The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection
Open accessAbstract
The mucosal immune system is the largest component of the entire immune system, having evolved to provide protection at the main sites of infectious threat: the mucosae. As SARS-CoV-2 initially infects the upper respiratory tract, its first interactions with the immune system must occur predominantly at the respiratory mucosal surfaces, during both inductive and effector phases of the response. However, almost all studies of the immune response in COVID-19 have focused exclusively on serum antibodies and systemic cell-mediated immunity including innate responses. This article proposes that there is a significant role for mucosal immunity and for secretory as well as circulating IgA antibodies in COVID-19, and that it is important to elucidate this in order to comprehend especially the asymptomatic and mild states of the infection, which appear to account for the majority of cases. Moreover, it is possible that mucosal immunity can be exploited for beneficial diagnostic, therapeutic, or prophylactic purposes.
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Cites
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
Blanco-Melo, D., Nilsson-Payant, B. E., Liu, W.-C., Uhl, S., Hoagland, D., Møller, R., Jordan, T. X., Oishi, K., Panis, M., Sachs, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.026 · Cited by 4,222
Immunology of COVID-19: Current State of the Science
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IgA dominates the early neutralizing antibody response to SARS-CoV-2
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Cervia, C., Nilsson, J., Zurbuchen, Y., Valaperti, A., Schreiner, J., Wolfensberger, A., Raeber, M. E., Adamo, S., Weigang, S., Emmenegger, M., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.040 · Cited by 408
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Intravascular and Mucosal Immunoglobulin A: Two Separate but Related Systems of Immune Defense?
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Cited by
Ndeupen, S., Qin, Z., Jacobsen, S., Bouteau, A., Estanbouli, H., & Igyártó, B. Z. (2021) · iScience · doi:10.1016/j.isci.2021.103479 · Cited by 678
The Proportion of SARS-CoV-2 Infections That Are Asymptomatic: A Systematic Review
Oran, D. P., & Topol, E. J. (2021) · Annals of Internal Medicine · doi:10.7326/m20-6976 · Cited by 533
The germinal centre B cell response to SARS-CoV-2
Laidlaw, B. J., & Ellebedy, A. H. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00657-1 · Cited by 268
Li, J., Xing, H., Meng, F., Liu, T., Hong, X., Han, X., Dong, Y., Li, M., Wang, Z., Zhang, S., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c01277 · Cited by 2
Metadata
- Authors
- Russell, M. W., Moldoveanu, Z., Ogra, P. L., & Mestecky, J.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-11-30
- Volume
- 11
- Pages
- 611337-611337
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3109360305
- Cited by
- 389
- References
- 34
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- gold
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- Russell, M. W., Moldoveanu, Z., Ogra, P. L., & Mestecky, J. (2020). Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.611337
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