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Cited by 228Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryMicroRNA in disease regulation

Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers

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Huang, Tao, Deng, Chu-Xia·2019·International Journal of Biological Sciences
DOI 10.7150/ijbs.27796PMC PMC6329932
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Abstract

Cancer related exosomes are nano-size membrane vesicles that play important roles in tumor microenvironment. Emerging evidence indicates that exosomes can load unique cargoes, including proteins and nucleic acids that reflect the condition of tumor. Therefore, exosomes are being used as diagnostic and prognostic biomarkers for various cancers. In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer.

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Authors
Huang, T., & Deng, C.-X.
Affiliations
University of Macau (MO)
Corresponding author
Deng, Chu-Xia
ORCID
Venue
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Published
2019
Volume
15
Issue
1
Pages
1-11
ISSN
1449-2288 (ISSN-L)
DOI
10.7150/ijbs.27796
PMC
PMC6329932
OpenAlex
W2904347274
Cited by
228
References
9
Citations by year
2026: 8 · 2025: 13 · 2024: 18 · 2023: 34 · 2022: 40 · 2021: 51 · 2020: 53 · 2019: 11
FWCI
2.82
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • International Journal of Biological Sciences (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Universidade de Macau (MYRG2016-00139)
  • Fundo para o Desenvolvimento das Ciências e da Tecnologia (065/2015/A2)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords
exosomes, tumor markers, cancer diagnosis, cancer prognosis, exosome biogenesis, exosomal cargo, tumor microenvironment, exosome detection, early cancer detection
MeSH terms
Humans, Neoplasms, Prognosis, Biomarkers, Tumor, Exosomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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