Tauopathies.
Abstract
Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include globular glial tauopathies, primary age-related tauopathy, which includes neurofibrillary tangle dementia, chronic traumatic encephalopathy (CTE), and aging-related tau astrogliopathy. Clinical symptoms include frontotemporal dementia, corticobasal syndrome, Richardson syndrome, parkinsonism, pure akinesia with gait freezing and, rarely, motor neuron symptoms or cerebellar ataxia. Some disorders show specific neuroimaging features, while examination of the cerebrospinal fluid awaits markers for in vivo stratification of cases. The possibility of cell-to-cell propagation is a novel aspect of the pathogenesis of tauopathies, which is partly reflected by the hierarchic involvement of anatomic regions. This concept might have relevance for the development of therapies. For cost-effective screening for tau pathologies in neuropathologic practice, examination of the hippocampus, amygdala, and basal ganglia is recommended. Uncommon morphologies or unusually extensive forms of tau pathologies should raise the suspicion of a genetic background. Ongoing multidisciplinary studies are needed to understand the whole spectrum and significanc…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Under pathological conditions, hyperphosphorylation of tau reduces its affinity for tubulin and is thought to drive abnormal aggregations of phosphorylated tau, such as neuropil threads or neurofibrillary tangles, resulting in tauopathies.
“However, under pathological conditions, the hyperphosphorylation of tau reduces its affinity for tubulin and is thought to drive abnormal aggregations of phosphorylated tau (p-tau), such as neuropil threads or neurofibrillary tangles (NFTs), resulting in tauopathies (Wang and Mandelkow, 2016; Kovacs, 2017).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Kovacs, 2017
In classical tauopathies where overt epilepsy infrequently occurs, tau hyperphosphorylation can arise from a variety of different causes.
“In classical tauopathies where overt epilepsy infrequently occurs, tau hyperphosphorylation can arise from a variety of different causes (Kovacs, 2017).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Kovacs, 2017
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498 · see citing works
Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492 · see citing works
Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098 · see citing works
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A., & Ghetti, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7737 · Cited by 1,474 · see citing works
Primary age-related tauopathy (PART): a common pathology associated with human aging
Crary, J. F., Trojanowski, J. Q., Schneider, J. A., Abisambra, J. F., Abner, E. L., Alafuzoff, I., Arnold, S. E., Attems, J., Beach, T. G., Bigio, E. H., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1349-0 · Cited by 1,467 · see citing works
Self-citationTau is a candidate gene for chromosome 17 frontotemporal dementia
Poorkaj, P., Bird, T. D., Wijsman, E., Nemens, E., Garruto, R. M., Anderson, L., Andreadis, A., Wiederholt, W. C., Raskind, M., & Schellenberg, G. D. (1998) · Annals of Neurology · doi:10.1002/ana.410430617 · Cited by 1,374 · see citing works
Bang, J., Spina, S., & Miller, B. L. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00461-4 · Cited by 1,144 · see citing works
Tau pathology and neurodegeneration
Spillantini, M. G., & Goedert, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70090-5 · Cited by 1,133 · see citing works
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.047 · Cited by 986 · see citing works
Murray, M. E., Graff-Radford, N. R., Ross, O. A., Petersen, R. C., Duara, R., & Dickson, D. W. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70156-9 · Cited by 972 · see citing works
the TBI/CTE group, McKee, A. C., Cairns, N. J., Dickson, D. W., Folkerth, R. D., Dirk Keene, C., Litvan, I., Perl, D. P., Stein, T. D., Vonsattel, J.-P., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1515-z · Cited by 885 · see citing works
Spreading of pathology in neurodegenerative diseases: a focus on human studies
Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
Clavaguera, F., Akatsu, H., Fraser, G. M., Crowther, R. A., Frank, S., Hench, J., Probst, A., Winkler, D. T., Reichwald, J., Staufenbiel, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301175110 · Cited by 750 · see citing works
Office of Rare Diseases Neuropathologic Criteria for Corticobasal Degeneration
Dickson, D. W., Bergeron, C., Chin, S. S., Duyckaerts, C., Horoupian, D., Ikeda, K., Jellinger, K., Lantos, P. L., Lippa, C. F., Mirra, S. S., et al. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.11.935 · Cited by 724 · see citing works
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy
PSP Genetics Study Group, Höglinger, G. U., Melhem, N. M., Dickson, D. W., Sleiman, P. M. A., Wang, L.-S., Klei, L., Rademakers, R., de Silva, R., Litvan, I., et al. (2011) · Nature Genetics · doi:10.1038/ng.859 · Cited by 603 · see citing works
The Neuropathology of Chronic Traumatic Encephalopathy
McKee, A. C., Stein, T. D., Kiernan, P. T., & Alvarez, V. E. (2015) · Brain Pathology · doi:10.1111/bpa.12248 · Cited by 585 · see citing works
Sabater, L., Gaig, C., Gelpí, E., Bataller, L., Lewerenz, J., Torres-Vega, E., Contreras, A., Giometto, B., Compta, Y., Embid, C., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70051-1 · Cited by 563 · see citing works
Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy
Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1509-x · Cited by 532 · see citing works
Self-citationInvited review: Neuropathology of tauopathies: principles and practice
Kovacs, G. G. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12208 · Cited by 492 · see citing works
Self-citationGhetti, B. F., Oblak, A. L., Boeve, B. F., Johnson, K. A., Dickerson, B. C., & Goedert, M. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12213 · Cited by 440 · see citing works
Staging of Argyrophilic Grains: An Age-Associated Tauopathy
Saito, Y., Ruberu, N. N., Sawabe, M., Arai, T., Tanaka, N., Kakuta, Y., Yamanouchi, H., & Murayama, S. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.9.911 · Cited by 432 · see citing works
Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration
Dickson, D. W. (1999) · Journal of Neurology · doi:10.1007/bf03161076 · Cited by 424 · see citing works
Williams, D. R., Holton, J. L., Strand, C., Pittman, A. M., de Silva, R., Lees, A. J., & Révész, T. (2007) · Brain · doi:10.1093/brain/awm104 · Cited by 415 · see citing works
Neuropathology of variants of progressive supranuclear palsy
Dickson, D. W., Ahmed, Z., Algom, A. A., Tsuboi, Y., & Josephs, K. A. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32833be924 · Cited by 386 · see citing works
Kovács, G. G., Milenković, I., Wöehrer, A., Höftberger, R., Gelpí, E., Haberler, C., Hönigschnabl, S., Reiner‐Concin, A., Heinzl, H., Jungwirth, S., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1157-y · Cited by 360 · see citing works
Self-citationKovács, G. G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020189 · Cited by 321 · see citing works
Self-citationProgressive Supranuclear Palsy: Pathology and Genetics
Dickson, D. W., Rademakers, R., & Hutton, M. L. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00054.x · Cited by 314 · see citing works
Tau protein as a differential biomarker of tauopathies
Sergeant, N., Delacourte, A., & Buée, L. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.020 · Cited by 312 · see citing works
Argyrophilic Grain Disease Is a Sporadic 4-Repeat Tauopathy
Togo, T., Sahara, N., Yen, S.-H., Cookson, N., Ishizawa, T., Hutton, M., de Silva, R., Lees, A., & Dickson, D. W. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.6.547 · Cited by 273 · see citing works
Ferrer, I., Santpere, G., & van Leeuwen, F. W. (2008) · Brain · doi:10.1093/brain/awm305 · Cited by 256 · see citing works
Corticobasal degeneration: a pathologically distinct 4R tauopathy
Kouri, N., Whitwell, J. L., Josephs, K. A., Rademakers, R., & Dickson, D. W. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.43 · Cited by 246 · see citing works
Neuropathological criteria of anti-IgLON5-related tauopathy
Gelpí, E., Höftberger, R., Graus, F., Ling, H., Holton, J. L., Dawson, T., Popović, M., Oblak, J. P., Högl, B., Schmutzhard, E., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1591-8 · Cited by 239 · see citing works
Self-citationClinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
Murray, M. E., Kouri, N., Lin, W.-L., Jack, C. R., Dickson, D. W., & Vemuri, P. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt231 · Cited by 237 · see citing works
Schmidt, M., Zhukareva, V., Newell, K., Lee, V., & Trojanowski, J. (2001) · Acta Neuropathologica · doi:10.1007/s004010000330 · Cited by 230 · see citing works
Lewis, J. M., & Dickson, D. W. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1507-z · Cited by 221 · see citing works
Kouri, N., Ross, O. A., Dombroski, B., Younkin, C. S., Serie, D. J., Soto-Ortolaza, A., Baker, M., Finch, N. C. A., Yoon, H., Kim, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms8247 · Cited by 219 · see citing works
Globular glial tauopathies (GGT): consensus recommendations
Ahmed, Z., Bigio, E. H., Budka, H., Dickson, D. W., Ferrer, I., Ghetti, B. F., Giaccone, G., Hatanpaa, K. J., Holton, J. L., Josephs, K. A., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1171-0 · Cited by 205 · see citing works
Self-citationDeep clinical and neuropathological phenotyping of P ick disease
Irwin, D. J., Brettschneider, J., McMillan, C. T., Cooper, F. I., Olm, C. A., Arnold, S. E., Deerlin, V. M. V., Seeley, W. W., Miller, B. L., Lee, E. B., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24559 · Cited by 204 · see citing works
Pick's Disease: A Modern Approach
Dickson, D. W. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00158.x · Cited by 197 · see citing works
PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.
Jellinger, K. A., Alafuzoff, I., Attems, J., Beach, T. G., Cairns, N. J., Crary, J. F., Dickson, D. W., Hof, P. R., Hyman, B. T., Jack, C. R., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1407-2 · Cited by 171 · see citing works
Self-citationLee, G. S., & Leugers, C. J. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00004-7 · Cited by 166 · see citing works
Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease
Jellinger, K. A., & Attems, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0156-7 · Cited by 157 · see citing works
Atypical Progressive Supranuclear Palsy With Corticospinal Tract Degeneration
Josephs, K. A., Katsuse, O., Beccano-Kelly, D. A., Lin, W.-L., Uitti, R. J., Fujino, Y., Boeve, B. F., Hutton, M. L., Baker, M., & Dickson, D. W. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000218446.38158.61 · Cited by 152 · see citing works
Argyrophilic grain disease: A late‐onset dementia with distinctive features among tauopathies
Tolnay, M., & Clavaguera, F. (2004) · Neuropathology · doi:10.1111/j.1440-1789.2004.00591.x · Cited by 150 · see citing works
Janocko, N. J., Brodersen, K. A., Soto-Ortolaza, A., Ross, O., Liesinger, A. M., Duara, R., Graff-Radford, N., Dickson, D., & Murray, M. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1044-y · Cited by 138 · see citing works
Kovács, G. G., Majtényi, K., Spina, S., Murrell, J. R., Gelpí, E., Höftberger, R., Fraser, G. M., Crowther, R. A., Goedert, M., Budka, H., et al. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318187a80f · Cited by 125 · see citing works
Self-citationPopescu, A., Lippa, C. F., Lee, V. M. ‐., & Trojanowski, J. Q. (2004) · Archives of Neurology · doi:10.1001/archneur.61.12.1915 · Cited by 117 · see citing works
Arima, K. (2006) · Neuropathology · doi:10.1111/j.1440-1789.2006.00669.x · Cited by 106 · see citing works
Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics
Kovács, G. G., Botond, G., & Budka, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0658-1 · Cited by 98 · see citing works
Self-citationArgyrophilic grains: A distinct disease or an additive pathology?
Josephs, K. A., Whitwell, J. L., Parisi, J. E., Knopman, D. S., Boeve, B. F., Geda, Y. E., Jack, C. R., Petersen, R. C., & Dickson, D. W. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.032 · Cited by 97 · see citing works
Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
Magdalinou, N. K., Lees, A. J., & Zetterberg, H. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-307539 · Cited by 93 · see citing works
Clinical Approach to Progressive Supranuclear Palsy
Ling, H. (2016) · Journal of Movement Disorders · doi:10.14802/jmd.15060 · Cited by 93 · see citing works
High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe
Schultz, C., Ghebremedhin, E., Tredici, K. D., Rüb, U., & Braak, H. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00113-1 · Cited by 91 · see citing works
A peculiar constellation of tau pathology defines a subset of dementia in the elderly
Kovács, G. G., Molnár, K., László, L., Ströbel, T., Botond, G., Hönigschnabl, S., Reiner‐Concin, A., Palkovits, M., Fischer, P. A., & Budka, H. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0819-x · Cited by 90 · see citing works
Self-citationCurrent concepts of neuropathological diagnostics in practice: neurodegenerative diseases
Kovács, G. G., & Budka, H. (2010) · Clinical Neuropathology · doi:10.5414/npp29271 · Cited by 85 · see citing works
Self-citationThe MAPT H1 haplotype is associated with tangle-predominant dementia
Santa‐María, I., Haggiagi, A. M., Liu, X., Wasserscheid, J., Nelson, P. T., Dewar, K., Clark, L. N., & Crary, J. F. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1017-1 · Cited by 83 · see citing works
Muñoz, D. G., Woulfe, J., & KERTESZ, A. E. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0266-x · Cited by 77 · see citing works
Kovács, G. G., Rozemüller, A. J. M., Swieten, J. C. V., Gelpí, E., Majtényi, K., Al‐Sarraj, S., Troakes, C., Bódi, I., King, A., Hortobágyi, T., et al. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01272.x · Cited by 72 · see citing works
Self-citationFu, Y., Nishihira, Y., Kuroda, S., Toyoshima, Y., Ishihara, T., Shinozaki, M., Miyashita, A., Piao, Y.-S., Tan, C., Tani, T., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0649-2 · Cited by 55 · see citing works
Ishihara, K., Araki, S., Ihori, N., Shiota, J., Kawamura, M., Yoshida, M., Hashizume, Y., & Nakano, I. (2005) · Neuropathology · doi:10.1111/j.1440-1789.2005.00598.x · Cited by 52 · see citing works
Tauopathy models and human neuropathology: similarities and differences
Frank, S., Clavaguera, F., & Tolnay, M. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0291-9 · Cited by 51 · see citing works
Clinical phenotypes in autopsy-confirmed Pick disease
Piguet, O., Halliday, G. M., Reid, W., Casey, B. J., Carman, R., Huang, Y. M., Xuereb, J. H., Hodges, J. R., & Kril, J. J. (2011) · Neurology · doi:10.1212/wnl.0b013e318207b1ce · Cited by 47 · see citing works
Tsuchiya, K., Mitani, K., Arai, T., Yamada, S., Komiya, T., Esaki, Y., Haga, C., Yamanouchi, H., & Ikeda, K. (2001) · Acta Neuropathologica · doi:10.1007/s004010100365 · Cited by 46 · see citing works
Kouri, N., Oshima, K., Takahashi, M., Murray, M. E., Ahmed, Z., Parisi, J. E., Yen, S. H., & Dickson, D. W. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1087-8 · Cited by 44 · see citing works
Tau accumulation in the nucleus accumbens in tangle-predominant dementia
Kawakami, I., Hasegawa, M., Arai, T., Ikeda, K., Oshima, K., Niizato, K., Aoki, N., Omi, K., Higashi, S., Hosokawa, M., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-40 · Cited by 41 · see citing works
Tolnay, M., & Probst, A. (2008) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)01251-1 · Cited by 41 · see citing works
Tacik, P. M., Sánchez-Contreras, M., Rademakers, R., Dickson, D. W., & Wszołek, Z. K. (2015) · Neurodegenerative Diseases · doi:10.1159/000440840 · Cited by 41 · see citing works
Patterns of Hippocampal Tau Pathology Differentiate Neurodegenerative Dementias
Milenković, I., Petrov, T., & Kovács, G. G. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000365548 · Cited by 36 · see citing works
Self-citationKERTESZ, A. E. (2003) · Movement Disorders · doi:10.1002/mds.10564 · Cited by 29 · see citing works
Expanding the phenotypic associations of globular glial tau subtypes
Burrell, J. R., Forrest, S. L., Bak, T. H., Hodges, J. R., Halliday, G. M., & Kril, J. J. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.03.006 · Cited by 29 · see citing works
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration
Pirker, S., Perju‐Dumbrava, L., Kovács, G. G., Traub‐Weidinger, T., Asenbaum, S., & Pirker, W. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.10.010 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Neuroinflammation as a common feature of neurodegenerative disorders
Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702 · see citing works
Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies
Rawat, P., Sehar, U., Bisht, J., Selman, A., Culberson, J., & Reddy, P. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112841 · Cited by 509 · see citing works
Neuropathology of Alzheimer's Disease
Trejo‐Lopez, J. A., Yachnis, A. T., & Prokop, S. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01146-y · Cited by 398 · see citing works
Microtubule-Associated Proteins: Structuring the Cytoskeleton
Bodakuntla, S., Jijumon, A. S., Villablanca, C., González-Billault, C. E., & Janke, C. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.07.004 · Cited by 366 · see citing works
Moloney, C. M., Lowe, V. J., & Murray, M. E. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12321 · Cited by 337 · see citing works
Tauopathies: new perspectives and challenges
Zhang, Y., Wu, K.-M., Yang, L., Dong, Q., & Yu, J.-T. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00533-z · Cited by 323 · see citing works
Molecular pathology of neurodegenerative diseases: principles and practice
Kovács, G. G. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2019-205952 · Cited by 243 · see citing works
Self-citationWang, W., Zhou, Q., Jiang, T., Li, S., Ye, J., Zheng, J., Wang, X., Liu, Y., Deng, M., Ke, D., et al. (2021) · Theranostics · doi:10.7150/thno.55680 · Cited by 242 · see citing works
Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies
Sinsky, J., Pichlerova, K., & Hanes, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179207 · Cited by 220 · see citing works
Traumatic Brain Injury: Mechanisms of Glial Response
Mira, R. G., Lira, M., & Cerpa, W. F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.740939 · Cited by 215 · see citing works
Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas
Área-Gómez, E., Guardia‐Laguarta, C., Schon, E. A., & Przedborski, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120848 · Cited by 169 · see citing works
Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles
Wordeman, L. G., & Vicente, J. J. (2021) · Cancers · doi:10.3390/cancers13225650 · Cited by 168 · see citing works
Profound degeneration of wake‐promoting neurons in Alzheimer's disease
Oh, J. Y., Eser, R. A., Ehrenberg, A. J., Morales, D. O., Petersen, C., Kudlacek, J., Dunlop, S. R., Theofilas, P., Resende, E. D. P. F., Cosme, C. G., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.06.3916 · Cited by 146 · see citing works
Calderón‐Garcidueñas, L., González-Maciel, A., Reynoso-Robles, R., Delgado‐Chávez, R., Mukherjee, P. S., Kulesza, R. J., Torres‐Jardón, R., Ávila-Ramírez, J., & Villarreal-Ríos, R. (2018) · Environmental Research · doi:10.1016/j.envres.2018.03.023 · Cited by 145 · see citing works
Vaquer‐Alicea, J., Diamond, M. I., & Joachimiak, Ł. A. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02301-7 · Cited by 134 · see citing works
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
Darwich, N. F., Phan, J. M., Kim, B., Suh, E. R., Papatriantafyllou, J. D., Changolkar, L. N., Nguyen, A. T., O’Rourke, C. M., He, Z., Porta, S., et al. (2020) · Science · doi:10.1126/science.aay8826 · Cited by 141 · see citing works
Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues
Samudra, N. P., Lane‐Donovan, C., VandeVrede, L. A., & Boxer, A. L. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168553 · Cited by 135 · see citing works
Photobiomodulation for Alzheimer’s Disease: Has the Light Dawned?
Hamblin, M. R. (2019) · Photonics · doi:10.3390/photonics6030077 · Cited by 109 · see citing works
Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy
Signaevsky, M., Prastawa, M. W., Farrell, K. W., Tabish, N., Baldwin, E., Han, N., Iida, M. A., Koll, J., Bryce, C., Purohit, D. P., et al. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0202-4 · Cited by 130 · see citing works
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sanchez-Varo, R. M., Mejias‐Ortega, M., Fernandez-Valenzuela, J. J., Nuñez‐Diaz, C., Cáceres-Palomo, L., Vegas‐Gomez, L., Sánchez‐Mejías, E., Trujillo‐Estrada, L., García‐León, J. A., Moreno‐González, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105404 · Cited by 130 · see citing works
Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration
Abramov, A. Y., Potapova, E., Владимирович, Д. В., & Dunaev, A. (2020) · Life · doi:10.3390/life10070101 · Cited by 125 · see citing works
Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease
Rai, S. K., Savastano, A., Singh, P., Mukhopadhyay, S., & Zweckstetter, M. (2021) · Protein Science · doi:10.1002/pro.4093 · Cited by 123 · see citing works
Frontotemporal Dementia, Where Do We Stand? A Narrative Review
Antonioni, A., Raho, E. M., Lopriore, P., Pace, A. P., Latino, R. R., Assogna, M., Mancuso, M., Gragnaniello, D., Granieri, E., Pugliatti, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411732 · Cited by 133 · see citing works
Astroglia and Tau: New Perspectives
Kovacs, G. G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00096 · Cited by 115 · see citing works
Self-citationFolding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease
Rutledge, B. S., Choy, W., & Duennwald, M. L. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101905 · Cited by 110 · see citing works
Glucose metabolism and AD: evidence for a potential diabetes type 3
González, A., Calfío, C., Churruca, M., & Maccioni, R. B. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-00996-8 · Cited by 112 · see citing works
Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding
Sang, D., Shu, T., Pantoja, C. F., de Opakua, A. I., Zweckstetter, M., & Holt, L. J. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.08.016 · Cited by 96 · see citing works
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus
Čarná, M., Onyango, I. G., Katina, S., Holub, D., Novotný, J., Nezvedová, M., Jha, D., Nedelská, Z., Lacovich, V., Vyvere, T. V., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12970 · Cited by 96 · see citing works
Torres, A. K., Jara, C., Olesen, M. A., & Tapia‐Rojas, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-83910-w · Cited by 93 · see citing works
Zola, N. K. N., Balty, C., Ruys, S. P. D., Vanparys, A., Huyghe, N. D., Herinckx, G., Johanns, M., Boyer, E., Kienlen‐Campard, P., Rider, M. H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39328-1 · Cited by 93 · see citing works
GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer’s disease-like filaments
Chakraborty, P., Ibáñez de Opakua, A., Purslow, J. A., Fromm, S. A., Chatterjee, D., Zachrdla, M., Zhuang, S., Puri, S., Wolozin, B., & Zweckstetter, M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2414176121 · Cited by 96 · see citing works
Combating deleterious phase transitions in neurodegenerative disease
Darling, A. L., & Shorter, J. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.118984 · Cited by 85 · see citing works
A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies
Imbimbo, B. P., Ippati, S., Watling, M., & Balducci, C. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12453 · Cited by 72 · see citing works
Liu, S., Hossinger, A., Heumüller, S.-E., Hornberger, A., Buravlova, O., Konstantoulea, K., Müller, S. A., Paulsen, L., Rousseau, F., Schymkowitz, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25855-2 · Cited by 72 · see citing works
Olesen, M. A., Villavicencio-Tejo, F., & Quintanilla, R. A. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00308-y · Cited by 71 · see citing works
Benbow, S. J., Strovas, T. J., Darvas, M., Saxton, A. D., & Kraemer, B. C. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz319 · Cited by 65 · see citing works
King, A., Bódi, I., & Troakes, C. (2020) · Brain Sciences · doi:10.3390/brainsci10080479 · Cited by 63 · see citing works
Does hearing loss lead to dementia? A review of the literature
Nadhimi, Y., & Llano, D. A. (2020) · Hearing Research · doi:10.1016/j.heares.2020.108038 · Cited by 62 · see citing works
Yadikar, H., Torres, I., Aiello, G., Kurup, M., Yang, Z., Lin, F. Y., Kobeissy, F. H., Yost, R. A., & Wang, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0224952 · Cited by 56 · see citing works
Oxidative Stress in Tauopathies: From Cause to Therapy
Bartolomé, F. B., Carro, E., & Alquézar, C. (2022) · Antioxidants · doi:10.3390/antiox11081421 · Cited by 57 · see citing works
Phosphorylation of nuclear Tau is modulated by distinct cellular pathways
Ulrich, G., Salvadè, A., Boersema, P. J., Calí, T., Foglieni, C., Sola, M., Picotti, P., Papin, S., & Paganetti, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-36374-4 · Cited by 52 · see citing works
Vacchi, E., Kaelin‐Lang, A., & Melli, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145030 · Cited by 50 · see citing works
Kaur, P., Khera, A., Alajangi, H. K., Sharma, A., Jaiswal, P. K., Singh, G., & Barnwal, R. P. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03164-z · Cited by 53 · see citing works
Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis
Sampietro, A., Pérez-Areales, F. J., Martínez, P., Arce, E. M., Galdeano, C., & Muñoz‐Torrero, D. (2022) · Pharmaceuticals · doi:10.3390/ph15050545 · Cited by 46 · see citing works
Kovács, G. G. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000664 · Cited by 44 · see citing works
Self-citationXia, Y., Sorrentino, Z. A., Kim, J. D., Strang, K. H., Riffe, C. J., & Giasson, B. I. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010178 · Cited by 46 · see citing works
Lionnet, A., Wade, M. A., Corbillé, A.-G., Prigent, A., Paillusson, S., Tasselli, M., Gonzales, J. A., Durieu, E., Rolli‐Derkinderen, M., Coron, E., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0568-3 · Cited by 43 · see citing works
Local structural preferences in shaping tau amyloid polymorphism
Louros, N. N., Wilkinson, M., Tsaka, G., Ramakers, M., Morelli, C., Garcia, T., Gallardo, R. U., D’Haeyer, S., Goossens, V., Audenaert, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45429-2 · Cited by 42 · see citing works
Wahl, D., Risen, S. J., Osburn, S. C., Emge, T., Sharma, S., Gilberto, V. S., Chatterjee, A., Nagpal, P., Moreno, J. A., & LaRocca, T. J. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03182-9 · Cited by 40 · see citing works
Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease
Kanmogne, M., & Klein, R. S. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.003 · Cited by 41 · see citing works
To target Tau pathologies, we must embrace and reconstruct their complexities
Limorenko, G., & Lashuel, H. A. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105536 · Cited by 39 · see citing works
Apolipoprotein D Upregulation in Alzheimer’s Disease but Not Frontotemporal Dementia
Bhatia, S., Kim, W. S., Shepherd, C. E., & Halliday, G. M. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1217-9 · Cited by 41 · see citing works
Abbas, K., Mustafa, M., Alam, M., Habib, S., Ahmad, W., Adnan, M., Hassan, M. I., & Usmani, N. (2025) · Neurogenetics · doi:10.1007/s10048-025-00821-y · Cited by 44 · see citing works
Exploitation of Marine Molecules to Manage Alzheimer’s Disease
Silva, M., Seijas, P., & Otero, P. (2021) · Marine Drugs · doi:10.3390/md19070373 · Cited by 43 · see citing works
Tapia-Arellano, A., Cabrera, P., Cortés-Adasme, E., Riveros, A. L., Hassan, N., & Kogan, M. J. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02526-0 · Cited by 40 · see citing works
Lorenzo, D. D. (2024) · ChemMedChem · doi:10.1002/cmdc.202400180 · Cited by 40 · see citing works
Darling, A. L., Dahrendorff, J., Creodore, S. G., Dickey, C. A., Blair, L. J., & Uversky, V. N. (2021) · Protein Science · doi:10.1002/pro.4060 · Cited by 37 · see citing works
The Roles of Peroxiredoxin 6 in Brain Diseases
Liao, J., Zhang, Y., Chen, X., & Zhang, J. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02427-5 · Cited by 39 · see citing works
Human brain pathology in myotonic dystrophy type 1: A systematic review
Weijs, R. W. J., Okkersen, K., van Engelen, B. G. M., Küsters, B., Lammens, M. M. Y., Aronica, E., Raaphorst, J., & van Walsum, A. V. C. (2021) · Neuropathology · doi:10.1111/neup.12721 · Cited by 37 · see citing works
Network of hotspot interactions cluster tau amyloid folds
Mullapudi, V., Vaquer‐Alicea, J., Bommareddy, V., Vega, A. R., Ryder, B. D., White, C. L., Diamond, M. I., & Joachimiak, Ł. A. (2023) · Nature Communications · doi:10.1038/s41467-023-36572-3 · Cited by 34 · see citing works
Montalbano, M., Majmundar, L., Sengupta, U., Fung, L., & Kayed, R. (2022) · Brain Pathology · doi:10.1111/bpa.13112 · Cited by 35 · see citing works
Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
Hwang, K., Vaknalli, R. N., Addo-Osafo, K., Vicente, M., & Vossel, K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903973 · Cited by 35 · see citing works
Cascio, F. L., Park, S., Sengupta, U., Puangmalai, N., Bhatt, N. N., Shchankin, N., Jerez, C., Moreno, N., Bittar, A., Xavier, R., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07499-w · Cited by 35 · see citing works
SV2A PET imaging in human neurodegenerative diseases
Bavarsad, M. S., & Grinberg, L. T. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1380561 · Cited by 33 · see citing works
“Prion-like” seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders
Zampar, S., Gregorio, S. E. D., Grimmer, G., Watts, J. C., & Ingelsson, M. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1436262 · Cited by 34 · see citing works
Pharmacological Modulators of Tau Aggregation and Spreading
Dominguez‐Meijide, A., Vasili, E., & Outeiro, T. F. (2020) · Brain Sciences · doi:10.3390/brainsci10110858 · Cited by 34 · see citing works
Tau protein aggregation: Key features to improve drug discovery screening
Giovannini, J., Smeralda, W., Jouanne, M., Santos, J. S. O., Catto, M., & Voisin‐Chiret, A. S. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.01.009 · Cited by 33 · see citing works
Tau protein quantification in skin biopsies differentiates tauopathies from alpha-synucleinopathies
Vacchi, E., Lazzarini, E., Pinton, S., Chiaro, G., Disanto, G., Marchi, F., Robert, T., Staedler, C., Galati, S., Gobbi, C., et al. (2022) · Brain · doi:10.1093/brain/awac161 · Cited by 33 · see citing works
Phosphorylation and Dephosphorylation of Tau Protein During Synthetic Torpor
Luppi, M., Hitrec, T., Cristoforo, A. D., Squarcio, F., Stanzani, A., Occhinegro, A., Chiavetta, P., Tupone, D., Zamboni, G., Amici, R., et al. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00057 · Cited by 31 · see citing works
Compartmentalized Signaling in Aging and Neurodegeneration
Benedetto, G. D., Iannucci, L. F., Surdo, N. C., Zanin, S., Conca, F., Grisan, F., Gerbino, A., & Lefkimmiatis, K. (2021) · Cells · doi:10.3390/cells10020464 · Cited by 29 · see citing works
Glycosylation in aging and neurodegenerative diseases
Zhang, W., Chen, T., Zhao, H., & Ren, S. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024136 · Cited by 28 · see citing works
The Quest for Cellular Prion Protein Functions in the Aged and Neurodegenerating Brain
Gavı́n, R., Lidón, L., Ferrer, I., & del Rı́o, J. A. (2020) · Cells · doi:10.3390/cells9030591 · Cited by 25 · see citing works
Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils
Savastano, A., Jaipuria, G., Andreas, L. B., Mandelkow�, E., & Zweckstetter, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-78161-0 · Cited by 25 · see citing works
Lalwani, A. K., Krishnan, K., Bagabir, S. A., Alkhanani, M., Almalki, A. H., Haque, S., Sharma, S. K., Singh, R. K. B., & Malik, M. Z. (2022) · Biomolecules · doi:10.3390/biom12030451 · Cited by 25 · see citing works
Sajad, M., Kumar, R., & Thakur, S. C. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.04.009 · Cited by 25 · see citing works
Vicente, M. C., Addo-Osafo, K., & Vossel, K. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1277613 · Cited by 25 · see citing works
Nanotechnology for tau pathology in Alzheimer's disease
Ma, R., Mu, Q., Xi, Y., Liu, G., & Liu, C. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101145 · Cited by 23 · see citing works
The Significance of Vascular Pathogenesis in the Examination of Corticobasal Syndrome
Dunalska, A., Pikul, J., Schok, K., Wiejak, K., & Alster, P. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.668614 · Cited by 23 · see citing works
Thornton, T., Mills, D. E., & Bliss, E. (2023) · Nutrients · doi:10.3390/nu15061537 · Cited by 25 · see citing works
Alrouji, M., Alshammari, M. S., Syed, T., & Shamsi, A. (2025) · Antioxidants · doi:10.3390/antiox14070774 · Cited by 21 · see citing works
Tubulin modifying enzymes as target for the treatment of tau-related diseases
Rogowski, K., Hached, K., Crozet, C., & van der Laan, S. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107681 · Cited by 21 · see citing works
Cytomegalovirus infection induces Alzheimer’s disease-associated alterations in tau
Mody, P. H., Marvin, K. N., Hynds, D. L., & Hanson, L. K. (2023) · Journal of NeuroVirology · doi:10.1007/s13365-022-01109-9 · Cited by 22 · see citing works
Das, B., Mathew, A. T., Baidya, A. T. K., Devi, B., Rampa, R. S., & Kumar, R. (2023) · Molecular Diversity · doi:10.1007/s11030-023-10645-3 · Cited by 19 · see citing works
Wang, R., Lu, K. P., & Zhou, X. Z. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15909 · Cited by 20 · see citing works
Bar, S., Wilson, K. A., Hilsabeck, T. A. U., Alderfer, S. A., Dammer, E. B., Burton, J. B., Shah, S., Holtz, A. N., Carrera, E. M., Beck, J. N., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01314-w · Cited by 19 · see citing works
Imaging pathological tau in atypical parkinsonisms: A review
Mena, A. M., & Strafella, A. P. (2022) · Clinical Parkinsonism & Related Disorders · doi:10.1016/j.prdoa.2022.100155 · Cited by 20 · see citing works
The genetic basis of multiple system atrophy
Tseng, F. S., Foo, J. Q. X., Mai, A. S., & Tan, E. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03905-1 · Cited by 19 · see citing works
Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics
Arar, S. H., Haque, M. A., & Kayed, R. (2023) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26561 · Cited by 19 · see citing works
Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
Jiang, Y., & MacNeil, L. T. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00664-x · Cited by 20 · see citing works
Loppinet, E., Besser, H. A., Sewa, A. S., Yang, F.-C., Jabrì, B., & Khosla, C. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2022.12.002 · Cited by 19 · see citing works
MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy
Ressler, H. W., Humphrey, J., Vialle, R. A., Babrowicz, B. M., Kandoi, S., Raj, T., Dickson, D. W., Ertekin‐Taner, N., Crary, J. F., & Farrell, K. W. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01839-3 · Cited by 17 · see citing works
Hall, J. R., Petersen, M. E., Johnson, L. A., & O’Bryant, S. E. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.774049 · Cited by 16 · see citing works
Interaction of Proteins Involved in Neuronal Proteinopathies
Kulichikhin, K. Y., Malikova, O. A., Zobnina, A. E., Zalutskaya, N. M., & Rubel, A. A. (2023) · Life · doi:10.3390/life13101954 · Cited by 17 · see citing works
Alyenbaawi, H., Allison, W. T., & Mok, S. (2020) · Biomolecules · doi:10.3390/biom10111487 · Cited by 18 · see citing works
McMurray, L., Macdonald, J. A., Ramakrishnan, N. K., Zhao, Y., Williamson, D. W., Tietz, O., Zhou, X., Kealey, S., Fagan, S. G., Smolek, T., et al. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00790 · Cited by 17 · see citing works
Tau oligomers impair memory and synaptic plasticity through the cellular prion protein
Balducci, C., Orsini, F., Cerovic, M., Beeg, M., Rocutto, B., Dacomo, L., Masone, A., Busani, E., Raimondi, I., Lavigna, G., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-01930-3 · Cited by 16 · see citing works
Davidson, R., Krider, R. I., Borsellino, P., Noorda, K., Alhwayek, G., & Vida, T. A. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110553 · Cited by 17 · see citing works
Tau in the gut, does it really matter?
Derkinderen, P., Rolli‐Derkinderen, M., Chapelet, G., Neunlist, M., & Noble, W. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15320 · Cited by 14 · see citing works
Reversible Tau Phosphorylation Induced by Synthetic Torpor in the Spinal Cord of the Rat
Hitrec, T., Squarcio, F., Cerri, M., Martelli, D., Occhinegro, A., Piscitiello, E., Tupone, D., Amici, R., & Luppi, M. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.592288 · Cited by 16 · see citing works
Tau Protein Biosensors in the Diagnosis of Neurodegenerative Diseases
Sadeghzadeh, J., Shahabi, P., Farhoudi, M., Kalan, A. E., Mobed, A., & Shahpasand, K. (2022) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2023.061 · Cited by 15 · see citing works
- Authors
- Kovács, G. G.
- Affiliations
- Medical University of Vienna (AT)
- Corresponding author
- Gábor Géza Kovács
- ORCID
- Gábor Géza Kovács
- Venue
- Handbook of Clinical Neurology
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 145
- Pages
- 355-368
- ISSN
- 0072-9752 (ISSN-L)
- OpenAlex
- W4247443907
- Cited by
- 225
- References
- 73
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 41 · 2023: 38 · 2022: 35 · 2021: 36 · 2020: 20 · 2019: 15 · 2018: 6 · 2014: 1
- FWCI
- 36.00
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Handbook of clinical neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- tauopathy, tau protein, neurodegenerative diseases, Pick's disease, progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, globular glial tauopathy, primary age-related tauopathy, chronic traumatic encephalopathy, frontotemporal dementia, corticobasal syndrome, Richardson syndrome, cell-to-cell transmission, cerebrospinal fluid biomarkers, neuroimaging
- MeSH terms
- Animals, Brain, Humans, tau Proteins, Tauopathies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
