Regular exercise alleviates metabolic dysfunction-associated steatohepatitis through rescuing mitochondrial oxidative stress and dysfunction in liver
Abstract
Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by severe mitochondrial dysfunction, associated with the production of mitochondrial reactive oxygen species (mROS). The substantial generation of mROS in the MASH liver, resulting from lipid surplus and electron transport chain (ETC) overload, impairs mitochondrial structure and functionality, thereby contributing to the development of severe hepatic steatosis and inflammation. Regular exercise represents an effective strategy for the treatment of MASH. Understanding the effects of exercise on oxidative stress and mitochondrial function is essential for effective treatment of MASH. This article reviews the pathological alterations in mitochondrial β-oxidation, ETC efficiency and mROS production within MASH liver. Additionally, it discusses how exercise influences the redox state and mitochondrial quality control mechanisms-such as biogenesis, mitophagy, fusion, and fission-within the MASH liver. The article emphasizes the importance of in-depth studies on exercise-induced MASH mitigation through the enhancement of mitochondrial redox balance, quality control, and function. Exploring the relationship between exercise and hepatic mitochondria could provide valuable insights into identifying potential therapeutic targets for MASH.
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Preclinical and clinical data support exercise-induced attenuation of fibrogenesis through reduced stellate cell activation and oxidative stress.
“Preclinical and clinical data also support exercise-induced attenuation of fibrogenesis through reduced stellate cell activation and oxidative stress [34].”
From Aerobic Exercise Training Leads to MASH Resolution as Defined by the MASH Resolution Index (2026) · cites this paper as [34]
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Flagged first, then by citations
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Self-citation
- Authors
- Lin, B., Wu, T., Nasb, M., Li, Z., & Chen, N.
- Affiliations
- Wuhan Sports University (CN)
- Corresponding author
- Li, Zeyun
- Chen, Ning
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2025-03
- Volume
- 230
- Pages
- 163-176
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W4407439093
- Cited by
- 26
- References
- 150
- Citations by year
- 2026: 18 · 2025: 8
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wuhan Sports University
- National Natural Science Foundation of China (32471186)
- Hubei Provincial Department of Education
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- nonalcoholic steatohepatitis, physical activity, mitochondrial oxidative stress, mitochondrial dysfunction, mitochondrial reactive oxygen species, electron transport chain, mitochondrial beta-oxidation, hepatic steatosis, liver inflammation, mitochondrial quality control, mitophagy, mitochondrial biogenesis, mitochondrial fission and fusion, mitochondrial redox balance
- MeSH terms
- Animals, Fatty Liver, Humans, Liver, Mitochondria, Mitochondria, Liver, Oxidation-Reduction, Exercise, Reactive Oxygen Species, Oxidative Stress, Mitophagy, Non-alcoholic Fatty Liver Disease
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