Medical Futility: Its Meaning and Ethical Implications
Abstract
The notion of medical futility has quantitative and qualitative roots that offer a practical approach to its definition and application. Applying these traditions to contemporary medical practice, we propose that when physicians conclude (either through personal experience, experiences shared with colleagues, or consideration of published empiric data) that in the last 100 cases a medical treatment has been useless, they should regard that treatment as futile. If a treatment merely preserves permanent unconsciousness or cannot end dependence on intensive medical care, the treatment should be considered futile. Unlike decision analysis, which defines the expected gain from a treatment by the joint product of probability of success and utility of outcome, our definition of futility treats probability and utility as independent thresholds. Futility should be distinguished from such concepts as theoretical impossibility, such expressions as "uncommon" or "rare," and emotional terms like "hopelessness." In judging futility, physicians must distinguish between an effect, which is limited to some part of the patient's body, and a benefit, which appreciably improves the person as a whole. Treatment that fails to provide the latter, whether or not it achieves the former, is "futile". Although exceptions and cautions should be borne in mind, we submit that physicians can judge a treatment to be futile and are entitled to withhold a procedure on this basis. In these cases, physicians should act in concert with other health care professionals, but need not obtain consent from patients or family members.
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From Principles of Clinical Ethics and Their Application to Practice (2021) · cites this paper as [21]
Cites
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,333 · see citing works
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379 · see citing works
Beecher, H. K. (1955) · JAMA · doi:10.1001/jama.1955.02960340022006 · Cited by 1,850 · see citing works
Freiman, J. A., Chalmers, T. C., Smith, H., & Kuebler, R. R. (1978) · New England Journal of Medicine · doi:10.1056/nejm197809282991304 · Cited by 1,628 · see citing works
An Evaluation of Outcome from Intensive Care in Major Medical Centers
Knaus, W. A., DRAPER, E. A., WAGNER, D. P., & ZIMMERMAN, J. E. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-3-410 · Cited by 1,191 · see citing works
Survival after Cardiopulmonary Resuscitation in the Hospital
Bedell, S. E., Delbanco, T. L., Cook, E. F., & Epstein, F. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198309083091001 · Cited by 860 · see citing works
The Physician's Responsibility toward Hopelessly Ill Patients
Wanzer, S. H., Adelstein, S. J., Cranford, R. E., Federman, D. D., Ed, H., Cg, M., Safar, P. J., Stone, A. A., Taussig, H. B., & van Eys, J. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404123101505 · Cited by 427 · see citing works
In-Hospital Cardiopulmonary Resuscitation
Taffet, G. E. (1988) · JAMA · doi:10.1001/jama.1988.03410140081027 · Cited by 412 · see citing works
Outcomes of Cardiopulmonary Resuscitation in the Elderly
Murphy, D. J., Murray, A. M., Robinson, B. E., & Campion, E. W. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-3-199 · Cited by 368 · see citing works
Blackhall, L. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172009 · Cited by 368 · see citing works
Youngner, S. J. (1988) · JAMA · doi:10.1001/jama.1988.03410140106033 · Cited by 315 · see citing works
Ethics and Communication in Do-Not-Resuscitate Orders
Tomlinson, T., & Brody, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198801073180109 · Cited by 267 · see citing works
The illusion of futility in clinical practice
Lantos, J. D., SINGER, P. A., Walker, R. M., Gramelspacher, G. P., Shapiro, G. R., Sánchez-González, M. Á., Stocking, C. B., Miles, S. H., & Siegler, M. A. (1989) · The American Journal of Medicine · doi:10.1016/s0002-9343(89)80487-5 · Cited by 258 · see citing works
The Therapeutic Revolution: Medicine, Meaning, and Social Change in Nineteenth-Century America
Rosenberg, C. E. (1977) · Perspectives in biology and medicine · doi:10.1353/pbm.1977.0040 · Cited by 237 · see citing works
Why Saying No to Patients in the United States Is So Hard
Daniels, N. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142109 · Cited by 186 · see citing works
The Physician's Obligation to Prolong Life: A Medical Duty without Classical Roots
Amundsen, D. W. (1978) · The Hastings Center Report · doi:10.2307/3560974 · Cited by 123 · see citing works
Survival after Cardiopulmonary Resuscitation in Babies of Very Low Birth Weight
Lantos, J. D., Miles, S. H., Silverstein, M. D., & Stocking, C. B. (1988) · New England Journal of Medicine · doi:10.1056/nejm198801143180206 · Cited by 120 · see citing works
Ethical Decisions in Discontinuing Mechanical Ventilation
Schneiderman, L. J., & Spragg, R. G. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804143181509 · Cited by 95 · see citing works
Self-citationThe Persistent Vegetative State: The Medical Reality (Getting the Facts Straight)
Cranford, R. E. (1988) · The Hastings Center Report · doi:10.2307/3562014 · Cited by 94 · see citing works
Results of cardiac resuscitation in 552 patients
Johnson, A. L., Tanser, P. H., Ulan, R. A., & Wood, T. E. (1967) · The American Journal of Cardiology · doi:10.1016/0002-9149(67)90397-9 · Cited by 93 · see citing works
Autonomy for Burned Patients When Survival Is Unprecedented
Imbus, S. H., & Zawacki, B. E. (1977) · New England Journal of Medicine · doi:10.1056/nejm197708112970605 · Cited by 78 · see citing works
Cost-Effectiveness Analysis in Health Care
Emery, D., & Schneiderman, L. J. (1989) · The Hastings Center Report · doi:10.2307/3562293 · Cited by 51 · see citing works
Self-citationPerkins, H. S. (1986) · Journal of General Internal Medicine · doi:10.1007/bf02602333 · Cited by 35 · see citing works
Cardiopulmonary Resuscitation of the Elderly
Gordon, M., & Hurowitz, E. E. (1984) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1984.tb00895.x · Cited by 25 · see citing works
Futile feeding at the end of life: Family virtues and treatment decisions
Miles, S. H. (1987) · Metamedicine · doi:10.1007/bf00489465 · Cited by 18 · see citing works
Continued Treatment of the Fatally Ill for the Benefit of Others
Yarborough, M. A. (1988) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1988.tb03435.x · Cited by 14 · see citing works
What does life support support?
Jonsen, A. R. (1987) · PubMed · Cited by 10 · see citing works
Self-citationAnencephalic infants and special relationships
Jecker, N. S. (1990) · Metamedicine · doi:10.1007/bf00489823 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The APACHE III Prognostic System
Knaus, W. A., Wagner, D. P., Draper, E. A., Zimmerman, J. E., Bergner, M., BASTOS, P. G., Sirio, C., Murphy, D. J., Lotring, T., Damiano, A., et al. (1991) · CHEST Journal · doi:10.1378/chest.100.6.1619 · Cited by 3,524 · see citing works
The APACHE III Prognostic System
Teres, D., & Lemeshow, S. A. (1992) · CHEST Journal · doi:10.1378/chest.102.6.1919b · Cited by 2,880 · see citing works
Principles of Clinical Ethics and Their Application to Practice
Varkey, B. (2021) · Medical Principles and Practice · doi:10.1159/000509119 · Cited by 1,171 · see citing works
Ethnicity and Attitudes Toward Patient Autonomy
Blackhall, L. J. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03530100060035 · Cited by 1,011 · see citing works
Increasing Incidence of Withholding and Withdrawal of Life Support From the Critically Ill
Prendergast, T. J., & Luce, J. M. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001282 · Cited by 726 · see citing works
Quill, T. E., & Brody, H. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-125-9-199611010-00010 · Cited by 721 · see citing works
Nates, J. L., Nunnally, M., Kleinpell, R., Blosser, S., Goldner, J., Birriel, B., Fowler, C. S., Byrum, D., Miles, W. S., Bailey, H., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001856 · Cited by 683 · see citing works
Bosslet, G. T., Pope, T. M., Rubenfeld, G. D., Lo, B., Truog, R. D., Rushton, C. H., Curtis, J. R., Ford, D. W., Osborne, M. L., Misak, C., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201505-0924st · Cited by 657 · see citing works
The APACHE III Prognostic System
Knaus, W. A. (1992) · CHEST Journal · doi:10.1016/s0012-3692(16)40910-4 · Cited by 626 · see citing works
Rethinking the Role of Tube Feeding in Patients with Advanced Dementia
Gillick, M. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420312 · Cited by 620 · see citing works
Murayama, K. M. (2007) · Cited by 477 · see citing works
Truog, R. D., Brett, A. S., & Frader, J. E. (1992) · New England Journal of Medicine · doi:10.1056/nejm199206043262310 · Cited by 465 · see citing works
Vincent, J. (1999) · Critical Care Medicine · doi:10.1097/00003246-199908000-00042 · Cited by 419 · see citing works
Reproduction at an advanced maternal age and maternal health
Sauer, M. V. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.03.004 · Cited by 380 · see citing works
Azoulay, É., Alberti, C., Bornstain, C., Leleu, G., Moreau, D., Récher, C., Chevret, S., Gall, J. L., Brochard, L. J., & Schlemmer, B. (2001) · Critical Care Medicine · doi:10.1097/00003246-200103000-00009 · Cited by 371 · see citing works
White, D. B. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.5.461 · Cited by 345 · see citing works
The Rise and Fall of the Futility Movement
Helft, P. R., Siegler, M. A., & Lantos, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430411 · Cited by 343 · see citing works
The Economics of Dying -- The Illusion of Cost Savings at the End of Life
Emanuel, E. J., & Emanuel, L. L. (1994) · New England Journal of Medicine · doi:10.1056/nejm199402243300806 · Cited by 335 · see citing works
Medical Futility in End-of-Life Care: Report of the Council on Ethical and Judicial Affairs
American Medical Association Council on Ethical and Judician Affairs (1999) · JAMA · doi:10.1001/jama.281.10.937 · Cited by 330 · see citing works
Opening the Black Box: How Do Physicians Communicate about Advance Directives?
Tulsky, J. A., Fischer, G. S., Rose, M. R., & Arnold, R. M. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-6-199809150-00003 · Cited by 323 · see citing works
Validation of a Rule for Termination of Resuscitation in Out-of-Hospital Cardiac Arrest
Morrison, L. J., Visentin, L. M., Kiss, A., Theriault, R., Eby, D., Vermeulen, M. J., Sherbino, J., & Verbeek, P. R. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052620 · Cited by 323 · see citing works
Predictive value of somatosensory evoked potentials for awakening from coma*
Robinson, L. R., Micklesen, P. J., Tirschwell, D., & Lew, H. L. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000053643.21751.3b · Cited by 279 · see citing works
Gray, W. A., Capone, R. J., & Most, A. S. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111143252001 · Cited by 268 · see citing works
Morrison, L., Kierzek, G., Diekema, D., Sayre, M., Silvers, S. M., Idris, A., & Mancini, M. (2010) · Circulation · doi:10.1161/circulationaha.110.970905 · Cited by 243 · see citing works
Outcomes of Critically Ill Cancer Patients in a University Hospital Setting
Kress, J. P., CHRISTENSON, J., Pohlman, A. S., Linkin, D. R., & HALL, J. B. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.9812055 · Cited by 255 · see citing works
Asch, D. A., Hansen-Flaschen, J. H., & Lanken, P. N. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.2.7842181 · Cited by 250 · see citing works
Withholding and Withdrawing Life-sustaining Therapy
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-6-478 · Cited by 242 · see citing works
A Multi-institution Collaborative Policy on Medical Futility
Halevy, A. (1996) · JAMA · doi:10.1001/jama.1996.03540070067035 · Cited by 235 · see citing works
Short-Rerm Mortality Predictions for Critically Ill Hospitalized Adults: Science and Ethics
Knaus, W. A., Wagner, D. P., & Lynn, J. (1991) · Science · doi:10.1126/science.1925596 · Cited by 232 · see citing works
Empathy development in medical education – A critical review
Pedersen, R. (2010) · Medical Teacher · doi:10.3109/01421590903544702 · Cited by 221 · see citing works
Puri, R., Iung, B., Cohen, D. J., & Rodés‐Cabau, J. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv756 · Cited by 217 · see citing works
(1997) · Critical Care Medicine · doi:10.1097/00003246-199705000-00028 · Cited by 202 · see citing works
Ebell, M. H., Jang, W., Shen, Y., & Geocadin, R. G. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.10037 · Cited by 198 · see citing works
Prehospital Termination of Resuscitation in Cases of Refractory Out-of-Hospital Cardiac Arrest
Sasson, C. (2008) · JAMA · doi:10.1001/jama.300.12.1432 · Cited by 197 · see citing works
Physician characteristics associated with decisions to withdraw life support.
Christakis, N. A., & Asch, D. A. (1995) · American Journal of Public Health · doi:10.2105/ajph.85.3.367 · Cited by 195 · see citing works
Knowing when to stop: futility in the ICU
Wilkinson, D. J. C., & Savulescu, J. (2011) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e328343c5af · Cited by 191 · see citing works
Do-not-resuscitate order after 25 years*
Burns, J. P., Edwards, J. D., Johnson, J. A., Cassem, N. H., & Truog, R. D. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000064743.44696.49 · Cited by 187 · see citing works
Defining Medical Futility and Improving Medical Care
Schneiderman, L. J. (2011) · Journal of Bioethical Inquiry · doi:10.1007/s11673-011-9293-3 · Cited by 186 · see citing works
Self-citationAntenatal Counseling Regarding Resuscitation at an Extremely Low Gestational Age
Batton, D. G. (2009) · PEDIATRICS · doi:10.1542/peds.2009-1060 · Cited by 186 · see citing works
Goto, Y., Funada, A., & Goto, Y. N. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002819 · Cited by 186 · see citing works
Fair Allocation of Intensive Care Unit Resources
(1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.4.ats7-97 · Cited by 182 · see citing works
Decision‐Making and Outcomes of Prolonged ICU Stays in Seriously Ill Patients
Teno, J. M., Fisher, E., Hamel, M. B., Wu, A. W., Murphy, D. J., Wenger, N. S., Lynn, J., & Harrell, F. E. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03144.x · Cited by 182 · see citing works
Consensus Statement on the Triage of Critically III Patients
Sprung, C. L. (1994) · JAMA · doi:10.1001/jama.1994.03510390070032 · Cited by 182 · see citing works
Rabeneck, L., McCullough, L. B., & Wray, N. P. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07369-2 · Cited by 179 · see citing works
Rab, T., Kern, K. B., Tamis‐Holland, J. E., Henry, T. D., McDaniel, M. C., Dickert, N. W., Cigarroa, J. E., Keadey, M. T., & Ramee, S. R. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.05.009 · Cited by 175 · see citing works
Danis, M., Federman, D. D., Fins, J. J., Fox, E., Kastenbaum, B. K., Lanken, P. N., Long, K., Lowenstein, E., Lynn, J., Rouse, F., et al. (1999) · Critical Care Medicine · doi:10.1097/00003246-199909000-00047 · Cited by 175 · see citing works
Luce, J. M. (1995) · Critical Care Medicine · doi:10.1097/00003246-199504000-00027 · Cited by 163 · see citing works
Outcome of bone marrow transplantation patients requiring mechanical ventilation
Huaringa, A. J., Leyva, F. J., Giralt, S. A., Blanco, J., Signes‐Costa, J., Velarde, H., & Champlin, R. E. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004000-00017 · Cited by 151 · see citing works
Burns, J. P., & Truog, R. D. (2007) · CHEST Journal · doi:10.1378/chest.07-1441 · Cited by 150 · see citing works
Use of the Medical Futility Rationale in Do-Not-Attempt-Resuscitation Orders
Curtis, J. R., Park, D. R., Krone, M., & Pearlman, R. A. (1995) · JAMA · doi:10.1001/jama.1995.03520260046031 · Cited by 150 · see citing works
Outcome of Patients Requiring Medical ICU Admission Following Bone Marrow Transplantation
Paz, H. L., Crilley, P. A., Weinar, M., & Brodsky, I. (1993) · CHEST Journal · doi:10.1378/chest.104.2.527 · Cited by 150 · see citing works
Grunau, B. E., Reynolds, J. C., Scheuermeyer, F. X., Stenstrom, R. J., Pennington, S. E., Cheung, C. C., Li, J., Habibi, M., Ramanathan, K., Barbic, D., et al. (2016) · Resuscitation · doi:10.1016/j.resuscitation.2016.01.021 · Cited by 143 · see citing works
Bashour, C. A., Yared, J., Ryan, T. A., Rady, M. Y., Mascha, E. J., Leventhal, M., & Starr, N. J. (2000) · Critical Care Medicine · doi:10.1097/00003246-200012000-00018 · Cited by 140 · see citing works
Prendergast, T. J., & Puntillo, K. (2002) · JAMA · doi:10.1001/jama.288.21.2732 · Cited by 138 · see citing works
Constructing an ethical stereotaxy for severe brain injury: balancing risks, benefits and access
Fins, J. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1079 · Cited by 137 · see citing works
Dzeng, E., Colaianni, A., Roland, M., Chander, G., Smith, T. J., Kelly, M. P., Barclay, S., & Levine, D. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.0295 · Cited by 136 · see citing works
Resolution of Futility by Due Process: Early Experience with the Texas Advance Directives Act
Fine, R. L., & Mayo, T. W. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-9-200305060-00011 · Cited by 135 · see citing works
Withdrawing life support and resolution of conflict with families
Way, J., Back, A. L., & Curtis, J. R. (2002) · BMJ · doi:10.1136/bmj.325.7376.1342 · Cited by 135 · see citing works
Perceptions of "futile care" among caregivers in intensive care units
Sibbald, R., Downar, J., & Hawryluck, L. (2007) · Canadian Medical Association Journal · doi:10.1503/cmaj.070144 · Cited by 133 · see citing works
Communicating about end-of-life care with patients and families in the intensive care unit
Curtis, J. R. (2004) · Critical Care Clinics · doi:10.1016/j.ccc.2004.03.001 · Cited by 132 · see citing works
Guidance on Forgoing Life-Sustaining Medical Treatment
Weise, K. L., Okun, A. L., Carter, B. S., Christian, C. W., COMMITTEE ON BIOETHICS, MEDICINE, S. O. H. A. P., COMMITTEE ON CHILD ABUSE AND NEGLECT, Katz, A. L., Laventhal, N. T., Macauley, R. C., et al. (2017) · Pediatrics · doi:10.1542/peds.2017-1905 · Cited by 166 · see citing works
Reasons doctors provide futile treatment at the end of life: a qualitative study
Willmott, L., White, B. P., Gallois, C., Parker, M., Graves, N., Winch, S., Callaway, L. K., Shepherd, N., & Close, E. (2016) · Journal of Medical Ethics · doi:10.1136/medethics-2016-103370 · Cited by 128 · see citing works
End-of-Life Decision Making in the Intensive Care Unit
Luce, J. M. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0071ci · Cited by 126 · see citing works
Verbeek, P. R., Vermeulen, M. J., Ali, F. H., Messenger, D. W., Summers, J., & Morrison, L. J. (2002) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2002.tb02144.x · Cited by 126 · see citing works
Jox, R. J., Schaider, A., Marckmann, G., & Borasio, G. D. (2012) · Journal of Medical Ethics · doi:10.1136/medethics-2011-100479 · Cited by 125 · see citing works
Danis, M., Mutran, E. J., Garrett, J. M., Stearns, S. C., Slifkin, R. T., Hanson, L. C., Williams, J. F., & Churchill, L. R. (1996) · Critical Care Medicine · doi:10.1097/00003246-199611000-00009 · Cited by 122 · see citing works
Medical Futility, Medical Necessity: The-Problem-without-a-Name
Callahan, D. (1991) · The Hastings Center Report · doi:10.2307/3562999 · Cited by 122 · see citing works
The negotiation of death: Clinical decision making at the end of life
Slomka, J. (1992) · Social Science & Medicine · doi:10.1016/0277-9536(92)90021-h · Cited by 121 · see citing works
Jecker, N. S., & Schneiderman, L. J. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90111-n · Cited by 121 · see citing works
Self-citationOutcome of children requiring admission to an intensive care unit after bone marrow transplantation*
Jacobe, S. J., Hassan, A. M., Veys, P. A., & Mok, Q. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000060011.88230.c8 · Cited by 118 · see citing works
Do-Not-Resuscitate Orders in Intensive Care Units
Jayes, R. L. (1993) · JAMA · doi:10.1001/jama.1993.03510180083039 · Cited by 117 · see citing works
Wissenberg, M., Folke, F., Hansen, C. M., Lippert, F. K., Kragholm, K. H., Risgaard, B., Rajan, S., Karlsson, L., Søndergaard, K. B., Hansen, S. M., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013122 · Cited by 115 · see citing works
Outcomes of Intensive Care for Patients With Human Immunodeficiency Virus Infection
Nickas, G., & Wachter, R. M. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.541 · Cited by 115 · see citing works
Karlawish, J. H., Quill, T., Meier, D. E., & Panel, F. T. A.-A. E.-O.-L. C. C. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-10-199905180-00018 · Cited by 114 · see citing works
Bernat (2005) · doi:10.1385/ncc:2:2:198 · Cited by 113 · see citing works
When is medical treatment futile?
Kasman, D. L. (2004) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2004.40134.x · Cited by 111 · see citing works
Arnold, R. M., & Kellum, J. A. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000065123.23736.12 · Cited by 110 · see citing works
Hope and Hopelessness at the End of Life
Sullivan, M. D. (2003) · The American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200307000-00002 · Cited by 109 · see citing works
End-of-life care policy: An integrated care plan for the dying
Divatia, J. V., Macaden, S. C., Muckaden, M. A., & Kulkarni, P. (2014) · Indian Journal of Critical Care Medicine · doi:10.4103/0972-5229.140155 · Cited by 109 · see citing works
Linecker, M., Krones, T., Berg, T., Niemann, C. U., Steadman, R. H., Dutkowski, P., Clavien, P., Busuttil, R. W., Truog, R. D., & Petrowsky, H. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.008 · Cited by 107 · see citing works
Winter, S. M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00609-4 · Cited by 107 · see citing works
Surrogate Decision Makers' Responses to Physicians' Predictions of Medical Futility
Zier, L. S., Burack, J. H., Micco, G. P., Chipman, A. K., Frank, J. A., & White, D. B. (2009) · CHEST Journal · doi:10.1378/chest.08-2753 · Cited by 106 · see citing works
Negotiating natural death in intensive care
Seymour, J. E. (2000) · Social Science & Medicine · doi:10.1016/s0277-9536(00)00042-3 · Cited by 106 · see citing works
Medically Futile Care: The Role of the Physician in Setting Limits
Veatch, R. M., & Spicer, C. M. (1992) · American Journal of Law & Medicine · doi:10.1017/s0098858800011333 · Cited by 106 · see citing works
Luce, J. M., & Alpers, A. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.1-00 · Cited by 104 · see citing works
A history of resolving conflicts over end-of-life care in intensive care units in the United States*
Luce, J. M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181e71530 · Cited by 102 · see citing works
Beyond futility to an ethic of care
Schneiderman, L. J., Faber‐Langendoen, K., & Jecker, N. S. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90130-9 · Cited by 101 · see citing works
Self-citationEnd-of-life care in the intensive care unit: A research agenda
Rubenfeld, G. D., & Curtis, J. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200110000-00025 · Cited by 98 · see citing works
A History of Ethics and Law in the Intensive Care Unit
Luce, J. M., & White, D. B. (2009) · Critical Care Clinics · doi:10.1016/j.ccc.2008.10.002 · Cited by 96 · see citing works
Is There a Limit to Massive Blood Transfusion After Severe Trauma?
Velmahos, G. C. (1998) · Archives of Surgery · doi:10.1001/archsurg.133.9.947 · Cited by 95 · see citing works
The relationship between age and outcome in out-of-hospital cardiac arrest patients
Andersen, L. W., Bivens, M. J., Giberson, T. A., Giberson, B., Mottley, J. L., Gautam, S., Salciccioli, J. D., Cocchi, M. N., McNally, B., & Donnino, M. W. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.05.015 · Cited by 93 · see citing works
Drennan, I. R., Lin, S., Sidalak, D., & Morrison, L. J. (2014) · Resuscitation · doi:10.1016/j.resuscitation.2014.07.011 · Cited by 93 · see citing works
Tomlinson, T., & Czlonka, D. (1995) · The Hastings Center Report · doi:10.2307/3562112 · Cited by 93 · see citing works
Do-not-attempt-cardiopulmonary-resuscitation decisions: an evidence synthesis
Perkins, G. D., Griffiths, F., Slowther, A.-M., George, R., Fritz, Z., Satherley, P., Williams, B., Waugh, N., Cooke, M. W., Chambers, S., et al. (2016) · Health Services and Delivery Research · doi:10.3310/hsdr04110 · Cited by 91 · see citing works
A randomized trial of ethics education for medical house officers.
Sulmasy, D. P., Geller, G., Levine, D. M., & Faden, R. R. (1993) · Journal of Medical Ethics · doi:10.1136/jme.19.3.157 · Cited by 89 · see citing works
MEADOW, W. L., Frain, L. N., Ren, Y., Lee, G. S., Soneji, S., & Lantos, J. D. (2002) · PEDIATRICS · doi:10.1542/peds.109.5.878 · Cited by 90 · see citing works
Point: The Ethics of Unilateral “Do Not Resuscitate” Orders
Curtis, J. R., & Burt, R. A. (2007) · CHEST Journal · doi:10.1378/chest.07-0745 · Cited by 90 · see citing works
Critically ill cancer patient in intensive care unit: Issues that arise
Kostakou, E., Rovina, N., Kyriakopoulou, M., Koulouris, N. G., & Koutsoukou, A. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2014.04.007 · Cited by 89 · see citing works
Fatally flawed? A review and ethical analysis of lethal congenital malformations
Wilkinson, D., Thiele, P., Watkins, A., & de Crespigny, L. (2012) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2012.03450.x · Cited by 86 · see citing works
Jecker, N. S. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400180012002 · Cited by 86 · see citing works
Self-citation
- Authors
- Schneiderman, L. J., Jecker, N. S., & Jonsen, A. R.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Schneiderman, Lawrence J.
- ORCID
- Jecker, Nancy S.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1990-06-15
- Volume
- 112
- Issue
- 12
- Pages
- 949-954
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2067149985
- Cited by
- 1,215
- References
- 28
- Citations by year
- 2026: 28 · 2025: 29 · 2024: 46 · 2023: 35 · 2022: 38 · 2021: 36 · 2020: 41 · 2019: 55 · 2018: 40 · 2017: 33 · 2016: 39 · 2015: 43 · 2014: 39 · 2013: 44 · 2012: 41
- FWCI
- 15.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics and bioethics in healthcare
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Ethics and Legal Issues in Pediatric Healthcare
- Keywords
- futility, treatment decision-making, withholding treatment, decision analysis, physician judgment, informed consent, end-of-life care
- MeSH terms
- Critical Care, Ethics, Medical, Euthanasia, Passive, Family, Humans, Patient Participation, Philosophy, Medical, Physician's Role, Probability, Risk Assessment, Patient Selection, Personal Autonomy, Paternalism, Moral Obligations, Withholding Treatment
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