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Cited by 528Lipoproteins and Cardiovascular HealthGenetic Associations and EpidemiologyParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease

Song, Yiqing, Stampfer, Meir J., Liu, Simin·2004·Annals of Internal Medicine
DOI 10.7326/0003-4819-141-2-200407200-00013
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Abstract

BACKGROUND: Apolipoprotein E (apoE) genotypes play critical roles in lipid metabolism and are believed to influence risk for coronary heart disease (CHD). Despite many population studies, however, the impact of apoE polymorphism on risk for CHD remains uncertain. PURPOSE: To qualitatively and quantitatively assess the evidence regarding the relation of apoE polymorphism to CHD risk. DATA SOURCES: All relevant reports and references from original and review papers published from 1966 to January 2004. STUDY SELECTION: Predefined criteria were used to identify 48 relevant studies. DATA EXTRACTION: A summary database that contained variables of study design, study sample and ethnicity, sex, apoE genotypes, CHD end points, plasma lipid levels, and other CHD risk factors was developed. DATA SYNTHESIS: The authors qualitatively evaluated many potential sources of heterogeneity. To quantify the extent of heterogeneity and assess the consistency of apoE-CHD associations, stratified analyses were conducted using the classic random-effects model. To further incorporate uncertainty due to between-study variation, the pooled odds ratios (ORs) and 95% credible intervals (CrIs) were estimated by using a Bayesian hierarchical model. Finally, the robustness of the pooled estimates was tested in multiple sensitivity analyses. Compared with individuals with the epsilon3/3 genotype, carriers of the apoE epsilon4 allele had a 42% higher risk for CHD (OR, 1.42 [95% CrI, 1.26 to 1.61]). The epsilon2 allele had no significant association with CHD risk (OR, 0.98 [CrI, 0.66 to 1.46]). LIMITATIONS: This meta-analysis did not include unpublished data or studies published in languages other than English. CONCLUSIONS: Inadequate statistical power, differences in geographic and ethnic background, allele frequency, sex, CHD phenotypes, study design, and potential gene-environment interactions may have contributed to the conflicting results of previous studies. The apoE epsilon4 allele is a significant risk factor for CHD.

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Crossref · 10.7326/0003-4819-141-2-200407200-00013

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2 retracted

Research works printed but not linked: 7

  1. Brouwer DA, 1997, West Indian Med J, 46, 47
  2. Yan S, 1999, Chin Med J (Engl), 112, 224
  3. de Andrade M, 1995, Am J Hum Genet, 56, 1379
  4. Weber M, 1997, Can J Cardiol, 13, 253
  5. Scaglione L, 1999, Nutr Metab Cardiovasc Dis, 9, 118
  6. Yang Z, 2001, Chin Med J (Engl), 114, 983
  7. Ordovas JM, 2001, Nutr Metab Cardiovasc Dis, 11, 118

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Metadata

Authors
Song, Y., Stampfer, M. J., & Liu, S.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2004-07-20
Volume
141
Issue
2
Pages
137-147
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-141-2-200407200-00013
OpenAlex
W2128519424
Cited by
528
References
94
Citations by year
2026: 7 · 2025: 9 · 2024: 14 · 2023: 10 · 2022: 14 · 2021: 15 · 2020: 13 · 2019: 23 · 2018: 14 · 2017: 15 · 2016: 23 · 2015: 27 · 2014: 38 · 2013: 22 · 2012: 38
FWCI
6.83
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL 26490)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 62290)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
apolipoprotein E, APOE polymorphism, coronary artery disease, APOE ε4, APOE ε2 allele, genetic risk factors, plasma lipids, lipid metabolism, gene-environment interaction
MeSH terms
Apolipoproteins E, Bayes Theorem, Coronary Disease, Genotype, Humans, Risk Factors, Sensitivity and Specificity, Genetic Heterogeneity, Lipid Metabolism

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