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Cited by 1,454

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Chemical Mutagens. Principles and Methods for Their Detection.

·1974·Annals of Internal Medicine

Abstract

This book discusses the development and validation of short-term assays designed to detect the mutagenic effects of environmental chemicals. Topics considered include the grasshopper neuroblast short-term assay for evaluating the effects of environmental chemicals on chromosomes and cell kinetics, a comparison of the mutagenic responses of lung-derived and skin-derived human diploid fibroblast populations, the L-arabinose resistance test with Salmonella typhimurium, the Bacillus subtilis multigene sporulation test for the detection of environmental mutagens, the L5178Y/TK gene mutation assay system, the induction of bacteriophage lambda by DNA-interacting chemicals, the granuloma pouch assay, the use of multiply marked Escherichia coli K12 strains in the host-mediated assay, and the detection of mutagens in human feces as an approach to the discovery of causes of colon cancer.

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Metadata

Venue
Annals of Internal Medicine
Published
1974-03-01
Volume
80
Issue
3
Pages
439-439
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
OpenAlex
W2141774935
Cited by
1,454
References
0
FWCI
31.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Chemical Mutagens. Principles and Methods for Their Detection. https://app.cochat.ai/papers/10.7326/0003-4819-80-3-439_4
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Chemical Mutagens. Principles and Methods for Their Detection. (1974). Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-80-3-439_4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.