The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Intravascular and Mucosal Immunoglobulin A: Two Separate but Related Systems of Immune Defense?
Abstract
Immunoglobulin A has long been referred to as the antibody of mucosal secretions. However, in the last few years there has been increased interest in serum IgA, in factors that regulate the various forms of IgA produced, and in the relationship between serum and mucosal IgA. Recent data indicate that in humans, the mucosal surfaces are neither the source nor the destination of serum IgA. By estimating the amounts of IgA produced at various sites throughout the body, we have shown that in humans more IgA is synthesized and secreted each day than IgG and IgM combined; about one third of this IgA is secreted directly into the vascular compartment and never reaches the mucosal surfaces. We also consider a possible role for serum IgA as the "discreet housekeeper," the relationship between cells that produce IgA in the serum and IgA in secretions, and factors that influence the various forms of IgA produced.
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Cites
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CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS
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PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR I G A-PRODUCING IMMUNOCYTES IN THE RABBIT
Craig, S. W., & Cebra, J. J. (1971) · The Journal of Experimental Medicine · doi:10.1084/jem.134.1.188 · Cited by 755
Inhibition of Bacterial Adherence by Secretory Immunoglobulin A: A Mechanism of Antigen Disposal
Williams, R. C., & Gibbons, R. J. (1972) · Science · doi:10.1126/science.177.4050.697 · Cited by 753
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The gut‐associated lymphoid system: nature and properties of the large dividing cells
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Cited by
Yel, L. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9357-x · Cited by 580
Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection
Russell, M. W., Moldoveanu, Z., Ogra, P. L., & Mestecky, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.611337 · Cited by 389
Physiology of IgA and IgA Deficiency
Cunningham-Rundles, C. (2001) · Journal of Clinical Immunology · doi:10.1023/a:1012241117984 · Cited by 366
Regulation of IgA synthesis and immune response by T cells and interleukins
McGhee, J. R., Mestecky, J., Elson, C. O., & Kiyono, H. (1989) · Journal of Clinical Immunology · doi:10.1007/bf00916814 · Cited by 276
The role of M cells in mucosal immunity
Hathaway, L. J., & Kraehenbuhl*, J.-P. (2000) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/pl00000693 · Cited by 131
Metadata
- Authors
- CONLEY, M. E., & DELACROIX, D. L.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1987-06-01
- Volume
- 106
- Issue
- 6
- Pages
- 892-899
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2094834014
- Cited by
- 375
- References
- 45
- FWCI
- 15.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- CONLEY, M. E., & DELACROIX, D. L. (1987). Intravascular and Mucosal Immunoglobulin A: Two Separate but Related Systems of Immune Defense? Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-106-6-892
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
