The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Adriamycin Cardiotoxicity in Man
Abstract
Noninvasive methods to detect early adriamycin-induced cardiac injury and to follow the course of the injury were prospectively studied. Serial physical examinations, chest X rays, electrocardiograms (ECG), and systolic time interval measurements were done. The pre-ejection period to left ventricular ejection time (PEP/LVET) ratio increased in eight of nine patients receiving a cumulative dose of 310 to 540 mg/m2 body surface area of adriamycin. Heart size increased in only two of these patients, and ECG changed in only one. PEP/LVET ratios improved 2 to 6 months after cessation of therapy. Persistently abnormal ratios improved in three of four patients after treatment with digoxin. Patients receiving a cumulative dose of 56 to 290 mg/m2 body surface area of adriamycin showed transient worsening of PEP/LVET ratios that returned to normal by 1 month after therapy. Patients receiving other chemotherapeutic agents had no increase in PEP/LVET ratios. Systolic time interval measurements are valuable in detecting early cardiotoxicity and in reducing the risk of life-threatening heart failure in patients receiving adriamycin.
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Citations
Cites
Systolic Time Intervals in Heart Failure in Man
WEISSLER, A. M., HARRIS, W. S., & SCHOENFELD, C. D. (1968) · Circulation · doi:10.1161/01.cir.37.2.149 · Cited by 1,217
Cited by
A critical review of the systolic time intervals.
Lewis, R. P., Rittogers, S. E., Froester, W. F., & Boudoulas, H. (1977) · Circulation · doi:10.1161/01.cir.56.2.146 · Cited by 624
Self-citationBRISTOW, M. R., MASON, J. W., BILLINGHAM, M. E., & DANIELS, J. R. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-88-2-168 · Cited by 417
Hassan, S., & Turner, P. (1983) · Postgraduate Medical Journal · doi:10.1136/pgmj.59.693.423 · Cited by 79
Metadata
- Authors
- RINEHART, J. J., LEWIS, R. P., & BALCERZAK, S. P.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1974-10-01
- Volume
- 81
- Issue
- 4
- Pages
- 475-478
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2024013564
- Cited by
- 190
- References
- 1
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Adriamycin Cardiotoxicity in Man. https://app.cochat.ai/papers/10.7326/0003-4819-81-4-475
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- RINEHART, J. J., LEWIS, R. P., & BALCERZAK, S. P. (1974). Adriamycin Cardiotoxicity in Man. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-81-4-475
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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