Circulating Tumor Cells
Open accessAbstract
Much remains to be learned about CTCs and their clinical potential as biomarkers and therapeutic targets.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,679 · see citing works
A Perspective on Cancer Cell Metastasis
Chaffer, C. L., & Weinberg, R. A. (2011) · Science · doi:10.1126/science.1203543 · Cited by 4,791 · see citing works
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Matera, J., Miller, M. C., Reuben, J. M., Doyle, G. V., Allard, W. J., Terstappen, L. W. M. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040766 · Cited by 4,602 · see citing works
Dissemination and growth of cancer cells in metastatic sites
Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc865 · Cited by 3,920 · see citing works
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476 · see citing works
Bono, J. S. D., Scher, H. I., Montgomery, B., Parker, C. C., Miller, M. C., Tissing, H., Doyle, G. V., Terstappen, L. W. M. M., Pienta, K. J., & Raghavan, D. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0872 · Cited by 2,189 · see citing works
EMT and Dissemination Precede Pancreatic Tumor Formation
Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136 · see citing works
Cohen, S. J., Punt, C. J. A., Iannotti, N. O., Saidman, B. H., Sabbath, K. D., Gabrail, N. Y., Picus, J., Morse, M., Mitchell, E. P., Miller, M. C., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.8923 · Cited by 1,843 · see citing works
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Stott, S. L., Hsu, C., Tsukrov, D. I., Yu, M., Miyamoto, D. T., Waltman, B. A., Rothenberg, S. M., Shah, A. M., Smas, M. E., Korir, G. K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012539107 · Cited by 1,637 · see citing works
Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell
Zong, C., Lu, S., Chapman, A. R., & Xie, X. S. (2012) · Science · doi:10.1126/science.1229164 · Cited by 1,154 · see citing works
Circulating Tumor Cells: Liquid Biopsy of Cancer
Alix‐Panabières, C., & Pantel, K. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.194258 · Cited by 1,136 · see citing works
Baccelli, I., Schneeweiß, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., Klein, C., Saini, M., Bäuerle, T., Wallwiener, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2576 · Cited by 1,050 · see citing works
Circulating tumour cells in cancer patients: challenges and perspectives
Pantel, K., & Alix‐Panabières, C. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.07.001 · Cited by 816 · see citing works
Single cell analysis: the new frontier in 'Omics'
Wang, D., & Bodovitz, S. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.03.002 · Cited by 669 · see citing works
Armstrong, A. J., Marengo, M. S., Oltean, S., Kemeny, G., Bitting, R. L., Turnbull, J. D., Herold, C. I., Marcom, P. K., George, D. J., & García-Blanco, M. A. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0490 · Cited by 646 · see citing works
Heitzer, E., Auer, M., Gasch, C., Pichler, M., Ulz, P., Hoffmann, E. M., Lax, S., Waldispuehl‐Geigl, J., Mauermann, O., Lackner, C., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4140 · Cited by 497 · see citing works
Ross, A., Cooper, B., Lazarus, H. M., Mackay, W., Moss, T., Ciobanu, N., Tallman, M. S., Kennedy, M., Davidson, N., & Sweet, D. (1993) · Blood · doi:10.1182/blood.v82.9.2605.bloodjournal8292605 · Cited by 487 · see citing works
Lianidou, E. S., & Markou, A. N. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.165068 · Cited by 265 · see citing works
Circulating Epithelial Cells in Patients with Benign Colon Diseases
Pantel, K., Denève, E., Nocca, D., Coffy, A., Vendrell, J.-P., Maudelondé, T., Riethdorf, S., & Alix‐Panabières, C. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.175570 · Cited by 256 · see citing works
Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector
Issadore, D., Chung, J., Shao, H., Liong, M., Ghazani, A. A., Castro, C. M., Weissleder, R., & Lee, H. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003747 · Cited by 247 · see citing works
Circulating Tumor Cells as Biomarkers in Prostate Cancer
Danila, D. C., Fleisher, M., & Scher, H. I. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2650 · Cited by 242 · see citing works
Königsberg, R., Obermayr, E., Bises, G., Pfeiler, G., Gneist, M., Wrba, F., Santis, M. D., Zeillinger, R., Hudec, M., & Dittrich, C. (2011) · Acta Oncologica · doi:10.3109/0284186x.2010.549151 · Cited by 241 · see citing works
Danila, D. C., Anand, A., Sung, C. C., Heller, G., Leversha, M. A., Cao, L., Lilja, H. G., Molina, A., Sawyers, C. L., Fleisher, M., et al. (2011) · European Urology · doi:10.1016/j.eururo.2011.07.011 · Cited by 192 · see citing works
Microsystems for the Capture of Low-Abundance Cells
Dharmasiri, U., Witek, M. A., Adams, A. A., & Soper, S. A. (2010) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.111808.073610 · Cited by 129 · see citing works
Magbanua, M. J. M., Sosa, E. V., Scott, J. H., Simko, J. P., Collins, C. C., Pinkel, D., Ryan, C. J., & Park, J. W. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-78 · Cited by 96 · see citing works
Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer
Hayashi, N., Nakamura, S., Tokuda, Y., Shimoda, Y., Yagata, H., Yoshida, A., Ota, H., Hortobágyi, G. N., Cristofanilli, M., & Ueno, N. T. (2011) · International Journal of Clinical Oncology · doi:10.1007/s10147-011-0260-0 · Cited by 83 · see citing works
A high-performance microsystem for isolating circulating tumor cells
Zheng, X., Cheung, L. S. L., Schroeder, J. A., Jiang, L., & Zohar, Y. (2011) · Lab on a Chip · doi:10.1039/c1lc20331b · Cited by 60 · see citing works
Strati, A. D., Kasimir‐Bauer, S., Markou, A. N., Parisi, C., & Lianidou, E. S. (2013) · Breast Cancer Research · doi:10.1186/bcr3395 · Cited by 45 · see citing works
Balić, M., Dandachi, N., Lin, H., & Datar, R. H. (2005) · PubMed · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [7]Alix-Panabières C Pantel K Clin. Chem 2013 59 110 23014601
Cited by
Sorted by citations
The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
Plaks, V., Kong, N., & Werb, Z. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.015 · Cited by 1,557 · see citing works
Self-citationCancer biomarker detection: recent achievements and challenges
Wu, L. J., & Qu, X. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00370e · Cited by 1,240 · see citing works
Liquid biopsy: current technology and clinical applications
Nikanjam, M., Kato, S., & Kurzrock, R. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01351-y · Cited by 963 · see citing works
Acoustic tweezers for the life sciences
Özçelik, A., Rufo, J., Guo, F., Gu, Y., Li, P., Lata, J. P., & Huang, T. J. (2018) · Nature Methods · doi:10.1038/s41592-018-0222-9 · Cited by 832 · see citing works
Acoustic separation of circulating tumor cells
Li, P., Mao, Z., Peng, Z., Zhou, L., Chen, Y., Huang, P., Truica, C. I., Drabick, J. J., El‐Deiry, W. S., Dao, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504484112 · Cited by 781 · see citing works
Cancer biomarker discovery and validation.
Goossens, N., Nakagawa, S., Sun, X., & Hoshida, Y. (2015) · PubMed · doi:10.3978/j.issn.2218-676x.2015.06.04 · Cited by 520 · see citing works
Applications of Raman spectroscopy in cancer diagnosis
Auner, G. W., Koya, S. K., Huang, C., Broadbent, B., Trexler, M., Auner, Z., Elias, A., Mehne, K. C., & Brusatori, M. (2018) · Cancer and Metastasis Reviews · doi:10.1007/s10555-018-9770-9 · Cited by 389 · see citing works
Rao, L., Wu, L., Liu, Z., Tian, R., Yu, G., Zhou, Z., Yang, K., Xiong, H., Zhang, A., Yu, G.-T., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18626-y · Cited by 379 · see citing works
Liu, X., Song, J., Zhang, H., Liu, X., Zuo, F., Zhao, Y., Zhao, Y., Yin, X., Guo, X., Wu, X. L., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.01.001 · Cited by 364 · see citing works
Factors involved in cancer metastasis: a better understanding to “seed and soil” hypothesis
Liu, Q., Zhang, H., Jiang, X., Qian, C., Liu, Z., & Luo, D. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0742-4 · Cited by 328 · see citing works
Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors
Zinger, A., Koren, L., Adir, O., Poley, M., Alyan, M., Yaari, Z. A., Noor, N., Krinsky, N., Simon, A., Gibori, H., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b02395 · Cited by 327 · see citing works
Chiang, S., Cabrera, R. M., & Segall, J. E. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00238.2015 · Cited by 310 · see citing works
Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy
Ding, Y., Li, W., Zhang, F., Liu, Z., Ezazi, N. Z., Liu, D., & Santos, H. A. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201802852 · Cited by 313 · see citing works
Rare cell isolation and analysis in microfluidics
Chen, Y., Li, P., Huang, P., Xie, Y., Mai, J. D., Wang, L., Nguyen, N., & Huang, T. J. (2014) · Lab on a Chip · doi:10.1039/c3lc90136j · Cited by 307 · see citing works
Mouse models of metastasis: progress and prospects
Gómez-Cuadrado, L., Tracey, N., Ma, R., Qian, B., & Brunton, V. G. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030403 · Cited by 298 · see citing works
GiniClust: detecting rare cell types from single-cell gene expression data with Gini index
Jiang, L., Chen, H., Pinello, L., & Yuan, G. (2016) · Genome biology · doi:10.1186/s13059-016-1010-4 · Cited by 296 · see citing works
Advances in digital polymerase chain reaction (dPCR) and its emerging biomedical applications
Cao, L., Cui, X., Hu, J., Li, Z., Choi, J. R., Yang, Q., Lin, M., Hui, L. Y., & Xu, F. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.09.082 · Cited by 293 · see citing works
Rationally Engineered Nucleic Acid Architectures for Biosensing Applications
Xiao, M., Lai, W., Man, T., Chang, B., Li, L., Chandrasekaran, A. R., & Pei, H. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00121 · Cited by 289 · see citing works
Dalili, A., Samiei, E., & Hoorfar, M. (2018) · The Analyst · doi:10.1039/c8an01061g · Cited by 281 · see citing works
Park, M., Reátegui, E., Li, W., Tessier, S. N., Wong, K. H. K., Jensen, A. E., Thapar, V., Ting, D. T., Toner, M., Stott, S. L., et al. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b12236 · Cited by 267 · see citing works
Liang, W., Zhao, Y., Huang, W., Gao, Y., Xu, W., Tao, J., Yang, M., Li, L., Wei, P., Shen, H., et al. (2019) · Theranostics · doi:10.7150/thno.28119 · Cited by 264 · see citing works
Recent advances in wavefront shaping techniques for biomedical applications
Yu, H., Park, J., Lee, K., Yoon, J. W., Kim, K., Lee, S., & Park, Y. (2015) · Current Applied Physics · doi:10.1016/j.cap.2015.02.015 · Cited by 246 · see citing works
Poudineh, M., Aldridge, P. M., Ahmed, S. U., Green, B. J., Kermanshah, L., Nguyen, V., Tu, C., Mohamadi, R. M., Nam, R. K., Hansen, A. R., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.239 · Cited by 248 · see citing works
Circulating Tumor Cells: A Review of Non–EpCAM-Based Approaches for Cell Enrichment and Isolation
Gabriel, M. T., Calleja, L. R., Chalopin, A., Ory, B., & Heymann, D. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2015.249706 · Cited by 238 · see citing works
Luo, W. (2023) · Theranostics · doi:10.7150/thno.82690 · Cited by 237 · see citing works
Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Shang, M., Soon, R. H., Lim, C. T., Khoo, B. L., & Han, J. (2019) · Lab on a Chip · doi:10.1039/c8lc00970h · Cited by 227 · see citing works
Rao, L., Meng, Q., Huang, Q., Wang, Z., Yu, G., Li, A., Ma, W., Zhang, N., Guo, S., Zhao, X., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201803531 · Cited by 226 · see citing works
Sun, Y., Wu, L. L., Liu, S., Jiang, M., Hu, B., Zhou, K., Guo, W., Xu, Y., Zhong, Y., Zhou, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24386-0 · Cited by 226 · see citing works
Circulating tumor cell clusters: What we know and what we expect (Review)
Hong, Y., Fang, F. Y., & Zhang, Q. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3747 · Cited by 219 · see citing works
Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers
Huang, T., & Deng, C.-X. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.27796 · Cited by 228 · see citing works
Threatening cancer with nanoparticle aided combination oncotherapy
Rawal, S. U., & Patel, M. M. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.015 · Cited by 204 · see citing works
Mechanisms and context underlying the role of autophagy in cancer metastasis
Dower, C. M., Wills, C. A., Frisch, S. M., & Wang, H. (2018) · Autophagy · doi:10.1080/15548627.2018.1450020 · Cited by 195 · see citing works
Strati, A. D., Koutsodontis, G., Papaxoinis, G., Angelidis, I., Zavridou, M., Economopoulou, P., Kotsantis, I., Avgeris, M., Mazel, M., Perisanidis, C., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx206 · Cited by 194 · see citing works
HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone
Day, K. C., Hiles, G. L., Kozminsky, M., Dawsey, S. J., Paul, A., Broses, L. J., Shah, R. B., Kunja, L. P., Hall, C. L., Palanisamy, N., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1656 · Cited by 184 · see citing works
Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy
Zhang, Y., Mi, X., Tan, X., & Xiang, R. (2019) · Theranostics · doi:10.7150/thno.29875 · Cited by 178 · see citing works
Circulating Tumor Cell Phenotyping via High‐Throughput Acoustic Separation
Wu, M., Huang, P., Zhang, R., Mao, Z., Chen, C., Kemeny, G., Li, P., Lee, A. V., Gyanchandani, R., Armstrong, A. J., et al. (2018) · Small · doi:10.1002/smll.201801131 · Cited by 176 · see citing works
Emerging Roles of Electrospun Nanofibers in Cancer Research
Chen, S., Boda, S. K., Batra, S. K., Li, X., & Xie, J. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201701024 · Cited by 175 · see citing works
Current signal amplification strategies in aptamer-based electrochemical biosensor: A review
He, L., Huang, R., Xiao, P., Liu, Y., Jin, L. J., Liu, H., Li, S., Deng, Y., Chen, Z., Li, Z., et al. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.12.054 · Cited by 174 · see citing works
Electrospun Fibers Control Drug Delivery for Tissue Regeneration and Cancer Therapy
Li, L., Hao, R., Qin, J., Song, J., Chen, X., Rao, F., Zhai, J., Zhao, Y., Zhang, L., & Xue, J. (2022) · Advanced Fiber Materials · doi:10.1007/s42765-022-00198-9 · Cited by 177 · see citing works
Zhou, G., Lin, M., Song, P., Chen, X., Chao, J., Wang, L., Huang, Q., Huang, W., Fan, C., & Zuo, X. (2014) · Analytical Chemistry · doi:10.1021/ac502276w · Cited by 168 · see citing works
Liang, L., Su, M., Li, L., Lan, F., Yang, G., Ge, S., Yu, J., & Song, X. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.01.137 · Cited by 164 · see citing works
Biomimetic platelet membrane-coated nanoparticles for targeted therapy
Han, H., Bártolo, R., Li, J., Shahbazi, M., & Santos, H. A. (2022) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2022.01.004 · Cited by 166 · see citing works
Sun, Y., Guo, W., Xu, Y., Shi, Y.-H., Gong, Z., Ji, Y., Du, M., Zhang, X., Hu, B., Huang, A., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1063 · Cited by 161 · see citing works
Catenacci, D. V. T., Chapman, C. G., Xu, P., Koons, A., Konda, V. J. A., Siddiqui, U. D., & Waxman, I. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.050 · Cited by 159 · see citing works
Circulating Tumor Cells Dynamics in Pancreatic Adenocarcinoma Correlate With Disease Status
Gemenetzis, G., Groot, V. P., Yu, J., Ding, D., Teinor, J. A., Javed, A. A., Wood, L. D., Burkhart, R. A., Cameron, J. L., Makary, M. A., et al. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002925 · Cited by 158 · see citing works
The fundamental role of mechanical properties in the progression of cancer disease and inflammation
Mierke, C. T. (2014) · Reports on Progress in Physics · doi:10.1088/0034-4885/77/7/076602 · Cited by 158 · see citing works
DNA tetrahedron nanostructures for biological applications: biosensors and drug delivery
Xie, N., Liu, S., Yang, X., He, X., Huang, J. L., & Wang, K. (2017) · The Analyst · doi:10.1039/c7an01154g · Cited by 152 · see citing works
Beyond the Capture of Circulating Tumor Cells: Next‐Generation Devices and Materials
Green, B. J., Safaei, T. S., Mepham, A. H., Labib, M., Mohamadi, R. M., & Kelley, S. O. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201505100 · Cited by 151 · see citing works
Greenlee, J. D., Subramanian, T., Liu, K., & King, M. R. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2199 · Cited by 151 · see citing works
Guo, W., Sun, Y., Shen, M., Ma, X.-L., Wu, J., Zhang, C.-Y., Zhou, Y., Xu, Y., Hu, B., Zhang, M., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1753 · Cited by 149 · see citing works
Bensch, F., Brouwers, A. H., Hooge, M. N. L., de Jong, J. R., van der Vegt, B., Sleijfer, S., de Vries, E. G. E., & Schröder, C. P. (2018) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-018-4099-8 · Cited by 149 · see citing works
Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread
Büll, C., Boltje, T. J., van Dinther, E. A. W., Peters, T., de Graaf, A. M. A., Leusen, J. H. W., Kreutz, M., Figdor, C. G., den Brok, M. H., & Adema, G. J. (2015) · ACS Nano · doi:10.1021/nn5061964 · Cited by 147 · see citing works
Li, W., Wang, H., Zhao, Z., Gao, H., Liu, C., Zhu, L., Wang, C., & Yang, Y. (2018) · Advanced Materials · doi:10.1002/adma.201805344 · Cited by 149 · see citing works
Yang, C., Chen, W., Wang, S., Shi, D., Zhang, C., Lin, X., Dou, R., & Xiong, B. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.29836 · Cited by 146 · see citing works
Bulfoni, M., Gerratana, L., Ben, F. D., Marzinotto, S., Sorrentino, M., Turetta, M., Scoles, G., Toffoletto, B., Isola, M., Beltrami, C. A., et al. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0687-3 · Cited by 145 · see citing works
Circulating Tumor Cells: Moving Biological Insights into Detection
Chen, L., Bode, A. M., & Dong, Z. (2017) · Theranostics · doi:10.7150/thno.18588 · Cited by 137 · see citing works
Application of liquid biopsy in precision medicine: opportunities and challenges
Wang, J., Chang, S., Li, G., & Sun, Y. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0526-7 · Cited by 138 · see citing works
DNA Nanotechnology‐Based Biosensors and Therapeutics
Shen, L., Wang, P., & Ke, Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002205 · Cited by 137 · see citing works
Circulating tumor cells as promising novel biomarkers in solid cancers
Lianidou, E. S., Strati, A. D., & Markou, A. N. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.896316 · Cited by 136 · see citing works
Recent Advances in the Generation of Antibody–Nanomaterial Conjugates
Sivaram, A. J., Wardiana, A., Howard, C. B., Mahler, S. M., & Thurecht, K. J. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700607 · Cited by 136 · see citing works
Chen, P., Wang, Y., He, Y., Huang, K., Wang, X., Zhou, R., Liu, T., Qu, R., Zhou, J., Wu, P., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c02080 · Cited by 135 · see citing works
Qian, W., Zhang, Y., & Chen, W. (2015) · Small · doi:10.1002/smll.201403658 · Cited by 134 · see citing works
Metastasis of circulating tumor cells: Favorable soil or suitable biomechanics, or both?
Azevedo, A. S., Follain, G., Patthabhiraman, S., Harlepp, S., & Goetz, J. G. (2015) · Cell Adhesion & Migration · doi:10.1080/19336918.2015.1059563 · Cited by 126 · see citing works
Ben, F. D., Turetta, M., Celetti, G., Piruska, A., Bulfoni, M., Cesselli, D., Huck, W. T. S., & Scoles, G. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201602328 · Cited by 127 · see citing works
The isolation and characterization of CTC subsets related to breast cancer dormancy
Vishnoi, M., Peddibhotla, S., Yin, W., Scamardo, A. T., George, G. C., Hong, D. S., & Marchetti, D. (2015) · Scientific Reports · doi:10.1038/srep17533 · Cited by 121 · see citing works
Jiang, B., Li, Y.-S., Guo, W., Zhang, X., Chen, Z., Su, J., Zhong, W., Yang, X., Yang, J., Shao, Y. W., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0047 · Cited by 121 · see citing works
Detection of cancer cells based on glycolytic-regulated surface electrical charges
Le, W., Chen, B., Cui, Z., Liu, Z., & Shi, D. (2019) · Biophysics Reports · doi:10.1007/s41048-018-0080-0 · Cited by 121 · see citing works
Kros, J. M., Mustafa, D. A. M., Dekker, L. J. M., Smitt, P. A. E. S., Luider, T. M., & Zheng, P. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou207 · Cited by 116 · see citing works
Circulating Glioma Cells Exhibit Stem Cell-like Properties
Liu, T., Xu, H., Huang, M., Ma, W., Saxena, D., Lustig, R. A., Alonso‐Basanta, M., Zhang, Z., O’Rourke, D. M., Zhang, L., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0650 · Cited by 112 · see citing works
Panikar, S. S., Cialla‐May, D., la Rosa, E. D., Salas, P., & Popp, J. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116122 · Cited by 111 · see citing works
Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies
Sáinz, B., Carron, E. C., Vallespinós, M., & Machado, H. L. (2016) · Mediators of Inflammation · doi:10.1155/2016/9012369 · Cited by 110 · see citing works
Wang, S., Zhao, X., Liu, F., Younis, M. R., Xia, X., & Wang, C. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04908 · Cited by 110 · see citing works
Kwan, T. T., Bardia, A., Spring, L. M., Giobbie‐Hurder, A., Kalinich, M., Dubash, T. D., Sundaresan, T. K., Hong, X., LiCausi, J. A., Ho, U. K., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0432 · Cited by 110 · see citing works
Wu, J., Wei, X., Gan, J., Huang, L., Shen, T., Lou, J., Liu, B., Zhang, J. X. J., & Qian, K. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504184 · Cited by 107 · see citing works
Chen, C., Zimmermann, M., Tinhofer, I., Kaufmann, A. M., & Albers, A. E. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.06.013 · Cited by 107 · see citing works
SERS Tags: The Next Promising Tool for Personalized Cancer Detection?
Fabris, L. (2016) · ChemNanoMat · doi:10.1002/cnma.201500221 · Cited by 104 · see citing works
Pei, H., Li, L., Han, Z., Wang, Y., & Tang, B. (2020) · Lab on a Chip · doi:10.1039/d0lc00577k · Cited by 104 · see citing works
Allen, T. A. (2024) · Cancers · doi:10.3390/cancers16071377 · Cited by 103 · see citing works
Poudineh, M., Labib, M., Ahmed, S. U., Nguyen, L. N. M., Kermanshah, L., Mohamadi, R. M., Sargent, E. H., & Kelley, S. O. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201608983 · Cited by 97 · see citing works
Passive microfluidic devices for cell separation
Zhang, T., Carlo, D. D., Lim, C. T., Zhou, T., Tian, G., Tang, T., Shen, A. Q., Li, W., Li, M., Yang, Y., et al. (2024) · Biotechnology Advances · doi:10.1016/j.biotechadv.2024.108317 · Cited by 97 · see citing works
Patterns of circulating tumor cells identified by CEP8, CK and CD45 in pancreatic cancer
Zhang, Y., Wang, F., Ning, N., Chen, Q., Yang, Z., Guo, Y., Xu, D., Zhang, D., Zhan, T., & Cui, W. (2014) · International Journal of Cancer · doi:10.1002/ijc.29070 · Cited by 95 · see citing works
An integrated microfluidic chip for one-step isolation of circulating tumor cells
Lee, T. Y., Hyun, K.-A., Kim, S.-I., & Jung, H.-I. (2017) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2016.05.163 · Cited by 94 · see citing works
Review: Microfluidics technologies for blood-based cancer liquid biopsies
Sun, Y., Haglund, T. A., Rogers, A. J., Ghanim, A. F., & Sethu, P. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.12.050 · Cited by 93 · see citing works
Detection Methods and Clinical Applications of Circulating Tumor Cells in Breast Cancer
Zhang, H., Lin, X., Huang, Y., Wang, M., Cen, C., Tang, S., Dique, M. R., Cai, L., Luis, M. A., Smollar, J., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.652253 · Cited by 94 · see citing works
The Role of CTCs as Tumor Biomarkers
Lianidou, E. S., Markou, A. N., & Strati, A. D. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-7215-0_21 · Cited by 92 · see citing works
Tang, Y., Qiao, G., Xu, E., Xuan, Y., Liao, M., & Yin, G. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s142149 · Cited by 93 · see citing works
Patient-derived cell line, xenograft and organoid models in lung cancer therapy
Huo, K.-G., D’Arcangelo, E., & Tsao, M. (2020) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-154 · Cited by 93 · see citing works
He, Y., Wang, L., Shi, J., Yao, J., Li, L. S., Zhang, R., Huang, C., Zou, J., & Wang, L. V. (2016) · Scientific Reports · doi:10.1038/srep39616 · Cited by 90 · see citing works
Gold-based SERS tags for biomedical imaging
Fabris, L. (2015) · Journal of Optics · doi:10.1088/2040-8978/17/11/114002 · Cited by 88 · see citing works
Barbazán, J., Alonso‐Alconada, L., Elkhatib, N., Geraldo, S., Gurchenkov, V., Glentis, A., van Niel, G., Palmulli, R., Fernández, B., Viaño, P., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1917 · Cited by 89 · see citing works
Ma, F., Wei, S.-H., & Zhang, C. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b01617 · Cited by 89 · see citing works
Enrichment of circulating head and neck tumour cells using spiral microfluidic technology
Kulasinghe, A., Tran, T., Blick, T., O'Byrne, K. J., Thompson, E. W., Warkiani, M. E., Nelson, C. C., Kenny, L., & Punyadeera, C. (2017) · Scientific Reports · doi:10.1038/srep42517 · Cited by 88 · see citing works
Electrochemical cytosensors for detection of breast cancer cells
Vajhadin, F., Ahadian, S., Travaš‐Sejdić, J., Lee, J., Mazloum‐Ardakani, M., Salvador, J., Aninwene, G. E., Bandaru, P., Sun, W., & Khademhossieni, A. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.111984 · Cited by 88 · see citing works
Huang, Q., Wang, Y., Chen, X., Wang, Y., Li, Z., Du, S., Wang, L., & Chen, S. (2017) · Nanotheranostics · doi:10.7150/ntno.22091 · Cited by 88 · see citing works
Quantum Dot Based Biotracking and Biodetection
Zhang, L., Li, X., Xie, H., Zhang, Z., & Pang, D. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04721 · Cited by 87 · see citing works
Wang, J., Ma, G., Li, M., Han, X., Xu, J., Liang, M., Mao, X., Chen, X., Xia, T., Liu, X., et al. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.07.026 · Cited by 87 · see citing works
Advanced nanomaterials as sample technique for bio-analysis
Sun, N., Yu, H., Wu, H., Shen, X., & Deng, C. (2021) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116168 · Cited by 85 · see citing works
The limitless applications of single-cell metabolomics
Guo, S., Zhang, C., & Le, A. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.07.015 · Cited by 84 · see citing works
Wilson, R., O’Connor, R., Gallops, C. E., Kwizera, E. A., Noroozi, B., Morshed, B. I., Wang, Y., & Huang, X. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12395 · Cited by 83 · see citing works
Pilati, P., D, S. M. M., Bertazza, L., Galdi, F., Briarava, M., Mammano, E., Tessari, E., Zavagno, G., & Nitti, D. (2011) · Annals of Surgical Oncology · doi:10.1245/s10434-011-2132-2 · Cited by 82 · see citing works
- Authors
- Plaks, V., Koopman, C. D., & Werb, Z.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Science
- Published
- 2013-09-13
- Volume
- 341
- Issue
- 6151
- Pages
- 1186-1188
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3842225
- OpenAlex
- W1970655967
- Semantic Scholar
- c5ec9788ebaa1ebec2b42bf2f36c381a2aa65417
- Cited by
- 722
- References
- 30
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 51 · 2023: 60 · 2022: 68 · 2021: 62 · 2020: 66 · 2019: 73 · 2018: 66 · 2017: 65 · 2016: 64 · 2015: 51 · 2014: 29 · 2013: 10 · 2012: 6
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Defense (W81XWH)
- National Institutes of Health (W81XWH)
- National Cancer Institute (R01CA057621)
- National Institute of Environmental Health Sciences (U01ES019458)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- circulating tumor cells, liquid biopsy, tumor markers, therapeutic target, cancer diagnosis
- MeSH terms
- Animals, Cell Count, Gene Expression Regulation, Humans, Neoplastic Cells, Circulating, Neoplasm Metastasis, Neoplasms, Disease Progression, Single-Cell Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review