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Cited by 428

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The Prevention of Hepatitis B with Vaccine: Report of the Centers for Disease Control Multi-Center Efficacy Trial Among Homosexual Men

FRANCIS, DONALD P., HADLER, STEPHEN C., THOMPSON, SUMNER E., MAYNARD, JAMES E., OSTROW, DAVID G., ALTMAN, NORMAN, BRAFF, ERWIN H., O'MALLEY, PAUL, HAWKINS, DONALD, JUDSON, FRANKLYN N., PENLEY, KENT, NYLUND, THOM, CHRISTIE, GRAHAM, MEYERS, FRANK, MOORE, JOSEPH N., GARDNER, ANN, DOTO, IRENE L., MILLER, JOE H., REYNOLDS, GLADYS H., MURPHY, BERT L., SCHABLE, CHARLES A., CLARK, BRIAN T., CURRAN, JAMES W., REDEKER, ALLAN G.·1982·Annals of Internal Medicine
DOI 10.7326/0003-4819-97-3-362
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Abstract

A randomized, double-blind, vaccine/placebo trial of the Merck 20-micrograms hepatitis B virus (HBV) vaccine was done among 1402 homosexual men attending venereal disease clinics in five American cities. Vaccination was followed by only minimal side effects. Two doses of vaccine induced antibody in 80% of vaccine recipients. A booster dose 6 months after the first dose induced antibody in 85% of recipients and markedly increased the proportion of recipients who produced high antibody titers. The incidence of HBV events was markedly less in the vaccine recipients compared to that in the placebo recipients (p = 0.0004). Between month 3 and 15 after the first dose, 56 more significant HBV events (hepatitis, or hepatitis B surface antigen positive, or both) occurred in the placebo group while only 11 occurred in the vaccine group. Ten of the 11 HBV events in the vaccine recipients occurred in hypo- or nonresponders to the vaccine. This vaccine appears to be safe, immunogenic, and efficacious in preventing infection with hepatitis B virus.

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Metadata

Authors
FRANCIS, D. P., HADLER, S. C., THOMPSON, S. E., MAYNARD, J. E., OSTROW, D. G., ALTMAN, N., BRAFF, E. H., O'MALLEY, P., HAWKINS, D., JUDSON, F. N., PENLEY, K., NYLUND, T., CHRISTIE, G., MEYERS, F., MOORE, J. N., GARDNER, A., DOTO, I. L., MILLER, J. H., REYNOLDS, G. H., MURPHY, B. L., SCHABLE, C. A., CLARK, B. T., CURRAN, J. W., & REDEKER, A. G.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1982-09-01
Volume
97
Issue
3
Pages
362-366
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-97-3-362
OpenAlex
W2137842517
Cited by
428
References
0
FWCI
38.40
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Prevention of Hepatitis B with Vaccine: Report of the Centers for Disease Control Multi-Center Efficacy Trial Among Homosexual Men. https://app.cochat.ai/papers/10.7326/0003-4819-97-3-362
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FRANCIS, D. P., HADLER, S. C., THOMPSON, S. E., MAYNARD, J. E., OSTROW, D. G., ALTMAN, N., BRAFF, E. H., O'MALLEY, P., HAWKINS, D., JUDSON, F. N., PENLEY, K., NYLUND, T., CHRISTIE, G., MEYERS, F., MOORE, J. N., GARDNER, A., DOTO, I. L., MILLER, J. H., REYNOLDS, G. H., . . . REDEKER, A. G. (1982). The Prevention of Hepatitis B with Vaccine: Report of the Centers for Disease Control Multi-Center Efficacy Trial Among Homosexual Men. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-97-3-362

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.