Cited by 119Cancer Risks and FactorsAdipokines, Inflammation, and Metabolic DiseasesCancer, Lipids, and Metabolism

From obesity to cancer: a review on proposed mechanisms

Tahergorabi, Zoya, Khazaei, Majid, Moodi, Mitra, Chamani, Elham·2016·Cell Biochemistry and Function

Abstract

Nowadays, obesity is considered as a serious and growing global health problem. It is documented that the overweight and obesity are major risk factors for a series of noncommunicable diseases, and in recent years, the obesity-cancer link has received much attention. Numerous epidemiological studies have shown that obesity is associated with increased risk of several cancer types, including colon, breast, endometrium, liver, kidney, esophagus, gastric, pancreatic, gallbladder, and leukemia, and can also lead to poorer treatment. We review here the epidemiological and experimental evidences for the association between obesity and cancer. Specifically, we discuss potential mechanisms focusing how dysfunctional angiogenesis, chronic inflammation, interaction of proinflammatory cytokines, endocrine hormones, and adipokines including leptin, adiponectin insulin, growth factors, estrogen, and progesterone and strikingly, cell metabolism alteration in obesity participate in tumor development and progression, resistance to chemotherapy, and targeted therapies such as antiangiogenic and immune therapies.

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Crossref · 10.1002/cbf.3229

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183 of 183 references verified0 citation errors · 0 not checkable

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Authors
Tahergorabi, Z., Khazaei, M., Moodi, M., & Chamani, E.
Affiliations
  • Birjand University of Medical Sciences (IR)
  • Mashhad University of Medical Sciences (IR)
Corresponding author
Chamani, Elham
Venue
Cell Biochemistry and Function
Publisher
Wiley
Published
2016-11-09
Volume
34
Issue
8
Pages
533-545
ISSN
  • 0263-6484 (ISSN-L)
  • 1099-0844
OpenAlex
W2564261821
Cited by
118
References
183
Citations by year
2026: 7 · 2025: 11 · 2024: 11 · 2023: 9 · 2022: 12 · 2021: 16 · 2020: 10 · 2019: 14 · 2018: 13 · 2017: 14 · 2016: 1
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Locations
  • Cell Biochemistry and Function (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
obesity, cancer risk, colon cancer, breast cancer, endometrial cancer, liver cancer, esophageal cancer, gastric cancer, pancreatic cancer, gallbladder cancer, leukemia, chronic inflammation, angiogenesis, inflammatory cytokines, endocrine hormones, adipokines, leptin, adiponectin, insulin, estrogen, progesterone, cancer metabolism, chemoresistance, anti-angiogenic therapy, immunotherapy
MeSH terms
Animals, Disease Models, Animal, Humans, Models, Biological, Neoplasms, Obesity

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