Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer

Schumacher, Marc; Kelkel, Mareike; Dicato, Mario; Diederich, Marc

doi:10.1016/j.biotechadv.2011.02.002

Cited by 138Marine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisSeaweed-derived Bioactive Compounds

Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer

Schumacher, Marc, Kelkel, Mareike, Dicato, Mario, Diederich, Marc·2011·Biotechnology Advances

DOI 10.1016/j.biotechadv.2011.02.002

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Abstract

Cancer is one of the most deadly diseases in the world. Although advances in the field of chemo-preventive and therapeutic medicine have been made regularly over the last ten years, the search for novel anticancer treatments continues. In this field, the marine environment, with its rich variety of organisms, is a largely untapped source of novel compounds with potent antitumor activity. Although many reviews of marine anticancer compounds have been published, we focus here on selected marine compounds that act on the six hallmarks of cancer presented namely self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replication, sustained angiogenesis and tissue invasion and metastasis.

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Cancer preventive compounds may stimulate anticancer immunity, inhibit inflammation, angiogenesis and tumor invasion, or protect from UV-radiation damage.
“Cancer preventive compounds may stimulate anticancer immunity, inhibit inflammation, angiogenesis and tumor invasion, or protect from UV-radiation damage [144,145,146,147].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [147]

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Aerogels—Airy Materials: Chemistry, Structure, and Properties
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Authors: Schumacher, M., Kelkel, M., Dicato, M., & Diederich, M.
Affiliations: Hôpital Kirchberg (LU)
Corresponding author: Diederich, Marc
ORCID: Schumacher, Marc
Kelkel, Mareike
Diederich, Marc
Venue: Biotechnology Advances
Publisher: Elsevier BV
Published: 2011-09
Volume: 29
Issue: 5
Pages: 531-547
ISSN: 0734-9750 (ISSN-L)
DOI: 10.1016/j.biotechadv.2011.02.002
OpenAlex: W2001546125
Cited by: 138
References: 169
Citations by year: 2026: 1 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 10 · 2017: 11 · 2016: 8 · 2015: 13 · 2014: 16 · 2013: 14 · 2012: 10
FWCI: 1.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biotechnology Advances (publishedVersion)
PubMed (publishedVersion)
Funders: Fonds National de la Recherche Luxembourg
Fondation Recherche Cancer et Sang
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords: marine natural products, anticancer agents, cancer hallmarks, chemoprevention, anticancer activity, angiogenesis, metastasis, tissue invasion, marine organisms
MeSH terms: Animals, Antineoplastic Agents, Biological Products, Biotechnology, Humans, Neoplasm Metastasis, Neovascularization, Pathologic, Apoptosis, Cell Growth Processes, Drug Discovery, Aquatic Organisms

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Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer

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