Cited by 976Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Bacteria, Colonic Fermentation, and Gastrointestinal Health

Macfarlane, George T, Macfarlane, Sandra·2012·Journal of AOAC INTERNATIONAL

Open this paper in CoChat — free account

Abstract

The colonic microbiota plays an important role in human digestive physiology and makes a significant contribution to homeostasis in the large bowel. The microbiome probably comprises thousands of different bacterial species. The principal metabolic activities of colonic microorganisms are associated with carbohydrate and protein digestion. Nutrients of dietary and host origin support the growth of intestinal organisms. Short-chain fatty acids (SCFAs), predominantly acetate, propionate, and butyrate, are the principal metabolites generated during the catabolism of carbohydrates and proteins. In contrast, protein digestion yields a greater diversity of end products, including SCFAs, amines, phenols, indoles, thiols, CO2, H2, and H2S, many of which have toxic properties. The majority of SCFAs are absorbed from the gut and metabolized in various body tissues, making a relatively small but significant contribution to the body's daily energy requirements. Carbohydrate fermentation is, for the most part, a beneficial process in the large gut, because the growth of saccharolytic bacteria stimulates their requirements for toxic products associated with putrefaction, for incorporation into cellular proteins, thereby protecting the host. However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel.

Integrity signals

Registry

Crossref · 10.5740/jaoacint.sge_macfarlane

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Self-citation
Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin.
(2013) · Gastroenterology Research · doi:10.1053/j · Cited by 2,759
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
The first known larva of the Australian tribe Mystropomini (Coleoptera: Carabidae: Paussinae)
Giulio, A. D., & Moore, W. (2009) · Intellectum (Universidad de La Sabana) · doi:10.1111/j.1440- · Cited by 2,279
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204
Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939
Self-citation
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,357
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,178

Flagged first, then by citations

Show all 91 references

Sorted by citations

Items 301–400 of 976

Association between Dietary Fibre Intake and Colorectal Adenoma: A Systematic Review and Meta-Analysis
Nucci, D., Fatigoni, C., Salvatori, T., Nardi, M., Realdon, S., & Gianfredi, V. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18084168 · Cited by 52
Effect of Lactobacillus plantarum-fermented mulberry pomace on antioxidant properties and fecal microbial community
Tang, S., Cheng, Y., Wu, T., Hu, F., Pan, S., & Xu, X. (2021) · LWT · doi:10.1016/j.lwt.2021.111651 · Cited by 51
Dietary fiber in plant cell walls—the healthy carbohydrates
An, Y., Lu, W., Li, W., Pan, L., Lu, M., Cesarino, I., Li, Z., & Zeng, W. (2022) · Food Quality and Safety · doi:10.1093/fqsafe/fyab037 · Cited by 50
Effects of Antibiotics on Bacterial Species Composition and Metabolic Activities in Chemostats Containing Defined Populations of Human Gut Microorganisms
Newton, D. F., Macfarlane, S., & Macfarlane, G. T. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00079-13 · Cited by 50
Self-citation
Health Benefits of Fiber Fermentation
Dahl, W. J., Agro, N. C., Eliasson, Å. M., Mialki, K., Olivera, J. D., Rusch, C. T., & Young, C. N. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1188737 · Cited by 53
Short chain fatty acids enriched fermentation metabolites of soluble dietary fibre from Musa paradisiaca drives HT29 colon cancer cells to apoptosis
Arun, K. B., Madhavan, A., Reshmitha, T. R., Thomas, S., & Nisha, P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216604 · Cited by 52
Amelioration of non-alcoholic steatohepatitis by Qushi Huayu decoction is associated with inhibition of the intestinal mitogen-activated protein kinase pathway
Leng, J., Huang, F., Hai, Y., Tian, H., Liu, W., Fang, Y., Hu, Y., & Peng, J. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153135 · Cited by 50
Effects of butyrate glycerides supplementation in high soybean meal diet on growth performance, intestinal morphology and antioxidative status of juvenile black sea bream, Acanthopagrus schlegelii
Volatiana, J. A., Sagada, G., Xu, B., Zhang, J., Ng, W., & Shao, Q. (2019) · Aquaculture Nutrition · doi:10.1111/anu.12984 · Cited by 49
Effects of Achyranthes bidentata Polysaccharides on Intestinal Morphology, Immune Response, and Gut Microbiome in Yellow Broiler Chickens Challenged with Escherichia coli K88
Liu, Z., Wang, X., Ou, S.-Q., Arowolo, M. A., Hou, D., & He, J. (2018) · Polymers · doi:10.3390/polym10111233 · Cited by 49
Cashew apple fiber prevents high fat diet-induced obesity in mice: an NMR metabolomic evaluation
Carvalho, D. V., Silva, L. K. D. F., Filho, E. G. A., Santos, F. A., de Lima, R. P., Viana, A. F. S. C., Nunes, P. I. G., Fonseca, S. G. D. C., de Melo, T. S., Viana, D. D. A., et al. (2019) · Food & Function · doi:10.1039/c8fo01575a · Cited by 49
Comparison of 16S rRNA Gene Based Microbial Profiling Using Five Next-Generation Sequencers and Various Primers
Park, C., Kim, S. B., Choi, S. H., & Kim, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.715500 · Cited by 52
Amino Acids in Microbial Metabolism and Function
Dai, Z., Wu, Z., Zhu, W., & Wu, G. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-85686-1_7 · Cited by 50
Nutrition and Physical Activity-Induced Changes in Gut Microbiota: Possible Implications for Human Health and Athletic Performance
Cella, V., Bimonte, V. M., Sabato, C., Paoli, A., Baldari, C., Campanella, M., Lenzi, A., Ferretti, E., & Migliaccio, S. (2021) · Foods · doi:10.3390/foods10123075 · Cited by 49
Formation of Short-Chain Fatty Acids, Excretion of Anthocyanins, and Microbial Diversity in Rats Fed Blackcurrants, Blackberries, and Raspberries
Jakobsdottir, G., Blanco, N., Xu, J., Ahrné, S., Molin, G., Sterner, O., & Nyman, M. (2013) · Journal of Nutrition and Metabolism · doi:10.1155/2013/202534 · Cited by 48
Human intestinal microbiota: Role in development and functioning of the nervous system
Averina, O. V., & Даниленко, В. Н. (2017) · Microbiology · doi:10.1134/s0026261717010040 · Cited by 49
The human gut microbiota with reference to autism spectrum disorder: considering the whole as more than a sum of its parts
Toh, M. C. W., & Allen‐Vercoe, E. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26309 · Cited by 51
The perfect hydrocolloid stabilizer: Imagination versus reality
Murray, B. S., Ettelaie, R., Sarkar, A., Mackie, A. R., & Dickinson, E. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.106696 · Cited by 47
Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity
Cunningham, A., Stephens, J. W., & Harris, D. A. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00858-4 · Cited by 49
From the Gastrointestinal Tract (GIT) to the Kidneys: Live Bacterial Cultures (Probiotics) Mediating Reductions of Uremic Toxin Levels via Free Radical Signaling
Vitetta, L., Linnane, A. W., & Gobe, G. C. (2013) · Toxins · doi:10.3390/toxins5112042 · Cited by 47
In vitro digestion and fermentation characteristics of canola co-products simulate their digestion in the pig intestine
Woyengo, T. A., Jha, R., Beltranena, E., & Zijlstra, R. T. (2015) · animal · doi:10.1017/s1751731115002566 · Cited by 47
Gut microbiota: An intermediary between metabolic syndrome and cognitive deficits in schizophrenia
Zeng, C., Yang, P., Cao, T., Gu, Y., Li, N., Zhang, B., Xu, P., Liu, Y., Luo, Z., & Cai, H. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110097 · Cited by 54
Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
Jensen, B. A. H., Holm, J. B., Larsen, I., von Burg, N., Derer, S., Sonne, S. B., Pærregaard, S. I., Damgaard, M. V., Indrelid, S., Rivollier, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21408-9 · Cited by 49
Heterophil/Lymphocyte Ratio Level Modulates Salmonella Resistance, Cecal Microbiota Composition and Functional Capacity in Infected Chicken
Thiam, M., Wang, Q., Sánchez, A. L. B., Zhang, J., Ding, J., Wang, H., Zhang, Q., Zhang, N., Wang, J., Li, Q., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.816689 · Cited by 46
The impact of dietary fiber consumption on human health: An umbrella review of evidence from 17,155,277 individuals
Veronese, N., Gianfredi, V., Solmi, M., Barbagallo, M., Dominguez, L. J., Mandalà, C., Palermo, C. D., Carruba, L., Solimando, L., Stubbs, B., et al. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.06.021 · Cited by 47
Beyond Sugar: A Holistic Review of Sweeteners and Their Role in Modern Nutrition
Dragomir, N., Grigore, D., & Pogurschi, E. (2025) · Foods · doi:10.3390/foods14183182 · Cited by 44
Temporal change in the gut community of rats fed high amylose cornstarch is driven by endogenous urea rather than strictly on carbohydrate availability
Kalmokoff, M. L., Zwicker, B. M., O’Hara, M., Matias, F. M. G., Green, J., Shastri, P., Green-Johnson, J. M., & Brooks, S. P. J. (2013) · Journal of Applied Microbiology · doi:10.1111/jam.12157 · Cited by 45
Microbial Interactions and Interventions in Colorectal Cancer
Raay, T. J. V., & Allen‐Vercoe, E. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0004-2016 · Cited by 49
Supplementation with compound polysaccharides contributes to the development and metabolic activity of young rat intestinal microbiota
Wang, M., Xie, Z., Li, L., Chen, Y., Yuan, L., Wang, Y., Lu, B., Zhang, S., Ma, F., Ma, C., et al. (2019) · Food & Function · doi:10.1039/c8fo02565g · Cited by 45
A Sensitive and Rapid Method to Determine the Adhesion Capacity of Probiotics and Pathogenic Microorganisms to Human Gastrointestinal Mucins
Ringot-Destrez, B., D’Alessandro, Z., Lacroix, J.-M., Mercier‐Bonin, M., Léonard, R., & Masselot, C. R. (2018) · Microorganisms · doi:10.3390/microorganisms6020049 · Cited by 45
In Vitro Fermentation Shows Polyphenol and Fiber Blends Have an Additive Beneficial Effect on Gut Microbiota States
Whitman, J. A., Doherty, L. A., Pantoja-Feliciano, I. G., Racicot, K., Anderson, D., Kensil, K., Karl, J. P., Gibson, G. R., & Soares, J. W. (2024) · Nutrients · doi:10.3390/nu16081159 · Cited by 45
Lactobacillus plantarum IFPL935 Favors the Initial Metabolism of Red Wine Polyphenols When Added to a Colonic Microbiota
Barroso, E., Sánchez‐Patán, F., Martín-Álvarez, P. J., Bartolomé, B., Moreno-Arribas, M. V., Peláez, C., Requena, T., de Wiele, T. V., & Martínez‐Cuesta, M. C. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf402816r · Cited by 46
Sodium butyrate protects against lipopolysaccharide-induced liver injury partially via the GPR43/ β-arrestin-2/NF-κB network
Luo, Q.-J., Sun, M.-X., Guo, Y., Tan, S.-W., Wu, X., Abassa, K.-K., Lin, L., Liu, H., Jiang, J., & Wei, X.-Q. (2020) · Gastroenterology report · doi:10.1093/gastro/goaa085 · Cited by 45
Effects of Sleeve Gastrectomy on Fecal Gut Microbiota and Short-Chain Fatty Acid Content in a Rat Model of Polycystic Ovary Syndrome
Lin, W., Wen, L., Wen, J., & Xiang, G. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.747888 · Cited by 44
Stool energy density is positively correlated to intestinal transit time and related to microbial enterotypes
Boekhorst, J., Venlet, N. V., Procházková, N., Hansen, M. L., Lieberoth, C. B., Bahl, M. I., Lauritzen, L., Pedersen, O. B., Licht, T. R., Kleerebezem, M., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01418-5 · Cited by 46
Prebiotics and synbiotics in ulcerative colitis
Laurell, A., & Sjöberg, K. (2016) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2016.1263680 · Cited by 44
Validated Postbiotic Screening Confirms Presence of Physiologically-Active Metabolites, Such as Short-Chain Fatty Acids, Amino Acids and Vitamins in Hylak® Forte
Patil, S. V., Sawant, S., Maier-Hauff, K., & Hampp, G. (2018) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9497-5 · Cited by 44
The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease
Lakshmanan, A. P., Za’abi, M. A., Ali, B. H., & Terranegra, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110992 · Cited by 45
Dietary Fiber Intake and Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis of Observational Studies
Nucci, D., Santangelo, O. E., Provenzano, S., Fatigoni, C., Nardi, M., Ferrara, P., & Gianfredi, V. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182111556 · Cited by 44
Dietary Protein Intake Level Modulates Mucosal Healing and Mucosa-Adherent Microbiota in Mouse Model of Colitis
Vidal-Lletjós, S., Andriamihaja, M., Blais, A., Grauso, M., Lepage, P., Davila, A.-M., Viel, R., Gaudichon, C., Leclerc, M., Blachier, F., et al. (2019) · Nutrients · doi:10.3390/nu11030514 · Cited by 42
Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation
Feng, J., Wang, L., Chen, Y., Xiong, Y., Wu, Q., Jiang, Z., & Yi, H. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107584 · Cited by 43
A fishy gut feeling – current knowledge on gut microbiota in teleosts
Tolås, I., Zhou, Z., Zhang, Z., Teame, T., Olsen, R. E., Ringø, E., & Rønnestad, I. (2025) · Frontiers in Marine Science · doi:10.3389/fmars.2024.1495373 · Cited by 52
A unique in vivo experimental approach reveals metabolic adaptation of the probiotic Propionibacterium freudenreichii to the colon environment
Saraoui, T., Parayre, S., Guernec, G., Loux, V., Montfort, J., Cam, A. L., Boudry, G., Jan, G., & Falentin, H. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-911 · Cited by 44
Dietary Patterns Impact Temporal Dynamics of Fecal Microbiota Composition in Children With Autism Spectrum Disorder
Berding, K., & Donovan, S. M. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00193 · Cited by 45
Faecal Transplantation, Pro- and Prebiotics in Parkinson’s Disease; Hope or Hype?
van Laar, T., Boertien, J. M., & Herranz, A. H. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191802 · Cited by 43
Dysbiosis of Gut Microbiome and Its Impact on Epigenetic Regulation
Lee, E. S., Song, E., & Nam, Y. D. (2017) · Journal of Clinical Epigenetics · doi:10.21767/2472-1158.100048 · Cited by 41
The Bridge Between Ischemic Stroke and Gut Microbes: Short-Chain Fatty Acids
Fang, Z., Chen, M., Qian, J., Wang, C., & Zhang, J. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01209-4 · Cited by 41
Gut Microbial Stability is Associated with Greater Endurance Performance in Athletes Undertaking Dietary Periodization
Furber, M., Young, G. R., Holt, G. S., Pyle, S., Davison, G., Roberts, M. G., Roberts, J., Howatson, G., & Smith, D. (2022) · mSystems · doi:10.1128/msystems.00129-22 · Cited by 43
Astragalus polysaccharides alleviates lipopolysaccharides-induced inflammatory lung injury by altering intestinal microbiota in mice
Ming, K., Zhuang, S., Ma, N., Nan, S., Li, Q., Ding, M., & Ding, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1033875 · Cited by 43
The effect of in vitro simulated colonic pH gradients on microbial activity and metabolite production using common prebiotics as substrates
Xie, Z., He, W., Gobbi, A., Bertram, H. C., & Nielsen, D. S. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03235-2 · Cited by 47
Dietary proline supplementation alters colonic luminal microbiota and bacterial metabolite composition between days 45 and 70 of pregnancy in Huanjiang mini-pigs
Ji, Y., Guo, Q., Yin, Y., Blachier, F., & Kong, X. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0233-5 · Cited by 41
Characterization of the fecal and mucosa-associated microbiota in dogs with colorectal epithelial tumors
Herstad, K. M. V., Moen, A. E. F., Gaby, J. C., Moe, L., & Skancke, E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198342 · Cited by 45
Relationship between intestinal microbiota, diet and biological systems: an integrated view
Ferreira, R. D. S., Mendonça, L. A. B. M., Ribeiro, C. F. A., Calças, N. C., Guimarães, R. D. C. A., do Nascimento, V. A., Freitas, K. D. C., Carvalho, C. M. E., de Castro, A. P., & Franco, O. L. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1836605 · Cited by 46
Iron Reshapes the Gut Microbiome and Host Metabolism
Botta, A. M., Barra, N. G., Lam, N. H., Chow, S., Pantopoulos, K., Schertzer, J. D., & Sweeney, G. (2021) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2021.10.2.160 · Cited by 44
Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli
Wagley, S., Newcombe, J., Laing, E., Yusuf, E., Sambles, C., Studholme, D. J., Ragione, R. M. L., Titball, R. W., & Champion, O. L. (2014) · BMC Microbiology · doi:10.1186/s12866-014-0262-y · Cited by 39
New insights into the impact of Lactobacillus population on host-bacteria metabolic interplay
Roy, C. I. L., Štšepetova, J., Sepp, E., Songisepp, E., Claus, S. P., & Mikelsaar, M. (2015) · Oncotarget · doi:10.18632/oncotarget.5906 · Cited by 39
A New Proposal for the Pathogenic Mechanism of Non-Coeliac/Non-Allergic Gluten/Wheat Sensitivity: Piecing Together the Puzzle of Recent Scientific Evidence
Leccioli, V., Oliveri, M., Romeo, M., Berretta, M., & Rossi, P. (2017) · Nutrients · doi:10.3390/nu9111203 · Cited by 39
Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution
Aguilera, X. L., Manzano, A., Pírela, D., & Bermúdez, V. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12081282 · Cited by 45
The role of gut microbiota in liver regeneration
Xu, Z., Jiang, N., Xiao, Y., Yuan, K., & Wang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1003376 · Cited by 41
Enzymatically prepared alginate oligosaccharides improve broiler chicken growth performance by modulating the gut microbiota and growth hormone signals
La, A. L. T. Z., Feng, Y., Hu, D., Feng, Y., Jin, X., Liu, D., Guo, Y., Cheng, G., & Hu, Y. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00887-4 · Cited by 43
Gastrointestinal barrier function, immunity, and neurocognition: The role of human milk oligosaccharide (hMO) supplementation in infant formula
Kassai, S., & de Vos, P. (2023) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13271 · Cited by 40
The Adequacy of Habitual Dietary Fiber Intake in Individuals With Inflammatory Bowel Disease: A Systematic Review
Day, A. S., Davis, R. W., Costello, S. P., Yao, C. K., Andrews, J. M., & Bryant, R. V. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.12.001 · Cited by 40
Identification of Lactobacillus Strains Capable of Fermenting Fructo-Oligosaccharides and Inulin
Renye, J. A., White, A. K., & Hotchkiss, A. T. (2021) · Microorganisms · doi:10.3390/microorganisms9102020 · Cited by 38
Modulatory role of gut microbiota in cholesterol and glucose metabolism: Potential implications for atherosclerotic cardiovascular disease
Roessler, J., Leistner, D. M., Landmesser, U., & Haghikia, A. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.08.018 · Cited by 39
Gut microbiome and metabolites: The potential key roles in pulmonary fibrosis
Wu, Y., Li, Y., Luo, Y., Zhou, Y., Ji, W., Chen, L., Liang, X., Wu, T., Tan, C., & Liu, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.943791 · Cited by 42
Amino Acid-Derived Bacterial Metabolites in the Colorectal Luminal Fluid: Effects on Microbial Communication, Metabolism, Physiology, and Growth
Blachier, F. (2023) · Microorganisms · doi:10.3390/microorganisms11051317 · Cited by 38
Use of probiotics in small animal veterinary medicine
Jugan, M. C., Rudinsky, A. J., Parker, V. J., & Gilor, C. (2017) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.250.5.519 · Cited by 39
Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome
Yu, L.-M., Zhao, K.-J., Wang, S., Wang, X., & Lü, B. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i8.894 · Cited by 37
Sodium butyrate ameliorates lipopolysaccharide‐induced cow mammary epithelial cells from oxidative stress damage and apoptosis
Li, L., Wang, H., Nie, X., Jiang, W., & Zhang, Y. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27565 · Cited by 37
Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanied injury in streptozotocin-nicotinamide-induced diabetic rats
Olaniyi, K. S., & Amusa, O. A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110226 · Cited by 39
Gut Microbiota and Their Derived Metabolites, a Search for Potential Targets to Limit Accumulation of Protein-Bound Uremic Toxins in Chronic Kidney Disease
Steenbeke, M., Valkenburg, S., Gryp, T., Biesen, W. V., Delanghe, J., Speeckaert, M. M., & Glorieux, G. (2021) · Toxins · doi:10.3390/toxins13110809 · Cited by 37
Pathological features-based targeted delivery strategies in IBD therapy: A mini review
Li, S., Zhang, F., & Zhang, Q. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113079 · Cited by 40
Advances in the Utilization of Tea Polysaccharides: Preparation, Physicochemical Properties, and Health Benefits
Wang, Q., Yang, X., Zhu, C., Liu, G., Sun, Y., & Qian, L. (2022) · Polymers · doi:10.3390/polym14142775 · Cited by 39
Fiber
Sims, I. M., & Monro, J. A. (2013) · Advances in food and nutrition research · doi:10.1016/b978-0-12-394294-4.00005-5 · Cited by 36
In Vitro Degradation and Fermentation of Three Dietary Fiber Sources by Human Colonic Bacteria
Bliss, D. Z., Weimer, P. J., Jung, H.-J. G., & Savik, K. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3054017 · Cited by 37
Efficacy and safety of probiotics in Parkinson’s constipation: A systematic review and meta-analysis
Xie, L., Chen, D., Xinghui, Z., & Cheng, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1007654 · Cited by 37
Gut microbiota in obesity and related complications: Unveiling the complex interplay
Islam, M. M., Islam, M. M., Rahman, M. A., Ripon, M. A. R., & Hossain, M. S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122211 · Cited by 37
Effects of monobutyrin and tributyrin on liver lipid profile, caecal microbiota composition and SCFA in high-fat diet-fed rats
Nguyen, T. D., Prykhodko, O., Hållenius, F. F., & NYMAN, M. E. (2017) · Journal of Nutritional Science · doi:10.1017/jns.2017.54 · Cited by 36
Importance of gastrointestinal in vitro models for the poultry industry and feed formulations
de Carvalho, N. M., Oliveira, D., Saleh, M. A. D., Pintado, M., & Madureira, A. R. (2020) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2020.114730 · Cited by 39
Short-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis
Lammert, C. S., Shin, A., Xu, H., Hemmerich, C. M., O’Connell, T. M., & Chalasani, N. (2021) · FEMS Microbiology Letters · doi:10.1093/femsle/fnab038 · Cited by 36
Probiotics: safety and toxicity considerations
Anadón, A., Arés, I., Martínez‐Larrañaga, M., & Martínez, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00065-3 · Cited by 36
Changes in the faecal bile acid profile in dogs fed dry food vs high content of beef: a pilot study
Herstad, K. M. V., Rønning, H. T., Bakke, A. M., Moe, L., & Skancke, E. (2018) · Acta veterinaria Scandinavica · doi:10.1186/s13028-018-0383-7 · Cited by 38
Degradation of fibres from fruit by-products allows selective modulation of the gut bacteria in an in vitro model of the proximal colon
de Souza, C. B., Jonathan, M. C., Saad, S. M. I., Schols, H. A., & Venema, K. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.026 · Cited by 35
Metabolic networks of the human gut microbiota
Selber‐Hnatiw, S., Sultana, T., Tse, W., Abdollahi, N., Abdullah, S., Rahbani, J. A., Alazar, D., Alrumhein, N. J., Aprikian, S., Arshad, R., et al. (2019) · Microbiology · doi:10.1099/mic.0.000853 · Cited by 38
Ethnic Differences Shape the Alpha but Not Beta Diversity of Gut Microbiota from School Children in the Absence of Environmental Differences
Liu, K., Zhang, Y., Li, Q., Li, H., Long, D., Yan, S., Huang, W., Long, R., & Huang, X. (2020) · Microorganisms · doi:10.3390/microorganisms8020254 · Cited by 33
Stool metabolome-microbiota evaluation among children and adolescents with obesity, overweight, and normal-weight using 1H NMR and 16S rRNA gene profiling
Jaimes, J. D. C., Slavíčková, A., Hurych, J., Cinek, O., Nichols, B., Vodolánová, L., Černý, K., & Havlík, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247378 · Cited by 38
Influenza A H1N1 Induced Disturbance of the Respiratory and Fecal Microbiome of German Landrace Pigs – a Multi-Omics Characterization
Gierse, L. C., Meene, A., Schultz, D., Schwaiger, T., Schröder, C., Mücke, P., Zühlke, D., Hinzke, T., Wang, H., Methling, K., et al. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00182-21 · Cited by 37
Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host
Bhutia, Y. D., Ogura, J., Sivaprakasam, S., & Ganapathy, V. (2017) · Current Colorectal Cancer Reports · doi:10.1007/s11888-017-0362-9 · Cited by 34
Microbial Biosynthesis: A Repertory of Vital Natural Products
Abdel-Aziz, S. M., Elsoud, M. M. A., & Anise, A. A. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811372-1.00003-8 · Cited by 35
The effects of mulberry polyphenols on the digestibility and absorption properties of pork myofibrillar protein in vitro
Cheng, J., Tang, D., Yang, H., Wang, X., Lin, Y., & Liu, X. (2023) · Meat Science · doi:10.1016/j.meatsci.2023.109205 · Cited by 34
Crucial functions of gut microbiota on gut–liver repair
Wang, Y., Yan, H., Zheng, Q., & Sun, X. (2025) · hLife · doi:10.1016/j.hlife.2025.01.001 · Cited by 39
Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions
Toribio-Mateas, M. A. (2018) · Microorganisms · doi:10.3390/microorganisms6020035 · Cited by 37
Malvidin 3‐Glucoside Modulated Gut Microbial Dysbiosis and Global Metabolome Disrupted in a Murine Colitis Model Induced by Dextran Sulfate Sodium
Liu, F., Wang, T. T. Y., Tang, Q., Xue, C., Li, R. W., & Wu, V. C. H. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900455 · Cited by 34
The link among microbiota, epigenetics, and disease development
El-Sayed, A., Aleya, L., & Kamel, M. S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-13862-1 · Cited by 37
Effects of Soluble and Insoluble Fractions from Bilberries, Black Currants, and Raspberries on Short-Chain Fatty Acid Formation, Anthocyanin Excretion, and Cholesterol in Rats
Jakobsdottir, G., Nilsson, U. J., Blanco, N., Sterner, O., & NYMAN, M. E. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5007566 · Cited by 33
The intestinal microbiome and surgical disease
Krezalek, M. A., Skowron, K. B., Guyton, K. L., Shakhsheer, B. A., Hyoju, S. K., & Alverdy, J. C. (2016) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2016.06.001 · Cited by 35
Colonic Microbiota and Metabolites Response to Different Dietary Protein Sources in a Piglet Model
Li, R., Chang, L., Hou, G., Song, Z., Fan, Z., He, X., & Hou, D. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00151 · Cited by 35
Different dietary protein sources in low protein diets regulate colonic microbiota and barrier function in a piglet model
Li, R., Hou, G., Jiang, X., Song, Z., Fan, Z., Hou, D., & He, X. (2019) · Food & Function · doi:10.1039/c9fo01154d · Cited by 35
Tributyrin‐supplemented high‐soya bean meal diets of juvenile black sea bream, Acanthopagrus schlegelii : Study on growth performance and intestinal morphology and structure
Volatiana, J. A., Wang, L., Gray, N., Tong, S., Zhang, G., & Shao, Q. (2019) · Aquaculture Research · doi:10.1111/are.14355 · Cited by 33
Effect of Lactobacillus gasseri PA3 on gut microbiota in an in vitro colonic simulation
Xiang, S., Fu, J., Ye, K., Zheng, Y., Zhu, X., Chen, J., & Chen, Y. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1236 · Cited by 33
Modulation of the intestinal microbiota and the metabolites produced by the administration of ice cream and a dietary supplement containing the same probiotics
Rodrigues, V. C. D. C., Duque, A. L. R. F., Fino, L. D. C., Simabuco, F. M., Sartoratto, A., Cabral, L., Noronha, M. F., Sivieri, K., & Antunes, A. E. C. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520000896 · Cited by 34

Authors: Macfarlane, G. T., & Macfarlane, S.
Affiliations: University of Dundee (GB)
Corresponding author: Macfarlane, Sandra
ORCID: Macfarlane, Sandra
Venue: Journal of AOAC INTERNATIONAL
Publisher: Oxford University Press (OUP)
Published: 2012-01-01
Volume: 95
Issue: 1
Pages: 50-60
ISSN: 1060-3271 (ISSN-L)
1944-7922
DOI: 10.5740/jaoacint.sge_macfarlane
OpenAlex: W2082808164
Cited by: 970
References: 91
Citations by year: 2026: 44 · 2025: 64 · 2024: 74 · 2023: 85 · 2022: 104 · 2021: 123 · 2020: 99 · 2019: 82 · 2018: 55 · 2017: 67 · 2016: 45 · 2015: 35 · 2014: 45 · 2013: 42 · 2012: 5
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of AOAC International (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: colonic microbiota, colonic fermentation, short-chain fatty acids, butyrate, acetate, propionate, carbohydrate digestion, protein digestion, putrefaction, colonic diseases, saccharolytic bacteria, intestinal homeostasis, dietary fiber
MeSH terms: Amino Acids, Butyrates, Colon, Colonic Neoplasms, Dietary Carbohydrates, Dietary Proteins, Fatty Acids, Volatile, Fermentation, Food Microbiology, Health, Humans, Hydrogen, Propionates, Oxidative Stress, Lactic Acid, Gastrointestinal Tract, Proteolysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bacteria, Colonic Fermentation, and Gastrointestinal Health

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks