Effects of Long-term Sulindac Therapy on Colonic Polyposis

Abstract

Brief Reports15 December 1991Effects of Long-term Sulindac Therapy on Colonic PolyposisJoaquim Rigau, MD, Josep M. Piqué, MD, Elisa Rubio, MD, Ramón Planas, MD, Josep M. Tarrech, MD, Josep M. Bordas, MDJoaquim Rigau, MD, Josep M. Piqué, MD, Elisa Rubio, MD, Ramón Planas, MD, Josep M. Tarrech, MD, Josep M. Bordas, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-12-952 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSulindac treatment has been reported to induce marked reductions in the number and size of adenomatous polyps in the rectal segment after subtotal colectomy (1). These findings were not conclusive, however, because spontaneous remission of rectal adenomas after colectomy and ileorectal anastomosis has been described in patients with familial polyposis (2). Gonzaga and co-workers (3) and Wadell and associates (4) have described patients for whom sulindac treatment has led to a decrease in diffuse adenomatous polyps in intact colons. We report our experience with seven patients having diffuse colonic polyposis treated with sulindac. Endogenous prostaglandin generation in the colonic mucosa...References1. WaddellLoughry WR. Sulindac for polyposis of the colon. J Surg Oncol. 1983;24:83-7. CrossrefMedlineGoogle Scholar2. NichollsSpringallGallagher RRP. Regression of rectal adenomas after colectomy and ileorectal anastomosis for familial adenomatous polyposis. Br Med J. 1988;296:1707-8. CrossrefMedlineGoogle Scholar3. GonzagaLimaCarneiroMacielAmarante RFSJJM. Sulindac treatment for familial polyposis coli [Letter]. Lancet. 1985;1:751. CrossrefMedlineGoogle Scholar4. WaddellGanserCeriseLoughry WGER. Sulindac for polyposis of the colon. Am J Surg. 1989;157:175-9. CrossrefMedlineGoogle Scholar5. SaperasPérez AyusoPocaBordasGayaPiqué EREJJJ. Increased gastric PGE2 biosynthesis in cirrhotic patients with gastric vascular ectasia. Am J Gastroenterol. 1990;85:138-44. MedlineGoogle Scholar6. MoorghenInceFinneySunterAppletonWatson MPKJDA. A protective effect of sulindac against chemically-induced primary colonic tumours in mice. J Pathol. 1988;156:341-7. CrossrefMedlineGoogle Scholar7. StrykerWolffCulpLibbeIlstrupMacCarty SBCSDR. Natural history of untreated colonic polyps. Gastroenterology. 1987;93:1009-13. CrossrefMedlineGoogle Scholar8. CappellForde MK. Spatial clustering of multiple hyperplastic, adenomatous, and malignant colonic polyps in individual patients. Dis Col Rectum. 1989;32:641-52. CrossrefMedlineGoogle Scholar9. BengoecheaMartinez-PeñuelaLarrinagaValerdiBorda OJBJF. Hyperplastic polyposis of the colorectum and adenocarcinoma in a 24-year-old man. Am J Surg Pathol. 1987;11:323-7. CrossrefMedlineGoogle Scholar10. NicholsonNeoptolemosClaytonTalbotBell MJHIP. Increased cell membrane arachidonic acid in experimental colorectal tumors. Gut. 1991;32:413-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Hospital General de Granollers; the Hospital Clínic de Barcelona: and the Hospital Germans Trias i Pujol de Badalona, Barcelona, Spain. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNonsteroidal anti-inflammatory drugs but not aspirin are associated with a lower risk of post-colonoscopy colorectal cancerPIK3CA mutations in colorectal and breast cancer: impact on oncogenesis and response to nonsteroidal anti-inflammatory drugsColorectal Carcinoma: A General Overview and Future Perspectives in Colorectal CancerClinical Effects of NSAIDs and COXIBs in Colon Cancer PreventionSulindacMalignant Tumors of the ColonEicosanoid pathway in colorectal cancer: Recent updatesThe Role of Inflammation in Colon CancereRapa Restores a Normal Life Span in a FAP Mouse ModelSulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/β-Catenin SignalingChemoprevention in familial adenomatous polyposisMolecular Alterations Associated with Sulindac-Resistant Colon Tumors in ApcMin/+ MiceCyclo-oxygenase-2 expression in photon-radiated and non-radiated uveal melanomasThe Safety and Efficacy of Celecoxib in Children With Familial Adenomatous PolyposisPrimary Prevention of Colorectal CancerNSAIDs: Old Drugs Reveal New Anticancer TargetsChemoprophylaxis in colorectal cancer: current concepts and a practical algorithm for useNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)Gastroduodenal involvement in patients with familial adenomatous polyposis. Prospective study of the nature and evolution of polyps: evaluation of the treatment and surveillance methods appliedAspirin for the Chemoprevention of Colorectal Adenomas: Meta-analysis of the Randomized TrialsPOLYPOSIS SYNDROMESCiclooxigenasa 2 y cáncer colorrectal: implicaciones terapéuticasNonsteroidal Anti-inflammatory