The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
The Link between the Metabolic Syndrome and Cancer
Open accessAbstract
Since the incidence of the metabolic syndrome is on the rise in the western world, its coherence to cancer is becoming more apparent. In this review we discuss the different potential factors involved in the increase of cancer in the metabolic syndrome including obesity, dyslipidemia and Type 2 Diabetes Mellitus (T2DM) as well as inflammation and hypoxia. We especially focus on the insulin and IGF systems with their intracellular signaling cascades mediated by different receptor subtypes, and suggest that they may play major roles in this process. Understanding the mechanisms involved will be helpful in developing potential therapeutics.
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Cites
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Prevalence of Overweight and Obesity in the United States
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Cited by
Challenges and Perspectives in the Treatment of Diabetes Associated Breast Cancer
Samuel, S. M., Varghese, E., Varghese, S., & Büsselberg, D. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.08.004 · Cited by 141
From obesity to cancer: a review on proposed mechanisms
Tahergorabi, Z., Khazaei, M., Moodi, M., & Chamani, E. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3229 · Cited by 118
Crawford, S. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00068 · Cited by 108
Agnoli, C., Grioni, S., Sieri, S., Sacerdote, C., Ricceri, F., Tumino, R., Frasca, G., Pala, V., Mattiello, A., Chiodini, P., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128891 · Cited by 76
Clinical interventions to break the obesity and cancer link: a narrative review
Bhardwaj, N. J., Chae, K., Sheng, J. Y., & Yeh, H.-C. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10055-1 · Cited by 5
Metadata
- Authors
- Braun, S., Bitton-Worms, K., & LeRoith, D.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2011
- Volume
- 7
- Issue
- 7
- Pages
- 1003-1015
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W2158145015
- Cited by
- 326
- References
- 96
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
