The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation
Open accessAbstract
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria through an autophagy mechanism, thus maintaining mitochondria and intracellular homeostasis. In recent years, mitophagy has received increasing attention as a research hotspot related to the pathogenesis of clinical diseases, such as neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases, and so on. It has been found that the regulation of mitophagy may become a new direction for the treatment of some diseases. In addition, numerous small molecule modulators of mitophagy have also been reported, which provides new opportunities to comprehend the procedure and potential of therapeutic development. Taken together, in this review, we summarize current understanding of the mechanism of mitophagy, discuss the roles of mitophagy and its relationship with diseases, introduce the existing small-molecule pharmacological modulators of mitophagy and further highlight the significance of their development.
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Cites
2 retracted
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Cited by
Lin, B., Wu, T., Nasb, M., Li, Z., & Chen, N. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.02.017 · Cited by 26
Self-citationThe pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease
Shen, Q., Yang, M., Wang, S., Chen, X., Chen, S., Zhang, R., Xiong, Z., & Leng, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1374644 · Cited by 15
Metadata
- Authors
- Lu, Y., Li, Z., Zhang, S., Zhang, T., Liu, Y., & Zhang, L.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2023
- Volume
- 13
- Issue
- 2
- Pages
- 736-766
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W4313578986
- Cited by
- 685
- References
- 215
- FWCI
- 114.56
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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