The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Naturally-occurring beta-lactamase inhibitors with antibacterial activity
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In the citing paper
“Clavulanic acid was first purified as a novel β-lactamase inhibitor from S. clavuligerus ATCC 27064, which was isolated from South American soil in 1971 (Higgens and Kastner, 1971; Brown et al., 1976).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Brown et al., 1976
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In the citing paper
“Clavulanic acid as a β-lactamase inhibitor was initially isolated from S. clavuligerus ATCC 27064 using the traditional fermentation system (Higgens and Kastner, 1971; Brown et al., 1976).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Brown et al., 1976
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Citations
Cites
Howarth, T. T., BROWN, A. G., & King, T. J. (1976) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c3976000266b · Cited by 162
Self-citationSTUDIES ON PENICILLINASE INHIBITORS PRODUCED BY MICROORGANISMS
Hata, T., Ōmura, S., IWAI, Y., Ohno, H., Takeshima, H., & YAMAGUCHI, N. (1972) · The Journal of Antibiotics · doi:10.7164/antibiotics.25.473 · Cited by 28
Research works printed but not linked: 2
- HOWARTH, T. T.; A. G. BROWN & T. J. KING: Clavulanic acid, a novel (3-lactam antibiotic isolated from Streptomyces clavuligerus. J.C.S. Chem. Comm. 1976 in press
- MIYAMURA, S. & H. OCHIAI: Inhibitors of 9- lactamases from Gram-negative bacilli. Proc. 8th Internat. Congr. Chemotherapy, Athens. pp. 218~223, 1973
Cited by
Sorted by citations
Carbapenems: Past, Present, and Future
Papp‐Wallace, K. M., Endimiani, A., Taracila, M. A., & Bonomo, R. A. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00296-11 · Cited by 1,609
Platforms for antibiotic discovery
Lewis, K. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3975 · Cited by 1,527
The role of natural product chemistry in drug discovery
Butler, M. S. (2004) · Journal of Natural Products · doi:10.1021/np040106y · Cited by 1,381
β-Lactamases and β-Lactamase Inhibitors in the 21st Century
Tooke, C. L., Hinchliffe, P., Bragginton, É. C., Colenso, C. K., Hirvonen, V. H. A., Takebayashi, Y., & SPENCER, J. M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.04.002 · Cited by 1,062
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Tyers, M., & Wright, G. D. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0141-x · Cited by 849
Metadata
- Authors
- BROWN, A. G., BUTTERWORTH, D., COLE, M., HANSCOMB, G., HOOD, J. D., READING, C., & ROLINSON, G. N.
- ORCID
- BROWN, A. G.
- Venue
- The Journal of Antibiotics
- Published
- 1976
- Volume
- 29
- Issue
- 6
- Pages
- 668-669
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2000168862
- Cited by
- 399
- References
- 2
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 13 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 7
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Antibiotics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis of β-Lactam Compounds
- Keywords
- beta-lactamase inhibitors, natural products, antibacterial activity, beta-lactam antibiotics, enzyme inhibition
- MeSH terms
- Amidohydrolases, Anti-Bacterial Agents, Bacteria, Enterobacteriaceae, Streptomyces, beta-Lactams, beta-Lactamase Inhibitors
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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