Age as a Risk Factor for Stroke in Atrial Fibrillation Patients

Marinigh, Ricarda; Lip, Gregory Y.H.; Fiotti, Nicola; Giansante, Carlo; Lane, Deirdre A.

doi:10.1016/j.jacc.2010.05.028

Cited by 232Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementVenous Thromboembolism Diagnosis and Management

Age as a Risk Factor for Stroke in Atrial Fibrillation Patients

Open access

Marinigh, Ricarda, Lip, Gregory Y.H., Fiotti, Nicola, Giansante, Carlo, Lane, Deirdre A.·2010·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2010.05.028

Open this paper in CoChat — free account

Abstract

The prevalence of atrial fibrillation (AF) is related to age and is projected to rise exponentially as the population ages and the prevalence of cardiovascular risk factors increases. The risk of ischemic stroke is significantly increased in AF patients, and there is evidence of a graded increased risk of stroke associated with advancing age. Oral anticoagulation (OAC) is far more effective than antiplatelet agents at reducing stroke risk in patients with AF. Therefore, increasing numbers of elderly patients are candidates for, and could benefit from, the use of anticoagulants. However, elderly people with AF are less likely to receive OAC therapy. This is mainly due to concerns about a higher risk of OAC-associated hemorrhage in the elderly population. Until recently, older patients were under-represented in randomized controlled trials of OAC versus placebo or antiplatelet therapy, and therefore the evidence base for the value of OAC in the elderly population was not known. However, analyses of the available trial data indicate that the expected net clinical benefit of warfarin therapy is highest among patients with the highest untreated risk for stroke, which includes the oldest age category. An important caveat with warfarin treatment is maintenance of a therapeutic international normalized ratio, regardless of the age of the patient, where time in therapeutic range should be > or =65%. Therefore, age alone should not prevent prescription of OAC in elderly patients, given an appropriate stroke and bleeding risk stratification.

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2010.05.028

Cites

82 of 82 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Elderly AF patients are at higher risk of stroke and thus are more likely to benefit from OAC than younger patients.
“Elderly AF patients are at higher risk of stroke and thus are more likely to benefit from OAC than younger patients, 841”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [841]

Dabigatran versus warfarin in patients with atrial fibrillation
Connolly, S. J., Ezekowitz, M. D., Yusuf, S., Eikelboom, J., Oldgren, J., Parekh, A., Pogue, J., Reilly, P. A., Themeles, E., Varrone, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905561 · Cited by 11,215 · see citing works
Atrial fibrillation as an independent risk factor for stroke: the Framingham study
Wolf, P. A., Abbott, R. D., & Kannel, W. B. (1991) · Stroke · doi:10.1161/01.str.22.8.983 · Cited by 7,388 · see citing works
Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach
Lip, G. Y. H., Nieuwlaat, R., Pisters, R., Lane, D. A., & Crijns, H. J. G. M. (2010) · Chest · doi:10.1378/chest.09-1584 · Cited by 6,879 · see citing works
Self-citation
Prevalence of Diagnosed Atrial Fibrillation in Adults: National Implications for Rhythm Management and Stroke Prevention: the AnTicoagulation and Risk Factors In Atrial Fibrillation (ATRIA) Study
Go, A. S., Hylek, E. M., Phillips, K. A., Chang, Y., Henault, L. E., Selby, J. V., & Singer, D. E. (2001) · JAMA · doi:10.1001/jama.285.18.2370 · Cited by 6,205 · see citing works
Validation of Clinical Classification Schemes for Predicting Stroke: Results From the National Registry of Atrial Fibrillation
Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001) · JAMA · doi:10.1001/jama.285.22.2864 · Cited by 4,832 · see citing works
Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
Hart, R. G., Pearce, L. A., & Aguilar, M. I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00007 · Cited by 4,793 · see citing works
A Novel User-Friendly Score (HAS-BLED) To Assess 1-Year Risk of Major Bleeding in Patients With Atrial Fibrillation
Pisters, R., Lane, D. A., Nieuwlaat, R., de Vos, C. B., Crijns, H. J. G. M., & Lip, G. Y. H. (2010) · CHEST Journal · doi:10.1378/chest.10-0134 · Cited by 4,517 · see citing works
Self-citation
Secular Trends in Incidence of Atrial Fibrillation in Olmsted County, Minnesota, 1980 to 2000, and Implications on the Projections for Future Prevalence
Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564 · see citing works
Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications
Feinberg, W. M. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.155.5.469 · Cited by 2,282 · see citing works
Effect of clopidogrel added to aspirin in patients with atrial fibrillation
The ACTIVE Investigators (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901301 · Cited by 2,102 · see citing works
Risk Factors for Stroke and Efficacy of Antithrombotic Therapy in Atrial Fibrillation
(1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420130036007 · Cited by 2,066 · see citing works
Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study
Lloyd-Jones, D. M., Wang, T. J., Leip, E. P., Larson, M. G., Levy, D., Vasan, R. S., D’Agostino, R. B., Massaro, J. M., Beiser, A., Wolf, P. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000140263.20897.42 · Cited by 2,041 · see citing works
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
(2006) · The Lancet · doi:10.1016/s0140-6736(06)68845-4 · Cited by 1,952 · see citing works
Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study
Heeringa, J., van der Kuip, D. A. M., Hofman, A., Kors, J. A., van Herpen, G., Stricker, B. H. C., Stijnen, T., Lip, G. Y. H., & Witteman, J. C. M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi825 · Cited by 1,939 · see citing works
Self-citation
Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
EAFT (European Atrial Fibrillation Trial) Study Group (1993) · The Lancet · doi:10.1016/0140-6736(93)92358-z · Cited by 1,877 · see citing works
PLACEBO-CONTROLLED, RANDOMISED TRIAL OF WARFARIN AND ASPIRIN FOR PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN CHRONIC ATRIAL FIBRILLATION
Petersen, P., GODTFREDSEN, J., Boysen, G., Andersen, E. D., & Andersen, B. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91200-2 · Cited by 1,814 · see citing works
Stroke Prevention in Atrial Fibrillation Study. Final results.
Prevention, S., & Atrial Fibrillation Investigators (1991) · Circulation · doi:10.1161/01.cir.84.2.527 · Cited by 1,696 · see citing works
Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial
Mant, J., Hobbs, F. R., Fletcher, K., Roalfe, A., Fitzmaurice, D., Lip, G. Y., & Murray, E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61233-1 · Cited by 1,556 · see citing works
Self-citation
The Effect of Low-Dose Warfarin on the Risk of Stroke in Patients with Nonrheumatic Atrial Fibrillation
The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators* (1990) · New England Journal of Medicine · doi:10.1056/nejm199011293232201 · Cited by 1,525 · see citing works
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation—Executive Summary
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.009 · Cited by 1,157 · see citing works
Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial
(1996) · The Lancet · doi:10.1016/s0140-6736(96)03487-3 · Cited by 1,092 · see citing works
Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation
Hylek, E. M., Evans‐Molina, C., Shea, C., Henault, L. E., & Regan, S. (2007) · Circulation · doi:10.1161/circulationaha.106.653048 · Cited by 1,054 · see citing works
PSYCHOSOMATIC MEDICINE
Lipowski, Z. J. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92478-7 · Cited by 944 · see citing works
Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
Connolly, S. J., Pogue, J., Eikelboom, J., Flaker, G., Commerford, P., Franzosi, M. G., Healey, J. S., & Yusuf, S. (2008) · Circulation · doi:10.1161/circulationaha.107.750000 · Cited by 870 · see citing works
A Risk Score for Predicting Stroke or Death in Individuals With New-Onset Atrial Fibrillation in the Community
Wang, T. J., Massaro, J. M., Levy, D. A., Vasan, R. S., Wolf, P. A., D’Agostino, R. B., Larson, M. G., Kannel, W. B., & Benjamin, E. J. (2003) · JAMA · doi:10.1001/jama.290.8.1049 · Cited by 779 · see citing works
Selecting Patients With Atrial Fibrillation for Anticoagulation: Stroke Risk Stratification in Patients Taking Aspirin
Gage, B. F., van Walraven, C., Pearce, L., Hart, R. G., Koudstaal, P. J., Boode, B. S. P., & Petersen, P. (2004) · Circulation · doi:10.1161/01.cir.0000145172.55640.93 · Cited by 749 · see citing works
Oral Anticoagulants vs Aspirin in Nonvalvular Atrial Fibrillation
van Walraven, C., Hart, R. G., Singer, D. E., Laupacis, A., Connolly, S. J., Petersen, P., Koudstaal, P. J., Chang, Y., & Hellemons, B. S. P. (2002) · JAMA · doi:10.1001/jama.288.19.2441 · Cited by 715 · see citing works
Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy
Hart, R. G., Pearce, L. A., Rothbart, R. M., McAnulty, J. H., ASINGER, R. W., & Halperin, J. L. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00489-1 · Cited by 662 · see citing works
The Net Clinical Benefit of Warfarin Anticoagulation in Atrial Fibrillation
Singer, D. E., Chang, Y., Fang, M. C., Borowsky, L. H., Pomernacki, N. K., Udaltsova, N., & Go, A. S. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-5-200909010-00003 · Cited by 655 · see citing works
Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study*1
STROKEPREVENTIONINATRIALFIBRIL (1994) · The Lancet · doi:10.1016/s0140-6736(94)91577-6 · Cited by 624 · see citing works
Why Do Patients With Atrial Fibrillation Not Receive Warfarin?
Bungard, T. J., Ghali, W. A., Teo, K. K., McAlister, F. A., & Tsuyuki, R. T. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.1.41 · Cited by 593 · see citing works
Warfarin Use among Ambulatory Patients with Nonvalvular Atrial Fibrillation: The AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
Go, A. S., Hylek, E. M., Borowsky, L. H., Phillips, K. A., Selby, J. V., & Singer, D. E. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-12-199912210-00004 · Cited by 586 · see citing works
Antithrombotic Therapy in Atrial Fibrillation
Singer, D. E., Albers, G. W., Dalen, J. E., Go, A. S., Halperin, J. L., & Manning, W. J. (2004) · CHEST Journal · doi:10.1378/chest.126.3_suppl.429s · Cited by 547 · see citing works
Independent predictors of stroke in patients with atrial fibrillation
The Stroke Risk in Atrial Fibrillation Working Group (2007) · Neurology · doi:10.1212/01.wnl.0000267275.68538.8d · Cited by 545 · see citing works
Advanced Age, Anticoagulation Intensity, and Risk for Intracranial Hemorrhage among Patients Taking Warfarin for Atrial Fibrillation
Fang, M. C., Chang, Y., Hylek, E. M., Rosand, J. M., Greenberg, S. M., Go, A. S., & Singer, D. E. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-10-200411160-00005 · Cited by 532 · see citing works
Factors Associated With Ischemic Stroke During Aspirin Therapy in Atrial Fibrillation
Hart, R. G., Pearce, L. A., McBride, R., Rothbart, R. M., & ASINGER, R. W. (1999) · Stroke · doi:10.1161/01.str.30.6.1223 · Cited by 532 · see citing works
Predictors of Thromboembolism in Atrial Fibrillation: I. Clinical Features of Patients at Risk
The Stroke Prevention in Atrial Fibrillation Investigators (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-1-1 · Cited by 476 · see citing works
Antithrombotic Therapy in Atrial Fibrillation
Albers, G. W., Dalen, J. E., Laupacis, A., Manning, W. J., Petersen, P., & Singer, D. E. (2001) · CHEST Journal · doi:10.1378/chest.119.1_suppl.194s · Cited by 391 · see citing works
Patients with nonvalvular atrial fibrillation at low risk of stroke during treatment with aspirin: Stroke Prevention in Atrial Fibrillation III Study
The SPAF III Writing Committee for the Stroke Prevention in Atrial Fibrillation Investigators (1998) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.279.16.1273 · Cited by 315 · see citing works
Effect of Age on Stroke Prevention Therapy in Patients With Atrial Fibrillation
van Walraven, C., Hart, R. G., Connolly, S. J., Austin, P. C., Mant, J., Hobbs, R. F., Koudstaal, P. J., Petersen, P., Pérez-Gómez, F., Knottnerus, J. A., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.526988 · Cited by 312 · see citing works
Echocardiographic Predictors of Stroke in Patients With Atrial Fibrillation
Atrial Fibrillation Investigators: Atrial Fibrillation, A. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.12.1316 · Cited by 303 · see citing works
Fixed Minidose Warfarin and Aspirin Alone and in Combination vs Adjusted-Dose Warfarin for Stroke Prevention in Atrial Fibrillation
Gulløv, A. L., Koefoed, B. G., Petersen, P., Pedersen, T. S., Andersen, E. D., GODTFREDSEN, J., & Boysen, G. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.14.1513 · Cited by 301 · see citing works
Warfarin treatment in patients with atrial fibrillation: Observing outcomes associated with varying levels of INR control
Morgan, C. L., McEwan, P. C., Tukiendorf, A., Robinson, P. A., Clemens, A., & Plumb, J. M. (2008) · Thrombosis Research · doi:10.1016/j.thromres.2008.09.016 · Cited by 295 · see citing works
Optimal Intensity of Warfarin Therapy for Secondary Prevention of Stroke in Patients with Nonvalvular Atrial Fibrillation
Yamaguchi, T. (2000) · Stroke · doi:10.1161/01.str.31.4.817 · Cited by 287 · see citing works
A randomised controlled trial of warfarin versus aspirin for stroke prevention in octogenarians with atrial fibrillation (WASPO)
Rash, A., Downes, T., Portner, R., Yeo, W. W., Morgan, N., & Channer, K. S. (2006) · Age and Ageing · doi:10.1093/ageing/afl129 · Cited by 283 · see citing works
Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation
Stroke Risk in Atrial Fibrillation Working Group (2008) · Stroke · doi:10.1161/strokeaha.107.501825 · Cited by 241 · see citing works
Risks and Benefits of Oral Anticoagulation Compared With Clopidogrel Plus Aspirin in Patients With Atrial Fibrillation According to Stroke Risk
Healey, J. S., Hart, R. G., Pogue, J. M., Pfeffer, M. A., Hohnloser, S. H., Caterina, R. D., Flaker, G., Yusuf, S., & Connolly, S. J. (2008) · Stroke · doi:10.1161/strokeaha.107.500199 · Cited by 225 · see citing works
Contrast sonography for detection of vesicoureteral reflux
Kaneko, K., Kuwatsuru, R., Fukuda, Y., Yamataka, A., Yabuta, K., Katayama, H., & Miyano, T. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92123-7 · Cited by 222 · see citing works
A clinical prediction rule to identify patients with atrial fibrillation and a low risk for stroke while taking aspirin
van Walraven, C., Hart, R. G., Wells, G. A., Petersen, P., Koudstaal, P. J., Gullov, A. L., Hellemons, B. S. P., Koefed, B. G., & Laupacis, A. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.8.936 · Cited by 209 · see citing works
Risk for systemic embolization of atrial fibrillation without mitral stenosis
Cabin, H. S., Clubb, K. S., Hall, C., Perlmutter, R. A., & Feinstein, A. R. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90323-s · Cited by 199 · see citing works
Patients with nonvalvular atrial fibrillation at low risk of stroke during treatment with aspirin. Stroke Prevention in Atrial Fibrillation III Study.
Cheung, R. (1998) · The HKU Scholars Hub (University of Hong Kong) · Cited by 189 · see citing works
Adjusted-dose warfarin versus aspirin for preventing stroke in patients with atrial fibrillation
Hart, R. G., Pearce, L. A., & Aguilar, M. I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-8-200710160-00018 · Cited by 173 · see citing works
Oral Anticoagulation Treatment in the Elderly
Palareti, G., Hirsh, J., Legnani, C., Manotti, C., D’Angelo, A., Pengo, V., Moia, M., Guazzaloca, G., Musolesi, S., & COCCHERI, S. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.470 · Cited by 140 · see citing works
Risk factors for thromboembolism during aspirin therapy in patients with atrial fibrillation: The stroke prevention in atrial fibrillation study
1 (1995) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/s1052-3057(10)80166-1 · Cited by 138 · see citing works
Risk factors for stroke in patients with nonrheumatic atrial fibrillation: A case-control study
Moulton, A. W., Singer, D. E., & Haas, J. S. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90008-l · Cited by 130 · see citing works
Risk Factors for Thromboembolic Complications in Chronic Atrial Fibrillation
Petersen, P. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.150.4.819 · Cited by 130 · see citing works
Bleeding Risk During Oral Anticoagulation in Atrial Fibrillation Patients Older Than 80 Years
Poli, D., Antonucci, E., Grifoni, E., Abbate, R., Gensini, G. F., & Prisco, D. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.046 · Cited by 129 · see citing works
Failure to prescribe warfarin to patients with nonrheumatic atrial fibrillation
Antani, M. R., Beyth, R. J., Covinsky, K. E., Anderson, P. A., Miller, D. G., Cebul, R. D., Quinn, L., & Landefeld, C. S. (1996) · Journal of General Internal Medicine · doi:10.1007/bf02598984 · Cited by 121 · see citing works
Effectiveness of fixed minidose warfarin in the prevention of thromboembolism and vascular death in nonrheumatic atrial fibrillation∗∗The investigators and institutions participating in the study are listed in the Appendix.
Pengo, V., Zasso, A., Barbero, F., Banzato, A., Nante, G., Parissenti, L., John, N., Noventa, F., & Volta, S. D. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00357-9 · Cited by 109 · see citing works
Antithrombotic treatment and the risk of death and stroke in patients with atrial fibrillation and a CHADS2 score=1
Gorin, L., Nonin, E., de Labriolle, A., Haguenoer, K., Cosnay, P., Babuty, D., Charbonnier, B., & Fauchier, L. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-10-0746 · Cited by 106 · see citing works
Should Patient Characteristics Influence Target Anticoagulation Intensity for Stroke Prevention in Nonvalvular Atrial Fibrillation?
Singer, D. E., Chang, Y., Fang, M. C., Borowsky, L. H., Pomernacki, N. K., Udaltsova, N. V., & Go, A. S. (2009) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.108.830232 · Cited by 106 · see citing works
Predictors of Major Vascular Events in Patients With a Transient Ischemic Attack or Minor Ischemic Stroke and With Nonrheumatic Atrial Fibrillation
van Latum, J. C., Koudstaal, P. J., Venables, G. S., van Gijn, J., Kappelle, L. J., & Algra, A. (1995) · Stroke · doi:10.1161/01.str.26.5.801 · Cited by 104 · see citing works
Mitral regurgitation reduces the risk of stroke in patients with nonrheumatic atrial fibrillation
Nakagami, H., Yamamoto, K., Ikeda, U., Mitsuhashi, T., Goto, T., & Shimada, K. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70231-5 · Cited by 98 · see citing works
Clinical Features and Functional Outcome of Intracerebral Hemorrhage in Patients Aged 85 and Older
Arboix, A., Vall‐Llosera, A., García‐Eroles, L., Massons, J., Oliveres, M., & Targa, C. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50109.x · Cited by 87 · see citing works
Female gender is a risk factor for stroke and thromboembolism in atrial fibrillation patients
Lip, G. Y. H., & Lane, D. A. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-02-0106 · Cited by 78 · see citing works
Self-citation
Prediction of Functional Outcome and In-Hospital Mortality After Admission With Oral Anticoagulant–Related Intracerebral Hemorrhage
Berwaerts, J., Dijkhuizen, R. S., Robb, O. J., & Webster, J. (2000) · Stroke · doi:10.1161/01.str.31.11.2558 · Cited by 78 · see citing works
Risk factors for stroke and other embolic events in patients with nonrheumatic atrial fibrillation.
Flegel, K. M., & Hanley, J. A. (1989) · Stroke · doi:10.1161/01.str.20.8.1000 · Cited by 71 · see citing works
Mortality and rate of stroke or embolism in atrial fibrillation during long‐term follow‐up in the embolism in left atrial thrombi (ELAT) study
Stöllberger, C., Chnupa, P., Abzieher, C., Länger, T., Finsterer, J., Klem, I., Hartl, E., Wehinger, C., & Schneider, B. (2004) · Clinical Cardiology · doi:10.1002/clc.4960270111 · Cited by 61 · see citing works
Postoperative Atrial Fibrillation - What Do We Really Know?
Banach, M., Kourliouros, A., Reinhart, K. M., Benussi, S., Mikhailidis, D. P., Jahangiri, M., Baker, W. L., Galanti, A., Rysz, J., Camm, A. J., et al. (2010) · Current Vascular Pharmacology · doi:10.2174/157016110791330807 · Cited by 59 · see citing works
Risk factors for thromboembolism in patients with paroxysmal atrial fibrillation
Inoue, H., & Atarashi, H. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01105-x · Cited by 52 · see citing works
Lower versus standard intensity oral anticoagulant therapy (OAT) in elderly warfarin-experienced patients with non-valvular atrial fibrillation
Cucchini, U., Denas, G., Davidson, B., Marzot, F., Jose, S. P., Iliceto, S., & Pengo, V. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-05-0311 · Cited by 44 · see citing works
Brief Intervention for Medical Inpatients with Unhealthy Alcohol Use
Merlo, L. J., Kumar, D., & Gold, M. S. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-8-200710160-00016 · Cited by 33 · see citing works
The Importance of Epidemiological Studies Should Not Be Downplayed
Feigin, V. L., & Howard, G. (2007) · Stroke · doi:10.1161/strokeaha.107.503250 · Cited by 31 · see citing works
Predictors of ischemic stroke in non-rheumatic atrial fibrillation
Yoshida, M., Nakamura, Y., Higashikawa, M., & Kinoshita, M. (1996) · International Journal of Cardiology · doi:10.1016/0167-5273(96)02726-x · Cited by 31 · see citing works
Bleeding risks with combination of oral anticoagulation plus antiplatelet therapy: Is clopidogrel any safer than aspirin when combined with warfarin?
Tay, K. H., Lane, D. A., & Lip, G. Y. H. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-10-0685 · Cited by 29 · see citing works
Self-citation
Predicción de eventos embólicos en pacientes con fibrilación auricular no valvular: evaluación del score CHADS2 en una población mediterránea
Ortiz, M. R., Romo, E., Mesa, D., Delgado, M., Anguita, M. P., Granados, A. L., Castillo, J. C., Arizón, J. M., & de Lezo, J. S. (2008) · Revista Española de Cardiología · doi:10.1157/13114954 · Cited by 27 · see citing works
Predictors of atrial fibrillation in patients following isolated surgical revascularization. A metaanalysis of 9 studies with 28 786 patients
Banach, M., Goch, A., Rysz, J., & Goch, J. H. (2007) · Cited by 24 · see citing works
Clinical research Predictors of atrial fibrillation in patients following isolated surgical revascularization. A metaanalysis of 9 studies with 28 786 patients
Banach, M., Misztal, M., Goch, A., Rysz, J., & Goch, J. H. (2007) · Archives of Medical Science · Cited by 18 · see citing works
Pathophysiological Insights into Atrial Fibrillation Following Cardiac Surgery: Implications for Current Pharmaceutical Design
Kairevičiūtė, D., Aidietis, A., & Lip, G. Y. H. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789105063 · Cited by 11 · see citing works
Self-citation
Predicting Embolic Events in Patients With Nonvalvular Atrial Fibrillation: Evaluation of the CHADS2 Score in a Mediterranean Population
Ortiz, M. R., Romo, E., Mesa, D., Delgado, M., Anguita, M. P., Granados, A. L., Castillo, J. C., Arizón, J. M., & de Lezo, J. S. (2008) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(08)60065-1 · Cited by 10 · see citing works
Bleeding rates in elderly patients on vitamin K antagonist therapy for nonvalvular atrial fibrillation
Tay, K.-H., Lip, G. Y. H., & Lane, D. A. (2009) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e32832aec47 · Cited by 6 · see citing works
Self-citation
Lessons Learnt in Implementation of ABCD Score in an Emergency Department
Bray, J., Bladin, C., Coughlan, K., & Patil, A. (2008) · Stroke · doi:10.1161/strokeaha.107.518431 · Cited by 5 · see citing works

Flagged first, then by citations

4 of the 86 references couldn’t be matched to a known paper.

Sorted by citations

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS).
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J., Blomström-Lundqvist, C., Boriani, G., Castellá, M., Dan, G., Dilaveris, P. E., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 2,605 · see citing works
Self-citation
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
Self-citation
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Self-citation
2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Europace · doi:10.1093/europace/eus027 · Cited by 2,722 · see citing works
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Calkins, H., Kuck, K., Cappato, R., Brugada, J., Camm, A., Chen, S.-A., Crijns, H., Damiano, R., Davies, D., Dimarco, J., et al. (2012) · Journal of interventional cardiac electrophysiology · doi:10.1007/s10840-012-9672-7 · Cited by 1,959 · see citing works
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.016 · Cited by 1,456 · see citing works
Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study
Olesen, J. B., Lip, G. Y. H., Hansen, M. L., Hansen, P. R., Tolstrup, J. S., Lindhardsen, J., Selmer, C., Ahlehoff, O., Olsen, A.-M. S., Gislason, G. H., et al. (2011) · BMJ · doi:10.1136/bmj.d124 · Cited by 1,428 · see citing works
Self-citation
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Self-citation
Use of the CHA 2 DS 2 -VASc and HAS-BLED Scores to Aid Decision Making for Thromboprophylaxis in Nonvalvular Atrial Fibrillation
Lane, D. A., & Lip, G. Y. H. (2012) · Circulation · doi:10.1161/circulationaha.111.060061 · Cited by 389 · see citing works
Self-citation
Atrial fibrillation and the risk of incident dementia: A meta-analysis
Santangeli, P., Biase, L. D., Bai, R., Mohanty, S., Pump, A., Brantes, M. C., Horton, R., Burkhardt, J. D., Lakkireddy, D., Reddy, Y. M., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.07.026 · Cited by 272 · see citing works
Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options—a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference
Kirchhof, P. F., Lip, G. Y. H., Gelder, I. C. V., Bax, J. J., Hylek, E. M., Kääb, S., Schotten, U., Wegscheider, K., Boriani, G., Brandes, A., et al. (2011) · EP Europace · doi:10.1093/europace/eur241 · Cited by 242 · see citing works
Self-citation
2020 Clinical guidelines for Atrial fibrillation and atrial flutter
Arakelyan, M. S., Bockeria, L. A., Vasilieva, E., Sp, G., Golukhova, E. Z., Gorev, M. V., Davtyan, K. V., Drapkina, O. M., Станиславовна, К. Е., Kuchinskaya, Е. А., et al. (2021) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2021-4594 · Cited by 255 · see citing works
Bleeding risk in ‘real world’ patients with atrial fibrillation: comparison of two established bleeding prediction schemes in a nationwide cohort
Olesen, J. B., Lip, G. Y. H., Hansen, P. R., Lindhardsen, J., Ahlehoff, O., Andersson, C., Weeke, P. E., Hansen, M. L., Gislason, G., & Torp-Pedersen, C. T. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04378.x · Cited by 201 · see citing works
Self-citation
Hypertension and atrial fibrillation: diagnostic approach, prevention and treatment. Position paper of the Working Group ‘Hypertension Arrhythmias and Thrombosis’ of the European Society of Hypertension
Manolis, A. J., Rosei, E. A., Coca, A., Cifkova, R., Erdine, S. E., Kjeldsen, S., Lip, G. Y. H., Narkiewicz, K., Parati, G., Redon, J., et al. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834f03bf · Cited by 198 · see citing works
Self-citation
Heart Failure in Elderly Patients: Distinctive Features and Unresolved Issues
Lazzarini, V., Mentz, R. J., Fiuzat, M., Metra, M., & O’Connor, C. M. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft028 · Cited by 188 · see citing works
Thromboembolic Risk, Bleeding Outcomes and Effect of Different Antithrombotic Strategies in Very Elderly Patients With Atrial Fibrillation: A Sub‐Analysis From the PREFER in AF ( PRE vention o F Thromboembolic Events– E uropean R egistry in A trial F ibrillation)
Patti, G., Lucerna, M., Pecen, L., Siller-Matula, J. M., Cavallari, I., Kirchhof, P. F., & Caterina, R. D. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005657 · Cited by 172 · see citing works
Time outside of therapeutic range in atrial fibrillation patients is associated with long-term risk of dementia
Jacobs, V., Woller, S. C., Stevens, S. M., May, H. T., Bair, T. L., Anderson, J. L., Crandall, B. G., Day, J. D., Johanning, K., Long, Y., et al. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.08.013 · Cited by 163 · see citing works
Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation
Fox, K. A. A., Lucas, J. E., Pieper, K. S., Bassand, J., Camm, A. J., Fitzmaurice, D. A., Goldhaber, S. Z., Goto, S., Haas, S. K., Hacke, W., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017157 · Cited by 152 · see citing works
Catheter Ablation of Atrial Fibrillation in Octogenarians: Safety and Outcomes
Santangeli, P., Biase, L. D., Mohanty, P. K., Burkhardt, J. D., Horton, R., Bai, R., Mohanty, S., Pump, A., Gibson, D. N., Couts, L., et al. (2012) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2012.02293.x · Cited by 149 · see citing works
Epidemiology of Atrial Fibrillation
Zhang, J., Johnsen, S. P., Guo, Y., & Lip, G. Y. H. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.10.010 · Cited by 146 · see citing works
Self-citation
Pharmacokinetics, safety, and tolerability of edoxaban in end-stage renal disease subjects undergoing haemodialysis
Marbury, T. C., Matsushima, N., Chen, S., Wickremasingha, P. K., He, L., Dishy, V., Brown, K. S., & Parasrampuria, D. A. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-06-0547 · Cited by 128 · see citing works
Risk Factors for Stroke and Thromboembolism in Relation to Age Among Patients With Atrial Fibrillation
Olesen, J. B., Fauchier, L., Lane, D. A., Taillandier, S., & Lip, G. Y. H. (2011) · CHEST Journal · doi:10.1378/chest.11-0862 · Cited by 107 · see citing works
Self-citation
Risk of Stroke or Systemic Embolism in Atrial Fibrillation Patients Treated With Warfarin: A Systematic Review and Meta-analysis
Albertsen, I. E., Rasmussen, L. H., Overvad, T. F., Graungaard, T., Larsen, T. B., & Lip, G. Y. H. (2013) · Stroke · doi:10.1161/strokeaha.113.000883 · Cited by 101 · see citing works
Self-citation
Current Status and Time Trends of Oral Anticoagulation Use Among Chinese Patients With Nonvalvular Atrial Fibrillation
Chang, S., Dong, J., Ma, C., Du, X., Wu, J., Tang, R., Xia, S., Guo, X., Yu, R., Long, D., et al. (2016) · Stroke · doi:10.1161/strokeaha.116.012988 · Cited by 97 · see citing works
Self-citation
Comprehensive risk reduction in patients with atrial fibrillation: Emerging diagnostic and therapeutic options
Lip, G. Y. H., Gelder, I. C. V., Bax, J. J., Hylek, E. M., Kääb, S., Schotten, U., Wegscheider, K., Boriani, G., Ezekowitz, M. D., Diener, H. C., et al. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-07-0517 · Cited by 91 · see citing works
Self-citation
Atrial Fibrillation in Older People: Concepts and Controversies
Zathar, Z., Karunatilleke, A., Fawzy, A. M., & Lip, G. Y. H. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00175 · Cited by 91 · see citing works
Self-citation
Underuse of Oral Anticoagulation for Individuals with Atrial Fibrillation in a Nursing Home Setting in France: Comparisons of Resident Characteristics and Physician Attitude
Bahri, O., Roca, F., Lechani, T., Druesne, L., Jouanny, P., Sérot, J., Boulanger, É., Puisieux, F. L., & Chassagne, P. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13200 · Cited by 89 · see citing works
Comparison of Atrial Fibrillation in the Young versus That in the Elderly: A Review
Sankaranarayanan, R., Kirkwood, G. J., Dibb, K. M., & Garratt, C. J. (2013) · Cardiology Research and Practice · doi:10.1155/2013/976976 · Cited by 78 · see citing works
Adherence to antithrombotic therapy guidelines improves mortality among elderly patients with atrial fibrillation: insights from the REPOSI study
On behalf of REPOSI investigators, Proietti, M., Nobili, A., Raparelli, V., Napoleone, L., Mannucci, P. M., & Lip, G. Y. H. (2016) · Clinical Research in Cardiology · doi:10.1007/s00392-016-0999-4 · Cited by 76 · see citing works
Self-citation
Enfermedad cardiovascular en el anciano
Jackson, C. F., & WENGER, N. K. (2011) · Revista Española de Cardiología · doi:10.1016/j.recesp.2011.05.001 · Cited by 68 · see citing works
Stroke risk in women with atrial fibrillation
Buhari, H., Fang, J., Han, L., Austin, P. C., Dorian, P., Jackevicius, C. A., Yu, A., Kapral, M. K., Singh, S. M., Tu, K., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad508 · Cited by 64 · see citing works
Stroke risk stratification in atrial fibrillation: a review of common risk factors
Oladiran, O. D., & Nwosu, I. F. (2019) · Journal of Community Hospital Internal Medicine Perspectives · doi:10.1080/20009666.2019.1593781 · Cited by 64 · see citing works
Increased burden of comorbidities and risk of cardiovascular death in atrial fibrillation patients in Europe over ten years: A comparison between EORP-AF pilot and EHS-AF registries
Proietti, M., Laroche, C., Nieuwlaat, R., Crijns, H. J. G. M., Maggioni, A. P., Lane, D. A., Boriani, G., & Lip, G. Y. H. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.05.016 · Cited by 59 · see citing works
Self-citation
Oral Anticoagulation in the Elderly and Frail
Bauersachs, R. M., & Herold, J. (2020) · Hämostaseologie · doi:10.1055/s-0040-1701476 · Cited by 60 · see citing works
Impact of advanced age on management and prognosis in atrial fibrillation: insights from a population-based study in general practice
Wolff, A., Shantsila, E., Lip, G. Y. H., & Lane, D. A. (2015) · Age and Ageing · doi:10.1093/ageing/afv071 · Cited by 58 · see citing works
Self-citation
Simplifying stroke risk stratification in atrial fibrillation patients: implications of the CHA2DS2-VASc risk stratification scores
Pamukçu, B., Lip, G. Y. H., & Lane, D. A. (2010) · Age and Ageing · doi:10.1093/ageing/afq059 · Cited by 57 · see citing works
Self-citation
Neural Stem Cell Plasticity: Advantages in Therapy for the Injured Central Nervous System
Ottoboni, L., Merlini, A., & Martino, G. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00052 · Cited by 55 · see citing works
Baseline Demographics and Clinical Characteristics in the All Nippon AF in the Elderly (ANAFIE) Registry
Koretsune, Y., Yamashita, T., Akao, M., Atarashi, H., Ikeda, T., Okumura, K., Shimizu, W., Tsutsui, H., Toyoda, Ḱ., Hirayama, A., et al. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0094 · Cited by 55 · see citing works
Stroke prevention in elderly patients with atrial fibrillation: challenges for anticoagulation
Sinnaeve, P., Brueckmann, M., Clemens, A., Oldgren, J., Eikelboom, J. W., & Healey, J. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02464.x · Cited by 54 · see citing works
Stroke in the elderly
Sharrief, A. Z., & Grotta, J. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00021-2 · Cited by 56 · see citing works
Cardiovascular Disease in the Elderly
Jackson, C. F., & WENGER, N. K. (2011) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2011.05.003 · Cited by 53 · see citing works
Age- and sex-specific analysis of patients with embolic stroke of undetermined source
Ntaios, G., Lip, G. Y. H., Vemmos, K. N., Korompoki, E., Manios, E. D., Vemmou, A., Rodríguez-Campello, A., Cuadrado‐Godia, E., Roquer, J., Arnao, V., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004199 · Cited by 53 · see citing works
Self-citation
Thromboembolic Prevention in Frail Elderly Patients With Atrial Fibrillation: A Practical Algorithm
Granziera, S., Cohen, A. T., Nante, G., Manzato, E., & Sergi, G. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.12.008 · Cited by 50 · see citing works
Anticoagulation in Patients Aged ≥75 years with Atrial Fibrillation: Role of Novel Oral Anticoagulants
Ng, K. H., Hart, R. G., & Eikelboom, J. W. (2013) · Cardiology and Therapy · doi:10.1007/s40119-013-0019-y · Cited by 49 · see citing works
GARFIELD-AF risk score for mortality, stroke, and bleeding within 2 years in patients with atrial fibrillation
Fox, K. A. A., Virdone, S., Pieper, K. S., Bassand, J., Camm, A. J., Fitzmaurice, D. A., Goldhaber, S. Z., Goto, S., Haas, S. K., Kayani, G., et al. (2021) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcab028 · Cited by 46 · see citing works
The CHADS 2 versus the New CHA 2 DS 2‐ VAS c Scoring Systems for Guiding Antithrombotic Treatment of Patients with Atrial Fibrillation: Review of the Literature and Recommendations for Use
Odum, L. E., Cochran, K. A., Aistrope, D. S., & Snella, K. A. (2012) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.2012.01023.x · Cited by 42 · see citing works
Atrial fibrillation and heart failure in the elderly
Kazemian, P., Oudit, G. Y., & Jugdutt, B. I. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9290-y · Cited by 42 · see citing works
New anticoagulant treatments to protect against stroke in atrial fibrillation
Potpara, T., Lip, G. Y. H., & Apostolakis, S. Z. (2012) · Heart · doi:10.1136/heartjnl-2012-301841 · Cited by 41 · see citing works
Self-citation
Barriers and enablers to adherence to anticoagulation in heart failure with atrial fibrillation: patient and provider perspectives
Ferguson, C., Inglis, S. C., Newton, P. J., Middleton, S., Macdonald, P. S., & Davidson, P. M. (2017) · Journal of Clinical Nursing · doi:10.1111/jocn.13759 · Cited by 41 · see citing works
Use of Warfarin in Elderly Patients With Non-Valvular Atrial Fibrillation – Subanalysis of the J-RHYTHM Registry –
Kodani, E., Atarashi, H., Inoue, H., Okumura, K., Yamashita, T., Origasa, H., & on behalf of the J-RHYTHM Registry Investigators (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0621 · Cited by 40 · see citing works
Atrial fibrillation: a geriatric perspective on the 2020 ESC guidelines
Polidori, M. C., Alves, M., Bahat, G., Boureau, A., Özkök, S., Pfister, R., Pilotto, A., Veronese, N., Bo, M., & on behalf of the Special Interest Group “Cardiovascular Diseases” of the EuGMS (2021) · European Geriatric Medicine · doi:10.1007/s41999-021-00537-w · Cited by 39 · see citing works
Out-of-range INR values and outcomes among new warfarin patients with non-valvular atrial fibrillation
Nelson, W. W., Wang, L., Başer, O., Damaraju, C. V., & Schein, J. R. (2014) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-014-0038-3 · Cited by 36 · see citing works
Impact of gender on event rates at 1 year in patients with newly diagnosed non-valvular atrial fibrillation: contemporary perspective from the GARFIELD-AF registry
Camm, A. J., Accetta, G., Almahmeed, W. A., Ambrosio, G., Goldhaber, S. Z., Haas, S. K., Janský, P., Kayani, G., Misselwitz, F., Oh, S., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-014579 · Cited by 38 · see citing works
Direct Oral Anticoagulants in Octogenarians With Atrial Fibrillation: It Is Never Too Late
Russo, V., Carbone, A., Rago, A., Golino, P., & Nigro, G. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000661 · Cited by 36 · see citing works
Clinical profile of direct oral anticoagulants versus vitamin K anticoagulants in octogenarians with atrial fibrillation: a multicentre propensity score matched real-world cohort study
Russo, V., Attena, E., Maio, M. D., Mazzone, C., Carbone, A., Parisi, V., Rago, A., D’Onofrio, A., Golino, P., & Nigro, G. (2019) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-019-01923-9 · Cited by 36 · see citing works
Identification of Markers Associated With Development of Stroke in “Clinically Low‐Risk” Atrial Fibrillation Patients
Shin, S. Y., Han, S. J., Kim, J. S., Im, S. I., Shim, J., Ahn, J., Lee, E. M., Park, Y. M., Kim, J. H., Lip, G. Y. H., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012697 · Cited by 36 · see citing works
Self-citation
Screening for undiagnosed atrial fibrillation in the community
Quinn, F. R., & Gladstone, D. (2014) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000018 · Cited by 34 · see citing works
Age Dependence of Risk Factors for Stroke and Death in Young Patients With Atrial Fibrillation
Melgaard, L., Rasmussen, L. H., Skjøth, F., Lip, G. Y. H., & Larsen, T. B. (2014) · Stroke · doi:10.1161/strokeaha.114.004903 · Cited by 33 · see citing works
Self-citation
Clinical outcome in Japanese elderly patients with non-valvular atrial fibrillation taking warfarin: A single-center observational study
Naganuma, M., Shiga, T., Sato, K., Murasaki, K., Hashiguchi, M., Mochizuki, M., & Hagiwara, N. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.11.005 · Cited by 32 · see citing works
Real‐World Clinical Characteristics and Treatment Patterns of Individuals Aged 80 and Older with Nonvalvular Atrial Fibrillation: Results from the ReAl‐life Multicenter Survey Evaluating Stroke Study
Biteker, M., Başaran, Ö., Doğan, V., Altun, İ., Karadeniz, F. Ö., Tekkeşin, A. İ., Çakıllı, Y., Türkkan, C., Hamidi, M., Demir, V., et al. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14855 · Cited by 32 · see citing works
Increased Risk of Stroke after Septicaemia: A Population-Based Longitudinal Study in Taiwan
Lee, J., Chung, W.-T., Lin, J., Peng, G., Muo, C., Lin, C., Wen, C.-P., Wang, I., Tseng, C., Kao, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089386 · Cited by 31 · see citing works
Major bleeding in users of direct oral anticoagulants in atrial fibrillation: A pooled analysis of results from multiple population‐based cohort studies
van den Ham, H. A., Souverein, P. C., Klungel, O. H., Platt, R. W., Ernst, P., Dell’Aniello, S., Schmiedl, S., Grave, B., Rottenkolber, M., Huerta, C., et al. (2021) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5317 · Cited by 31 · see citing works
Reasons for and consequences of vitamin K antagonist discontinuation in very elderly patients with non‐valvular atrial fibrillation
Bertozzo, G., Zoppellaro, G., Granziera, S., Marigo, L., Rossi, K., Petruzzellis, F., Perissinotto, E., Manzato, E., Nante, G., & Pengo, V. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13427 · Cited by 30 · see citing works
A review of the safety of anticoagulants in older people using the medicines management pathway: weighing the benefits against the risks
Bajorek, B. V. (2011) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098611400495 · Cited by 29 · see citing works
Lone atrial fibrillation - an overview
Potpara, T., & Lip, G. Y. H. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12281 · Cited by 28 · see citing works
Self-citation
Guía ESC 2020 sobre el diagnóstico y tratamiento de la fibrilación auricular, desarrollada en colaboración de la European Association of Cardio-Thoracic Surgery (EACTS)
Hindricks, G., Potpara, T. S., Dagres, N., Arbelo, E., Bax, J. J., Blomström-Lundqvist, C., Boriani, G., Castellá, M., Dan, G., Dilaveris, P. E., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.10.022 · Cited by 24 · see citing works
Self-citation
Novel Oral Anticoagulants in Cardiovascular Disease
Gallego, P., Roldán, V., & Lip, G. Y. H. (2013) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248413501392 · Cited by 27 · see citing works
Self-citation
Catheter Ablation for Atrial Fibrillation in Elderly Patients: an Updated Meta-analysis of Comparative Studies
Boehmer, A. A., Rothe, M., Ruckes, C., Eckardt, L., Kaess, B. M., & Ehrlich, J. R. (2024) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2024.08.263 · Cited by 26 · see citing works
Left atrial appendage occlusion for stroke prevention in diabetes mellitus patients with atrial fibrillation: Long‐term results
Litwinowicz, R. A., Bartuś, M., Ceranowicz, P., Brzeziński, M., Kapelak, B., Lakkireddy, D., & Bartuś, K. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12824 · Cited by 26 · see citing works
AF and Venous Thromboembolism - Pathophysiology, Risk Assessment and CHADS-VASc score.
Shariff, N., Aleem, A., Singh, M., Li, Y. Z., & Smith, S. J. (2012) · Europe PMC (PubMed Central) · doi:10.4022/jafib.649 · Cited by 25 · see citing works
Non‐vitamin K vs vitamin K oral anticoagulants in patients aged > 80 year with atrial fibrillation and low body weight
Russo, V., Attena, E., Maio, M. D., Carbone, A., Parisi, V., Rago, A., Grieco, F. V., Buonauro, A., Golino, P., & Nigro, G. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13335 · Cited by 25 · see citing works
Safety of direct oral anticoagulants in real–world clinical practice: translating the trials to everyday clinical management
Fawzy, A. M., Yang, W., & Lip, G. Y. H. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1578344 · Cited by 24 · see citing works
Self-citation
Clinical Guidelines on Frailty
Tkacheva, O. N., Kotovskaya, Y. V., Рунихина, Н. К., Frolova, E. V., Naumov, A. V., Vorobyeva, N. M., Сергеевна, О. В., Mkhitaryan, E. A., Шарашкина, Н. В., Tyukhmenev, E. A., et al. (2025) · Russian Journal of Geriatric Medicine · doi:10.37586/2686-8636-1-2025-6-48 · Cited by 28 · see citing works
Non-vitamin K antagonist oral anticoagulants: impact of non-adherence and discontinuation
Rivera‐Caravaca, J. M., Esteve‐Pastor, M. A., Roldán, V., Marín, F. R., & Lip, G. Y. H. (2017) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2017.1351542 · Cited by 23 · see citing works
Self-citation
Left Atrial Appendage Occlusion for Secondary Stroke Prevention in Patients with Atrial Fibrillation: Long-Term Results
Litwinowicz, R. A., Bartuś, M., Malec‐Litwinowicz, M., Michalski, M., Banaszkiewicz, K., Kapelak, B., Lakkireddy, D., & Bartuś, K. (2019) · Cerebrovascular Diseases · doi:10.1159/000500850 · Cited by 23 · see citing works
Electrophysiology and heart rhythm disorders in older adults.
Goyal, P., & Rich, M. W. (2016) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2016.08.001 · Cited by 23 · see citing works
Homocysteine in non-valvular atrial fibrillation: Role and clinical implications
Yao, Y., Shang, M., Dong, J., & Ma, C. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.10.012 · Cited by 22 · see citing works
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
Sawhney, J. P. S., Kothiwale, V. A., Bisne, V., Durgaprasad, R., Jadhav, P. P., Chopda, M., Vanajakshamma, V., Meena, R., Vijayaraghavan, G., Chawla, K., et al. (2018) · Indian Heart Journal · doi:10.1016/j.ihj.2018.09.001 · Cited by 22 · see citing works
Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke
Mao, Y., Kong, Q., Li, R., Zhang, X., Gui, Y., Li, Y., Li, C., Zhao, Y., Liu, L., & Ding, Z. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.03.006 · Cited by 21 · see citing works
Effect of advanced age on plasma homocysteine levels and its association with ischemic stroke in non-valvular atrial fibrillation.
Yao, Y., Gao, L., Zhou, Y., Zhao, J.-H., Lv, Q., Dong, J., & Shang, M. (2017) · PubMed Central · doi:10.11909/j.issn.1671-5411.2017.12.004 · Cited by 20 · see citing works
To treat or not to treat very elderly naïve patients with atrial fibrillation with vitamin K antagonists (VKA): results from the VENPAF cohort
Granziera, S., Bertozzo, G., Pengo, V., Marigo, L., Denas, G., Petruzzellis, F., Rossi, K., Infante, T., Jose, S. P., Perissinotto, E., et al. (2015) · Internal and Emergency Medicine · doi:10.1007/s11739-015-1236-2 · Cited by 20 · see citing works
Actualización en cardiología geriátrica
Dı́az-Castro, Ó., Datino, T., López‐Palop, R., & Martínez‐Sellés, M. (2011) · Revista Española de Cardiología · doi:10.1016/s0300-8932(11)70002-1 · Cited by 20 · see citing works
Atrial fibrillation and thromboprophylaxis in heart failure: the need for patient-centered approaches to address adherence
Ferguson, C., Inglis, S. C., Newton, P. J., Middleton, S., Davidson, P. M., & Macdonald (2013) · Vascular Health and Risk Management · doi:10.2147/vhrm.s39571 · Cited by 20 · see citing works
New Oral Anticoagulants in Nonvalvular Atrial Fibrillation
Fatima, U., Kulkarni, A., Stapleton, D. D., & Kaluski, E. (2016) · Clinical Cardiology · doi:10.1002/clc.22582 · Cited by 19 · see citing works
Atrial Fibrillation Is Not an Independent Determinant of Mortality Among Critically Ill Acute Ischemic Stroke Patients: A Propensity Score-Matched Analysis From the MIMIC-IV Database
Wu, C.-S., Chen, P., Chang, S., Lee, C., Yang, L., Chen, Y., & Jhou, H. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.730244 · Cited by 19 · see citing works
Oral Anticoagulant Use and Appropriateness in Elderly Patients with Atrial Fibrillation in Complex Clinical Conditions: ACONVENIENCE Study
Bonanad, C., Formiga, F., Anguita, M. P., Torregrossa, R. P., & Gullón, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247423 · Cited by 19 · see citing works
Catheter ablation of atrial fibrillation in the elderly: does the benefit outweigh the risk?
Kennedy, R. T., & Oral, H. (2013) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.13.2 · Cited by 19 · see citing works
A meta-epidemiological study of subgroup analyses in cochrane systematic reviews of atrial fibrillation
Paquette, M., Alotaibi, A., Nieuwlaat, R., Santesso, N. A., & Mbuagbaw, L. C. E. (2019) · Systematic Reviews · doi:10.1186/s13643-019-1152-z · Cited by 19 · see citing works
Real-world persistence to direct oral anticoagulants in patients with atrial fibrillation: a systematic review and network meta-analysis
Deitelzweig, S. B., Fusco, M. D., Kang, A. L., Savone, M., Mokgokong, R., Keshishian, A. V., Gutierrez, C., & Cappelleri, J. C. (2021) · Current Medical Research and Opinion · doi:10.1080/03007995.2021.1897555 · Cited by 19 · see citing works
Evaluation of the Risk of Stroke Without Anticoagulation Therapy in Men and Women With Atrial Fibrillation Aged 66 to 74 Years Without Other CHA2DS2-VASc Factors
Abdel-Qadir, H. M., Singh, S. M., Pang, A., Austin, P. C., Jackevicius, C. A., Tu, K., Dorian, P., & Ko, D. T. (2021) · JAMA Cardiology · doi:10.1001/jamacardio.2021.1232 · Cited by 18 · see citing works
Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan ― Insights From GARFIELD-AF ―
Koretsune, Y., Etoh, T., Katsuda, Y., Suetsugu, T., Kumeda, K., Sakuma, I., Eshima, K., Shibuya, M., Ando, S., Yokota, N., et al. (2018) · Circulation Journal · doi:10.1253/circj.cj-18-0655 · Cited by 18 · see citing works
Non-persistence to Oral Anticoagulation Treatment in Patients with Non-valvular Atrial Fibrillation in the USA
Dhamane, A. D., Hernandez, I., Fusco, M. D., Gutierrez, C., Ferri, M., Russ, C., Tsai, W.-L., Emir, B., Yüce, H., & Keshishian, A. V. (2021) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-021-00501-w · Cited by 18 · see citing works
Risk versus Benefit of Non-Vitamin K Dependent Anticoagulants Compared to Warfarin for the Management of Atrial Fibrillation in the Elderly
Ogbonna, K. C., & Jeffery, S. M. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0075-y · Cited by 17 · see citing works
Diving to the foot of an iceberg: The SEARCH for undiagnosed atrial fibrillation
Lane, D. A., & Potpara, T. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-05-0437 · Cited by 17 · see citing works
Self-citation
Treatment of Nonagenarians With Atrial Fibrillation: Insights From the Berlin Atrial Fibrillation (BAF) Registry
Wutzler, A., von Ulmenstein, S., Attanasio, P., Huemer, M., Parwani, A. S., Boldt, L., & Haverkamp, W. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.012 · Cited by 17 · see citing works
Stroke risk stratification scores in atrial fibrillation: current recommendations for clinical practice and future perspectives
Durrant, J., Lip, G. Y. H., & Lane, D. A. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.161 · Cited by 17 · see citing works
Self-citation
The problem of underdosing with direct-acting oral anticoagulants in elderly patients with nonvalvular atrial fibrillation
Fernández, C. S., Gullón, A., & Formiga, F. (2020) · Journal of Comparative Effectiveness Research · doi:10.2217/cer-2019-0197 · Cited by 17 · see citing works
CHA 2 DS 2 -VASc Scores and Major Bleeding in Patients With Nonvalvular Atrial Fibrillation Who Are Receiving Rivaroxaban
Peacock, W. F., Tamayo, S. G., Patel, M. R., Sicignano, N., Hopf, K. P., & Yuan, Ž. (2016) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2016.09.032 · Cited by 16 · see citing works
Device Closure or Antithrombotic Therapy After Cryptogenic Stroke in Elderly Patients With a High-Risk Patent Foramen Ovale
Lee, P. H., Kim, J., Song, J., Kwon, S. U., Kim, B. J., Lee, J. S., Sun, B. J., Woo, J. S., Ann, S. H., Suh, J., et al. (2024) · Journal of Stroke · doi:10.5853/jos.2023.03265 · Cited by 16 · see citing works
Microglial repopulation induced by PLX3397 protects against ischemic brain injury by suppressing neuroinflammation in aged mice
Li, X., Shan, J., Liu, X., Huang, Z., Xu, G., & Ren, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112473 · Cited by 16 · see citing works

Authors: Marinigh, R., Lip, G. Y. H., Fiotti, N., Giansante, C., & Lane, D. A.
Affiliations: University of Trieste (IT)
Birmingham City Hospital (GB)
Corresponding author: Lane, Deirdre A.
ORCID: Lip, Gregory Y.H.
Fiotti, Nicola
Giansante, Carlo
Lane, Deirdre A.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2010-09
Volume: 56
Issue: 11
Pages: 827-837
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2010.05.028
OpenAlex: W152570996
Cited by: 232
References: 86
Citations by year: 2026: 3 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 14 · 2019: 19 · 2018: 15 · 2017: 16 · 2016: 18 · 2015: 14 · 2014: 10 · 2013: 16 · 2012: 19
FWCI: 3.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1049 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Bayer Healthcare
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Keywords: atrial fibrillation, ischemic stroke, age as risk factor, oral anticoagulation, warfarin, antiplatelet therapy, bleeding risk, elderly patients, stroke risk stratification, time in therapeutic range, underrepresentation in clinical trials
MeSH terms: Age Factors, Atrial Fibrillation, Fibrinolytic Agents, Humans, Risk Factors, Treatment Outcome, Risk Assessment, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Age as a Risk Factor for Stroke in Atrial Fibrillation Patients

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks