Cited by 81HIV Research and TreatmentHIV-related health complications and treatmentsHIV/AIDS Research and Interventions

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Plasma Cytokines, Cytokine Antagonists, and Disease Progression in African Women Infected with HIV-1

Thea, Donald M., Porat, Reuven, Nagimbi, Khondi, Baangi, Matela, St. Louis, Michael E., Kaplan, Gilla, Dinarello, Charles A., Keusch, Gerald T.·1996·Annals of Internal Medicine

DOI 10.7326/0003-4819-124-8-199604150-00009

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Abstract

OBJECTIVES: To examine the relation of circulating cytokines and cytokine antagonists to the progression of human immunodeficiency virus type 1 (HIV-1) disease. DESIGN: Cross-sectional analysis. SETTING: An ambulatory acquired immunodeficiency syndrome (AIDS) research clinic in Kinshasa, Zaire. PATIENTS: 48 women with AIDS, 51 women with HIV infection who were clinically asymptomatic, and 11 female controls who did not have HIV infection, all from Zaire. MEASUREMENTS: Plasma levels of interleukin-1beta, tumor necrosis factor-alpha (TNF-alpha), interleukin-6, interleukin-8, interferon-gamma, interleukin-1beta receptor antagonist (interleukin-1Ra), and TNF soluble receptor p55 (TNFsRp55) were assayed by specific radioimmunoassays. Plasma levels of interferon-gamma were assayed by commercial enzyme-linked immunosorbent assay. The Wilcoxon rank-sum test was used to assess the significance of mean and median differences between groups. RESULTS: Of the 48 patients with AIDS, circulating interleukin-1beta was detected in 2, TNF-alpha in 4, interleukin-6 in 3, and interleukin-8 in 12. None of these factors were seen in any of the 11 controls. Median values of interleukin-1beta (320 pg/mL), TNF-alpha (210 pg/mL), and interleukin-8 (750 pg/mL) were elevated in HIV-infected asymptomatic patients compared with patients with AIDS (2-, 2.6-, and 18.7-fold higher, respectively; P < 0.001). Interleukin-1Ra and TNFsRp55 levels were substantially higher than interleukin-1beta and TNF-alpha levels in HIV-infected asymptomatic patients (73- and 14-fold, respectively) and were higher than those in patients with AIDS (17.8- and 1.74-fold, respectively). CONCLUSION: High circulating levels of the proinflammatory cytokines interleukin-1beta and TNF-alpha, combined with an excess of their natural inhibitors interleukin-1Ra and TNF-sRp55, were seen in clinically asymptomatic HIV-1-positive African women but not in African women with AIDS or in HIV-negative controls. Circulating cytokine antagonists may play a clinical role in modulating cytokine-associated symptoms in the early phases of HIV infection.

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Authors: Thea, D. M., Porat, R., Nagimbi, K., Baangi, M., St. Louis, M. E., Kaplan, G., Dinarello, C. A., & Keusch, G. T.
Affiliations: Centers for Disease Control and Prevention (US)
From the New England Medical Center, Boston, Massachusetts; International Collaboration in AIDS Research Unit and Ministry of Health, Kinshasa, Zaire; Centers for Disease Control and Prevention, Atlanta, Georgia; and Rockefeller University, New York, New York.
Corresponding author: Thea, Donald M.
ORCID: Thea, Donald M.
Dinarello, Charles A.
Keusch, Gerald T.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 1996-04-15
Volume: 124
Issue: 8
Pages: 757-762
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-124-8-199604150-00009
OpenAlex: W1991721706
Cited by: 81
References: 0
Citations by year: 2026: 2 · 2024: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 3
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ai026698-03)
National Institute of Allergy and Infectious Diseases (AI 24755, P01-AI-26698, AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: HIV-1, AIDS, disease progression, plasma cytokines, cytokine antagonists, IL-1β, TNF-α, interleukin-6, interleukin-8, interferon-gamma, interleukin-1 receptor antagonist, inflammatory cytokines, asymptomatic HIV infection, African women
MeSH terms: Acquired Immunodeficiency Syndrome, Cross-Sectional Studies, Female, HIV Seropositivity, Humans, Nutritional Status, Democratic Republic of the Congo, Cytokines, Disease Progression

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Plasma Cytokines, Cytokine Antagonists, and Disease Progression in African Women Infected with HIV-1

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