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Cited by 88Circadian rhythm and melatoninDementia and Cognitive Impairment ResearchSleep and related disorders

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Weaker Circadian Activity Rhythms are Associated with Poorer Executive Function in Older Women

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Walsh, Christine M., Blackwell, Terri, Tranah, Gregory J., Stone, Katie L., Ancoli-Israel, Sonia, Redline, Susan, Paudel, Misti, Kramer, Joel H., Yaffe, Kristine·2014·Sleep
DOI 10.5665/sleep.4260PMC PMC4548515
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Abstract

Study objectives Older adults and patients with dementia often have disrupted circadian activity rhythms (CARs). Disrupted CARs are associated with health declines and could affect cognitive aging. We hypothesized that among older women, weaker CARs would be associated with poorer cognitive function 5 y later. Design Prospective observational study. Setting Three US clinical sites. Participants There were 1,287 community-dwelling older women (82.8 ± 3.1 y) participating in an ongoing prospective study who were free of dementia at the baseline visit. Measurements and results Baseline actigraphy was used to determine CAR measures (amplitude, mesor, and rhythm robustness, analyzed as quartiles; acrophase analyzed by peak activity time 15:51). Five years later, cognitive performance was assessed with the Modified Mini-Mental Status Examination (3MS), California Verbal Learning Task (CVLT), digit span, Trail Making Test B (Trails B), categorical fluency, and letter fluency. We compared cognitive performance with CARs using analyses of covariance adjusted for a number of health factors and comorbidities. Women in the lowest quartile for CAR amplitude performed worse on Trails B and categorical fluency compared to women in the highest quartile (group difference (d) = 30.42 sec, d = -1.01 words respectively, P Conclusion Weaker circadian activity rhythm patterns are associated with worse cognitive function, especially executive function, in older women without dementia. Further inves…

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    From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [26]

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Metadata

Authors
Walsh, C. M., Blackwell, T., Tranah, G. J., Stone, K. L., Ancoli-Israel, S., Redline, S., Paudel, M., Kramer, J. H., & Yaffe, K.
Affiliations
  • San Francisco VA Medical Center (US)
  • California Pacific Medical Center (US)
  • Department of Psychiatry, University of California, San Diego, CA
  • Brigham and Women's Hospital (US)
  • University of Minnesota (US)
  • University of California, San Francisco (US)
ORCID
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2014-12-01
Volume
37
Issue
12
Pages
2009-2016
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.5665/sleep.4260
PMC
PMC4548515
OpenAlex
W2325112840
Cited by
88
References
2
Citations by year
2026: 1 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 5
FWCI
2.55
Type
journal article
Language
en
Open access
Locations
  • SLEEP (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute for Health and Care Research
  • National Institutes of Health
  • National Institute on Aging (R01AG005394, R01AG005407, R01AG027576, K24AG031155, R01AG026720, R01AG027574)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR035584, R01AR035582, R01AR035583)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
circadian activity rhythm, executive function, older women, cognitive aging, actigraphy, rhythm amplitude, mesor, acrophase, Trail Making Test, cognitive decline, community-dwelling older adults
MeSH terms
Aged, Aged, 80 and over, Aging, Circadian Rhythm, Cognition, Cognition Disorders, Dementia, Female, Humans, Models, Biological, Neuropsychological Tests, Prospective Studies, Residence Characteristics, Sleep, United States, Comorbidity, Actigraphy, Executive Function

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