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Cited by 10Clinical Nutrition and GastroenterologyPharmaceutical Practices and Patient OutcomesPharmacogenetics and Drug Metabolism

Prevalence and clinical significance of interactions drug-enteral nutrition in Intensive Care Units

Open access
Reis, Adriano Max Moreira, Carvalho, Rhanna Emanuela F. Lima de, Faria, Leila Marcia Pereira de, Oliveira, Regina Célia de, Zago, Karine Santana de Azevedo, Cavelagna, Milena Ferreira, Silva, Adriano Gomes, Luis Neto, Manoel +1 more·2014·Revista Brasileira de Enfermagem
DOI 10.5935/0034-7167.20140011
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Abstract

Estudo multicêntrico, transversal e retrospectivo, que objetivou determinar a prevalência de interações fármaco-nutrição enteral (NE) em Unidades de Terapia Intensiva (UTI) de sete hospitais de ensino do Brasil, e analisar a significância clínica das mesmas. Foram coletadas informações sobre medicamentos e NE administrados com 24 horas e 120 horas de internação. Para identificação das interações fármaco-NE empregou-se o software Drug Reax®. Foram investigados 1.124 prontuários. Destes, 320 pacientes, com 24 horas de internação, estavam em uso de NE, sendo que 20 (6,3%) apresentaram interação fármaco-NE. Dos 504 pacientes, com 120 horas de internação, 39 (7,7%) apresentaram interação fármaco-NE. As potenciais interações fármaco-NE mais frequentes foram: fenitoína-NE, levotiroxina-NE e varfarina-NE. As interações fármaco-NE podem interferir na qualidade e no custo da assistência prestada em UTI e, desta forma, é essencial que a equipe de saúde tenha conhecimento sobre as mesmas.

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  • In 320 ICU patients, the most frequent clinically significant drug-enteral nutrition interactions concerned phenytoin, warfarin and L-T4.

    “In 320 ICU patients, the most frequent clinically significant drug–enteral nutrition interactions concerned phenytoin, warfarin and L-T4 (97).”

    From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [97]

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Authors
Reis, A. M. M., Carvalho, R. E. F. L. D., Faria, L. M. P. D., Oliveira, R. C. D., Zago, K. S. D. A., Cavelagna, M. F., Silva, A. G., Luis Neto, M., & Cassiani, S. H. D. B.
Affiliations
  • Universidade Federal de Minas Gerais (BR)
  • Universidade Estadual do Ceará (BR)
  • Universidade de Pernambuco (BR)
  • Universidade Federal de Uberlândia (BR)
  • Universidade de São Paulo (BR)
  • Universidade Federal de São Paulo (BR)
ORCID
Venue
Revista Brasileira de Enfermagem
Publisher
GN1 Genesis Network
Published
2014
Volume
67
Issue
1
Pages
85-90
ISSN
0034-7167 (ISSN-L)
DOI
10.5935/0034-7167.20140011
OpenAlex
W2062999591
Cited by
10
References
15
Citations by year
2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Revista Brasileira de Enfermagem (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
enteral nutrition, intensive care unit, drug-drug interactions, phenytoin, warfarin, levothyroxine, prevalence, clinical significance, critically ill patients
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Enteral Nutrition, Female, Humans, Intensive Care Units, Male, Middle Aged, Retrospective Studies, Food-Drug Interactions, Young Adult

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