Bioactive compounds from marine yeast inhibits lung cancer
Open accessAbstract
Anticancer agents derived from natural products such as various sources like plants, animals and microorganisms.Marine-derived microorganism has become important sources of new bioactive molecules.The products isolated from marine sources possess cytotoxic activities against many cancers.Secondary metabolites as a source of Candida albicans natural drugs many of the medicines prescribed today are natural products obtained from terrestrial plants and microorganisms.The major components (80-90%) of cell wall of are carbohydrates, mannose or polymers of mannose covalently associated with proteins to form glycoproteins.The American Cancer Society has estimated 159,260 deaths due to lung cancer from diagnosis of 224,210 new cases in the United States in 2014.The International Agency for Research on Cancer estimated over 1 million new cancers cases in India in 2012 (10, 14, 934).In this study, we aimed to find new bioactive compounds from crude culture extracts produced by C. albicans as isolated from coastal mangrove ecosystem and docking studies were carried out.
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
- Authors
- Sekar, M., Poomalai, S., Gunasekaran, M., Mani, P., & Krishnamurthy, A.
- Affiliations
- Bioinformatics- Department of Zoology, Annamalai University, Chidambaram, India.
- Annamalai University (IN)
- BIOVIA (US)
- Venue
- Journal of Applied Pharmaceutical Science
- Publisher
- SAGE Publications
- Published
- 2015-07
- Volume
- 5
- Issue
- S2
- Pages
- 007-015
- ISSN
- 2231-3354 (ISSN-L)
- OpenAlex
- W1869249477
- Cited by
- 8
- References
- 24
- Citations by year
- 2023: 2 · 2022: 1 · 2020: 3 · 2019: 1 · 2016: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Applied Pharmaceutical Science (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- marine yeast, Candida albicans, lung cancer, anticancer activity, bioactive compounds, secondary metabolites, mangroves, molecular docking, cytotoxicity, yeast cell wall
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