The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Theranostic DNAzymes
Open accessAbstract
DNAzymes are catalytically active DNA molecules that are obtained via in vitro selection.RNA-cleaving DNAzymes have attracted significant attention for both therapeutic and diagnostic applications due to their excellent programmability, stability, and activity.They can be designed to cleave a specific mRNA to down-regulate gene expression.At the same time, DNAzymes can sense a broad range of analytes.By combining these two functions, theranostic DNAzymes are obtained.This review summarizes the progress of DNAzyme for theranostic applications.First, in vitro selection of DNAzymes is briefly introduced, and some representative DNAzymes related to biological applications are summarized.Then, the applications of DNAzyme for RNA cleaving are reviewed.DNAzymes have been used to cleave RNA for treating various diseases, such as viral infection, cancer, inflammation and atherosclerosis.Several formulations have entered clinical trials.Next, the use of DNAzymes for detecting metal ions, small molecules and nucleic acids related to disease diagnosis is summarized.Finally, the theranostic applications of DNAzyme are reviewed.The challenges to be addressed include poor DNAzyme activity under biological conditions, mRNA accessibility, delivery, and quantification of gene expression.Possible solutions to overcome these challenges are discussed, and future directions of the field are speculated.
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Li, Y., & Breaker, R. R. (1999) · Journal of the American Chemical Society · doi:10.1021/ja990592p · Cited by 587
Progress in antisense technology
Crooke, S. T. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.104408 · Cited by 417
Ke, G., Wang, C., Ge, Y., Zheng, N., Zhu, Z., & Yang, C. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3082439 · Cited by 196
Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems
Cui, L., Peng, R., Fu, T., Zhang, X., Wu, C., Chen, H., Liang, H., Yang, C. J., & Tan, W. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04170 · Cited by 81
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DNA Nanotechnology-Enabled Drug Delivery Systems
Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,118
Zhou, W., Saran, R., & Liu, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00063 · Cited by 931
Self-citationMcConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 477
DNAzyme‐Loaded Metal–Organic Frameworks (MOFs) for Self‐Sufficient Gene Therapy
Wang, H., Chen, Y., Wang, H., Liu, X., Zhou, X., & Wang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201902714 · Cited by 417
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Metadata
- Authors
- Zhou, W., Ding, J., & Liu, J.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2017
- Volume
- 7
- Issue
- 4
- Pages
- 1010-1025
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W4232144512
- Cited by
- 252
- References
- 4
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- gold
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