Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors
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Herein, a pH- and thermo-dual responsive UCST micelle system was developed for delivering IR780 and DOX, which could achieve NIR laser-controlled drug release and PA imaging guidance for chemo-photothermal synergistic therapy of both primary breast tumors and their metastases.
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The pH difference between normal tissue/blood and the extracellular environment of the tumor is intrinsic, which has been widely used in drug sustained-release systems.
“The pH difference between normal tissue/blood and the extracellular environment of the tumor is intrinsic, which has been widely used in drug sustained-release systems.40”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [40]
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- Authors
- Yang, Z., Cheng, R., Zhao, C., Sun, N., Luo, H., Chen, Y., Liu, Z., Li, X., Liu, J., & Tian, Z.
- Affiliations
- Xi'an Jiaotong University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Sun Yat-sen University (CN)
- Corresponding author
- Liu, Jie
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2018
- Volume
- 8
- Issue
- 15
- Pages
- 4097-4115
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC6096383
- OpenAlex
- W2887002424
- Cited by
- 89
- References
- 36
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 10 · 2023: 8 · 2022: 15 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 2
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Theranostics (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- polymeric micelles, upper critical solution temperature, pH-responsive drug delivery, thermosensitive drug delivery, photoacoustic imaging, chemo-photothermal therapy, IR780, doxorubicin, breast cancer
- MeSH terms
- Animals, Breast Neoplasms, Combined Modality Therapy, Disease Models, Animal, Doxorubicin, Drug Carriers, Drug Therapy, Hydrogen-Ion Concentration, Hyperthermia, Induced, Indoles, Infrared Rays, Mice, Inbred BALB C, Micelles, Phototherapy, Polymers, Temperature, Nanostructures, Photoacoustic Techniques
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