The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Macrophage Polarization in Inflammatory Diseases
Open accessAbstract
Diversity and plasticity are two hallmarks of macrophages. M1 macrophages (classically activated macrophages) are pro-inflammatory and have a central role in host defense against infection, while M2 macrophages (alternatively activated macrophages) are associated with responses to anti-inflammatory reactions and tissue remodeling, and they represent two terminals of the full spectrum of macrophage activation. Transformation of different phenotypes of macrophages regulates the initiation, development, and cessation of inflammatory diseases. Here we reviewed the characters and functions of macrophage polarization in infection, atherosclerosis, obesity, tumor, asthma, and sepsis, and proposed that targeting macrophage polarization and skewing their phenotype to adapt to the microenvironment might hold great promise for the treatment of inflammatory diseases.
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Citations
Cites
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Macrophage Diversity Enhances Tumor Progression and Metastasis
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BackgroundInfluentialAlternative activation of macrophages: mechanism and functions
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Cited by
Implications of macrophage polarization in autoimmunity
Funes, S. C., Rios, M., Escobar‐Vera, J., & Kalergis, A. M. (2018) · Immunology · doi:10.1111/imm.12910 · Cited by 1,005
Macrophage polarization in pathology
Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673
The pathology of the foreign body reaction against biomaterials
Klopfleisch, R., & Jung, F. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35958 · Cited by 524
Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy
Xu, B., Cui, Y., Wang, W., Li, S., Lyu, C., Wang, S., Bao, W., Wang, H., Qin, M., Liu, Z., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003563 · Cited by 404
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments
Xu, J., Ding, L., Mei, J., Hu, Y., Kong, X., Dai, S., Bu, T., Xiao, Q., & Ding, K. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02325-5 · Cited by 389
Metadata
- Authors
- Liu, Y.-C., Zou, X.-B., Chai, Y.-F., & Yao, Y.-M.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2014
- Volume
- 10
- Issue
- 5
- Pages
- 520-529
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W2100128950
- Cited by
- 1,085
- References
- 99
- FWCI
- 16.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, Y.-C., Zou, X.-B., Chai, Y.-F., & Yao, Y.-M. (2014). Macrophage Polarization in Inflammatory Diseases. International Journal of Biological Sciences. https://doi.org/10.7150/ijbs.8879
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
