Cited by 242Alzheimer's disease research and treatmentsProtein Degradation and InhibitorsCholinesterase and Neurodegenerative Diseases

A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

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Wang, Weijin, Zhou, Qiuzhi, Jiang, Tao, Li, Shihong, Ye, Jinwang, Zheng, Jie, Wang, Xin, Liu, Yanchao +5 more·2021·Theranostics

Abstract

, which provides a promising drug candidate for AD and the related tauopathies.

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Crossref · 10.7150/thno.55680

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  • Induced turnover of tau by the UPS, and the degradability of tau species, has been demonstrated by a tau-KEAP1 chimeric peptide PROTAC molecule, as well as by a VHL-tau PROTAC.

    “Importantly, induced turnover of tau by the UPS, and the degradability of tau species, has been demonstrated by a tau–kelch-like ECH-associated protein 1 (KEAP1) chimeric peptide PROTAC molecule188, as well as by a VHL–tau PROTAC189.”

    From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [189]

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Authors
Wang, W., Zhou, Q., Jiang, T., Li, S., Ye, J., Zheng, J., Wang, X., Liu, Y., Deng, M., Ke, D., Wang, Q., Wang, Y., & Wang, J.-Z.
Affiliations
  • Huazhong University of Science and Technology (CN)
  • Nantong University (CN)
Corresponding author
  • Wang, Yipeng
  • Wang, Jian-Zhi
Venue
Theranostics
Published
2021
Volume
11
Issue
11
Pages
5279-5295
ISSN
1838-7640 (ISSN-L)
OpenAlex
W3139364923
Cited by
242
References
41
Citations by year
2026: 53 · 2025: 62 · 2024: 51 · 2023: 32 · 2022: 33 · 2021: 11
FWCI
20.24
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Theranostics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
PROTACs, small-molecule degraders, tau clearance, Alzheimer's disease, tauopathy, cognitive function, drug candidates
MeSH terms
Alzheimer Disease, Animals, Brain, Cell Line, Cognition, Disease Models, Animal, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Neuronal Plasticity, Neurons, tau Proteins, Tauopathies, Proteasome Endopeptidase Complex, Mice, Small Molecule Libraries, Ubiquitination, HEK293 Cells, Proteolysis

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