Cited by 976Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Bacteria, Colonic Fermentation, and Gastrointestinal Health

Macfarlane, George T, Macfarlane, Sandra·2012·Journal of AOAC INTERNATIONAL

Open this paper in CoChat — free account

Abstract

The colonic microbiota plays an important role in human digestive physiology and makes a significant contribution to homeostasis in the large bowel. The microbiome probably comprises thousands of different bacterial species. The principal metabolic activities of colonic microorganisms are associated with carbohydrate and protein digestion. Nutrients of dietary and host origin support the growth of intestinal organisms. Short-chain fatty acids (SCFAs), predominantly acetate, propionate, and butyrate, are the principal metabolites generated during the catabolism of carbohydrates and proteins. In contrast, protein digestion yields a greater diversity of end products, including SCFAs, amines, phenols, indoles, thiols, CO2, H2, and H2S, many of which have toxic properties. The majority of SCFAs are absorbed from the gut and metabolized in various body tissues, making a relatively small but significant contribution to the body's daily energy requirements. Carbohydrate fermentation is, for the most part, a beneficial process in the large gut, because the growth of saccharolytic bacteria stimulates their requirements for toxic products associated with putrefaction, for incorporation into cellular proteins, thereby protecting the host. However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel.

Integrity signals

Registry

Crossref · 10.5740/jaoacint.sge_macfarlane

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Self-citation
Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin.
(2013) · Gastroenterology Research · doi:10.1053/j · Cited by 2,759
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
The first known larva of the Australian tribe Mystropomini (Coleoptera: Carabidae: Paussinae)
Giulio, A. D., & Moore, W. (2009) · Intellectum (Universidad de La Sabana) · doi:10.1111/j.1440- · Cited by 2,279
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204
Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939
Self-citation
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,357
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,178

Flagged first, then by citations

Show all 91 references

Sorted by citations

Items 101–200 of 976

The human gut microbiome and aging
Bradley, E. S., & Haran, J. P. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2359677 · Cited by 197
Food Intake and Eating Behavior After Bariatric Surgery
Al‐Najim, W., Docherty, N. G., & le Roux, C. W. (2018) · Physiological Reviews · doi:10.1152/physrev.00021.2017 · Cited by 185
Gut microbiota in obstructive sleep apnea–hypopnea syndrome: disease-related dysbiosis and metabolic comorbidities
Ko, C., Liu, Q., Su, H., Zhang, H.-P., Fan, J., Yang, J., Hu, A., Liu, Y., Chou, D., & Zeng, Y. (2019) · Clinical Science · doi:10.1042/cs20180891 · Cited by 176
Manipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies
Shanahan, F., & Quigley, E. M. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.050 · Cited by 172
Expanding role of gut microbiota in lipid metabolism
Ghazalpour, A., Cespedes, I., Bennett, B. J., & Allayee, H. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000278 · Cited by 177
Diet, nutrients and the microbiome
Dahl, W. J., Rivero‐Mendoza, D., & Lambert, J. M. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.006 · Cited by 175
How Diet and Physical Activity Modulate Gut Microbiota: Evidence, and Perspectives
Campaniello, D., Corbo, M. R., Sinigaglia, M., Speranza, B., Racioppo, A., Altieri, C., & Bevilacqua, A. (2022) · Nutrients · doi:10.3390/nu14122456 · Cited by 178
Gut microbiota and pro/prebiotics in Alzheimer’s disease
Pluta, R. M., Ułamek-Kozioł, M., Januszewski, S., & Czuczwar, S. J. (2020) · Aging · doi:10.18632/aging.102930 · Cited by 177
The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration
Zheng, Z., & Wang, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775526 · Cited by 178
Interaction between diet composition and gut microbiota and its impact on gastrointestinal tract health
Rajoka, M. S. R., Shi, J., Mehwish, H. M., Zhu, J., Li, Q., Shao, D., Huang, Q., & Yang, H. (2017) · Food Science and Human Wellness · doi:10.1016/j.fshw.2017.07.003 · Cited by 174
Dual role of microbiota-derived short-chain fatty acids on host and pathogen
Mirzaei, R., Dehkhodaie, E., Bouzari, B., Rahimi, M., Gholestani, A., Hosseini‐Fard, S. R., Keyvani, H., Teimoori, A., & Karampoor, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112352 · Cited by 167
Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74
Canani, R. B., Filippis, F. D., Nocerino, R., Laiola, M., Paparo, L., Calignano, A., Caro, C. D., Coretti, L., Chiariotti, L., Gilbert, J. A., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01206-17 · Cited by 167
Cereal-derived arabinoxylans: Structural features and structure–activity correlations
Wang, J., Bai, J., Fan, M., Li, T., Li, Y., Qian, H., Wang, L., Zhang, H., Qi, X., & Rao, Z. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.12.016 · Cited by 169
The Role of Gut Microbiota in an Ischemic Stroke
Pluta, R. M., Januszewski, S., & Czuczwar, S. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020915 · Cited by 163
Clinical translation of advanced colonic drug delivery technologies
Awad, A., Madla, C. M., McCoubrey, L. E., Ferraro, F., Gavins, F. K. H., Buanz, A. B. M., Gaisford, S., Orlu, M., Siepmann, F., Siepmann, J., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114076 · Cited by 171
The Effect of Gut Microbiota and Probiotics on Metabolism in Fish and Shrimp
Ringø, E., Harikrishnan, R., Soltani, M., & Ghosh, K. (2022) · Animals · doi:10.3390/ani12213016 · Cited by 156
The microbiota-gut-brain axis as a key regulator of neural function and the stress response: Implications for human and animal health
Wiley, N., Dinan, T. G., Ross, R. P., Stanton, C., Clarke, G. A., & Cryan, J. F. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.1256 · Cited by 190
The relationship among gut microbiota, short-chain fatty acids, and intestinal morphology of growing and healthy broilers
Liao, X., Shao, Y., Sun, G., Yang, Y., Zhang, L., Guo, Y., Luo, X., & Lü, L. (2020) · Poultry Science · doi:10.1016/j.psj.2020.08.033 · Cited by 161
Extensive Summary of the Important Roles of Indole Propionic Acid, a Gut Microbial Metabolite in Host Health and Disease
Jiang, H., Chen, C., & Gao, J. (2022) · Nutrients · doi:10.3390/nu15010151 · Cited by 153
Effect of oral consumption of probiotic Lactobacillus planatarum P-8 on fecal microbiota, SIgA, SCFAs, and TBAs of adults of different ages
Wang, L., Zhang, J., Guo, Z., Kwok, L., Ma, C., Zhang, W., Lv, Q., Huang, W., & Zhang, H. (2013) · Nutrition · doi:10.1016/j.nut.2013.11.018 · Cited by 150
Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet
Vervier, K., Moss, S., Kumar, N., Adoum, A., Barne, M., Browne, H. P., Kaser, A., Kiely, C. J., Neville, A., Powell, N., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-325177 · Cited by 154
Antioxidant activity of aqueous extract of passion fruit (Passiflora edulis) leaves: In vitro and in vivo study
da Silva-Maia, J. K., Cazarin, C. B. B., Colomeu, T. C., Batista, Â. G., Meletti, L. M. M., Paschoal, J. A. R., Bogusz, S., Furlan, M. F., Reyes, F. G. R., Augusto, F., et al. (2013) · Food Research International · doi:10.1016/j.foodres.2012.12.043 · Cited by 145
Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double-blind, placebo-controlled crossover study
Macfarlane, S., Cleary, S., Bahrami, B., Reynolds, N., & Macfarlane, G. T. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12453 · Cited by 148
Self-citation
Prebiotics from Seaweeds: An Ocean of Opportunity?
Cherry, P., Yadav, S., Strain, C., Allsopp, P. J., McSorley, E. M., Ross, R. P., & Stanton, C. (2019) · Marine Drugs · doi:10.3390/md17060327 · Cited by 151
Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health
Ashcroft, S. P., Stocks, B., Egan, B., & Zierath, J. R. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.008 · Cited by 149
Exploring the Role of Gut Microbiome in Colon Cancer
Chattopadhyay, I., Dhar, R., Pethusamy, K., Seethy, A. A., Srivastava, T. P., Sah, R., Sharma, J. N., & Karmakar, S. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03498-9 · Cited by 147
Interactions between dietary flavonoids and the gut microbiome: a comprehensive review
Baky, M. H., Elshahed, M. S., Wessjohann, L. A., & Farag, M. A. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521003627 · Cited by 148
Akkermansia muciniphila : is it the Holy Grail for ameliorating metabolic diseases?
Yan, J., Sheng, L., & Li, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1984104 · Cited by 143
Genetic and microbiome influence on lipid metabolism and dyslipidemia
Matey-Hernandez, M. L., Williams, F. M. K., Potter, T. I. T., Valdes, A. M., Spector, T. D., & Menni, C. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00053.2017 · Cited by 134
Fermented blueberry pomace with antioxidant properties improves fecal microbiota community structure and short chain fatty acids production in an in vitro mode
Cheng, Y., Wu, T., Chu, X., Tang, S., Cao, W., Liang, F., Fang, Y., Pan, S., & Xu, X. (2020) · LWT · doi:10.1016/j.lwt.2020.109260 · Cited by 137
Vegetable-Based Diets for Chronic Kidney Disease? It Is Time to Reconsider
Cases, A., Cigarrán, S., Mas, S., & González‐Parra, E. (2019) · Nutrients · doi:10.3390/nu11061263 · Cited by 130
How to Manipulate the Microbiota: Prebiotics
Louis, P., Flint, H. J., & Michel, C. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-31248-4_9 · Cited by 129
The Intestine of Drosophila melanogaster: An Emerging Versatile Model System to Study Intestinal Epithelial Homeostasis and Host-Microbial Interactions in Humans
Capo, F., Wilson, A., & Cara, F. D. (2019) · Microorganisms · doi:10.3390/microorganisms7090336 · Cited by 136
Anoxic Conditions Promote Species-Specific Mutualism between Gut Microbes In Silico
Heinken, A., & Thiele, I. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.00101-15 · Cited by 123
A Review on Role of Microbiome in Obesity and Antiobesity Properties of Probiotic Supplements
Sivamaruthi, B. S., Kesika, P., Suganthy, N., & Chaiyasut, C. (2019) · BioMed Research International · doi:10.1155/2019/3291367 · Cited by 128
Microplastics as an aquatic pollutant affect gut microbiota within aquatic animals
Li, W., Chen, X., Li, M., Cai, Z., Gong, H., & Yan, M. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127094 · Cited by 126
Short-Chain Fatty Acids in Chronic Kidney Disease: Focus on Inflammation and Oxidative Stress Regulation
Magliocca, G., Mone, P., Iorio, B. R. D., Heidland, A., & Marzocco, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105354 · Cited by 130
Inter‐individual differences determine the outcome of wheat bran colonization by the human gut microbiome
Paepe, K. D., Kerckhof, F., Verspreet, J., Courtin, C. M., & de Wiele, T. V. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13819 · Cited by 116
How can we define “optimal microbiota?”: a comparative review of structure and functions of microbiota of animals, fish, and plants in agriculture
Ikeda-Ohtsubo, W., Brugman, S., Warden, C. H., Rebel, J. M. J., Folkerts, G., & Pieterse, C. M. J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00090 · Cited by 115
The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications
Gomes, S., Oliveira, C. S., Azevedo‐Silva, J., Casanova, M. R., Barreto, J., Pereira, H., Chaves, S. R., Rodrigues, L. R., Casal, M., Côrte‐Real, M., et al. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180530102050 · Cited by 116
Summer Meeting 2013: growth and physiology of bifidobacteria
Vuyst, L. D., Moens, F., Selak, M., Rivière, A., & Leroy, F. (2013) · Journal of Applied Microbiology · doi:10.1111/jam.12415 · Cited by 124
Carbohydrates great and small, from dietary fiber to sialic acids: How glycans influence the gut microbiome and affect human health
Coker, J. K. C., Moyne, O., Rodionov, D. A., & Zengler, K. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1869502 · Cited by 117
Modulatory effects of polysaccharides from plants, marine algae and edible mushrooms on gut microbiota and related health benefits: A review
Zhang, H., Jiang, F., Zhang, J., Wang, W., Li, L., & Yan, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.01.166 · Cited by 114
Microbiota–Host Transgenomic Metabolism, Bioactive Molecules from the Inside
Turroni, S., Brigidi, P., Cavalli, A., & Candela, M. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00244 · Cited by 111
Heat stress affects fecal microbial and metabolic alterations of primiparous sows during late gestation
He, J., Guo, H., Zheng, W., Xue, Y., Zhao, R., & Yao, W. (2019) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-019-0391-0 · Cited by 112
Colorectal cancer diagnostic model utilizing metagenomic and metabolomic data of stool microbial extracellular vesicles
Kim, D. J., Yang, J., Seo, H., Lee, W. H., Lee, D. H., Kym, S., Park, Y. S., Kim, J. G., Jang, I., Kim, Y.-K., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59529-8 · Cited by 108
Factors Determining Colorectal Cancer: The Role of the Intestinal Microbiota
Nistal, E., Fernández-Fernández, N., Vivas, S., & Olcoz, J. L. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00220 · Cited by 111
Short chain fatty acids produced by Cutibacterium acnes inhibit biofilm formation by Staphylococcus epidermidis
Nakamura, K., O’Neill, A. M., Williams, M. R., Cau, L., Nakatsuji, T., Horswill, A. R., & Gallo, R. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-77790-9 · Cited by 114
Personalizing protein nourishment
Dallas, D. C., Sanctuary, M. R., Qu, Y., Khajavi, S. H., Zandt, A. E. V., Dyandra, M., Frese, S. A., Barile, D., & German, J. B. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1117412 · Cited by 113
A diet change from dry food to beef induces reversible changes on the faecal microbiota in healthy, adult client-owned dogs
Herstad, K. M. V., Gajardo, K., Bakke, A. M., Moe, L., Ludvigsen, J., Rudi, K., Rud, I., Sekelja, M., & Skancke, E. (2017) · BMC Veterinary Research · doi:10.1186/s12917-017-1073-9 · Cited by 113
Development of a fast and cost-effective gas chromatography–mass spectrometry method for the quantification of short-chain and medium-chain fatty acids in human biofluids
Lotti, C., Rubert, J., Fava, F., Tuohy, K. M., Mattivi, F., & Vrhovšek, U. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0493-5 · Cited by 104
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas
McCurry, M. D., D’Agostino, G. D., Walsh, J. T., Bisanz, J. E., Zalosnik, M. I., Dong, X., Morris, D. J., Korzenik, J. R., Edlow, A. G., Balskus, E. P., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.005 · Cited by 117
Unique aspects of fiber degradation by the ruminal ethanologen Ruminococcus albus 7 revealed by physiological and transcriptomic analysis
Christopherson, M. R., Dawson, J. A., Stevenson, D. M., Cunningham, A. C., Bramhacharya, S., Weimer, P. J., Kendziorski, C. M., & Suen, G. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1066 · Cited by 105
High-protein diet modifies colonic microbiota and luminal environment but not colonocyte metabolism in the rat model: The increased luminal bulk connection
Liu, X., Blouin, J.-M., Santacruz, A., Lan, A., Andriamihaja, M., Wilkanowicz, S., Benetti, P.-H., Tomé, D., Sanz, Y., Blachier, F., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00400.2013 · Cited by 103
Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro
Gao, B., Wang, R., Peng, Y., & Li, X. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.06.006 · Cited by 104
Recent advances in utilization of pectins in biomedical applications: a review focusing on molecular structure-directing health-promoting properties
Zhang, S., Waterhouse, G. I. N., Xu, F., He, Z., Du, Y., Lian, Y., Wu, P., & Sun‐Waterhouse, D. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1988897 · Cited by 107
Dietary trans -10, cis -12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice
Marques, T. M., Wall, R., O’Sullivan, Ó., Fitzgerald, G. F., Shanahan, F., Quigley, E. M. M., Cotter, P. D., Cryan, J. F., Dinan, T. G., Ross, R. P., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004206 · Cited by 103
Systems biology of host–microbe metabolomics
Heinken, A., & Thiele, I. (2015) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1301 · Cited by 99
INTESTINAL MICROBIOTA IN DIGESTIVE DISEASES
Passos, M. D. C. F., & Moraes-Filho, J. P. P. (2017) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.201700000-31 · Cited by 125
Dietary Fiber Future Directions: Integrating New Definitions and Findings to Inform Nutrition Research and Communication
Jones, J. M. (2013) · Advances in Nutrition · doi:10.3945/an.112.002907 · Cited by 100
Gut microbiota composition in children with obstructive sleep apnoea syndrome: a pilot study
Valentini, F., Evangelisti, M., Arpinelli, M., Nardo, G. D., Borro, M., Simmaco, M., & Villa, M. P. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.10.017 · Cited by 107
Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice
Higashimura, Y., Naito, Y., Takagi, T., Uchiyama, K., Mizushima, K., Ushiroda, C., Ohnogi, H., Kudo, Y., Yasui, M., Inui, S., et al. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00324.2015 · Cited by 98
Advances and future perspectives in epithelial drug delivery
Mohammed, Y., Holmes, A. M., Kwok, P. C. L., Kumeria, T., Namjoshi, S., Imran, M., Matteucci, L., Ali, M., Tai, W., Benson, H. A., et al. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114293 · Cited by 99
Exploring the Potential of Human Milk and Formula Milk on Infants’ Gut and Health
Chong, H.-Y., Tan, L. T., Law, J. W., Hong, K., Ratnasingam, V., Mutalib, N. A., Lee, L., & Letchumanan, V. (2022) · Nutrients · doi:10.3390/nu14173554 · Cited by 110
Sex differences in gut fermentation and immune parameters in rats fed an oligofructose-supplemented diet
Shastri, P., McCarville, J. L., Kalmokoff, M. L., Brooks, S. P. J., & Green-Johnson, J. M. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0031-0 · Cited by 103
In vitro colonisation of the distal colon by Akkermansia muciniphila is largely mucin and pH dependent
Herreweghen, F. V., den Abbeele, P. V., Mulder, T. D., Weirdt, R. D., Geirnaert, A., Hernandez‐Sanabria, E., Vilchez‐Vargas, R., Jáuregui, R., Pieper, D. H., Belzer, C., et al. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0013 · Cited by 97
Impact of the Gut Microbiota Balance on the Health–Disease Relationship: The Importance of Consuming Probiotics and Prebiotics
Olvera-Rosales, L. B., Cruz-Guerrero, A. E., Ramírez‐Moreno, E., Lira, A. Q., Contreras‐López, E., Ordaz, J. J., Ovando, A. C., Añorve‐Morga, J., Calderón‐Ramos, Z. G., Arias‐Rico, J., et al. (2021) · Foods · doi:10.3390/foods10061261 · Cited by 108
Glycolysis for Microbiome Generation
Wolfe, A. J. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mbp-0014-2014 · Cited by 101
Associations between the gut microbiota and host responses to high altitude
Karl, J. P., Berryman, C. E., Young, A., Radcliffe, P. N., Branck, T. A., Pantoja-Feliciano, I. G., Rood, J. C., & Pasiakos, S. M. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00253.2018 · Cited by 97
Alcohol Induced Alterations to the Human Fecal VOC Metabolome
Couch, R. D., Dailey, A., Zaidi, F., Navarro, K., Forsyth, C. B., Mutlu, E., Engen, P. A., & Keshavarzian, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119362 · Cited by 96
Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-Induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease
Kirpich, I., Petrosino, J. F., Ajami, N. J., Feng, W., Wang, Y., Liu, Y., Beier, J. I., Barve, S. S., Yin, X., Wei, X., et al. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.017 · Cited by 96
Role of LAB in silage fermentation: Effect on nutritional quality and organic acid production—An overview
Kim, D., Lee, K. D., & Choi, K. C. (2021) · AIMS Agriculture and Food · doi:10.3934/agrfood.2021014 · Cited by 103
Dietary resistant starch dose-dependently reduces adiposity in obesity-prone and obesity-resistant male rats
Belobrajdic, D. P., King, R. A., Christophersen, C. T., & Bird, A. R. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-93 · Cited by 95
Building a Beneficial Microbiome from Birth
Castanys‐Muñoz, E., Martín, M. J., & Vázquez, E. (2016) · Advances in Nutrition · doi:10.3945/an.115.010694 · Cited by 96
In vitro digestibility and prebiotic potential of a novel polysaccharide from Rosa roxburghii Tratt fruit
Wang, L., Li, C., Huang, Q., Fu, X., & Liu, R. H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.11.021 · Cited by 93
Fecal metabonomics combined with 16S rRNA gene sequencing to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect of You-gui pill
Chen, R., Wang, J., Zhan, R., Zhang, L., & Wang, X. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112139 · Cited by 97
Chinese yam peel enhances the immunity of the common carp (Cyprinus carpio L.) by improving the gut defence barrier and modulating the intestinal microflora
Meng, X., Hu, W., Wu, S., Zhu, Z.-X., Lu, R., Yang, G., Qin, C., Yang, L., & Nie, G. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.10.066 · Cited by 91
Crocin-I alleviates the depression-like behaviors probably via modulating “microbiota-gut-brain” axis in mice exposed to chronic restraint stress
Xiao, Q., Shu, R., Wu, C., Tong, Y., Xiong, Z., Zhou, J., Yu, C., Xie, X., & Fu, Z. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.041 · Cited by 93
Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice
Jump, R., Polinkovsky, A., Hurless, K. N., Sitzlar, B. M., Eckart, K. E., Tomas, M. E., Deshpande, A., Nerandzic, M. M., & Donskey, C. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101267 · Cited by 92
The ATG16L1–T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients
Sadabad, M. S., Regeling, A., de Goffau, M. C., Blokzijl, T., Weersma, R. K., Penders, J., Faber, K. N., Harmsen, H. J. M., & Dijkstra, G. D. H. (2014) · Gut · doi:10.1136/gutjnl-2014-307289 · Cited by 98
Diet Rich in Simple Sugars Promotes Pro-Inflammatory Response via Gut Microbiota Alteration and TLR4 Signaling
Fajstova, A., Galanova, N., Coufal, S., Malkova, J., Kostovcik, M., Cermakova, M., Pelantova, H., Kuzma, M., Sediva, B., Hudcovic, T., et al. (2020) · Cells · doi:10.3390/cells9122701 · Cited by 90
Dietary fat and gut microbiota: mechanisms involved in obesity control
Coelho, O. G. L., Cândido, F. G., & Alfenas, R. D. C. G. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1481821 · Cited by 90
Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women
Karl, J. P., Meydani, M., Barnett, J. B., Vanegas, S. M., Goldin, B., Kane, A., Rasmussen, H., Saltzman, E., Vangay, P., Knights, D., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.139683 · Cited by 89
Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon
Fleischer, J., Bumbalo, R., Bautze, V., Strotmann, J. M., & Breer, H. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2165-0 · Cited by 86
Mechanisms of the intestinal and urinary microbiome in kidney stone disease
Miller, A. W., Penniston, K. L., Fitzpatrick, K., Agudelo, J., Tasian, G., & Lange, D. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00647-5 · Cited by 89
Short chain fatty acids could prevent fat deposition in pigs via regulating related hormones and genes
Jiao, A., Yu, B., He, J., Yu, J., Zheng, P., Luo, Y., Luo, J., Mao, X., & Chen, D. (2020) · Food & Function · doi:10.1039/c9fo02585e · Cited by 88
Dietary Protein Metabolism by Gut Microbiota and its Consequences for Chronic Kidney Disease Patients
Mafra, D., Barros, A. F. H., & Fouque, D. P. (2013) · Future Microbiology · doi:10.2217/fmb.13.103 · Cited by 85
Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology
Engevik, M. A., & Versalovic, J. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0012-2016 · Cited by 87
Meta-analysis of alcohol induced gut dysbiosis and the resulting behavioral impact
Qamar, N., Castano, D., Patt, C., Chu, T.-C., Cottrell, J. A., & Chang, S. L. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112196 · Cited by 84
Physical exercise, gut, gut microbiota, and atherosclerotic cardiovascular diseases
Chen, J., Guo, Y., Gui, Y., & Xu, D. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-017-0653-9 · Cited by 89
Branched Short-Chain Fatty Acid Isovaleric Acid Causes Colonic Smooth Muscle Relaxation via cAMP/PKA Pathway
Blakeney, B. A., Crowe, M. S., Mahavadi, S., Murthy, K. S., & Grider, J. R. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5417-5 · Cited by 82
The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Sarubbo, F., Cavallucci, V., & Pani, G. (2022) · Cells · doi:10.3390/cells11030382 · Cited by 89
Uremia and chronic kidney disease: The role of the gut microflora and therapies with pro- and prebiotics
Vitetta, L., & Gobe, G. C. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200714 · Cited by 80
Whole grains, type 2 diabetes, coronary heart disease, and hypertension: Links to the aleurone preferred over indigestible fiber
Lillioja, S., Neal, A. L., Tapsell, L. C., & Jacobs, D. R. (2013) · BioFactors · doi:10.1002/biof.1077 · Cited by 82
A comprehensive review on nutraceutical potential of underutilized cereals and cereal-based products
Rawat, M., Varshney, A., Rai, M., Chikara, A., Pohty, A. L., Joshi, A., Binjola, A., Singh, C. P., Rawat, K., Rather, M. A., et al. (2023) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2023.100619 · Cited by 91
Arabinoxylan in Wheat Is More Responsible Than Cellulose for Promoting Intestinal Barrier Function in Weaned Male Piglets
Chen, H., Wang, W., Degroote, J., Possemiers, S., Chen, D., SMET, S. D., & Michiels, J. (2014) · Journal of Nutrition · doi:10.3945/jn.114.201772 · Cited by 81
Microbial and metabolic interactions between the gastrointestinal tract and Clostridium difficile infection
Theriot, C. M., & Young, V. B. (2013) · Gut Microbes · doi:10.4161/gmic.27131 · Cited by 83
Apparent total-tract macronutrient digestibility, serum chemistry, urinalysis, and fecal characteristics, metabolites and microbiota of adult dogs fed extruded, mildly cooked, and raw diets1
Algya, K. M., Cross, T.-W., Leuck, K. N., Kastner, M. E., Toshiro, B. A. B. A., Lye, L., de Godoy, M. R. C., & Swanson, K. S. (2018) · Journal of Animal Science · doi:10.1093/jas/sky235 · Cited by 80
Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model
Kovatcheva‐Datchary, P., Shoaie, S., Lee, S., Wahlstrom, A. M., Nookaew, I., Hallén, A., Perkins, R., Nielsen, J., & Bäckhed, F. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.090 · Cited by 77
Interactions of probiotics and prebiotics with the gut microbiota
Ballan, R., Battistini, C., Xavier-Santos, D., & Saad, S. M. I. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.03.008 · Cited by 84

Authors: Macfarlane, G. T., & Macfarlane, S.
Affiliations: University of Dundee (GB)
Corresponding author: Macfarlane, Sandra
ORCID: Macfarlane, Sandra
Venue: Journal of AOAC INTERNATIONAL
Publisher: Oxford University Press (OUP)
Published: 2012-01-01
Volume: 95
Issue: 1
Pages: 50-60
ISSN: 1060-3271 (ISSN-L)
1944-7922
DOI: 10.5740/jaoacint.sge_macfarlane
OpenAlex: W2082808164
Cited by: 970
References: 91
Citations by year: 2026: 44 · 2025: 64 · 2024: 74 · 2023: 85 · 2022: 104 · 2021: 123 · 2020: 99 · 2019: 82 · 2018: 55 · 2017: 67 · 2016: 45 · 2015: 35 · 2014: 45 · 2013: 42 · 2012: 5
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of AOAC International (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: colonic microbiota, colonic fermentation, short-chain fatty acids, butyrate, acetate, propionate, carbohydrate digestion, protein digestion, putrefaction, colonic diseases, saccharolytic bacteria, intestinal homeostasis, dietary fiber
MeSH terms: Amino Acids, Butyrates, Colon, Colonic Neoplasms, Dietary Carbohydrates, Dietary Proteins, Fatty Acids, Volatile, Fermentation, Food Microbiology, Health, Humans, Hydrogen, Propionates, Oxidative Stress, Lactic Acid, Gastrointestinal Tract, Proteolysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bacteria, Colonic Fermentation, and Gastrointestinal Health

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks