The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Detecting Circulating Tumor Cells: Current Challenges and New Trends
Open accessAbstract
Circulating tumor cells (CTCs) in the blood stream play a critical role in establishing metastases. The clinical value of CTCs as a biomarker for early cancer detection, diagnosis, prognosis, prediction, stratification, and pharmacodynamics have been widely explored in recent years. However, the clinical utility of current CTC tests is limited mainly due to methodological constraints. In this review, the pros and cons of the reported CTC assays are comprehensively discussed. In addition, the potential of tumor cell-derived materials as new targets for CTC detection, including circulating tumor microemboli, cell fragments, and circulating DNA, is evaluated. Finally, emerging approaches for CTC detection, including telomerase-based or aptamer-based assays and cell functional analysis, are also assessed. Expectantly, a thorough review of the current knowledge and technology of CTC detection will assist the scientific community in the development of more efficient CTC assay systems.
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Clusters of circulating tumor cells traverse capillary-sized vessels
Au, S. H., Storey, B. D., Moore, J. C., Tang, Q., Chen, Y.-L., Javaid, S., Sarioglu, A. F., Sullivan, R., Madden, M. W., O’Keefe, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524448113 · Cited by 478
Detection and beyond: challenges and advances in aptamer-based biosensors
Yoo, H., Jo, H., & Oh, S. S. (2020) · Materials Advances · doi:10.1039/d0ma00639d · Cited by 334
Rare cell isolation and analysis in microfluidics
Chen, Y., Li, P., Huang, P.-H., Xie, Y., Mai, J. D., Wang, L., Nguyen, N.-T., & Huang, T. J. (2014) · Lab on a Chip · doi:10.1039/c3lc90136j · Cited by 307
Recent advances in microfluidic methods in cancer liquid biopsy
Iliescu, F. S., Poenar, D. P., Yu, F., Ni, M., Chan, K. H., Cima, I., Taylor, H. K., Cima, I., & Iliescu, C. (2019) · Biomicrofluidics · doi:10.1063/1.5087690 · Cited by 51
Metadata
- Authors
- Hong, B., & Zu, Y.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2013
- Volume
- 3
- Issue
- 6
- Pages
- 377-394
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2166535928
- Cited by
- 351
- References
- 136
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- gold
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