Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women
Open accessAbstract
Objective: Previous cross‐sectional studies have observed alterations in activity rhythms in dementia patients but the direction of causation is unclear. We determined whether circadian activity rhythms measured in community‐dwelling older women are prospectively associated with incident dementia or mild cognitive impairment (MCI). Methods: Activity rhythm data were collected from 1,282 healthy community‐dwelling women from the Study of Osteoporotic Fractures (SOF) cohort (mean age 83 years) with wrist actigraphy for a minimum of three 24‐hour periods. Each participant completed a neuropsychological test battery and had clinical cognitive status (dementia, MCI, normal) adjudicated by an expert panel approximately 5 years later. All analyses were adjusted for demographics, body mass index (BMI), functional status, depression, medications, alcohol, caffeine, smoking, health status, and comorbidities. Results: After 4.9 years of follow‐up, 195 (15%) women had developed dementia and 302 (24%) had developed MCI. Older women with decreased activity rhythms had a higher likelihood of developing dementia or MCI when comparing those in the lowest quartiles of amplitude (odds ratio [OR] = 1.57; 95% CI, 1.09–2.25) or rhythm robustness (OR = 1.57; 95% CI, 1.10–2.26) to women in the highest quartiles. An increased risk of dementia or MCI (OR = 1.83; 95% CI, 1.29–2.61) was found for women whose timing of peak activity occurred later in the day (after 3:51 PM) when compared to those with average timing (1:34 PM–3:51 PM). Interpretation: Older, healthy women with decreased circadian activity rhythm amplitude and robustness, and delayed rhythms have increased odds of developing dementia and MCI. If confirmed, future studies should examine whether interventions (physical activity, bright light exposure) that influence activity rhythms will reduce the risk of cognitive deterioration in the elderly. ANN NEUROL 2011
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In older adults, less-robust circadian rhythms and more fragmented patterns of activity are risk factors for the development of dementia.
“In older adults, less-robust circadian rhythms and more fragmented patterns of activity are risk factors for the development of dementia250.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [250]
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Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works
Sheikh (1986) · doi:10.1300/j018v05n01_09 · Cited by 7,236 · see citing works
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781 · see citing works
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472 · see citing works
Risk Factors for Hip Fracture in White Women
Cummings, S. R., Nevitt, M. C., Browner, W. S., Stone, K., Fox, K. M., Ensrud, K. E., Cauley, J., Black, D., & Vogt, T. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503233321202 · Cited by 3,595 · see citing works
Self-citationNeurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works
The Role of Actigraphy in the Study of Sleep and Circadian Rhythms
Ancoli-Israel, S., Cole, R., Alessi, C., Chambers, M., Moorcroft, W., & Pollak, C. P. (2003) · Sleep · doi:10.1093/sleep/26.3.342 · Cited by 2,751 · cited 1× · see citing works
“Circadian measurements derived from wrist actigraphy have been compared to measures derived from other methods considered to be reference standards.(37) For example, actigraphic sleep/wake predictions have the same circadian period as polysomnography (PSG) sleep/wake scores.”
MethodSelf-citationThe Mini-Mental State Examination
Folstein, M. F. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790060110016 · Cited by 1,975 · see citing works
Automatic sleep/wake identification from wrist activity.
Cole, R., Kripke, D., Gruen, W., Mullaney, D., & Gillin, J. (1992) · Sleep · doi:10.1093/sleep/15.5.461 · Cited by 1,971 · see citing works
Entrainment of the circadian clock in the liver by feeding
Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800 · see citing works
The Mini-Cog: a cognitive ?vital signs? measure for dementia screening in multi-lingual elderly
Soo Borson, B., Scanlan, J. M., Brush, M. B., VITALIANO, P. P., & Dokmak, A. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/1099-1166(200011)15:11 · Cited by 1,792 · see citing works
Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776 · see citing works
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656 · see citing works
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401 · see citing works
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Sakurai, T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2092 · Cited by 1,276 · see citing works
Jorm, A. F., & Jacomb, P. A. (1989) · Psychological Medicine · doi:10.1017/s0033291700005742 · Cited by 1,104 · see citing works
Clinical Gerontology; A Guide to Assessment and Intervention
Essa, M. (1987) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1987.41.3.478 · Cited by 1,065 · see citing works
The Role of Sleep in Cognition and Emotion
Walker, M. P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04416.x · Cited by 1,024 · see citing works
Sleep in Normal Aging and Dementia
Bliwise, D. L. (1993) · SLEEP · doi:10.1093/sleep/16.1.40 · Cited by 854 · see citing works
A time to think: circadian rhythms in human cognition
Schmidt, C., Collette, F., Cajochen, C., & Peigneux, P. (2007) · Cognitive Neuropsychology · doi:10.1080/02643290701754158 · Cited by 778 · see citing works
The role of locus coeruleus in the regulation of cognitive performance
Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G. (1999) · Science · doi:10.1126/science.283.5401.549 · Cited by 715 · see citing works
The contribution of sleep to hippocampus-dependent memory consolidation
Marshall, L., & Born, J. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.09.001 · Cited by 667 · see citing works
Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia
Reid, K. J., Baron, K. G., Lu, B., Naylor, E., Wolfe, L., & Zee, P. C. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.04.014 · Cited by 665 · cited 1× · see citing works
“Other studies have shown that physical activity also has a positive effect on circadian activity rhythms.(30,31) In addition, exposure to ambient light is known to influence cognition and affective state and bright light has phase-shifting properties that have been shown to improve cognitive performance.”
BackgroundClinical Gerontology: A Guide to Assessment and Intervention
Brink, T. L. (1986) · Medical Entomology and Zoology · Cited by 592 · see citing works
The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei
Harmar, A. J., Marston, H. M., Shen, S., Spratt, C., West, K. M., Sheward, W. J., Morrison, C. F., Dorin, J. R., Piggins, H. D., Reubi, J.-C., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00736-5 · Cited by 549 · see citing works
Drug data coding and analysis in epidemiologic studies
Pahor, M., Chrischilles, E. A., Guralnik, J. M., Brown, S. L., Wallace, R. B., & Carbonin, P. (1994) · European Journal of Epidemiology · doi:10.1007/bf01719664 · Cited by 490 · see citing works
Circadian rest—activity rhythm disturbances in alzheimer's disease
Someren, E. J. W. V., Hagebeuk, E. E. O., Lijzenga, C., Scheltens, P., Rooij, S. E. J. A. D., Jonker, C., Pot, A. M., Mirmiran, M., & Swaab, D. F. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00370-3 · Cited by 453 · see citing works
Association of sleep-wake habits in older people with changes in output of circadian pacemaker
Czeisler, C. A., Dumont, M., Duffy, J. F., Steinberg, J. D., Richardson, G. S., Brown, E. N., Sánchez, R., Ríos, C. D., & Ronda, J. M. (1992) · The Lancet · doi:10.1016/0140-6736(92)92817-y · Cited by 437 · see citing works
Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood
Hampp, G., Ripperger, J. A., Houben, T., Schmutz, I., Blex, C., Perreau‐Lenz, S., Brunk, I., Spanagel, R., Ahnert‐Hilger, G., Meijer, J. H., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.012 · Cited by 419 · see citing works
Behavioral State Instability in Orexin Knock-Out Mice
Mochizuki, T., Crocker, A. J., McCormack, S. L., Yanagisawa, M., Sakurai, T., & Scammell, T. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0586-04.2004 · Cited by 397 · see citing works
Sleep Problems and Institutionalization of the Elderly
Pollak, C. P., & PERLICK, D. A. (1991) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879100400405 · Cited by 396 · see citing works
Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment
Weitzman, E. D., Moline, M. L., Czeisler, C. A., & Zimmerman, J. C. (1982) · Neurobiology of Aging · doi:10.1016/0197-4580(82)90018-5 · Cited by 367 · see citing works
Use of Wrist Activity for Monitoring Sleep/Wake in Demented Nursing-Home Patients
Ancoli‐Israel, S., Clopton, P., Klauber, M. R., Fell, R. L., & Mason, W. J. (1997) · SLEEP · doi:10.1093/sleep/20.1.24 · Cited by 348 · see citing works
Self-citationAncoli-Israel, S., Gehrman, P., Martin, J. L., Shochat, T., Marler, M., Corey-Bloom, J., & Levi, L. (2003) · Behavioral Sleep Medicine · doi:10.1207/s15402010bsm0101_4 · Cited by 347 · see citing works
Self-citationMieda, M., Willie, J. T., Hara, J., Sinton, C. M., Sakurai, T., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400590101 · Cited by 341 · see citing works
Living by the clock: The circadian pacemaker in older people
Hofman, M. A., & Swaab, D. F. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.07.001 · Cited by 335 · see citing works
Effects of aging on central and peripheral mammalian clocks
Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152318499 · Cited by 317 · see citing works
Ancoli‐Israel, S., Klauber, M. R., Jones, D. W., Kripke, D. F., Martin, J. L., Mason, W. J., Pat‐Horenczyk, R., & Fell, R. L. (1997) · SLEEP · doi:10.1093/sleep/20.1.18 · Cited by 302 · see citing works
Self-citationEffect of Light Treatment on Sleep and Circadian Rhythms in Demented Nursing Home Patients
Ancoli‐Israel, S., Martin, J. L., Kripke, D. F., Marler, M., & Klauber, M. R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50060.x · Cited by 297 · see citing works
Self-citationCircadian modulation of learning and memory in fear-conditioned mice.
Chaudhury, D., & Colwell, C. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00471-5 · Cited by 282 · see citing works
Circadian and sleep disturbances in the elderly
Someren, E. J. W. V. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00191-1 · Cited by 273 · see citing works
Light Treatment for Sleep Disorders: Consensus Report
Eastman, C. I., Boulos, Z., Terman, M., Campbell, S. S., Dijk, D., & Lewy, A. J. (1995) · Journal of Biological Rhythms · doi:10.1177/074873049501000208 · Cited by 272 · see citing works
Wu, J. C., Kelsoe, J. R., Schachat, C., Bunney, B. G., DeModena, A., Golshan, S., Gillin, J. C., Potkin, S. G., & Bunney, W. E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.018 · Cited by 263 · see citing works
Hippocampal-dependent learning requires a functional circadian system
Ruby, N. F., Hwang, C. E., Wessells, C., Fernandez, F., Zhang, P., Sapolsky, R., & Heller, H. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808259105 · Cited by 234 · see citing works
Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease
Satlin, A., Volicer, L., Stopa, E. G., & Harper, D. G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00059-n · Cited by 232 · see citing works
Actigraphy and Motion Analysis: New Tools for Psychiatry
Teicher, M. H. (1995) · Harvard Review of Psychiatry · doi:10.3109/10673229509017161 · Cited by 231 · see citing works
Circadian regulation of hippocampal long-term potentiation
Chaudhury, D., Wang, L. M., & Colwell, C. S. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405276352 · Cited by 231 · see citing works
How Accurately Does Wrist Actigraphy Identify the States of Sleep and Wakefulness?
Pollak, C. P., Tryon, W. W., Nagaraja, H. N., & Dzwonczyk, R. R. (2001) · SLEEP · doi:10.1093/sleep/24.8.957 · Cited by 223 · see citing works
Sleep disorders in aging and dementia
Bombois, S., Derambure, P., Pasquier, F., & Monaca, C. C. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0052-7 · Cited by 217 · see citing works
Peak of circadian melatonin rhythm occurs later within the sleep of older subjects
Duffy, J. F., Zeitzer, J. M., Rimmer, D. W., Klerman, E. B., Dijk, D., & Czeisler, C. A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00268.2001 · Cited by 211 · see citing works
Marler, M., Gehrman, P., Martin, J. L., & Ancoli‐Israel, S. (2005) · Statistics in Medicine · doi:10.1002/sim.2466 · Cited by 209 · see citing works
Self-citationLight deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats
González, M. M. C., & Aston‐Jones, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703615105 · Cited by 196 · see citing works
Pallier, P. N., Maywood, E. S., Zheng, Z., Chesham, J. E., Inyushkin, A. N., Dyball, R. E. J., Hastings, M. H., & Morton, A. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0649-07.2007 · Cited by 193 · see citing works
Vasopressin and the Output of the Hypothalamic Biological Clock
Kalsbeek, A., Fliers, E., Hofman, M. A., Swaab, D. F., & Buijs, R. M. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01956.x · Cited by 192 · see citing works
Sleep Disorders Medicine. Basic Science, Technical Considerations and Clinical Aspects.
Olejniczak, P. W. (1999) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199911000-00009 · Cited by 190 · see citing works
Age‐Related Changes of Circadian Rhythms and Sleep‐Wake Cycles
Yoon, I., Kripke, D. F., Elliott, J. A., Youngstedt, S. D., Rex, K. M., & Hauger, R. L. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51356.x · Cited by 185 · see citing works
Functions of orexins in peripheral tissues
Heinonen, M. V., Purhonen, A., Mäkelä, K. A., & Herzig, K. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01836.x · Cited by 180 · see citing works
Sleep/wake patterns In Alzheimer's disease: relationships with cognition and function
Moe, K. E., Vitiello, M. V., Larsen, L. H., & Prinz, P. N. (1995) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1995.tb00145.x · Cited by 175 · see citing works
Sleep disturbances in older adults with mild cognitive impairment
Beaulieu‐Bonneau, S., & Hudon, C. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209009120 · Cited by 172 · see citing works
Circadian clocks: genes, sleep, and cognition
Kyriacou, C. P., & Hastings, M. H. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.03.007 · Cited by 171 · see citing works
Age-related attenuation of the evening circadian arousal signal in humans
Münch, M. Y., Knoblauch, V., Blatter, K., Schroder, C. M., Schnitzler, C., Kräuchi, K., Wirz‐Justice, A., & Cajochen, C. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.004 · Cited by 158 · see citing works
Asai, M., Yoshinobu, Y., Kaneko, S., Mori, A., Nikaido, T., Moriya, T., Akiyama, M., & Shibata, S. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10010 · Cited by 151 · see citing works
Hastings, M. H., Maywood, E. S., & Reddy, A. B. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01715.x · Cited by 146 · see citing works
Circadian phase-shifting effects of nocturnal exercise in older compared with young adults
Baehr, E. K., Eastman, C. I., Revelle, W., Olson, S. H. L., Wolfe, L. F., & Zee, P. C. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00761.2002 · Cited by 141 · see citing works
Alzheimer’s Disease: Sleep and Sleep/Wake Patterns
Vitiello, M. V., & Prinz, P. N. (1989) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30679-7 · Cited by 139 · see citing works
Circadian Patterns of Sleep, Sleepiness, and Performance in Older and Younger Adults
Buysse, D. J., Monk, T. H., Carrier, J., & Begley, A. E. (2005) · SLEEP · doi:10.1093/sleep/28.11.1365 · Cited by 131 · see citing works
Actigraphy: A Means of Assessing Circadian Patterns in Human Activity
Brown, A. C., Smolensky, M. H., D’Alonzo, G. E., & Redman, D. P. (1990) · Chronobiology International · doi:10.3109/07420529009056964 · Cited by 130 · see citing works
Sleep waking and neurobehavioural performance
Rogers, N. L. (2003) · Frontiers in bioscience · doi:10.2741/1174 · Cited by 125 · see citing works
Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges
Benca, R., Duncan, M. J., Frank, E., McClung, C., Nelson, R. J., & Vicentic, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.005 · Cited by 125 · see citing works
Disturbances of sleep and cognitive functioning in patients with dementia
Loewenstein, R. J., Weingartner, H., Gillin, J. C., et al. (1982) · Neurobiology of Aging · doi:10.1016/0197-4580(82)90025-2 · Cited by 122 · see citing works
Human circadian rhythms in constant dim light (8 lux) with knowledge of clock time
Middleton, B., Arendt, J., & Stone, B. M. (1996) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1996.d01-67.x · Cited by 116 · see citing works
Complex Effects of Melatonin on Human Circadian Rhythms in Constant Dim Light
Middleton, B., Arendt, J., & Stone, B. M. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200508 · Cited by 109 · see citing works
Light Treatment for Sleep Disorders: Consensus Report
Campbell, S. S., Terman, M., Lewy, A. J., Dijk, D., Eastman, C. I., & Boulos, Z. (1995) · Journal of Biological Rhythms · doi:10.1177/074873049501000207 · Cited by 108 · see citing works
Circadian Activity Rhythms and Mortality: The Study of Osteoporotic Fractures
Tranah, G. J., BLACKWELL, T. L., Ancoli‐Israel, S., Paudel, M. L., Ensrud, K. E., Cauley, J. A., Redline, S. S., Hillier, T. A., Cummings, S. R., & Stone, K. L. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02674.x · Cited by 106 · see citing works
Self-citationREST/ACTIVITY RHYTHMS AND MORTALITY RATES IN OLDER MEN: MROS SLEEP STUDY
Paudel, M. L., Taylor, B. C., Ancoli‐Israel, S., BLACKWELL, T. L., Stone, K. L., Tranah, G. J., Redline, S. S., Cummings, S. R., Ensrud, K. E., & for the Osteoporotic Fractures in Men (MrOS) Study Group (2010) · Chronobiology International · doi:10.3109/07420520903419157 · Cited by 105 · see citing works
Self-citationSleep disturbances in nursing homes
Neikrug, A. B., & Ancoli‐Israel, S. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0051-8 · Cited by 100 · see citing works
Self-citationActigraphy Scoring Reliability in the Study of Osteoporotic Fractures
Blackwell, T., Ancoli‐Israel, S., Gehrman, P., Schneider, J. L., Pedula, K. L., & Stone, K. L. (2005) · SLEEP · doi:10.1093/sleep/28.12.1599 · Cited by 99 · see citing works
Self-citationCircadian abnormalities in older adults
Youngstedt, S. D., Kripke, D. F., Elliott, J. A., & Klauber, M. R. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.310311.x · Cited by 94 · see citing works
Circadian Phase in Adults of Contrasting Ages
Kripke, D. F., Youngstedt, S. D., Elliott, J. A., Tuunainen, A., Rex, K. M., Hauger, R. L., & Marler, M. (2005) · Chronobiology International · doi:10.1080/07420520500180439 · Cited by 85 · see citing works
Chokroverty, S. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6 · Cited by 84 · see citing works
The relationship between dementia severity and rest/activity circadian rhythms
Gehrman, P., Marler, M., Martin, J. L., Shochat, T., Corey-Bloom, J., & Ancoli-Israel, S. (2005) · Neuropsychiatric Disease and Treatment · doi:10.2147/nedt.1.2.155.61043 · Cited by 82 · see citing works
Self-citationAge-related changes in electrophysiological properties of the mouse suprachiasmatic nucleus in vitro
Nygård, M., Hill, R. H., Wikström, M. A., & Kristensson, K. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.12.006 · Cited by 82 · see citing works
Lifestyle predicts falls independent of physical risk factors
Faulkner, K. A., Cauley, J. A., Studenski, S. A., Landsittel, D. P., Cummings, S. R., Ensrud, K. E., Donaldson, M. G., & Nevitt, M. C. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0909-y · Cited by 80 · see citing works
Self-citationThe Timing of Activity Rhythms in Patients With Dementia Is Related to Survival
Gehrman, P., Marler, M., Martin, J. L., Shochat, T., Corey‐Bloom, J., & Ancoli‐Israel, S. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.10.m1050 · Cited by 69 · see citing works
Self-citationCIRCADIAN RHYTHMS IN HEALTHY AGING—EFFECTS DOWNSTREAM FROM THE PACEMAKER
Monk, T. H., & Kupfer, D. J. (2000) · Chronobiology International · doi:10.1081/cbi-100101051 · Cited by 67 · see citing works
Lumbar spine listhesis in older African American women
Vogt, M. T., Rubin, D. A., Palermo, L., Christianson, L., Kang, J. D., Nevitt, M. C., & Cauley, J. A. (2003) · The Spine Journal · doi:10.1016/s1529-9430(03)00024-x · Cited by 64 · see citing works
Self-citationHofman, M. A., & Swaab, D. F. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02016-0 · Cited by 64 · see citing works
Strong resetting of the mammalian clock by constant light followed by constant darkness
Chen, R., Seo, D.-O., Bell, E., von Gall, C., & Lee, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2191-08.2008 · Cited by 53 · see citing works
Müller, U., Czymmek, J., Thöne-Otto, A. I. T., & von Cramon, D. Y. (2006) · Brain Injury · doi:10.1080/02699050500443467 · Cited by 47 · see citing works
Non-pharmacologic management of sleep disturbance in Alzheimer's disease
David, R., Zeitzer, J. M., Friedman, L., Noda, A. M., O'Hara, R. M., Robert, P. H., & Yesavage, J. A. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0050-9 · Cited by 43 · see citing works
Subjective Alertness Rhythms in Elderly People
Monk, T. H., Buysse, D. J., Reynolds, C. F., Kupfer, D. J., & Houck, P. R. (1996) · Journal of Biological Rhythms · doi:10.1177/074873049601100308 · Cited by 37 · see citing works
Aging regulates 5-HT1B receptors and serotonin reuptake sites in the SCN
Duncan, M. J., Crafton, C. J., & Wheeler, D. L. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02397-5 · Cited by 25 · see citing works
An activity monitor study on the sleep‐wake rhythm of healthy aged people residing in their homes
Sakurai, N., & Sasaki, M. (1998) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1998.tb01060.x · Cited by 24 · see citing works
Espeland, M. A., Rapp, S. R., Robertson, J., Granek, I. A., Murphy, C. V., Albert, M., & Bassford, T. L. (2006) · Clinical Trials · doi:10.1191/1740774506cn140oa · Cited by 22 · see citing works
Mäkelä, K. A., Wigren, H., Zant, J. C., et al. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02068.x · Cited by 21 · see citing works
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Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis
Shi, L., Chen, S.-J., Ma, M.-Y., Bao, Y.-P., Han, Y., Wang, Y.-M., Shi, J., Vitiello, M. V., & Lu, L. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.06.010 · Cited by 1,009 · see citing works
Mechanisms linking circadian clocks, sleep, and neurodegeneration
Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878 · see citing works
Connections between sleep and cognition in older adults
Yaffe, K., Falvey, C. M., & Hoang, T. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70172-3 · Cited by 796 · see citing works
Self-citationRhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Sleep, Cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis
Bubu, O. M., Brannick, M., Mortimer, J., Umasabor-Bubu, O., Sebastião, Y. V., Wen, Y., Schwartz, S., Borenstein, A. R., Wu, Y., Morgan, D., et al. (2017) · Sleep · doi:10.1093/sleep/zsw032 · Cited by 673 · see citing works
Circadian misalignment and health
Baron, K. G., & Reid, K. J. (2014) · International Review of Psychiatry · doi:10.3109/09540261.2014.911149 · Cited by 645 · see citing works
Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004291 · Cited by 563 · see citing works
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70317 · Cited by 524 · see citing works
Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease
Musiek, E. S., Xiong, D. D., & Holtzman, D. M. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.121 · Cited by 529 · see citing works
Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease
Musiek, E. S., Bhimasani, M., Zangrilli, M. A., Morris, J. C., Holtzman, D. M., & Ju, Y.-E. S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4719 · Cited by 465 · see citing works
Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms
Lanctôt, K. L., Amatniek, J., Ancoli‐Israel, S., Arnold, S. E., Ballard, C., Cohen‐Mansfield, J., Ismail, Z., Lyketsos, C., Miller, D. S., Musiek, E., et al. (2017) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.07.001 · Cited by 395 · see citing works
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Lucey, B. P., Hicks, T. J., McLeland, J. S., Toedebusch, C. D., Boyd, J., Elbert, D. L., Patterson, B. W., Baty, J., Morris, J. C., Ovod, V., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25117 · Cited by 362 · see citing works
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Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278 · see citing works
Di Marco, L. Y., Marzo, A., Muñoz-Ruiz, M., Ikram, M. A., Kivipelto, M., Ruefenacht, D., Venneri, A., Soininen, H., Wanke, I., Ventikos, Y. A., et al. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-132225 · Cited by 215 · see citing works
Di Meco, A., Joshi, Y. B., & Praticò, D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.011 · Cited by 205 · see citing works
Midlife sleep characteristics associated with late life cognitive function
Virta, J. J., Heikkilä, K., Perola, M., Koskenvuo, M., Räihä, I., Rinne, J. O., & Kaprio, J. (2013) · Sleep · doi:10.5665/sleep.3052 · Cited by 200 · see citing works
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Reid, K. J. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.05.001 · Cited by 152 · see citing works
Blackman, J., Swirski, M., Clynes, J., Harding, S., Leng, Y., & Coulthard, E. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13229 · Cited by 141 · see citing works
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Finger, A., & Kramer, A. (2021) · Acta Physiologica · doi:10.1111/apha.13548 · Cited by 117 · see citing works
Memory complaints and risk of cognitive impairment after nearly 2 decades among older women
Kaup, A. R., Nettiksimmons, J., LeBlanc, E. S., & Yaffe, K. (2015) · Neurology · doi:10.1212/wnl.0000000000002153 · Cited by 109 · see citing works
Self-citationDevore, E. E., Grodstein, F., & Schernhammer, E. S. (2016) · Neuroepidemiology · doi:10.1159/000442418 · Cited by 107 · see citing works
Bokenberger, K., Ström, P., Dahl Aslan, A. K., Johansson, A. L. V., Gatz, M., Pedersen, N. L., & Åkerstedt, T. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw127 · Cited by 96 · see citing works
Smagula, S. F., Ancoli-Israel, S., Blackwell, T., Boudreau, R., Stefanick, M. L., Paudel, M. L., Stone, K. L., & Cauley, J. A. (2015) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.06.007 · Cited by 63 · see citing works
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Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58 · see citing works
Cochrane, A., Robertson, I. H., & Coogan, A. N. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0802-2 · Cited by 55 · see citing works
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59 · see citing works
Kim, E., Nohara, K., Wirianto, M., Escobedo, G., Lim, J. Y., Morales, R., Yoo, S.-H., & Chen, Z. (2021) · Biomolecules · doi:10.3390/biom11071004 · Cited by 51 · see citing works
Is sleep disruption a risk factor for Alzheimer's disease?
Macedo, A. C., Balouch, S., & Tabet, N. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161287 · Cited by 49 · see citing works
Chen, H.-F., Huang, C.-Q., You, C., Wang, Z.-R., & Si-qing, H. (2013) · Archives of Medical Research · doi:10.1016/j.arcmed.2013.01.002 · Cited by 48 · see citing works
Smagula, S. F., Boudreau, R. M., Stone, K., Reynolds, C. F., Bromberger, J. T., Ancoli-Israel, S., Dam, T.-T., Barrett-Connor, E., & Cauley, J. A. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1102925 · Cited by 46 · see citing works
Self-citationWiner, J. R., Lok, R., Weed, L., He, Z., Poston, K. L., Mormino, E. C., & Zeitzer, J. M. (2024) · Alzheimer's Research & Therapy · doi:10.1186/s13195-024-01411-0 · Cited by 44 · see citing works
Association of the sleep regularity index with incident dementia and brain volume
Yiallourou, S. R., Cribb, L., Cavuoto, M. G., Rowsthorn, E., Nicolazzo, J., Gibson, M., Baril, A.-A., & Pase, M. P. (2024) · Neurology · doi:10.1212/wnl.0000000000208029 · Cited by 33 · see citing works
Nonpharmacologic Treatment and Prevention Strategies for Dementia
Yaffe, K., & Hoang, T. (2013) · Continuum · doi:10.1212/01.con.0000429178.14354.67 · Cited by 28 · see citing works
Self-citationSleep in Neurodegenerative Disorders
Malkani, R., & Attarian, H. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-015-0016-x · Cited by 12 · see citing works
Neurodegenerative Changes after Mild Traumatic Brain Injury
Fakhran, S., & Alhilali, L. (2014) · Progress in Neurological Surgery · doi:10.1159/000358787 · Cited by 12 · see citing works
- Authors
- Tranah, G. J., Blackwell, T., Stone, K. L., Ancoli‐Israel, S., Paudel, M. L., Ensrud, K. E., Cauley, J. A., Redline, S., Hillier, T. A., Cummings, S. R., Yaffe, K., & for the SOF Research Group
- Affiliations
- California Pacific Medical Center (US)
- University of California San Diego (US)
- University of Minnesota (US)
- University of Pittsburgh (US)
- Brigham and Women's Hospital (US)
- Kaiser Permanente Center for Health Research (US)
- San Francisco VA Medical Center (US)
- Corresponding author
- Tranah, Gregory J.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2011-11
- Volume
- 70
- Issue
- 5
- Pages
- 722-732
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC3244839
- OpenAlex
- W2034831738
- Cited by
- 525
- References
- 97
- Citations by year
- 2026: 30 · 2025: 46 · 2024: 38 · 2023: 44 · 2022: 41 · 2021: 48 · 2020: 54 · 2019: 29 · 2018: 39 · 2017: 36 · 2016: 30 · 2015: 26 · 2014: 30 · 2013: 18 · 2012: 13
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Funders
- National Institute on Aging (AG030474, R01AG005394, AG005407, AG026720, R01AG008415, AG05394, R01AG005407, R01AG027576, K24AG031155, AG027574-22A1, R01AG030474, AG 08415, AG-05407, R01AG026720, AG005394-22A1, R01AG027574, AG027576-22)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR035584, AR35583, AR 35582, R01AR035582, R01AR046238, R01AR035583)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian activity rhythm, dementia, mild cognitive impairment, older women, actigraphy, rhythm amplitude, sleep timing, cognitive decline, community-dwelling older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, Circadian Rhythm, Dementia, Female, Humans, Neuropsychological Tests, Risk Factors, Women, Cohort Studies, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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