Evidence on Demand: OpenEvidence versus Established LLMs on the Orthopaedic In-Training Examination
Open accessAbstract
Background: Large language models (LLMs) are increasingly used in medical education, yet head-to-head comparisons of contemporary multimodal and clinically oriented (retrieval-grounded) models on orthopedic in-service examinations remain limited. Methods: A cross-sectional comparative study was conducted using 265 multiple-choice questions from the publicly available 2014 Orthopaedic In-Training Examination (OITE). Questions were categorized by AAOS subspecialty and by cognitive taxonomy (T1 recall, T2 interpretation, T3 reasoning) and stratified into text-only (n=111) versus image-based items (n=164). ChatGPT-5 Plus and Gemini 2.5 Pro were evaluated on the full dataset, while OpenEvidence was evaluated on the text-only subset. Accuracy was scored against the official answer key and comparisons were done using McNemar and Cochran Q tests. Results: Overall accuracy on the full 2014 OITE was 80.0% for Gemini 2.5 Pro and 78.1% for ChatGPT-5, with no statistically significant difference (p=0.59). Across the text-only subset, Gemini 2.5 Pro and OpenEvidence each scored 84.7% versus 81.1% for ChatGPT-5 (p=0.71), and OpenEvidence demonstrated strong T3 reasoning performance (82.7%). Subspecialty performance varied without statistically significant differences. LLMs demonstrated highest accuracy in basic science and the largest numerical discrepancy was in Oncology (Gemini 77.3% vs ChatGPT-5 54.5%). Conclusion: A retrieval-grounded, evidence based LLM (OpenEvidence) performed comparably to multimodal LLMs on text-based orthopaedic in-training examination questions at or above senior resident PGY-5 benchmark-level performance with no significant differences in overall accuracy. These findings suggest that OpenEvidence may provide educational utility comparable to general-purpose models while offering source transparency.
AI snapshot
Written from the paper’s full text.
TL;DR
This cross-sectional study compared ChatGPT-5, Gemini 2.5 Pro, and OpenEvidence on the 2014 Orthopaedic In-Training Examination (OITE), finding high accuracy across models with no statistically significant overall differences. Gemini 2.5 Pro and OpenEvidence each scored 84.7% on the shared text-only subset, while ChatGPT-5 scored 81.1%.
Key findings
- On the full 265-question 2014 OITE, Gemini 2.5 Pro achieved 80.0% accuracy (212/265) and ChatGPT-5 achieved 78.1% (207/265), with no significant difference (p = 0.59); both exceeded the reported PGY-5 national mean/benchmark.
- On the 111 text-only questions where all three models could be compared, Gemini 2.5 Pro and OpenEvidence both scored 84.7% (94/111), versus ChatGPT-5 at 81.1% (90/111), with no significant difference (p = 0.71).
- OpenEvidence, despite text-only input, performed comparably to multimodal models and scored 82.7% on text-based complex reasoning (T3) questions; all three models answered 72.1% (80/111) of text-only questions correctly, and only 5.4% (6/111) were missed by all three.
- Subspecialty differences were not statistically significant; the largest numerical gap was Oncology, where Gemini 2.5 Pro scored 77.3% versus ChatGPT-5 at 54.5%, and OpenEvidence scored 100% on Foot and Ankle text-only questions.
Methods
- Cross-sectional comparative study using the complete 2014 OITE; 265 multiple-choice questions were included after excluding items requiring video playback or with corrupted data.
- Questions were classified by AAOS orthopaedic subspecialty and by Buckwalter cognitive taxonomy: T1 recall, T2 interpretation, and T3 complex reasoning; subsets were text-only (n = 111) and image-based (n = 154).
- ChatGPT-5 (Auto), Gemini 2.5 Pro, and OpenEvidence were prompted with a standardized structure; OpenEvidence was evaluated only on text-only questions because it lacks image input. Outputs were scored against the official OITE answer key, with McNemar’s and Cochran’s Q tests and significance at p < 0.05.
Limitations
- The paper states that using only the 2014 OITE limits generalizability, that prior LLM exposure to the 2014 OITE cannot be excluded, and that OpenEvidence’s lack of image interpretation prevented full three-model comparison on image-based items.
- The paper also states that subspecialty analyses had small question counts (16 in Hand to 49 in Trauma), resident benchmarks came from prior literature, newer model versions were not used, and only paid model versions were tested.
- Evident from the text: the qualitative error-character review was exploratory rather than formal, and many subspecialty and taxonomy comparisons were underpowered and not statistically significant.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
16 of 19 cited sources checked · 6 supported · 0 flagged · accuracy not yet measured
- Premisecitation
Prior benchmark studies can quickly become outdated as new model versions are released.
“Given the rapid evolution of LLMs, prior benchmark studies can quickly become outdated as new model versions are released (Yang et al. 2025).”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Yang et al. 2025 source
- Findingown data
The difference in overall accuracy between the two multimodal models was not statistically significant (p = 0.59).
“The difference in overall accuracy between the two multimodal models was not statistically significant (p = 0.59) (Table 1).”
Quote in the paperNot a substantial claim - Findingown data
All three models answered 72.1% (80/111) of questions correctly.
“All three models answered 72.1% (80/111) of questions correctly (Figure 4).”
Quote in the paperNot a substantial claim - Findingown data
Only 5.4% (6/111) of questions were answered incorrectly by all three models.
“Only 5.4% (6/111) of questions were answered incorrectly by all three models.”
Quote in the paperNot a substantial claim - Findingreasoning
Gemini 2.5 Pro's errors more frequently reflected misinterpretation of the question stem or application of overly aggressive clinical judgement despite demonstrating sound underlying knowledge.
“Gemini 2.5 Pro's errors more frequently reflected misinterpretation of the question stem or application of overly aggressive clinical judgement despite demonstrating sound underlying knowledge.”
Quote in the paperSubstantial claim
- Findingown data
ChatGPT-5 incorrect responses most commonly reflected confident factual errors, in which the clinical reasoning framework applied was appropriate, but the specific conclusion was incorrect.
“ChatGPT-5 incorrect responses most commonly reflected confident factual errors, in which the clinical reasoning framework applied was appropriate, but the specific conclusion was incorrect.”
Quote in the paperNot a substantial claim - Findingown data
Gemini-2.5Pro demonstrated numerically higher accuracy than ChatGPT-5 on T2 interpretation questions (76.3% vs 68.4%; p = 0.44).
“Regarding image-based performance, Gemini-2.5Pro demonstrated numerically higher accuracy than ChatGPT-5 on T2 interpretation questions, which include radiographs, MRI, CT, and clinical photograph (76.3% vs 68.4%; p = 0.44).”
Quote in the paperNot a substantial claim - Findingown data
When stratified by taxonomy, no statistically significant performance differences were observed between the models across any domain.
“When stratified by taxonomy, no statistically significant performance differences were observed between the models across any domain.”
Quote in the paperSubstantial claim - Findingown data
Both multimodal models demonstrated performance exceeding the national mean score for PGY-5 residents (74%).
“Both multimodal models demonstrated performance exceeding the national mean score for PGY-5 residents (74%).”
Quote in the paperSubstantial claim - Findingown data
The differences on the text-only subset were not statistically significant (p = 0.71).
“These differences were not statistically significant (p = 0.71) (Table 2).”
Quote in the paperNot a substantial claim - Findingown data
Overall accuracy did not differ significantly between models.
“While overall accuracy did not differ significantly between models, variation across subspecialties and cognitive taxonomies suggests meaningful differences in how these systems retrieve and apply orthopaedic knowledge.”
Quote in the paperSubstantial claim - Findingown data
OpenEvidence contributed the highest number of unique correct responses (7 total).
“OpenEvidence also contributed the highest number of unique correct responses (7 total) (Figure 4).”
Quote in the paperNot a substantial claim - Findingown data
For complex reasoning (T3) items, Gemini 2.5 Pro demonstrated a slight increase over ChatGPT-5 (79.2% vs 76.8%; p = 0.60).
“Similarly, for complex reasoning (T3) items, Gemini 2.5 Pro demonstrated a slight increase over ChatGPT-5 (79.2% vs. 76.8%;p = 0.60).”
Quote in the paperNot a substantial claim - Findingown data
OpenEvidence achieved a perfect score on the Foot and Ankle section (100%) compared to ChatGPT-5 and Gemini 2.5 Pro (82.5%).
“Open Evidence achieved a perfect score on the Foot and Ankle section (100%) compared to ChatGPT-5 and Gemini 2.5 Pro (82.5%).”
Quote in the paperNot a substantial claim - Findingown data
Both models achieved their highest accuracy in Basic Science (>93%).
“Both models achieved their highest accuracy in Basic Science (>93%).”
Quote in the paperNot a substantial claim - Findingown data
A qualitative review of model-generated explanations for incorrect responses revealed potentially meaningful differences in error character across models.
“A qualitative review of model-generated explanations for incorrect responses revealed potentially meaningful differences in error character across models.”
Quote in the paperNot a substantial claim - Interpretationreasoning
Strong performance on standardized examinations suggests that trainees will increasingly encounter accurate automated responses to factual and structured clinical questions.
“Rather, their strong performance on standardized examinations suggests that trainees will increasingly encounter accurate automated responses to factual and structures clinical questions.”
Quote in the paperNot a substantial claim - Interpretationreasoning
The accuracy estimates reported here may reflect, at least in part, familiarity with previously encountered content rather than generalizable clinical reasoning ability.
“As a result, the accuracy estimates reported here may reflect, at least in part, familiarity with previously encountered content rather than generalizable clinical reasoning ability.”
Quote in the paperSubstantial claim - Interpretationown data
Variation across subspecialties and cognitive taxonomies suggests meaningful differences in how these systems retrieve and apply orthopaedic knowledge.
“While overall accuracy did not differ significantly between models, variation across subspecialties and cognitive taxonomies suggests meaningful differences in how these systems retrieve and apply orthopaedic knowledge.”
Quote in the paperSubstantial claim - Study design and conductreasoning
The study was limited to a single OITE exam year (2014), which meaningfully limits generalizability.
“The study we conducted was limited to a single OITE exam year (2014), which meaningfully limits generalizability.”
Quote in the paperSubstantial claim - Interpretationown data
Our findings and those of existing work suggest that contemporary large language models can match or exceed published PGY-5 benchmarks on structured orthopaedic assessments.
“Our findings and those of existing work suggest that contemporary LLMs can match or exceed published PGY-5 benchmarks on structured orthopaedic assessments.”
Quote in the paperSubstantial claim - Interpretationown data
The pattern of subspecialty and taxonomy-level variation observed across models suggests that large language model performance is uneven in ways that are not captured by aggregate accuracy alone.
“For program directors, the pattern of subspecialty and taxonomylevel variation observed across models suggests that LLM performance is uneven in ways that are not captured by aggregate accuracy alone, and that residents should be coached to use these tools critically rather than as authoritative sources.”
Quote in the paperSubstantial claim - Interpretationreasoning
Questions anchored to 2014 standards of care may no longer reflect current accepted practice.
“Questions anchored to 2014 standards of care may no longer reflect current accepted practice.”
Quote in the paperSubstantial claim- Rests on an assumption: Orthopaedic surgery has evolved considerably since 2014 across clinical guidelines, implant technology, surgical techniques, and evidence-based management across subspecialties.
- Classified as probably not a substantial claim. 28
- May combine two claims. 47
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationGemini 2.5 Pro has achieved ≥85-90% accuracy on national pediatric surgery and obstetrics-gynecology exams, well above local passing thresholds of approximately 60% for each assessment.
“In specialty board examinations, Gemini 2.5 Pro has achieved ≥ 85-90% accuracy on national pediatric surgery and obstetrics-gynecology exams, well above local passing thresholds, which were approximately 60% for each assessment (Wielochowska et al. 2025).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Wielochowska et al. 2025 source
The Results report 96.63% accuracy on the obstetrics–gynecology specialization exam, above the 60% success threshold specified in the Introduction. The paper does not report a pediatric surgery exam result or its passing threshold, so it supports only the obstetrics–gynecology portion of the claim. (LLM, conf=0.90)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationIn medicine, large language models have demonstrated strong performance on complex reasoning tasks and standardized examinations, suggesting a potential role in clinical care and medical education.
“In medicine, these models have demonstrated strong performance on complex reasoning tasks and standardized examinations, suggesting a potential role in clinical care and medical education (Singhal et al. 2023).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Singhal et al. 2023 source
The Model development and evaluation section reports state-of-the-art performance on USMLE-style questions, and the Methods describe medical questions involving complex multi-step reasoning. The Main and Discussion sections describe potential clinical applications while stressing that substantial limitations remain. The paper does not explicitly connect these results to a potential role in medical education. (LLM, conf=0.84)
Experimental — accuracy not yet measured
May combine two claims.
InterpretationcitationGemini 2.5 Pro fared relatively better on Taxonomy 3 (clinical reasoning) questions, consistent with reports that newer Gemini models often excel on complex and integrative problem solving tasks.
“Gemini 2.5 Pro fared relatively better on Taxonomy 3 (clinical reasoning) questions, consistent with reports than newer Gemini models often excel on complex and integrative problem solving tasks (Wielochowska et al. 2025;Sheikhalishahi et al. 2025;Boczkowski et al. 2025).”
Quote in the paperNot a substantial claim3 of 3 sources checked- cites Wielochowska et al. 2025 source
The Results report high accuracy on clinical cases (91.67%), which supports the narrower point that Gemini 2.5 Pro performed well on clinical tasks. But the paper does not use Taxonomy 3 or establish that newer Gemini models often excel on complex, integrative tasks; its clinical-case accuracy was numerically lower than theoretical-question accuracy (97.19%), with no significant difference (p=0.313). (LLM, conf=0.82)
Experimental — accuracy not yet measured - cites Sheikhalishahi et al. 2025 source
The Discussion (page unavailable) reports that Gemini 2.5 Flash outperformed the compared ChatGPT models on Persian internal-medicine board questions and describes an advantage in text-based clinical reasoning. It does not establish that newer Gemini models often excel across complex and integrative problem-solving tasks. The cited study tested Flash, not Gemini 2.5 Pro, and did not analyze Taxonomy 3 questions. (LLM, conf=0.84)
Experimental — accuracy not yet measured - cites Boczkowski et al. 2025 source
The Discussion (page unavailable) says Gemini 2.5 Pro’s high pediatric-surgery exam score may indicate a predisposition for processing complex medical data. It does not establish that newer Gemini models often excel at complex, integrative problem-solving tasks. Its clinical-reasoning comparison found no significant advantage over theoretical questions; the cited paper does not assess the citing authors’ Taxonomy 3 category. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationEarly research demonstrated that GPT-3.5 could attain passing-level performance on licensing examinations such as the USMLE without specialty-specific training.
“Early research demonstrated that GPT-3.5 could attain passinglevel performance on licensing examinations such as the United States Medical Licensing Examination (USMLE) without specialty-specific training (Kung et al. 2023).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Kung et al. 2023 source
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationSeveral studies have evaluated large language model performance on high-stakes examinations, including the USMLE, demonstrating passing-level performance without specific fine-tuning.
“Several studies have evaluated LLM performance on high-stakes examinations, including the United States Medical Licensing Examination (USMLE), demonstrating passing-level performance without specific fine-tuning (Brin et al. 2023;Bicknell et al. 2024;Kung et al. 2023).”
Quote in the paperNot a substantial claim3 of 3 sources checked- cites Brin et al. 2023 source
The Discussion (page unavailable) says previous studies found that LLMs could pass the USMLE, and the Results report high accuracy on this paper’s USMLE-type questions. But this study tested only 80 selected soft-skills questions, not the full examination, and our copy does not establish the claim’s ‘without specific fine-tuning’ qualifier. (LLM, conf=0.86)
Experimental — accuracy not yet measured - cites Bicknell et al. 2024 source
The Introduction’s “Previous Assessments of LLM Accuracy in Medical Contexts” reports that ChatGPT achieved passing scores on USMLE Step exams in a prior study. This paper’s own Methods describe testing ChatGPT through ordinary chat sessions, but the copy does not explicitly establish the claimed absence of specific fine-tuning; its Study Limitations also say its questions were USMLE-style, not actual exam questions. (LLM, conf=0.82)
Experimental — accuracy not yet measured - cites Kung et al. 2023 source
Classified as probably not a substantial claim.
PremisecitationRetrieval-augmented large language models with targeted retrievals and agentic workflows can provide more evidence-grounded and clinically actionable responses to real-world clinical questions than base models alone.
“Recent work has shown that these LLMs, augmented with targeted retrievals and agentic workflows, can provide more evidence-grounded and therefore clinically actionable responses to real-world clinical questions than base models can alone (Low et al. 2025).”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Low et al. 2025 source
May combine two claims.
PremisecitationComparative evaluations of ChatGPT-5 and Gemini 2.5 on internal medicine subspecialty board examinations demonstrate higher overall accuracy for Gemini, while relative performance varies across subspecialties rather than remaining consistent across domains.
“More recent comparative evaluations of ChatGPT-5 and Gemini 2.5 on internal medicine subspecialty board examinations demonstrate higher overall accuracy for Gemini, while also showing that relative performance varies across subspecialties rather than remaining consistent across domains (Sheikhalishahi et al. 2025).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Sheikhalishahi et al. 2025 source
May combine two claims.
PremisecitationSubsequent evaluations of GPT-4 and GPT-4 Omni documented substantially higher accuracy, frequently exceeding 88-90% correct responses, and outperforming earlier large language models on tasks requiring both factual recall and clinical reasoning.
“Subsequent evaluations of GPT-4 and GPT-4 Omni documented substantially higher accuracy, frequently exceeding 88-90% correct responses, and, most notably, outperforming earlier LLMs on tasks requiring both factual recall and clinical reasoning (Bicknell et al. 2024;Chen et al. 2024).”
Quote in the paperNot a substantial claim2 of 2 sources checked- cites Bicknell et al. 2024 source
The Results report that GPT-4o scored 90.4% overall and outperformed GPT-4 and GPT-3.5; the diagnostics and management results also show improvements over earlier models. However, GPT-4 scored 81.1% overall, so the suggestion that both newer models frequently exceeded 88–90% is not supported by the overall results. (LLM, conf=0.88)
Experimental — accuracy not yet measured - cites Chen et al. 2024 source
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationIn medical education settings, OpenEvidence and similar platforms have been reported to assist students integrate guideline-based reasoning and efficiently locate relevant literature during clinical rotations.
“In medical education settings, OpenEvidence and similar platforms have been reported to assist students integrate guideline-based reasoning and efficiently locate relevant literature during clinical rotations (Patel et al. 2025).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Patel et al. 2025 source
Classified as probably not a substantial claim. May combine two claims.
PremisecitationOpenEvidence is a clinician-facing large language model that grounds responses in cited, peer-reviewed medical sources, which may improve transparency and reduce hallucinations but does not eliminate them entirely.
“OpenEvidence (OpenEvidence, Inc.) is one such platform; it is a clinician-facing LLM that grounds responses in cited, peer-reviewed medical sources, which may improve transparency and reduce hallucinations but does not eliminate them entirely (Hurt et al. 2025).”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Hurt et al. 2025 source
The Methods describe OpenEvidence as an AI-powered platform designed to assist clinicians, and the Conclusions say its responses offered support through citations of peer-reviewed sources. The paper does not establish that those citations improve transparency or reduce hallucinations. Its Introduction discusses hallucinations as a limitation of ChatGPT, not as an outcome assessed for OpenEvidence. (LLM, conf=0.86)
Experimental — accuracy not yet measured
May combine two claims.
Findingown dataPerformance varied by orthopaedic subspecialty but showed no statistically significant differences between models (p > 0.05 for all pairwise comparisons).
“Performance varied by orthopaedic subspecialty but showed no statistically significant differences between models (p > 0.05 for all pairwise comparisons).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataOpenEvidence's incorrect responses showed a qualitatively different pattern: explanations were either absent or consisted of brief, citation-grounded statements that described correct clinical principles yet arrived at the wrong answer choice, suggesting errors more consistent with answer-selection limitations than reasoning or knowledge failures.
“OpenEvidence's incorrect responses showed a qualitatively different pattern: explanations were either absent or consisted of brief, citation-grounded statements that described correct clinical principles yet arrived at the wrong answer choice, suggesting errors more consistent with answer-selection limitations than reasoning or knowledge failures.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataGemini 2.5 Pro achieved the highest overall accuracy at 80.0% (212/265), followed by ChatGPT-5 at 78.1% (207/265).
“Gemini 2.5 Pro achieved the highest overall accuracy at 80.0% (212/265), followed by ChatGPT-5 at 78.1% (207/ 265).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe largest numerical discrepancy was observed in Oncology, where Gemini 2.5 Pro achieved higher accuracy than ChatGPT-5 by 22.7 percentage points (77.3% vs 54.5%), though this did not reach statistical significance.
“The largest numerical discrepancy was observed in Oncology, where Gemini 2.5 Pro achieved higher accuracy than ChatGPT-5 by 22.7 percentage points (77.3% vs. 54.5%),though this did not reach statistical significance.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataIn the shared text-only subset, Gemini 2.5 Pro and OpenEvidence each achieved 84.7% accuracy, while ChatGPT-5 slightly trailed at 81.1%.
“In this shared subset, where all three models could be directly compared, Gemini 2.5 Pro and OpenEvidence each achieved 84.7% accuracy, while ChatGPT-5 Plus slightly trailed both at 81.1%.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataA total of 265 multiple-choice questions were included in the final dataset.
“A total of 265 multiple-choice questions were included in the final dataset.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOn text-only questions, all three models demonstrated highest accuracy in Adult Spine, with OpenEvidence performing in the same range as the multimodal models.
“On text only questions, all three models demonstrated highest accuracy in Adult Spine, with OpenEvidence performing in the same range to the multimodal models (Figure 2).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataWithin the text-only subset, OpenEvidence achieved 100% accuracy on Foot and Ankle questions, whereas ChatGPT-5 Plus scored 77.3% followed by Gemini 2.5 Pro scored at 68.2%.
“Within the text-only subset, OpenEvidence achieved 100% accuracy on Foot and Ankle questions, whereas ChatGPT-5 Plus scored 77.3% followed by Gemini 2.5 Pro scored at 68.2% here (Table 3, Figure 3).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor T2 interpretation questions, Gemini 2.5 Pro showed numerically higher accuracy than ChatGPT-5 (76.3% vs 68.4%; p = 0.44), though this was not statistically significant.
“In contrast, Gemini 2.5 Pro showed numerically higher accuracy than ChatGPT-5 on questions requiring interpretation of images or data (T2) (76.3% vs. 68.4%;p = 0.44), though this data was not statistically significant.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOn the subset of 111 text-only questions, Gemini 2.5 Pro and OpenEvidence achieved identical accuracy (84.7%, 94/111), outperforming ChatGPT-5 (81.1%, 90/111).
“On the subset of 111 text-only questions where all three models could be directly compared, Gemini 2.5 Pro and OpenEvidence achieved identical accuracy (84.7%, 94/111), outperforming ChatGPT-5 (81.1%, 90/111).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataChatGPT-5, Gemini 2.5 Pro, and OpenEvidence demonstrated high accuracy on the 2014 OITE, with performance at or above published senior resident benchmarks.
“In this study, ChatGPT-5, Gemini 2.5 Pro, and OpenEvidence demonstrated high accuracy on the 2014 OITE, with performance at or above published senior resident benchmarks.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Findingown dataQuestions were stratified into text-only (n=111) and image-based (n=154) subsets.
“Questions were further stratified into text-only (n=111) and image-based (n=154) subsets to accommodate the different input capabilities of the AI models.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataFor factual recall (T1) questions, ChatGPT-5 achieved 88.1% accuracy compared to Gemini 2.5 Pro 84.7% (p = 0.59) and OpenEvidence 86.4% (p = 0.87).
“For factual recall (T1) questions, Chat-GPT-5 achieved slightly higher accuracy (88.1%) compared to Gemini 2.5 Pro (84.7%; p = 0.59) and OpenEvidence (86.4%; p = 0.87).”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataOpenEvidence's strong performance in our text-only OITE questions is consistent with these findings and suggests that retrieval-based reasoning can perform as well as or better than general multimodal models on exam-style clinical questions, particularly when questions rely on standards of care.
“OpenEvidence's strong performance in our text-only OITE questions is consistent with these findings and suggests that retrieval-based reasoning can perform as well as or better than general multimodal models on exam-style clinical questions, particularly when questions rely on standards of care (Table 2).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable). May combine two claims.
PremisecitationComparing performance across different model architectures may help orthopaedic trainees and educators decide which tools are appropriate for evidence-based studying and rotation-level clinical reasoning, and identify where supervision is most needed.
“Rather than identifying a single 'best' model, comparing performance across different model architectures may help orthopaedic trainees and educators decide which tools appropriate for evidencebased studying and rotation-level clinical reasoning, and identify where supervision is most needed given known limitations (Xu et al. 2025).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Xu et al. 2025
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Interpretationown dataOpenEvidence's Taxonomy 3 performance was comparable to that of Gemini 2.5 Pro despite its lack of multimodal input, suggesting that explicit evidence retrieval can support reasoning on clinical scenarios involving multiple steps.
“OpenEvidence's Taxonomy 3 performance was comparable to that of Gemini 2.5 Pro despite its lack of multimodal input, suggesting that explicit evidence retrieval can support reasoning on clinical scenarios involving multiple steps (Table 1 and 2).”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationThe Orthopaedic In-Training Examination serves as the primary standardized assessment for orthopaedic residents in the United States and a predictor of performance on the American Board of Orthopaedic Surgery Part 1 certifying examination.
“The Orthopaedic In-Training Examination (OITE), administered annually by the American Academy of Orthopaedic Surgeons (AAOS), serves as the primary standardized assessment for orthopaedic residents in the United States and a predictor of performance on the American Board of Orthopaedic Surgey (ABOS) Part 1 certifying examination (Swanson et al. 2013).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Swanson et al. 2013 source
May combine two claims.
InterpretationreasoningChatGPT-5 Plus performed best on Taxonomy 1 (recall-oriented) items, aligning with its broad exposure to factual medical content and its strength in direct knowledge retrieval.
“ChatGPT-5 Plus performed best on Taxonomy 1 (recall-oriented) items, aligning with its broad exposure to factual medical content and its strength in direct knowledge retrieval.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataThe absolute differences were small (a 3.6 percentage point difference between ChatGPT-5 and the other two models) and did not reach statistical significance (p = 0.71), indicating that no model consistently outperformed the others on purely text-based items.
“The absolute differences were small (a 3.6 percentage point difference between ChatGPT-5 and the other two models), and they did not reach statistical significance (p = 0.71), indicating that no model consistently outperformed the others on purely text-based items (Table 2).”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductown dataSubspecialty analyses were limited by small question counts per domain, ranging from 16 questions in Hand to 49 in Trauma, which reduces statistical power and limits the reliability of domain-level comparisons.
“Subspecialty analyses were further limited by small question counts per domain, ranging from 16 questions in Hand to 49 in Trauma, which reduces statistical power and limits the reliability of domain-level comparisons.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
InterpretationreasoningLarge language model performance remains imperfect, particularly for questions that require nuanced clinical judgment, integration of multiple pieces of information, or differentiation between closely related management options.
“Despite these high accuracies reported across prior studies, LLM performance remains imperfect, particularly for questions that require nuanced clinical judgment, integration of multiple pieces of information, or differentiation between closely related management options.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductreasoningOpenEvidence currently supports text-only input, so it was evaluated solely on the text-only question subset (n=111).
“As OpenEvidence currently supports text-only input, it was evaluated solely on the text-only question subset (n=111).”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataWhile the T2 image-based difference did not reach statistical significance, it suggests potential variation in visual reasoning capability between model architectures.
“While this difference did not reach statistical significance, it suggests potential variation in visual reasoning capability between model architectures.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationreasoningIn several cases, ChatGPT-5 appeared to apply more contemporary clinical guidelines that diverge from the 2014 examination key, which may reflect the model's training on more recent literature.
“In several cases, the model appeared to apply more contemporary clinical guidelines that diverge from the 2014 examination key, which may itself reflect the model's training on more recent literature.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningA model answering correctly by 2014 standards could theoretically provide outdated guidance by contemporary standards, and performance on this exam may not predict accuracy on more recent OITE administrations.
“As a result, a model answering correctly by 2014 standards could theoretically provide outdated guidance by contemporary standards, and performance on this exam may not predict accuracy on more recent OITE administrations.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S4 (based). May combine two claims.
Premisenone givenPrior work has examined older model generations or focused on general medical licensing tests, but no previous study has assessed these newer architectures, head-to-head, on a specialty-specific orthopaedic assessment.
“Prior work has examined older model generations or focused on general medical licensing tests, but no previous study has assessed these newer architectures, head-to-head, on a specialty-specific orthopaedic assessment.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Interpretationown dataThe comparable performance of OpenEvidence and general-purpose models on text-based questions, combined with its qualitatively distinct error profile, suggests that retrieval-grounded platforms may offer a more transparent and verifiable starting point for evidence-based self-study.
“The comparable performance of OpenEvidence and general-purpose models on text-based questions, combined with its qualitatively distinct error profile, suggests that retrieval-grounded platforms may offer a more transparent and verifiable starting point for evidence-based self-study -particularly for subspecialties with well-established clin-”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenThe paid versions of these models were used, so performance may differ for users who utilize the free versions, which may rely on older or smaller models.
“We also used the paid versions of these models, so performance may differ for users who utilize the free versions, which may rely on older or smaller models.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningThese factors may influence external validity and limit conclusions about performance on newer exams, updated model releases, or current clinical standards.
“These factors may influence external validity and limit conclusions made about performance on newer exams, updated model releases, or current clinical standards.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenResident benchmarks were taken from prior literature, and newer model versions such as ChatGPT 5.2 and Gemini 3.0 were not used in the study.
“In addition, resident benchmarks were taken from prior literature, and newer model versions such as ChatGPT 5.2 and Gemini 3.0 were not used in our study.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationcitationGeneral-purpose large language models from different model families have converged to a similarly high performance level on structured, multiple-choice assessments, with variability concentrated more in subspecialty-specific reasoning style than in raw score.
“This data suggests that general-purpose LLMs from different model families have converged to a similarly high performance level on structured, multiple-choice assessments, with variability concentrated more in subspecialty-specific reasoning style than in raw score.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
InterpretationreasoningThe overlap likely reflects convergence on well-established clinical knowledge, but shared exposure to publicly available exam content during model training cannot be excluded as contributing to agreement on specific items.
“While this overlap likely reflects convergence on well-established clinical knowledge, it cannot be excluded that shared exposure to publicly available exam content during model training contributed to agreement on specific items, a possibility that underscores the need for contamination-resistant evaluation designs in future work.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductreasoningOpenEvidence does not allow for image interpretation, which only allows comparison of all three models using text-only questions.
“OpenEvidence also does not allow for image interpretation, which only allows us to compare all three models using text only questions.”
Quote in the paperSubstantial claimMay combine two claims.
Premisenone givenThis study is the first to directly compare the performance of three contemporary frontier large language models on the OITE, and the first to evaluate a retrieval-augmented system on this exam format.
“This study is the first to directly compare the performance of three contemporary frontier LLMs (ChatGPT 5 Plus, Gemini 2.5 Pro, and Open Evidence) on the OITE, and the first to evaluate a retrieval-augmented system (OpenEvidence) on this exam format.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataAcross the text-only questions, all three models agreed on the correct answer for 72.1% of items, and only 5.4% were missed by all models, demonstrating substantial overlap in their strengths.
“Across the text-only questions, all three models agreed on the correct answer for 72.1% of items, and only 5.4% were missed by all models, demonstrating substantial overlap in their strengths (Figure 4).”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataThis pattern is consistent with OpenEvidence contributing the highest number of unique correct responses (n=7), suggesting that when it diverged from the other models it did so on the basis of evidence-grounded reasoning rather than pattern-matched responses.
“This pattern is consistent with OpenEvidence contributing the highest number of unique correct responses among the three models (n=7, Figure 4), suggesting that when it diverged from the other models it did so on the basis of evidencegrounded reasoning rather than pattern-matched responses.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S4 (based).
Study design and conductnone givenPrior exposure of large language models to the 2014 OITE during model training cannot be excluded.
“Additionally, prior exposure of LLMs to the 2014 OITE during model training cannot be excluded.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataWhile overall accuracy was similar across models, differences in performance on specific subspecialties and cognitive tasks reflect variation in how each model handles distinct types of clinical knowledge.
“These results indicate that while overall accuracy was similar across models, differences in performance on specific subspecialties within orthopaedic surgery and cognitive tasks reflect variation in how each model handles distinct types of clinical knowledge.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable). May combine two claims.
Interpretationnone givenExamination accuracy reflects a narrow dimension of medical knowledge and should not be equated with the clinical reasoning or real-world competency of senior trainees.
“However, examination accuracy reflects a narrow dimension of medical knowledge and should not be equated with the clinical reasoning or real-world competency of senior trainees.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
InterpretationreasoningChatGPT-5 and Gemini 2.5 Pro may offer broader utility across question types including image and video-based items, but their tendency toward confident errors warrants active verification of model outputs rather than passive acceptance.
“ChatGPT-5 and Gemini 2.5 Pro may offer broader utility across question types including image and video-based items, but their tendency toward confident errors warrants active verification of model outputs rather than passive acceptance.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable), S4 (based). May combine two claims.
InterpretationreasoningThese limitations likely reflect the probabilistic nature of current models and their reliance on pattern recognition rather than true causal clinical reasoning.
“These limitations likely reflect the probabilistic nature of current models and their reliance on pattern recognition rather than true causal clinical reasoning.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenClassifications were done by two reviewers S.P and S.H and disagreements were resolved by a third review, A.K.
“Classifications were done by two reviewers S.P and S.H and disagreements were resolved by a third review, A.K.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataOpenEvidence performed comparably to the multimodal models despite lacking visual input capabilities, excelling particularly in text-based reasoning (T3) questions (82.7%).
“Notably, OpenEvidence performed comparably to the multimodal models despite lacking visual input capabilities, excelling particularly in text-based reasoning (T3) questions (82.7%).”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductnone givenA standardized prompt structure was used for all interactions to ensure consistency and to minimize variability.
“A standardized prompt structure was used for all interactions to ensure consistency and to minimize variability (Figure 1).”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductreasoningDirect three-way comparison across all models is limited to the shared text-only subset, while ChatGPT-5 and Gemini 2.5 Pro were additionally evaluated across the full 265-question dataset.
“Consequently, direct three-way comparison across all models is limited to this shared subset, while ChatGPT-5 and Gemini 2.5 Pro were additionally evaluated across the full 265-question dataset including image and video-based items.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductreasoningThe study was exempt from Institutional Review Board oversight because it involved publicly available, de-identified educational materials and no human subjects.
“As this study involved publicly available, de-identified educational materials and no human subjects, it was exempt from Institutional Review Board (IRB) oversight.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
PremisecitationQuestions were classified by cognitive taxonomy based on Buckwalter et al: Taxonomy 1 recall and recognition of facts, Taxonomy 2 interpretation of data, images, or diagnostic studies, and Taxonomy 3 complex clinical reasoning, problem-solving, and management decisions.
“Additionally, questions were classified by cognitive taxonomy based on established medical education frameworks defined by Buckwalter et al: Taxonomy 1 (T1): Recall and recognition of facts, Taxonomy 2 (T2): Interpretation of data, images, or diagnostic studies, and Taxonomy 3 (T3): Complex clinical reasoning, problem-solving, and management decisions (Buckwalter et al. 1981).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Buckwalter et al. 1981 source
Classified as probably not a substantial claim.
Study design and conductnone givenThe chat context was reset after every question to prevent information leakage or memory bias between items.
“The chat context was reset after every question to prevent information leakage or memory bias between items.”
Quote in the paperSubstantial claim
The paper relies on this without support.
OpenEvidence has not previously been evaluated on standardized orthopaedic examinations such as the OITE as part of a broader comparative analysis of large language models.
“Although OpenEvidence is increasingly used by physicians and trainees for pointof-care questions, it has not previously been evaluated on standardized orthopaedic examinations such as the OITE as part of a broader comparative analysis of LLMs.”
The paper relies on this without support.
Orthopaedic surgery has evolved considerably since 2014 across clinical guidelines, implant technology, surgical techniques, and evidence-based management across subspecialties.
“Orthopaedic surgery has evolved considerably since 2014 across clinical guidelines, implant technology, surgical techniques, and evidence-based management across subspecialties.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Video questions are both excluded and included
MinorThe question-selection criteria exclude items requiring video playback, but the input protocol says the full dataset included video-based items.
“Items requiring video playback or those with corrupted data were excluded.”
“ChatGPT-5 and Gemini 2.5 Pro were additionally evaluated across the full 265-question dataset including image and video-based items.”
Foot and Ankle comparison uses conflicting model accuracies
MinorThe results state that both multimodal models scored 82.5% in the Foot and Ankle comparison with OpenEvidence. The discussion describes the text-only comparison with OpenEvidence as 77.3% for ChatGPT-5 and 68.2% for Gemini 2.5 Pro.
“Open Evidence achieved a perfect score on the Foot and Ankle section (100%) compared to ChatGPT-5 and Gemini 2.5 Pro (82.5%).”
“Within the text-only subset, OpenEvidence achieved 100% accuracy on Foot and Ankle questions, whereas ChatGPT-5 Plus scored 77.3% followed by Gemini 2.5 Pro scored at 68.2% here (Table 3, Figure 3).”
Cites
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Large language models encode clinical knowledge
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Comparing ChatGPT and GPT-4 performance in USMLE soft skill assessments
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Performance of large language models on a neurology board-style examination
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Use of an educational taxonomy for evaluation of cognitive performance
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ChatGPT-4 Omni Performance in USMLE Disciplines and Clinical Skills: Comparative Analysis
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Limitations of large language models in clinical problem-solving arising from inflexible reasoning
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Examining the Role of Large Language Models in Orthopedics: Systematic Review
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Fidelity of Medical Reasoning in Large Language Models
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Utility of AAOS OITE Scores in Predicting ABOS Part I Outcomes: AAOS Exhibit Selection
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Systematic Review on Large Language Models in Orthopaedic Surgery
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Flagged first, then by citations
- Authors
- Khan, A. A., Lalvani, S. S., Pourarbab, S., Hyeamang, L. J., Lew, R. M., Hussain, Z. B., Nicholson, G. P., & Garrigues, G. E.
- Affiliations
- Rush University Medical Center (US)
- Midwest Orthopaedics at Rush
- ORCID
- Venue
- Journal of Orthopaedic Experience & Innovation
- Published
- 2026-09-26
- Volume
- 7
- Issue
- 2
- ISSN
- 2691-6541 (ISSN-L)
- OpenAlex
- W7214501069
- Cited by
- 0
- References
- 22
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Orthopaedic Experience & Innovation (publishedVersion, cc-by-nc-nd)
- Funders
- American Board of Orthopaedic Surgery
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Innovations in Medical Education
- Health Sciences › Medicine › Rehabilitation › Musculoskeletal Disorders and Rehabilitation
- Keywords
- large language models, OpenEvidence, ChatGPT, Gemini, Orthopaedic In-Training Examination, orthopaedic residency, multiple-choice question accuracy, retrieval-augmented generation, image-based questions, cognitive taxonomy, orthopaedic subspecialties, orthopedic oncology, source transparency, medical education
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-30.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-30.
Cited sources are checked by gpt-6-sol.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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