The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications
Open accessAbstract
Leptin is a hormone secreted by adipose tissue in direct proportion to amount of body fat. The circulating leptin levels serve as a gauge of energy stores, thereby directing the regulation of energy homeostasis, neuroendocrine function, and metabolism. Persons with congenital deficiency are obese, and treatment with leptin results in dramatic weight loss through decreased food intake and possible increased energy expenditure. However, most obese persons are resistant to the weight-reducing effects of leptin. Recent studies suggest that leptin is physiologically more important as an indicator of energy deficiency, rather than energy excess, and may mediate adaptation by driving increased food intake and directing neuroendocrine function to converse energy, such as inducing hypothalamic hypogonadism to prevent fertilization. Current studies investigate the role of leptin in weight-loss management because persons who have recently lost weight have relative leptin deficiency that may drive them to regain weight. Leptin deficiency is also evident in patients with diet- or exercise-induced hypothalamic amenorrhea and lipoatrophy. Replacement of leptin in physiologic doses restores ovulatory menstruation in women with hypothalamic amenorrhea and improves metabolic dysfunction in patients with lipoatrophy, including lipoatrophy associated with HIV or highly active antiretroviral therapy. The applications of leptin continue to grow and will hopefully soon be used therapeutically.
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Cites
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Abnormal splicing of the leptin receptor in diabetic mice
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Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
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Leptin-Replacement Therapy for Lipodystrophy
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“5%, improves hyperlipidemia (57, 58), and reverses hepatic steatosis (53, 54).”
BackgroundA leptin missense mutation associated with hypogonadism and morbid obesity
Strobel, A., Issad, T., Camoin, L., Ozata, M., & Strosberg, A. D. (1998) · Nature Genetics · doi:10.1038/ng0398-213 · Cited by 1,158
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STAT3 signalling is required for leptin regulation of energy balance but not reproduction
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“The binding of leptin to the ObRb receptor activates several signal transduction pathways, including Janus kinase signal transducer and activator of transcription 3 (JAK-STAT3), which is important for regulation of energy homeostasis (15), and phosphatidylinositol 3-kinase (PI3K), which is important for regulation of…”
BackgroundRapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science · doi:10.1126/science.1089459 · Cited by 987 · cited 2×
“When administered in leptin-deficient mice, leptin has increased the number of synapses on neurons that secrete the anorexigenic neuropeptide proopiomelanocortin and decreased the number of synapses on neurons that secrete the orexigenic neuropeptide Y (26).”
Background
Cited by
Unravelling the effects of the environment and host genotype on the gut microbiome
Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509
Leptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593
Self-citationMeasuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin
Shah, N. R., & Braverman, E. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033308 · Cited by 554
Functions of interoception: From energy regulation to experience of the self
Quigley, K. S., Kanoski, S., Grill, W. M., Barrett, L. F., & Tsakiris, M. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.008 · Cited by 286
Frodermann, V., Rohde, D., Courties, G., Severe, N., Schloss, M. J., Amatullah, H., McAlpine, C. S., Cremer, S., Hoyer, F. F., Ji, F., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0633-x · Cited by 292
Metadata
- Authors
- Kelesidis, T., Kelesidis, I., Chou, S., & Mantzoros, C. S.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2010-01-19
- Volume
- 152
- Issue
- 2
- Pages
- 93-100
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2149166783
- Cited by
- 666
- References
- 29
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Kelesidis, T., Kelesidis, I., Chou, S., & Mantzoros, C. S. (2010). Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-152-2-201001190-00008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
