 54 · see citing works
Role of Adenosine A1 and A2A Receptors in the Alcohol Withdrawal Syndrome
Kaplan, G. B., Bharmal, N. H., Leite‐Morris, K. A., et al. (1999) · Alcohol · doi:10.1016/s0741-8329(99)00033-6 · Cited by 51 · see citing works
Diurnal Effects of Acute and Chronic Administration of Ethanol on Sleep in Rats
Kubota, T., De, A., Brown, R. A., Simasko, S. M., & Krueger, J. M. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02651.x · Cited by 49 · see citing works
Biphasic stimulant and sedative effects of ethanol
Erblich, J., Earleywine, M., Erblich, B., & Bovbjerg, D. H. (2002) · Addictive Behaviors · doi:10.1016/s0306-4603(02)00221-6 · Cited by 48 · see citing works
The Effects of Drugs of Abuse on Clock Genes
Perreau‐Lenz, S., & Spanagel, R. (2008) · Drug News & Perspectives · doi:10.1358/dnp.2008.21.4.1213350 · Cited by 48 · see citing works
Models of sleep regulation in mammals
Tobler, I., Franken, P., Trachsel, L., & Borbély, A. A. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00024.x · Cited by 48 · see citing works
Sleep during chronic ethanol administration and withdrawal in rats.
Mendelson, W. B., Majchrowicz, E., Mirmirani, N., Dawson, S. D., Gillin, J. C., & Wyatt, R. J. (1978) · Journal of Studies on Alcohol · doi:10.15288/jsa.1978.39.1213 · Cited by 46 · see citing works
Role of Adenosine and the Orexinergic Perifornical Hypothalamus in Sleep-Promoting Effects of Ethanol
Sharma, R., Sahota, P. K., & Thakkar, M. M. (2014) · SLEEP · doi:10.5665/sleep.3490 · Cited by 46 · see citing works
Self-citation
Blockade of adenosine and dopamine receptors inhibits the development of rapid tolerance to ethanol in mice
Batista, L. C., Prediger, R. D., Morato, G. S., & Takahashi, R. N. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0014-7 · Cited by 45 · see citing works
Circadian clocks, brain function, and development
Frank, E., Sidor, M. M., Gamble, K. L., Cirelli, C., Sharkey, K. M., Hoyle, N. P., Tikotzky, L., Talbot, L. S., McCarthy, M. J., & Hasler, B. P. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12335 · Cited by 45 · see citing works
Pharmacological Treatment of Insomnia in Alcohol Recovery: A Systematic Review
Kolla, B. P., Mansukhani, M. P., & Schneekloth, T. D. (2011) · Alcohol and Alcoholism · doi:10.1093/alcalc/agr073 · Cited by 44 · see citing works
Disruptions in Sleep Time and Sleep Architecture in a Mouse Model of Repeated Ethanol Withdrawal
Veatch, L. M. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00134.x · Cited by 43 · see citing works
Sleep homeostasis in alcohol-dependent, depressed and healthy control men
Brower, K. J., Hoffmann, R. F., Conroy, D. A., Arnedt, J. T., & Armitage, R. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0195-5 · Cited by 42 · see citing works
Temporal drinking patterns and variation in social consequences
Dawson, D. A. (1996) · Addiction · doi:10.1046/j.1360-0443.1996.911116234.x · Cited by 42 · see citing works
Chronic ethanol intake modulates photic and non-photic circadian phase responses in the Syrian hamster
Seggio, J. A., Logan, R. W., & Rosenwasser, A. M. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.05.001 · Cited by 42 · see citing works
Effects of a 3-Hour Sleep Delay on Sleep Homeostasis in Alcohol Dependent Adults
Armitage, R., Hoffmann, R. F., Conroy, D. A., Arnedt, J. T., & Brower, K. J. (2012) · SLEEP · doi:10.5665/sleep.1638 · Cited by 38 · see citing works
Acute Ethanol Disrupts Photic and Serotonergic Circadian Clock Phase-Resetting in the Mouse
Brager, A. J., Ruby, C. L., Prosser, R. A., & Glass, J. D. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01483.x · Cited by 38 · see citing works
Alcohol tolerance in humans is enhanced by prior caffeine antagonism of alcohol-induced impairment.
Fillmore, M. T. (2003) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.11.1.9 · Cited by 38 · see citing works
Alcohol tolerance in humans is enhanced by prior caffeine antagonism of alcohol-induced impairment.
Fillmore, M. T. (2003) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.11.1.9 · Cited by 36 · see citing works
Effects of the acute administration of ethanol on the sleep of the rat: A dose-response study
Mendelson, W. B., & Hill, S. Y. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90272-1 · Cited by 33 · see citing works
Chronic ethanol intoxication enhances [3H]CCPA binding and does not reduce A1 adenosine receptor function in rat cerebellum
Concas, A., Mascia, M. P., Cuccheddu, T., Floris, S., Mostallino, M. C., Perra, C., Satta, S., & Biggio, G. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00208-1 · Cited by 31 · see citing works
Chronic alcohol treatment in rats alters sleep by fragmenting periods of vigilance cycling in the light period with extended wakenings
Mukherjee, S., & Simasko, S. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.026 · Cited by 29 · see citing works
Pharmacology of ethanol and glutamate antagonists on rodent sleep: A comparative study
Prospero-Garcia, O. E., Criado, J., & Henriksen, S. J. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90442-1 · Cited by 29 · see citing works
Persistence of abnormal REM sleep response to ethanol as a result of previous ethanol ingestion
Gitlow, S. E., Bentkover, S. H., Dziedzic, S. W., et al. (1973) · Psychopharmacology · doi:10.1007/bf00429083 · Cited by 29 · see citing works
Nicotine Administration in the Cholinergic Basal Forebrain Increases Alcohol Consumption in C 57 BL /6 J Mice
Sharma, R., Sahota, P. K., & Thakkar, M. M. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12353 · Cited by 27 · see citing works
Self-citation
Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABAA receptor systems
Dar, M. S. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.09.016 · Cited by 26 · see citing works
Rapid Eye Movement Sleep: Regulation and Function
Mahowald, M. W. (2012) · SLEEP · doi:10.5665/sleep.1840 · Cited by 24 · see citing works
Rapid Eye Movement Sleep: Regulation and Function
Mallick, B. N., Pandi-Perumal, S. R., McCarley, R. W., & Morrison, A. R. (2011) · Medical Entomology and Zoology · Cited by 23 · see citing works
Effects of ethanol injection to the preoptic area on sleep and temperature in rats
Ticho, S. R., Stojanović, M. O., Leković, G. P., et al. (1992) · Alcohol · doi:10.1016/0741-8329(92)90065-i · Cited by 23 · see citing works
Effects of Muscimol or Homotaurine on Sleep–Wake States in Alcohol-Dependent Rats During Withdrawal
Rouhani, S., DALL'AVA-SANTUCCI, J., Băjenaru, O., et al. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00521-2 · Cited by 23 · see citing works
Rapid tolerance development to the NREM sleep promoting effect of alcohol
Sharma, R., Sahota, P., & Thakkar, M. M. (2014) · SLEEP · doi:10.5665/sleep.3598 · Cited by 23 · see citing works
Temporal drinking patterns and variation in social consequences
Dawson, D. A. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02266.x · Cited by 23 · see citing works
Effects of chronic and acute ethanol administration on sleep in laboratory rats.
Hill, S. Y., & Reyes, R. B. (1978) · Journal of Studies on Alcohol · doi:10.15288/jsa.1978.39.47 · Cited by 21 · see citing works
Dose–response study of chronic alcohol induced changes in sleep patterns in rats
Mukherjee, S., Kazerooni, M., & Simasko, S. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.079 · Cited by 21 · see citing works
Brain adenosinergic modulation of acute ethanol-induced motor impairment.
Ms, D. (1993) · PubMed · Cited by 20 · see citing works
Intrastriatal adenosine A1 receptor antisense oligodeoxynucleotide blocks ethanol-induced motor incoordination
Phan, T. A., Gray, A. M., & Nyce, J. W. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00147-7 · Cited by 18 · see citing works
Effects of l-tryptophan and ethanol on sleep parameters in the rat
Hill, S. Y., & Reyes, R. B. (1978) · Psychopharmacology · doi:10.1007/bf00427384 · Cited by 16 · see citing works
Relationship of ethanol blood level to REM and non-REM sleep time and distribution in the rat
Hattan, D. G., & Eacho, P. I. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90607-0 · Cited by 16 · see citing works
Acute Binge Alcohol Administration Reverses Sleep-Wake Cycle in Sprague Dawley Rats
Sharma, R., Bradshaw, K., Sahota, P. K., & Thakkar, M. M. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12463 · Cited by 15 · see citing works
Self-citation
The Mammalian Circadian Clock in the Suprachiasmatic Nucleus Exhibits Rapid Tolerance to Ethanol In Vivo and In Vitro
Lindsay, J. H., Glass, J. D., Amicarelli, M., & Prosser, R. A. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12303 · Cited by 14 · see citing works
Evidence for Possible P eriod 2 Gene Mediation of the Effects of Alcohol Exposure During the Postnatal Period on Genes Associated with Maintaining Metabolic Signaling in the Mouse Hypothalamus
Agapito, M. A., Barreira, J. C., Logan, R. W., & Sarkar, D. K. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01871.x · Cited by 12 · see citing works
Adenosine and glycine in REM-sleep regulation
Thakkar, M. M., Sharma, R., Engemann, S. C., et al. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511921179.028 · Cited by 1 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Short- and long-term health consequences of sleep disruption
Medic, G., Wille, M., & Hemels, M. (2017) · Nature and Science of Sleep · doi:10.2147/nss.s134864 · Cited by 1,776 · see citing works
Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies
Fernandez, R., Moore, V., Van Ryswyk, E., Varcoe, T., Rodgers, R., March, W., Moran, L., Avery, J., McEvoy, D., & Davies, M. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s127475 · Cited by 137 · see citing works
The Effects of Sleep Quality and Resilience on Perceived Stress, Dietary Behaviors, and Alcohol Misuse: A Mediation-Moderation Analysis of Higher Education Students from Asia, Europe, and North America during the COVID-19 Pandemic
Du, C., Zan, M. C. H., Cho, M. J., Fenton, J. I., Hsiao, P. Y., Hsiao, R., Keaver, L., Lai, C.-C., Lee, H., Ludy, M.-J., et al. (2021) · Nutrients · doi:10.3390/nu13020442 · Cited by 108 · see citing works
Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A <sub>1</sub> receptors
Elmenhorst, E.-M., Elmenhorst, D., Benderoth, S., Kroll, T., Bauer, A., & Aeschbach, D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803770115 · Cited by 51 · see citing works
Epigenome-wide association study of alcohol use disorder in five brain regions
Zillich, L., Frank, J., Streit, F., Friske, M. M., Foo, J. C., Sirignano, L., Heilmann-Heimbach, S., Dukal, H., Degenhardt, F., Hoffmann, P., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01228-7 · Cited by 36 · see citing works
A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
Wang, C., Huang, T., Song, W., Zhu, J., Liu, Y., Chen, X., Sun, X., Wu, Q., Chen, H., Liao, H., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.957112 · Cited by 19 · see citing works
The Cyclical Battle of Insomnia and Mental Health Impairment in Firefighters: A Narrative Review
Holland-Winkler, A. M., Greene, D. R., & Oberther, T. J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082169 · Cited by 9 · see citing works

[Rapid eye movement-related and none rapid eye movement-related classification in obstructive sleep apnea hypopnea syndrome].
Chai, L.-P., Xie, X., Zeng, Y.-H., et al. (2010) · PubMed · Cited by 1 · see citing works
Correlations using the NREM-REM sleep cycle frequency support distinct regulation mechanisms for REM and NREM sleep
Bon, O. L., Staner, L., Rivelli, S. K., Hoffmann, G., Pelc, I., & Linkowski, P. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00917.2001 · Cited by 39 · see citing works
217. REM/NREM Sleep-Dependent OSA: What Makes the Difference?
Seo, M. C., Kim, E.-J., Joo, E.-J., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.230
Assessing the Physiologic Endotypes Responsible for REM- and NREM-Based OSA
Joosten, S. A., Landry, S. A., Wong, A., Mann, D., Terrill, P. I., Sands, S. A., Turton, A., Beatty, C., Thomson, L. D. J., Hamilton, G. S., et al. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.10.080 · Cited by 91 · see citing works
The relationship between each length of REM - NREM sleep cycle and sleep stage
Sawai, H., Matsumoto, M., & Koyama, E. (2021) · IEEE Global Conference on Life Sciences and Technologies (LifeTech) · doi:10.1109/lifetech52111.2021.9391838 · Cited by 11 · see citing works

Authors: Thakkar, M. M., Sharma, R., & Sahota, P.
Affiliations: Harry S. Truman Memorial Veterans' Hospital (US)
Corresponding author: Thakkar, Mahesh M.
ORCID: Thakkar, Mahesh M.
Sharma, Rishi
Sahota, Pradeep
Venue: Alcohol
Publisher: Elsevier BV
Published: 2015-06
Volume: 49
Issue: 4
Pages: 299-310
ISSN: 0741-8329 (ISSN-L)
DOI: 10.1016/j.alcohol.2014.07.019
PMC: PMC4427543
OpenAlex: W2041098567
Cited by: 262
References: 134
Citations by year: 2026: 15 · 2025: 24 · 2024: 29 · 2023: 30 · 2022: 30 · 2021: 29 · 2020: 31 · 2019: 19 · 2018: 20 · 2017: 18 · 2016: 8 · 2015: 7 · 2013: 1 · 2012: 1
FWCI: 1.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Alcohol (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Harry S. Truman Memorial Veterans Hospital
National Institute on Alcohol Abuse and Alcoholism (AA020334, AA0174720)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep homeostasis, sleep disruption, adenosine, adenosine uptake, basal forebrain cholinergic neurons, wake-promoting neurons, binge drinking, alcohol withdrawal, insomnia, excessive daytime sleepiness, sleep architecture, alcoholism, sleep-wake regulation
MeSH terms: Adenosine, Ethanol, Alcoholism, Animals, Central Nervous System Depressants, Electroencephalography, Homeostasis, Humans, Immunohistochemistry, Sleep, Sleep Wake Disorders, Wakefulness, Microdialysis, Models, Animal, Mice, Rats, Cholinergic Neurons, Binge Drinking, Basal Forebrain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alcohol disrupts sleep homeostasis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks