The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy
Open accessAbstract
Reactive oxygen species (ROS)-generating anticancer agents can act through two different mechanisms: (i) elevation of endogenous ROS production in mitochondria, or (ii) formation/delivery of exogenous ROS within cells.However, there is a lack of research on the development of ROS-generating nanosystems that combine endogenous and exogenous ROS to enhance oxidative stress-mediated cancer cell death.Methods: A ROS-generating agent based on polymer-modified zinc peroxide nanoparticles (ZnO2 NPs) was presented, which simultaneously delivered exogenous H2O2 and Zn 2+ capable of amplifying endogenous ROS production for synergistic cancer therapy.Results: After internalization into tumor cells, ZnO2 NPs underwent decomposition in response to mild acidic pH, resulting in controlled release of H2O2 and Zn 2+ .Intriguingly, Zn 2+ could increase the production of mitochondrial O2• -and H2O2 by inhibiting the electron transport chain, and thus exerted anticancer effect in a synergistic manner with the exogenously released H2O2 to promote cancer cell killing.Furthermore, ZnO2 NPs were doped with manganese via cation exchange, making them an activatable magnetic resonance imaging contrast agent.Conclusion: This study establishes a ZnO2-based theranostic nanoplatform which achieves enhanced oxidative damage to cancer cells by a two-pronged approach of combining endogenous and exogenous ROS.
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Cites
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Modulation of oxidative stress as an anticancer strategy
Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579
Trachootham, D., Zhou, Y., Zhang, H., Demizu, Y., Chen, Z., Pelicano, H., Chiao, P. J., Achanta, G., Arlinghaus, R. B., Liu, J., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.009 · Cited by 1,080
Cell-permeable, mitochondrial-targeted, peptide antioxidants
Szeto, H. H. (2006) · The AAPS Journal · doi:10.1007/bf02854898 · Cited by 316
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Self-citationLiu, B., Bian, Y., Liang, S., Yuan, M., Dong, S., He, F., Gai, S., Yang, P., Cheng, Z., & Lin, J. (2022) · ACS Nano · doi:10.1021/acsnano.1c07893 · Cited by 257
Defect modified zinc oxide with augmenting sonodynamic reactive oxygen species generation
Liu, Y., Wang, Y., Zhen, W., Wang, Y., Zhang, S., Zhao, Y., Song, S., Wu, Z., & Zhang, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120075 · Cited by 189
Self-citationMetal peroxides for cancer treatment
He, J., Fu, L.-H., Qi, C., Lin, J., & Huang, P. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.026 · Cited by 93
Metadata
- Authors
- Lin, L.-S., Wang, J.-F., Song, J., Liu, Y., Zhu, G., Dai, Y., Shen, Z., Tian, R., Song, J., Wang, Z., Tang, W., Yu, G., Zhou, Z., Yang, Z., Huang, T., Niu, G., Yang, H.-H., Chen, Z.-Y., & Chen, X.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2019
- Volume
- 9
- Issue
- 24
- Pages
- 7200-7209
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2978439222
- Cited by
- 179
- References
- 4
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lin, L.-S., Wang, J.-F., Song, J., Liu, Y., Zhu, G., Dai, Y., Shen, Z., Tian, R., Song, J., Wang, Z., Tang, W., Yu, G., Zhou, Z., Yang, Z., Huang, T., Niu, G., Yang, H.-H., Chen, Z.-Y., & Chen, X. (2019). Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy. Theranostics. https://doi.org/10.7150/thno.39831
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