Cited by 976Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Bacteria, Colonic Fermentation, and Gastrointestinal Health

Macfarlane, George T, Macfarlane, Sandra·2012·Journal of AOAC INTERNATIONAL

Open this paper in CoChat — free account

Abstract

The colonic microbiota plays an important role in human digestive physiology and makes a significant contribution to homeostasis in the large bowel. The microbiome probably comprises thousands of different bacterial species. The principal metabolic activities of colonic microorganisms are associated with carbohydrate and protein digestion. Nutrients of dietary and host origin support the growth of intestinal organisms. Short-chain fatty acids (SCFAs), predominantly acetate, propionate, and butyrate, are the principal metabolites generated during the catabolism of carbohydrates and proteins. In contrast, protein digestion yields a greater diversity of end products, including SCFAs, amines, phenols, indoles, thiols, CO2, H2, and H2S, many of which have toxic properties. The majority of SCFAs are absorbed from the gut and metabolized in various body tissues, making a relatively small but significant contribution to the body's daily energy requirements. Carbohydrate fermentation is, for the most part, a beneficial process in the large gut, because the growth of saccharolytic bacteria stimulates their requirements for toxic products associated with putrefaction, for incorporation into cellular proteins, thereby protecting the host. However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel.

Integrity signals

Registry

Crossref · 10.5740/jaoacint.sge_macfarlane

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Self-citation
Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin.
(2013) · Gastroenterology Research · doi:10.1053/j · Cited by 2,759
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
The first known larva of the Australian tribe Mystropomini (Coleoptera: Carabidae: Paussinae)
Giulio, A. D., & Moore, W. (2009) · Intellectum (Universidad de La Sabana) · doi:10.1111/j.1440- · Cited by 2,279
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204
Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939
Self-citation
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,357
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,178

Show all 91 references

Sorted by citations

Items 601–700 of 976

Small Intestinal Levels of the Branched Short-Chain Fatty Acid Isovalerate Are Elevated during Infection with Heligmosomoides polygyrus and Can Promote Helminth Fecundity
Kennedy, M. H. E., Brosschot, T. P., Lawrence, K. M., FitzPatrick, R. D., Lane, J. M., Mariene, G. M., Wasmuth, J. D., & Reynolds, L. A. (2021) · Infection and Immunity · doi:10.1128/iai.00225-21 · Cited by 13
Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: A randomized crossover dietary trial
Brignardello, J., Fountana, S., Posma, J. M., Chambers, E. S., Nicholson, J. K., Wist, J., Frost, G. S., García‐Pérez, I., & Holmes, E. C. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab211 · Cited by 16
Associations of Habitual Dietary Intake With Fecal Short-Chain Fatty Acids and Bowel Functions in Irritable Bowel Syndrome
Calderón, G., Patel, C., Camilleri, M., James-Stevenson, T. N., Bohm, M. E., Siwiec, R. M., Rogers, N. A., Wo, J. M., Lockett, C. J., Gupta, A., et al. (2021) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001521 · Cited by 12
Involvement of the Complex Polysaccharide Structure of Pectin in Regulation of Biological Functions
Gotoh, S., Kitaguchi, K., & Yabe, T. (2021) · Reviews in Agricultural Science · doi:10.7831/ras.9.0_221 · Cited by 12
Environmental factors influence yak milk composition by modulating short-chain fatty acid metabolism in intestinal microorganisms
Zhang, Y., Zhao, H., Li, Q., Dorji, T., Yuan, H., Su, G., & Yang, J. (2022) · LWT · doi:10.1016/j.lwt.2022.113608 · Cited by 13
Solid organ transplantation and gut microbiota: a review of the potential immunomodulatory properties of short-chain fatty acids in graft maintenance
Jardou, M., Brossier, C., Marquet, P., Picard, N., Druilhe, A., & Lawson, R. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1342354 · Cited by 14
Exploring the Role of Inulin in Targeting the Gut Microbiota: An Innovative Strategy for Alleviating Colonic Fibrosis Induced By Irradiation
Ji, K., Zhang, M., Du, L., Liu, Y., Xu, C., He, N., Wang, Q., Wang, Q., Gu, Y., Song, H., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03432 · Cited by 13
Review: Gut microbiota: Therapeutic targets of ginseng polysaccharides against multiple disorders
Wang, N., & Xin, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138527 · Cited by 12
Temporal Dynamics of Chronic Inflammation on the Cecal Microbiota in IL-10-/- Mice
Overstreet, A.-M. C., Ramer‐Tait, A. E., Suchodolski, J. S., Hostetter, J. M., Wang, C., Jergens, A. E., Phillips, G. J., & Wannemuehler, M. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585431 · Cited by 12
Implications of Gut-Brain axis in the pathogenesis of Psychiatric disorders
Taniguchi, K., Ikeda, Y., Nagase, N., Tsuji, A., Kitagishi, Y., & Matsuda, S. (2021) · AIMS bioengineering · doi:10.3934/bioeng.2021021 · Cited by 12
Goat milk fermented with combined lactic acid bacterium alter microbial community structures and levels of the targeted short-chain fatty acids in the large intestine of mice
Ma, H., Yu, Z., Zhao, Y., Li, L., Liu, Y., & Liu, Y. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111352 · Cited by 12
Sugary vs salty food industry leftovers in postweaning piglets: effects on gut microbiota and intestinal volatile fatty acid production
Tretola, M., Ferrari, L., Luciano, A., Mazzoleni, S., Rovere, N., Fumagalli, F., Ottoboni, M., & Pinotti, L. (2022) · animal · doi:10.1016/j.animal.2022.100584 · Cited by 12
Spatiotemporally resolved tools for analyzing gut microbiota
Zhu, X., Zhang, K., Teng, X., Xia, X., Deng, R., & Li, J. (2023) · Chem · doi:10.1016/j.chempr.2023.02.021 · Cited by 12
Gut Microbiota and Metabolism
İlhan, N. (2018) · International journal of medical biochemistry/International journal of medical biochemistry : · doi:10.14744/ijmb.2018.92400 · Cited by 13
Cardamine hupingshanensis aqueous extract improves intestinal redox status and gut microbiota in Se‐deficient rats
Cheng, Y., Huang, Y., Liu, K., Pan, S., Qin, Z., Wu, T., & Xu, X. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10707 · Cited by 12
[Retracted] The Relationship between Urinary Stones and Gut Microbiomeby 16S Sequencing
Zhou, C., Li, K., Zhao, L., Li, W., Guo, Z., Jing-yao, X., Qi, X., & Yuan, H. (2020) · BioMed Research International · doi:10.1155/2020/1582187 · Cited by 12
Retracted
From gut microbial ecology to lipid homeostasis: Decoding the role of gut microbiota in dyslipidemia pathogenesis and intervention
Lv, J., Zhao, H., Yu, Y., Wang, J.-H., Zhang, X., Guo, Z.-Q., Jiang, W., Wang, K., & Guo, L. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i30.108680 · Cited by 19
A beverage containing orange pomace improves laxation and modulates the microbiome in healthy adults: A randomised, blinded, controlled trial
Dennis-Wall, J. C., Burns, A. M., Solch-Ottaiano, R. J., Ukhanova, M., Dahl, W. J., Christman, M. C., Boileau, T. W.-M., Brauchla, M. C., Shin, J.-E., Nieves, C., et al. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103438 · Cited by 11
Gut Microbiome and Kidney Disease in Pediatrics: Does Connection Exist?
Vasylyeva, T. L., & Singh, R. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00235 · Cited by 11
Ethnicity influences gut metabolites and microbiota of the tribes of Assam, India
Dehingia, M., Sen, S., Bhaskar, B., Joishy, T. K., Deka, M., Talukdar, N. C., & Khan, M. R. (2017) · Metabolomics · doi:10.1007/s11306-017-1206-y · Cited by 12
Advances in the Detection, Mechanism and Therapy of Chronic Kidney Disease
Dong, Y. J., Qu, X., Wu, G., Luo, X., Tang, B., Wu, F., Fan, L., Sooranna, D., & Liang, T. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191119094354 · Cited by 11
Soybean Oil Modulates the Gut Microbiota Associated with Atherogenic Biomarkers
Korach-Rechtman, H., Rom, O., Mazouz, L., Freilich, S., Jeries, H., Hayek, T., Aviram, M., & Kashi, Y. (2020) · Microorganisms · doi:10.3390/microorganisms8040486 · Cited by 10
Rhamnolipids Regulate Lipid Metabolism, Immune Response, and Gut Microbiota in Rats
Zhang, B., Qin, S., Wu, Y., Zhang, R., Xu, Y., & Yang, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.886256 · Cited by 11
Short-chain fatty acids promote jejunal barrier function and caecal muscle contractibility in laying hens ex vivo
Yosi, F., Sharma, S., Sener-Aydemir, A., Koger, S., Baskara, A. P., & Metzler-Zebeli, B. U. (2021) · British Poultry Science · doi:10.1080/00071668.2021.2008312 · Cited by 10
Biomarkers and De Novo Protein Design Can Improve Precise Amino Acid Nutrition in Broilers
Cambra‐López, M., Marín‐García, P. J., Lledó, C., Cerisuelo, A., & Pascual, J. J. (2022) · Animals · doi:10.3390/ani12070935 · Cited by 10
Fecal short chain fatty acids modify therapeutic effects of sleeve gastrectomy
Shen, C., Chen, Y., Wang, Q., Sun, Y., Lin, H., Ni, M., Chen, Y., Zhang, L., Jin, J., Ying, X., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1277035 · Cited by 10
A high fiber diet or supplementation with Lactococcus lactis subspecies cremoris to pregnant mice confers protection against intestinal injury in adult offspring
Barbian, M. E., Owens, J. A., Naudin, C. R., Denning, P. W., Patel, R. M., & Jones, R. M. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2337317 · Cited by 10
Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection-
Sayol-Altarriba, A., Aira, A., Villasante, A., Albarracín, R., Faneca, J., Casals, G., Villanueva‐Cañas, J. L., & Casals‐Pascual, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2415488 · Cited by 11
Gut microbiota-targeted dietary supplementation with fermentable fibers and polyphenols prevents hypobaric hypoxia-induced increases in intestinal permeability
Karl, J. P., Fagnant, H. S., Radcliffe, P. N., Wilson, M. A., Karis, A. J., Sayers, B., Wijeyesekera, A., Gibson, G. R., Lieberman, H. R., Giles, G. E., et al. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00109.2025 · Cited by 13
Effect of daily co-exposure to inulin and chlorpyrifos on selected microbiota endpoints in the SHIME® model
Condette, C. J., Djekkoun, N., Reygner, J., Dépeint, F., Delanaud, S., Rhazi, L., Bach, V., & Khorsi‐Cauet, H. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.118961 · Cited by 11
Can Supplemented Skim Milk (SKM) Boost Your Gut Health?
de Carvalho, N. M., Oliveira, D., Costa, C. M., Pintado, M., & Madureira, A. R. (2022) · Fermentation · doi:10.3390/fermentation8030126 · Cited by 10
Whole Pulses and Pulse Fiber: Modulating Gastrointestinal Function and the Microbiome
Dahl, W. J., & Alvarez, M. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-12763-3_7 · Cited by 10
Dietary fibre intake and its association with inflammatory markers in adolescents
Swann, O. G., Breslin, M. C., Kilpatrick, M., O’Sullivan, T. A., Mori, T. A., Beilin, L. J., & Oddy, W. H. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520001609 · Cited by 10
Divergent gut microbiota in two closely related house mouse subspecies under common garden conditions
Bendová, B., Mikula, O., Bímová, B. V., Čížková, D., Daniszová, K., Ďureje, Ľ., Hiadlovská, Z., Macholán, M., Martin, J., Piálek, J., et al. (2022) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiac078 · Cited by 10
Comparative Quality Assessment of Five Bread Wheat and Five Barley Cultivars Grown in Romania
Moroșan, E., Secăreanu, A. A., Musuc, A. M., Mititelu, M., Ioniță, A. C., Ozon, E. A., Răducan, I. D., Rusu, A. I., Dărăban, A. M., & Karampelas, O. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191711114 · Cited by 10
The Potential Health Benefits of the Subtropical Fruits Kiwifruit, Feijoa and Tamarillo
Skinner, S. J. M., Hunter, D. C., Cho, S., & Skinner, M. A. (2013) · Wiley eBooks · doi:10.1002/9781118635551.ch8 · Cited by 10
Unraveling the etiology of shrimp diseases: a review through the perspectives of gut microbial dynamics
Murugan, R., Priya, P. S., Boopathi, S., Haridevamuthu, B., Kumar, T. T. A., & Arockiaraj, J. (2024) · Aquaculture International · doi:10.1007/s10499-024-01437-z · Cited by 9
Black soldier fly larvae meal in an extruded food: effects on nutritional quality and health parameters in healthy adult cats
Bosch, G., Loureiro, B. A., Schokker, D., Kar, S. K., Paul, A., & Sluczanowski, N. (2024) · Journal of Insects as Food and Feed · doi:10.1163/23524588-00001093 · Cited by 9
Antitumor properties of traditional lactic acid bacteria: Short-chain fatty acid production and interleukin 12 induction
Mobasherpour, P., Yavarmanesh, M., & Dovom, M. R. E. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36183 · Cited by 9
Gastrointestinal microbiota and metabolites responses to dietary cereal grains in an adult pig model
Feng, G., Deng, M., Li, R., Hou, G., Ouyang, Q., Jiang, X., Liu, X., Tang, H., Chen, F., Pu, S., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1442077 · Cited by 9
In vitro characterization of lactic acid bacteria and bifidobacteria from wild and domestic pigs: probiotic potential for post-weaning piglets
Kavanová, K., Kostovová, I., Morávková, M., Kubasová, T., & Crhánová, M. (2025) · BMC Microbiology · doi:10.1186/s12866-024-03711-9 · Cited by 9
The gut microbiota in high-altitude medicine: intersection of hypoxic adaptation and disease management
Chen, Q., Huang, D., Liu, J., Jia, N., Shen, Z., Pei, C., Chen, C., Liu, Y., Wang, Y., Shi, S., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1705487 · Cited by 11
In vitro caecum fermentation and in vivo ( Gallus gallus ) of calcium delivery systems fabricated by desalted duck egg white peptides and chitosan oligosaccharide on gut health
Zhao, M., Ma, A., He, H., Zhang, X., Jia, L. C., & Hou, T. (2021) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15336 · Cited by 9
Genomics and epidemiology for gastric adenocarcinomas
GE4GAC group (2017) · Applied cancer research/Applied Cancer Research · doi:10.1186/s41241-017-0011-2 · Cited by 9
Demonstrating a link between diet, gut microbiota and brain: 14C radioactivity identified in the brain following gut microbial fermentation of 14C-radiolabeled tyrosine in a pig model
Murray, M., Barlow, C. K., Blundell, S. A., Bücking, M., Gibbon, A., Göckener, B., Kaminskas, L. M., Leitner, P., Selby-Pham, S. N. B., Sinclair, A. J., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1127729 · Cited by 10
The nanocomposites of modified attapulgite with vitamin E and mannan oligosaccharide regulated the intestinal epithelial barrier and improved intestinal microbiota composition to prevent diarrhea in weaned piglets
Zha, A., Tan, B., Wang, J., Qi, M., Deng, Y., Liao, P., & Yin, Y. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12642 · Cited by 9
Exploring the potential prebiotic effects of Opuntia dillenii (Ker Gawl). Haw (Cactaceae) cladodes on human intestinal microbiota
Rocha, S. D. S., da Silva, S. R. F., da Silva, J. Y. P., de Medeiros, V. P. B., Aburjaile, F. F., Carvalho, R. D. D. O., da Silva, M. S., Tavares, J. F., do Nascimento, Y. M., Lima, M. D. S., et al. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106259 · Cited by 9
Porcine in vitro digestion and fermentation characteristics of corn wet distillers’ grains and dried distillers grains with solubles without or with multi-enzyme
Zangaro, C. A., Patterson, R., & Woyengo, T. A. (2019) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2019.114205 · Cited by 9
PROBIOTIC APPROACHES FOR TARGETING INFLAMMATORY BOWEL DISEASE: AN UPDATE ON ADVANCES AND OPPORTUNITIES IN MANAGING THE DISEASE.
Kumar, M., Rajkumar, H., Nagpal, R., Singh, B., Parasannanavar, D. J., Verma, V., Kumar, A., Marotta, F., Catanzaro, R., Cuffari, B., et al. (2016) · PubMed · Cited by 9
Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice
Zhan, A., Luo, Y., Qin, H., Lin, W., & Tian, L. (2022) · Bioelectromagnetics · doi:10.1002/bem.22427 · Cited by 9
Health-related quality of life is associated with fecal microbial composition in breast cancer survivors
Smith, K. S., Tissier, A., Bail, J. R., Novak, J. R., Morrow, C. D., Demark‐Wahnefried, W., & Frugé, A. D. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07496-3 · Cited by 9
The Microbiota of the Human Gastrointestinal Tract
Tuohy, K. M., & Scott, K. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407825-3.00001-0 · Cited by 9
Role of short-chain fatty acids in the gut-brain axis in schizophrenia: contribution to immune activation and pathophysiology in humans and micePreprint
Zhu, F., Wang, W., Ma, Q., Yang, Z., Fan, Y., Ju, Y., Guo, R., Wang, Q., Mu, X., Zhao, B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.11.021915 · Cited by 9
Effects of senotherapeutics on gut microbiome dysbiosis and intestinal inflammation in Crohn's disease: A pilot study
Sangfuang, N., McCoubrey, L. E., Awad, A., Marzorati, M., Ghyselinck, J., Verstrepen, L., Munck, J. D., Medts, J. D., Gaisford, S., & Basit, A. W. (2025) · Translational research · doi:10.1016/j.trsl.2025.02.004 · Cited by 10
Microbiota and inflammatory bowel disease: the dual effect mechanism of polysaccharide therapy
Yang, J., Huang, Q., Long, J., & Jia, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1666866 · Cited by 13
The effect of a diverting ileostomy formation on nutritional status and energy intake of patients undergoing colorectal surgery
Migdanis, A., Koukoulis, G., Mamaloudis, I., Baloyiannis, I., Migdanis, I., Vagena, X., Malissiova, E., & Tzovaras, G. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.08.002 · Cited by 8
Gut Microbiota and Lymphocyte Subsets in Canine Leishmaniasis
Meazzi, S., Lauzi, S., Martini, V., Ferriani, R., Peri, M., Zanzani, S. A., & Giordano, A. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.868967 · Cited by 8
Culturing clinical Methanobrevibacter smithii using GG medium in a minimal anaerobe atmosphere.
Pilliol, V., Guindo, C. O., Terrer, E., Aboudharam, G., Drancourt, M., & Grine, G. (2023) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2023.106704 · Cited by 8
Use of fiber-containing enteral formula in pediatric clinical practice: an expert opinion review
Lionetti, P., Wine, E., Ran‐Ressler, R. R., Minor, G. J., Major, G., Zemrani, B., Gottrand, F., & Romano, C. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2217355 · Cited by 9
Standardisation of the C:N ratio in ileal digesta changes relationships among fermentation end-products during in vitro hindgut fermentation in pigs
Lammers-Jannink, K., Pellikaan, W. F., de Vries, S., Stigter, E. C. A., & Gerrits, W. J. J. (2023) · animal · doi:10.1016/j.animal.2023.101026 · Cited by 8
The Intervention of Probiotics on Type 2 Diabetes Mellitus in Animal Models
Qu, Q., He, P., Zhang, Y., Yang, S., & Zeng, P. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200815 · Cited by 10
Impact of Nutrition on the Gut Microbiota
Ishiguro, E. E., Haskey, N., & Campbell, K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810541-2.00006-3 · Cited by 8
Microbial fermentation of Fossence™, a short-chain fructo-oligosaccharide, under simulated human proximal colonic condition and assessment of its prebiotic effects- A pilot study
Tiwari, D. P., Shah, P., den Abbeele, P. V., Marzorati, M., Calatayud, M., Ghyselinck, J., Dubey, A. K., Narayanan, S., & Jain, M. (2021) · FEMS Microbiology Letters · doi:10.1093/femsle/fnab147 · Cited by 8
Effects of Bacillus subtilis BSNK-5-Fermented Soymilk on the Gut Microbiota by In Vitro Fecal Fermentation
Gao, Y., Hou, L., Hu, M., Li, D., Tian, Z., Wen, W., Fan, B., Li, S., & Wang, F. (2022) · Foods · doi:10.3390/foods11213501 · Cited by 10
Microbial Interactions and Interventions in Colorectal Cancer
Raay, T. J. V., & Allen‐Vercoe, E. (2018) · ASM Press eBooks · doi:10.1128/9781555819705.ch4 · Cited by 8
Seasonal Effects on the Fecal Microbial Composition of Wild Greater Thick-Tailed Galagos (Otolemur crassicaudatus)
Long, C., Scheun, J., Sauther, M. L., Cuozzo, F. P., Millette, J. B., & Tordiffe, A. S. W. (2023) · International Journal of Primatology · doi:10.1007/s10764-023-00407-1 · Cited by 7
An open-label pilot single-subject study to monitor the impact of a Food-Based enteral formula on faecal short-chain fatty acid concentrations in children admitted to intensive care with sepsis
O’Connor, G., Sun, Y., Gardiner, B., Audu, G., Bajaj‐Elliott, M., & Eaton, S. D. (2023) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2023.12.002 · Cited by 8
In Vitro Fermentation of Animal and Plant Protein Isolates by the Human Gut Microbiota Under High and Low Carbohydrate Conditions
Behounek, M., Cochran, D., Romero, H. M., Yang, Q., Ding, W. R., Morton, M., Majumder, K., Powers, R., & Rose, D. J. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300555 · Cited by 8
Improved diet-based nutritional interventions can improve childhood obesity with the synergistic regulation of gut microbiota
Zhou, M., Peng, C., Miao, Z., Wang, K., Zhou, H., Li, Y., Xiao, G., & Wu, X. (2017) · Beneficial Microbes · doi:10.1163/18762891-bja00019 · Cited by 8
Dietary β‐Mannanase Affects the Growth, Antioxidant, and Immunes Responses of African Catfish, Clarias gariepinus, and Its Challenge Against Aeromonas hydrophila Infection
Adeshına, İ., Paray, B. A., Bhat, E. A., Sherzada, S., Fawole, O. O., Bawa, D., da Cruz, T. P., & TIAMIYU, L. O. (2024) · Aquaculture Nutrition · doi:10.1155/2024/5263495 · Cited by 7
Gut microbiota changes in healthy individuals, obstructive sleep apnea patients, and patients treated using continuous positive airway pressure: a whole-genome metagenomic analysis
Xue, X., Zhao, Z., Zhao, L., Gao, Y., Xu, W., Cai, W.-M., Chen, S., Li, T., Nie, T.-Y., Dong, R., et al. (2024) · Sleep And Breathing · doi:10.1007/s11325-024-03185-z · Cited by 7
Mediterranean diet and colorectal adenomas: a systematic review and meta-analysis of observational studies
Nasab, S. J., Clark, C. C. T., & Entezari, M. H. (2023) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000861 · Cited by 9
A narrative review on dietary components and patterns and age-related macular degeneration
Koçyiğit, E., Gövez, N. E., Arslan, S., & Ağagündüz, D. (2024) · Nutrition Research Reviews · doi:10.1017/s0954422424000015 · Cited by 7
Starch gelatinization implications for nutrient digestibility and fermentation products in the faeces of Beagle dogs
Loureiro, B. A., OLIVEIRA, M. C., Peixoto, M. C., Ribeiro, E. M., Schauf, S., Castrillo, C., & Carciofí, A. C. (2024) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2024.115894 · Cited by 7
Ginger Extract Improves Cognitive Dysfunction via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease
Zahedi, E., Naseri, F. M., Zamani, E., Nikbakhtzadeh, M., Rastegar, T., Sanaeirad, A., & Sadr, S. S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04583-w · Cited by 9
Resveratrol and β-hydroxy-β-methylbutyric acid supplementation promotes ileal development and digestive function by altering microbial community abundance and metabolites in Tibetan sheep
Gan, J., Ji, Q., Su, Q., Hou, S., & Gui, L. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1470992 · Cited by 7
Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation
Díez, H., Benitez, M. J., Fernández, S., Torres‐Alemán, I., Garrido, J. J., & Wandosell, F. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.07.002 · Cited by 9
A Low to Medium-Shear Extruded Kibble with Greater Resistant Starch Increased Fecal Oligosaccharides, Butyric Acid, and Other Saccharolytic Fermentation By-Products in Dogs
Alvarenga, I. C., Jackson, M. I., Jewell, D. E., & Aldrich, C. G. (2021) · Microorganisms · doi:10.3390/microorganisms9112293 · Cited by 7
Microbiota intestinal humana y dieta
Pereira, C. A. P. (2019) · Ciencia y Tecnología · doi:10.18779/cyt.v12i1.176 · Cited by 11
Promising role of D-amino acids in irritable bowel syndrome
Ikeda, Y., Taniguchi, K., Sawamura, H., Tsuji, A., & Matsuda, S. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i31.4471 · Cited by 9
Isomaltooligosaccharides inhibit early colorectal carcinogenesis in a 1,2-dimethylhydrazine-induced rat model
Chen, X., Li, S., Lin, C., Zhang, Z., Liu, X., Wang, C., Chen, J., Yang, B., Yuan, J., & Zhang, Z. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.995126 · Cited by 7
Crosstalk between the aging intestinal microflora and the brain in ischemic stroke
Pluta, R. M., Jabłoński, M., Januszewski, S., & Czuczwar, S. J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.998049 · Cited by 7
Effects of Dietary Bacillus subtilis BC02 Supplementation on Growth Performance, Antioxidant Capacity, and Cecal Microbes in Broilers
Ren, X., Zhang, Y., Lu, H. B., Jiao, N., Jiang, S., Li, Y., Li, J., & Yang, W. (2023) · Agriculture · doi:10.3390/agriculture13081561 · Cited by 7
Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice
Lednovich, K., Gough, S., Priyadarshini, M., Pandya, N., Nnyamah, C., Xu, K., Wicksteed, B. L., Mishra, S. P., Jain, S., Zapater, J. L., et al. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0184 · Cited by 10
Effectiveness of probiotic- and fish oil-loaded water-in-oil-in-water (W 1 /O/W 2 ) emulsions at alleviating ulcerative colitis
Gu, Q., Jiang, Z., Li, K., Li, Y., Yan, X., McClements, D. J., Ma, C., & Liu, F. (2024) · Food & Function · doi:10.1039/d4fo00258j · Cited by 7
The Human Gut Microbiome and Its Role in Obesity and the Metabolic Syndrome
Mullin, G. E., & Delzenne, N. M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0548-5_7 · Cited by 7
Molecular Phenotyping and Genomic Characterization of a Novel Neuroactive Bacterium Strain, Lactobacillus murinus HU-1
Lebovitz, Y., & Theus, M. H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01162 · Cited by 7
Modulation of the microbiota-gut-brain axis by bioactive food, prebiotics, and probiotics decelerates the course of Alzheimer's disease
Cuervo-Zanatta, D., Pérez-Grijalva, B., González-Magaña, E., Hernández-Acosta, J., Murugesan, S., García-Mena, J., & Perez‐Cruz, C. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819489-8.00019-3 · Cited by 7
Dietary Fiber, Soluble and Insoluble, Carbohydrates, Fructose, and Lipids
Wong, J. M., Comelli, E. M., Kendall, C. W. C., Sievenpiper, J. L., Noronha, J. C., & Jenkins, D. J. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804024-9.00022-7 · Cited by 8
Limosilactobacillus fermentum TY-S11 ameliorates hypercholesterolemia via promoting cholesterol excretion and regulating gut microbiota in high-cholesterol diet-fed apolipoprotein E-deficient mice
Deng, Y., Wang, J., Wang, R., Wang, Y., Shu, X., Wang, P., Chen, C., & Zhang, F. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32059 · Cited by 6
Comparative analysis of transcriptomics and metabolomics provides insights into the mechanisms of VPAHPND invasion and hepatopancreatic damage in Litopenaeus vannamei
Zhao, Z., Wang, B., Jiang, K., Liu, M., & Wang, L. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109920 · Cited by 6
Diet as a Modulator of Gut Microbiota May Reduce Alzheimer’s Disease Risk
Ochocińska, A., Podstawka, I., Kępka, A., & Waszkiewicz, N. (2025) · Nutrients · doi:10.3390/nu17193053 · Cited by 6
Safety of sugar alcohols on human health: a review
Qadir, A. M., & Omer, R. A. (2025) · International Journal of Food Science & Technology · doi:10.1093/ijfood/vvag012 · Cited by 6
Hydrolysis of pea protein differentially modulates its effect on iron bioaccessibility, sulfur availability, composition and activity of gut microbial communities in vitro
Zhang, Y. Y., Stockmann, R., Ng, K., & Ajlouni, S. (2023) · Food & Function · doi:10.1039/d3fo00504f · Cited by 7
Relationship of migraine and other forms of chronic pain
Ray, J. C., Matharu, M. S., & Hutton, E. J. (2024) · Handbook of clinical neurology · doi:10.1016/b978-0-12-823357-3.00027-6 · Cited by 6
In Vitro Digestion and Fermentation of Cowpea Pod Extracts and Proteins Loaded in Ca(II)-Alginate Hydrogels
Traffano-Schiffo, M. V., Aguirre‐Calvo, T. R., Navajas-Porras, B., Avanza, M. V., Rufián‐Henares, J. Á., & Santagapita, P. R. (2024) · Foods · doi:10.3390/foods13193071 · Cited by 6
The influence of the gut microbiome on obesity
Blanco, C. E. (2020) · Journal of the American Association of Nurse Practitioners · doi:10.1097/jxx.0000000000000480 · Cited by 8
Kang‐Xian Pills Inhibit Inflammatory Response and Decrease Gut Permeability to Treat Carbon Tetrachloride‐Induced Chronic Hepatic Injury through Modulating Gut Microbiota
Wang, L., Cui, H., Li, Y., Cao, M., Man, S., Guo, L., Miao, J., Jia, J., Bian, Y., & Zhang, Z. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/8890182 · Cited by 6
Higher fiber complementary food alters Fecal microbiota composition and normalizes stool form in Malawian children: A randomized trial
Lungu, E., Auger, J., Piano, A., & Dahl, W. J. (2021) · African Journal of Food Agriculture Nutrition and Development · doi:10.18697/ajfand.99.20200 · Cited by 6
Epigenetic Regulation of Gastrointestinal Epithelial Barrier and Developmental Origins of Health and Disease
Lallès, J. P., Michel, C., Theodorou, V., & Segain, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801383-0.00017-7 · Cited by 6

Authors: Macfarlane, G. T., & Macfarlane, S.
Affiliations: University of Dundee (GB)
Corresponding author: Macfarlane, Sandra
ORCID: Macfarlane, Sandra
Venue: Journal of AOAC INTERNATIONAL
Publisher: Oxford University Press (OUP)
Published: 2012-01-01
Volume: 95
Issue: 1
Pages: 50-60
ISSN: 1060-3271 (ISSN-L)
1944-7922
DOI: 10.5740/jaoacint.sge_macfarlane
OpenAlex: W2082808164
Cited by: 970
References: 91
Citations by year: 2026: 44 · 2025: 64 · 2024: 74 · 2023: 85 · 2022: 104 · 2021: 123 · 2020: 99 · 2019: 82 · 2018: 55 · 2017: 67 · 2016: 45 · 2015: 35 · 2014: 45 · 2013: 42 · 2012: 5
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of AOAC International (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: colonic microbiota, colonic fermentation, short-chain fatty acids, butyrate, acetate, propionate, carbohydrate digestion, protein digestion, putrefaction, colonic diseases, saccharolytic bacteria, intestinal homeostasis, dietary fiber
MeSH terms: Amino Acids, Butyrates, Colon, Colonic Neoplasms, Dietary Carbohydrates, Dietary Proteins, Fatty Acids, Volatile, Fermentation, Food Microbiology, Health, Humans, Hydrogen, Propionates, Oxidative Stress, Lactic Acid, Gastrointestinal Tract, Proteolysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bacteria, Colonic Fermentation, and Gastrointestinal Health

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks